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7553490 |
Vaccines against Escherichia coli O157 infection
This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of using of these conjugates and/or...
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7534431 |
Methods and compositions for administering therapeutic and diagnostic agents
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
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7521432 |
Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging
Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging.
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7385039 |
Methods and compositions for regulating imidazoline receptors
The present invention relates to methods and compositions for regulating the activity of imidazoline receptors. In particular, the invention relates to pharmaceutical compositions comprising...
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7344714 |
Production of motif-specific and context-independent antibodies using peptide libraries as antigens
The present invention is related to a method for producing motif-specific, context-independent antibodies which are specific to at least one modified amino acid residue in the context of variable...
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7264808 |
Synthetic peptide for neurological disorders
The purified nerve growth factor consisting of 116 amino acids from the venom of Naja kaouthia snake was fragmented by trypsin digestion. The fragments were isolated individually by high pressure...
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7238361 |
Smart drug delivery system
The present invention provides prodrug and multi-prodrug complexes comprising drugs specifically bound to synthetic receptors in such a manner that active drug becomes available only in the...
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7205162 |
Artificial antibodies, method of producing the same and use thereof
Artificial antibodies or antibody mimics are described. They consist of polymers that carry specific binding sites mimicking the properties of antibodies. There is also described a method for...
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7037669 |
Assays for amphetamine and methamphetamine using stereospecific reagents
Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I may be employed in assays for the determination of an amphetamine and/or a methamphetamine. Immunogenic conjugates of...
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7022492 |
Ecstasy haptens and immunogens
Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I are employed in assays for the determination of an methylenedioxyamphetamine, a methylene-dioxyethamphetamine, and/or a...
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7005453 |
Use of hop acids to inhibit growth of Staphylococcus aureus and prevent toxic shock syndrome
The present invention provides methods, products, and compositions for selectively inhibiting the growth of Staphylococcus aureus without preventing the growth of Lactobacillus species....
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7005132 |
Prodrug compositions and drug delivery methods using synthetic receptors
The present invention provides prodrug and multiprodrug complexes comprising drugs specifically bound to synthetic receptors in such a manner that active drug becomes available only in the presence...
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6991911 |
Assay for entactogens
Methods, compositions and kits are disclosed. The methods are directed to determining the presence of entactogen analytes such as, for example, 3,4-methylenedioxyamphetamine (MDA),...
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6936259 |
CAMP factor of Streptococcus uberis
The CAMP factor gene of Streptococcus uberis ( S. uberis ) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs,...
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6932969 |
Ig fractions having immunomodulatory activity
The invention concerns a method for preparing Ig fractions from human polyvalent intravenous Immunoglobulins (IV Ig) which are in particular likely to be responsible for the immunomodulatory effect...
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6713059 |
Antibodies raised against immunogenic conjugates of gram-negative bacterial autoinducer molecules
The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a...
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6699474 |
Vaccine and immunserum against drugs of abuse
Addictive drugs like cocaine, heroin or amphetamines are spreading in an epidemic manner in the western world and are an important factor in the spread of the acquired immune deficiency syndrome...
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6686454 |
Antibodies to specific regions of cyclosporine related compounds
This invention relates to the production of polyclonal and monoclonal antibodies to specific regions of cyclosporine (CSA) and/or CSA metabolites/derivatives. The reactivity of these polyclonal and...
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6632615 |
Method for isolating a target biological material, capture phase, detecting phase and reagent containing them
The invention concerns a method for isolating a target biological material contained in a sample, which consists in providing a capture phase comprising an organic molecule having at least a...
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6407217 |
Imidazolinone haptens and antigens and enzyme conjugates prepared therefrom
The present invention provides an imidazolinone hapten having the structural formula Further provided are an antigen and an enzyme conjugate which are prepared from the imidazolinone hapten. The...
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6391301 |
Agent for identifying and treating metastasizing tumors
The present invention relates to a novel composition for identifying and suppressing the growth of tumor cells, which comprises antibodies which react with proteins having N-glycosidically bonded...
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6350449 |
Antibodies to meningococcal polysaccharide conjugate vaccines
The invention relates to chemically-modified group B polysaccharides of Neisseria meningitidis . The invention also provides vaccines in which the respective modified polysaccharides are...
