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7390627 |
Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins
Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the...
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7390488 |
Compositions and methods for producing vascular occlusion
The present invention relates generally to methods and compositions for targeting, delivering, and activating platelet-dependent vascular occlusion agents. In particular, antibodies carrying...
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7378091 |
Antibodies against carbonic anhydrase IX (CA IX) tumor antigen
The present invention relates generally to the generation and characterization of anti-CA IX monoclonal antibodies. The invention further relates to the use of such anti-CA IX antibodies in the...
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7375192 |
Antibodies that specifically bind to chemokine beta-4
The present invention relates to antibodies and related molecules that specifically bind to CK-B4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as...
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7371534 |
Sensitive intracellular calcium assay
A sensitive intracellular calcium assay is disclosed comprising conveniently a reagent comprised of a dye precursor capable of entering cells and being hydrolyzed to a dye, whereby the dye...
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7368113 |
Hormonally up-regulated, neu-tumor-associated kinase
This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the nucleotide sequence encoding it....
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7365127 |
Process for the preparation of polymer conjugates
A process for efficiently preparing polymer conjugates such as branched PEG-polypeptide conjugates, in large scale without column chromatography clean up of the activated PEG linkers to remove...
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7364862 |
Method of diagnosing, monitoring, staging, imaging and treating prostate cancer
The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating prostate cancer.
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7361347 |
Cytotoxic CD44 antibody immunoconjugates
The invention relates to novel conjugates of CD44 antibodies with cytotoxic compounds, pharmaceutical compositions comprising such compounds, and their use in tumor therapy.
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7361346 |
Therapeutic compositions that produce an immune response
The invention provides a method for stimulating the production of antibodies to a cryptic epitope on a soluble antigen by administering to a patient having such a cryptic epitope a binding agent...
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7361338 |
Methods to inhibit growth of prostate cancer cells
A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is...
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7358340 |
PRO19563 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7357930 |
Methods and formulations for targeting infectious agents bearing host cell proteins
A formulation is disclosed for the treatment of diseases caused by an infectious agent which acquires host membranes protein during its life cycle. The formulation is a targeting pharmaceutical...
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7354587 |
Use of immunoconjugates to enhance the efficacy of multi-stage cascade boosting vaccines
Humoral and cellular immune responses against tumor cells and infectious agents are induced in a mammal using a vaccine comprising immunoconjugates that comprise antibodies and anti-idiotype...
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7351797 |
Labeled peptides, and processes and intermediates useful for their preparation
The invention provides intermediates and methods that allow for site-specific modification of peptides after synthesis. Accordingly, functional molecules can be selectively linked to a peptide to...
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7341730 |
Inhibitors of angiogenesis and tumor growth
This invention provides for polypeptides that have surprising anti-angiogenic activity. These peptides are derived from Saposin B, a previously known protein involved in the hydrolysis of...
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7341728 |
Internalisation of virus into cells
A chimeric transmembrane protein which promotes viral entry into cells comprises: (i) an extracellular domain capable of binding a virus; and (ii) an intracellular internalisation signal.
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7335759 |
Recombinant immunogens for the generation of antivenoms to the venom of scorpions of the genus Centruroides
The invention concerns genes and fusion of genes that code for scorpion toxins and the corresponding polypeptides. The invention also concerns the use of the polypeptides as immunogens for the...
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7320786 |
Photodynamic therapy treatment for eye disease
This invention discloses methods, kits, and instructions to treat neovasculature diseases of the eye through the administration of a targeted photosensitizing agent and subsequent exposure to light...
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7318924 |
Antibodies against cancer
An isolated binding partner of a Cripto-1 protein, Pim-1 protein or an antigen present in a colon cancer cell lysate is described. The binding partner inhibits growth of one or more cancer cell...
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7318921 |
Therapeutic compositions that alter the immune response
The invention is therapeutic methods and compositions that alter the immunogenicity of the host.
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7311911 |
Methods for inhibiting angiogenesis
The present invention provides methods for reducing or inhibiting angiogenesis in a tissue, by contacting α5β1 integrin in the tissue with an agent that interferes with the specific binding of...
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7311906 |
Anti-viral activity of an anti-thymidine kinase monoclonal antibody
Monoclonal antibodies to thymidine kinase 1 are disclosed which are useful in methods of detecting, diagnosing, and treating viral infection.
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7309776 |
PRO12970 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7306782 |
Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases
The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide...
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7303926 |
Methods and compositions for dual phototherapy
The present invention discloses dye-azide derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds of the present invention may contain either a mixture...
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7303749 |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for...
