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7381407 |
Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods...
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7361347 |
Cytotoxic CD44 antibody immunoconjugates
The invention relates to novel conjugates of CD44 antibodies with cytotoxic compounds, pharmaceutical compositions comprising such compounds, and their use in tumor therapy.
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7357914 |
Use of metal chelates in human or animal feeding
The present invention relates to the use in human and animal nutrition (monogastric and polygastric animals) of known chelates of bivalent metal Mg, Ca, Mn, Co, Cu, Zn and Fe with methionine...
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7348453 |
Labile linkage for compound delivery to a cell
Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The...
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7332164 |
Heterobifunctional polymeric bioconjugates
Heterobifunctional polymeric prodrug platforms for delivering biologically active compounds, including proteins, monoclonal antibodies and the like are disclosed. One preferred compound is
...
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7320791 |
Monoclonal antibody for analysis and clearance of polyethylene glycol and polyethylene glycol-modified molecules
A novel anti-polyethylene glycol monoclonal antibody and its preparation are disclosed. Such an antibody can be used for determining polyethylene glycol concentration in vitro or accelerating the...
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7306782 |
Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases
The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide...
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7303749 |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for...
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7229620 |
Method for radiolabeling antibodies with yttrium-90
Methods and kits for radiolabeling proteins, peptides and ligands with radiolytic isotopes, particularly yttrium-90, are disclosed, whereby sufficient purity, specific activity and binding affinity...
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7189816 |
Compounds
An antibody, or a derivate or a fragment thereof, having a binding structure for a target structure is described. The antibody is displayed in, and on the cell surface of, human gastrointestinal...
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7163680 |
Treatment and diagnosis of cancer
The present invention is directed to the use of antibodies or binding portions thereof, probes, ligands, or other biological agents which either recognize an extracellular domain of prostate...
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7147917 |
Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
Water-dispersible nanoparticles are prepared by applying a coating of a multiply amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic...
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7147856 |
Stable radioiodine conjugates and methods of their synthesis
Methods are described for conjugating radioiodinated peptides or carbohydrate structures to proteins with improved yields and qualities of conjugates. In one method, specially designed...
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7129327 |
Polypeptide and protein derivatives and process for their preparation
Protein and polypeptid derivatives and their salts are claimed characterized in that a protein or polypeptide is conjugated via an intermediate grouping containing at least one radical of the...
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7122189 |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
Activated polymeric bicine derivatives such as
as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
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7118745 |
Engineering antibodies that bind irreversibly
The present invention provides a mutant antibody comprising a reactive site not present in the wild-type of the antibody and a complementarity-determining region that specifically binds to a metal...
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7108915 |
Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
Water-dispersible nanoparticles are prepared by applying a coating of a multiply amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic...
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7105160 |
Antibody-serum protein hybrids
Hybrid proteins are described which comprise one or more antigen-binding antibody fragments covalently linked to one or more serum carrier proteins. The hybrid proteins can bind antigens, have a...
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7097835 |
Immunoselective targeting agents and methods of use thereof
The present invention provides immunoselective targeting agents that bind to transporters that are transiently accessible on the surface of neuronal cells, and that deliver compounds selectively to...
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7087229 |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
Activated polymeric bicine derivatives such as,
as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
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7048925 |
Acid-sensitive polyacetals and methods
Polyacetals comprising a recurring units represented by a formula selected from the group consisting of formula (I) and (II):
wherein A comprises at least one acetal group; B is selected...
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7045605 |
Modified antibodies to prostate-specific membrane antigen and uses thereof
Modified antibodies, or antigen-binding fragments thereof, to the extracellular domain of human prostate specific membrane antigen (PSMA) are provided. The modified anti-PSMA antibodies, or...
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7012135 |
Biological products
There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein...
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7001994 |
Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins
Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose 6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl...
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6998106 |
Radioconjugation of internalizing antibodies
Antibodies to cell surface ligands such as EGFRvIII can be used to therapeutically or diagnostically deliver a radiolabel to tumor cells with high selectivity. The utility of radioconjugated...
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6994840 |
Kit for radiolabeling ligands with yttrium-90
Methods and kits for radiolabeling proteins, peptides and ligands with radiolytic isotopes, particularly yttrium-90, are disclosed, whereby sufficient purity, specific activity and binding affinity...
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6953568 |
Targeting of molecules to large vessel endothelium using EPCR
Endothelial protein C receptor (EPCR) is found primarily on endothelial cells of large vessels. EPCR translocates from the plasma membrane surface to the nucleus. Molecules which bind to EPCR can...