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6231852 |
Method for reducing BCL-2 expressing cells resistance to death
Methods for controlling cell death when the cell is exposed to one or more potentially lethal cellular insults. In one method, cell death is inhibited by introducing a reactive oxygen species...
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6228362 |
Boron neutron capture therapy using pre-targeting methods
The present invention provides a method for targeting boron atoms to tumor cells in a patient. The method includes the steps of (A) administering a targeting composition comprising a conjugate of...
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6103233 |
Cellular and serum protein anchors and conjugates
First and second compounds are provided, where the first compound is administered to a mammalian host into blood for covalent bonding to blood components, where the components have an extended...
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5843440 |
Cellular and serum protein anchors for modulating pharmacokinetics
Novel bifunctional reagents useful in reducing the biological effect of an undesirable blood-borne agent are provided. The reagents comprise conjugates of a first binding member specific for a...
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5807688 |
Catalytic antibodies for carbamate activation by a non-spontaneous reaction mechanism
Catalytic antibodies capable of catalysing activation of a carbamate (--O--CO--NH--) containing prodrug suitable for Antibody Directed Abzyme Prodrug Therapy (ADAPT) by catalysing breakdown of the...
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5599538 |
Autoantibodies which enhance the rate of a chemical reaction
Autoantibodies which enhance the rate of a chemical reaction of a substrate, processes for their preparation, their use and compositions thereof are disclosed. In particular, an autoantibody...
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5540908 |
Detection of hypoxia with reagents containing 2-nitroimidazole compounds and methods of making such reagents
Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly...
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5256409 |
Immunogenic composition against tricyclic antidepressant drugs
An immunogenic composition for raising antisera to a drug comprising immunologically active carrier protein to which is bound at least two types of hapten, each hapten comprising a drug molecule...
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5124146 |
Differential delivery of therapeutic agents across the blood brain barrier
A method for the delivery of therapeutic agents across the blood brain barrier is disclosed which utilizes drug neutralization technology, and the selective permeability o This invention was made...
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5037645 |
Immunological methods for treating schizophrenia
Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these...
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5026545 |
Treatment of allergy and composition therefor
A pharmaceutical composition comprises an immune complex of an allergen and a purified antibody specific thereto, the allergen being selected from a specific subclass of antigen which causes...
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4863713 |
Method and system for administering therapeutic and diagnostic agents
A method and system for localizing a diagnostic or therapeutic agent to an internal target site. The system includes (1) an epitopic compound, (2) a binding protein which is effective to bind...
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4834973 |
Immunological methods for treating mammals
Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these...
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4830852 |
Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins and methods of preparing such polysaccharides and conjugates
Covalently-modified neutral bacterial polysaccharides; covalent conjugates of such polysaccharides linked by a bigeneric spacer, with immunogenic bacterial membrane or other proteins, which...
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4824941 |
Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems
A new specific antibody to 5'-terminal mono-, di- or triphosphorylated (2'-5')adenyl-adenoisine oligonucleotides and a method of producing it have been found. The antibody can be used for the...
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4742159 |
Digitalis antibodies, process for the preparation thereof and the use thereof for the therapy of digitalis intoxications
The present invention provides a process for the preparation of digitalis antibodies in which appropriate mammals are immunized with a digoxin bound to protein, the animal serum is obtained, the...
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4689400 |
Enhancement of specific antibody production with anti-IgD antibodies
A method is disclosed for the production of antibodies to haptens which comprises binding the hapten to an antibody from one species, injecting the antibody-hapten into another species, and...
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4661345 |
Method for treating pertussis
Method of inhibiting the adhesion of Bordetella pertussis to the cilia of human respiratory cells to treat pertussis, agents and compositions useful in the method. Agents are also useful to...
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4620977 |
Treatment methods, particularly for psychoactive drug dependence
Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these...
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4550019 |
Manufacture and use of fowl egg antibodies
Immunological preparations are prepared by immunizing hens with an immunogen having a molecular or particle weight of at least 30,000, to a stage of hyper-immunization at which there occurs a...
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