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7297336 |
Factor IXa specific antibodies displaying factor VIIIa like activity
Ligands such as antibodies that can bind factor IX/factor IXa and increase the procoagulant activity of factor IXa (FIXa), pharmaceutical compositions containing such ligands, methods for treating...
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7288255 |
Prevention of immunoreactivity by depleting or inhibiting antigen presenting cells
The invention includes compositions and methods for depleting antigen presenting cells, or for impairing the biological function of antigen presenting cells, which compositions are useful for...
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7288254 |
Use of immunotoxins to induce immune tolerance to pancreatic islet transplantation
The invention provides a method of treating diabetes in a subject, comprising administering to the diabetic subject an immunotoxin, thereby reducing the subject's T-cell population, and...
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7288247 |
Antibodies for use in targeted and temporary treatment of humans and animals
An antibody or an antibody fragment that binds to an epitope under specifically chosen conditions; the binding of which to the epitope is broken under specifically chosen different conditions....
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7282567 |
Monoclonal antibody hPAM4
This invention relates to monovalent and multivalent, monospecific antibodies and to multivalent, multispecific antibodies. One embodiment of these antibodies has one or more identical binding...
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7282342 |
Methods for detecting weakly immunogenic analytes
GPE antibodies recognize GPE with high specificity. When used in a radioimmunoassay, they reliably measure the concentration of GPE. They may be used to extend the half-life of GPE both in vivo and...
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7276488 |
Vector system
The present invention provides a vector system comprising a nucleotide sequence coding for an antibody. In particular, the present invention relates to the use of such a vector system in a subject,...
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7273932 |
Antisense oligonucleotides for fertility and menstrual cycle regulation and for chemopreventive and chemotherapeutic use
The invention relates to antisense oligonucleotides, in particular to antisense oligonucleotides to receptor genes, and the use of such oligonucleotides to regulate reproductive function and as...
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7267820 |
Neurotransmission disorders
There is disclosed a method for diagnosing neurotransmission or developmental disorders in a mammal comprising the step of detecting in a bodily fluid of said mammal autoantibodies to an epitope of...
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7264805 |
Proteins with a high immunoreactivity and a method for the production thereof
The invention relates to (glyco-) proteins, in particular monoclonal antibodies, which have an immunoreactivity of >81%, preferably >90%. The inventive monoclonal antibodies are produced...
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7256004 |
Variants of humanized anti-carcinoma monoclonal antibody CC49
The invention is directed towards mouse-human chimeric variants of CC49 monoclonal antibodies with minimal murine content. A first aspect of the invention provides CDR variants of humanized...
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7247302 |
Method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
The present invention provides a method for inhibiting immunoglobulin-induced toxicity resulting from immunotherapy in a subject comprising administering an immunoglobulin or Ig fusion protein...
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7238786 |
Monoclonal antibody cPAM4
This invention relates to monovalent and multivalent, monospecific antibodies and to monovalent and multivalent, multispecific antibodies. One embodiment of these antibodies has one or more...
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7232888 |
Antibodies against tumor surface antigens
The present invention relates to improved antibodies against tumor surface antigens and their use in the treatment of tumors. Of particular interest are highly stable, humanized, high affinity...
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7230082 |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7226601 |
Conjugate between a modified superantigen and a target-seeking compound and the use of the conjugate
A method for the treatment of a disease in a mammal by administering a therapeutically effective amount of a conjugate comprising a biospecific affinity counterpart and a peptide, wherein the...
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7226596 |
Compositions and methods for the treatment of tumors
The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the...
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7226595 |
Modified Chimeric superantigens and their use
A conjugate between a target-seeking moiety and a modified superantigen, characterized in that the superantigen is a wild-type superantigen (SA I) in which an amino acid residue in a superantigen...
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7223844 |
Broadly cross-reactive neutralizing antibodies against human immunodeficiency virus selected by Env-CD4-co-receptor complexes
The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4,...
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7223397 |
Potentiation of anti-CD38-Immunotoxin cytotoxicity
The present invention is directed to the use of agents that induce high levels of cell surface molecules to provide targets for immunotoxins directed against the same cell surface molecules. A...
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7223393 |
Amphiregulin antibodies and their use to treat cancer and psoriasis
The present invention is directed to anti-AR antibodies, preferably humanized monoclonal antibodies having the amino acid sequences disclosed herein. The present invention includes a pharmaceutical...
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7220414 |
Degradable polyacetal polymers
Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers...
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7214374 |
12832, a novel human kinase-like molecule and uses thereof
Novel human kinase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase-like proteins, the invention further provides isolated...
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