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RE38827 |
Adhesive sealant composition
This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first...
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6890533 |
Betulinol derivatives
The present invention is directed to betulinol derivatives and betulinol-antibody conjugates having the formulae:
and
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6878374 |
Biodegradable polyacetals
A polymer comprising recurring units represented by formula (I):
wherein X is selected from the group consisting of C(O)OR 1 , C(O)SR 1 , C(O)NR 1 R 2 , and VZ, where R 1 and R 2 are...
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6814964 |
Supramolecules containing binding and therapeutic molecules bound to hybridized nucleic acids
A supramolecule has a first supramolecular component including a first effector molecule covalently joined to a first nucleic acid, and a second supramolecular component including a second effector...
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6800296 |
Modification of surfaces using biological recognition events
The present invention provides a novel surface engineering strategy that uses biomolecular interactions to immobilize surface modifying ligands on biomaterial architectures. The surface modified...
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6759509 |
Branched peptide linkers
Conjugates containing a targeting ligand, such as an antibody, a therapeutically active drug and a branched peptide linker. The branched peptide linker contains two or more amino acid moieties that...
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6756037 |
Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups
The present invention is directed to polymer conjugates of biologically active agents and methods of preparing the same. In preferred aspects of the invention, the conjugates are of the formula ...
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6737267 |
Non-peptidyl moiety-conjugated CD4-gamma2 and CD4-IgG2 immunoconjugates, and uses thereof
This invention provides an immunoconjugate which comprises 1) a non-peptidyl toxin and 2) a CD4-gamma2 chimeric heavy chain homodimer linked thereto. This invention also provides an immunoconjugate...
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6716410 |
Reagents and methods for diagnosing, imaging and treating atherosclerotic disease
The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL...
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6709652 |
Pretargeting methods and compounds
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for...
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6685912 |
Post-labeling stabilization of radiolabeled proteins and peptides
The subject invention relates to the use of ascorbic acid and derivatives thereof in stabilizing radiolabeled proteins and peptides against oxidation loss of radiolabel and autoradiolysis. Ascorbic...
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6677164 |
Multivalent polymers, processes for their preparation, and their use for preparing biologically active compounds
The present invention provides biologically active linear polypeptides that possess a plurality of biologically active groups, methods employing such peptides to target molecules to cells, and...
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6676941 |
Antibody conjugate formulations for selectively inhibiting VEGF
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
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6663861 |
Method of producing antibodies by immunization with conjugates of molecules coupled to charge-modified proteins
A method for raising antibodies against molecules, particularly molecules with low immunogenicity, by coupling the molecule to a carrier containing a balanced charge mixture of proteins is...
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6660267 |
Prevention and treatment of sepsis
Compositions and methods are described for preventing and treating sepsis in humans and animals. Surgical patients, low birth weight infants, and burn and trauma victims can be treated...
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6656876 |
Squaric acid activated carrier usable for immobilization of compounds containing amine groups
A storage stable composition comprising a carrier usable for the immobilization of compounds containing an amine group, for instance biomolecules and/or affinity ligands. The carrier has been...
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6653104 |
Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
The present invention relates to immunotoxins that effectively kill malignant cells having a given marker. The immunotoxins are reagents that comprise internalizing antibodies conjugated to...
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6653084 |
Anti-erbB-2 antibodies to human receptor related to but distinct from EGF receptor
The isolation, cloning and characterization of a human gene related to but distinct from the EGF receptor gene has been described. Nucleotide sequence of the gene and amino acid sequence of the...
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6645494 |
Anti-CD40L immunotoxins for the treatment of diseases
An immunotoxin molecule is described which comprises an antibody specific for human CD40L antigen located on the surface of a human cell, coupled to a toxin molecule or active fragment thereof,...
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6630579 |
Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
A cytotoxic agent comprising one or more modified doxorubicins/daunorubicin linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a...
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6623926 |
Methods for producing 5′-nucleic acid-protein conjugates
Disclosed herein is a method for generating a 5′-nucleic acid-protein conjugate, the method involving: (a) providing a nucleic acid which carries a reactive group at its 5′ end; (b) providing a...
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6620413 |
OB protein-polymer chimeras
The present invention concerns long-half derivative of the obesity protein OB. The invention specifically concerns OB protein-immunoglobulin chimeras and polyethylene glycol (PEG)-OB derivatives,...
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RE38008 |
Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof
Methods for improved targeting of antibody, antibody fragments, peptides hormones, steroid hormones and conjugates thereof are disclosed. Enhanced delivery to target cells of antibodies or...
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