|
Match
|
Document |
Document Title |
|
|
7628992 |
Modification of clostridial toxins for use as transport proteins
A chemical conjugate for treating a nerve cell related disorder is provided. This conjugate includes an active or inactive Clostridial toxin having specificity for a target nerve cell. The toxin is...
|
|
|
7608265 |
Treatment for bacterial infections
The present invention is concerned with compounds, medicaments and treatments for Clostridium difficile infection, together with novel isolated antibodies and their use in same. The present...
|
|
|
7563874 |
Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof...
|
|
|
7192596 |
Recombinant toxin fragments
A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to...
|
|
|
7151159 |
Amino acid sequences for therapeutic and prophylactic use against diseases due to clostridium difficile toxins
The invention relates to monoclonal antibodies capable of recognizing and neutralizing epitopes from the ligand domain, the translocation domain or the catalytic domain of the enterotoxin (toxin A)...
|
|
|
6969520 |
Active immunization against clostridium difficile disease
The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile ...
|
|
|
6805857 |
Method of modulating factor D, factor H and CD4 cell immune response with a polystyrene sulfonate, alginate, and saline infusion solution
Anthrax bio-terrorism is a poor man's nuclear bomb with devastating effects on the freedom and economy of any nation. No nation is immune. Urgently, there is a need for life saving technology that...
|
|
|
6743430 |
Multicomponent vaccine containing clostridial and non-clostridial organisms in a low dose
Disclosed herein is a multicomponent low dose vaccine comprising a safe and immunogenically effective combination of a protective antigen component or components of clostridial organism, a...
|
|
|
6680168 |
Passive immunization against clostridium difficile disease
The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile ...
|
|
|
6667035 |
Amino acid sequences for therapeutic and prophylactic use against diseases due to Clostridium difficile toxins
The invention relates to monoclonal antibodies capable of recognizing and neutralizing epitopes from the ligand domain, the translocation domain or the catalytic domain of the enterotoxin (toxin A)...
|
|
|
6656468 |
Clostridial toxin disease therapy
Treating humans and animals intoxicated with a bacterial toxin by administration of antitoxin. Avian antitoxin in an aqueous solution in therapeutic amount that is orally administrable.
|
|
|
6517826 |
Anionic polymers as toxin binders and antibacterial agents
The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of...
|
|
|
6447785 |
Method for treating hypercalcemia
A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A...
|
|
|
6290960 |
Vaccine and antitoxin for the treatment of C. difficile disease
The present investion provides vaccines capable of protecting a vaccinated recipient from the morbidity and mortality associated with C. difficile infection. These vaccines are produced with...
|
|
|
6203794 |
Modification of clostridial toxins for use as transport proteins
A chemical conjugate for treating a nerve cell related disorder is provided. The conjugate includes an active or inactive Clostridial toxin having specificity for a target nerve cell. The toxin is...
|
|
|
6096310 |
Oral immunotherapy of bacterial overgrowth
The object of the present invention is the oral administration of animal immunoglobulins for the treatment of gastrointestinal disorders caused by bacterial and/or yeast overgrowth. Immunoglobulins...
|
|
|
5773000 |
Therapeutic treatment of clostridium difficile associated diseases
The effective treatment of Clostridium difficile associated diseases, such as Clostridium difficile colitis, pseudomembranous colitis and antibiotic associated diarrhea, by administering an...
|
|
|
5762934 |
Clostridium difficile toxin disease therapy
The present invention includes methods and compositions for treating humans and other animals intoxicated with at least one clostridial toxin by administration of antitoxin. In particular, the...
|
|
|
5736139 |
Treatment of Clostridium difficile induced disease
The present provides neutralizing antitoxin directed against C. difficile toxins. These antitoxins are produced in arian species using soluble recombinant C. difficile toxin proteins. The avian...
|
|
|
5601823 |
Avian antitoxins to clostridium difficle toxin A
The present invention includes methods and compositions for treating humans and other animals intoxicated with at least one Clostridial toxin by administration of antitoxin. In particular, the...
|
|
|
5599539 |
Therapy for clostridial botulinum toxin
Treating humans and animals intoxicated with a bacterial toxin by administration of antitoxin. Avian antitoxin in an aqueous solution in therapeutic amount that is orally administrable.
|
|
|
5562907 |
Method to prevent side-effects and insensitivity to the therapeutic uses of toxins
Human-derived or human-compatible antitoxins are administered is an adjunct to therapy with a toxin, such as botulinum toxin or an immunotoxin, or as an adjunct to therapy with a combination of...
|
|
|
5130128 |
Use of honey as vaccine
Anti-honey food products are disclosed, such food products being obtained from animals hyperimmunized against at least one antigen found in honey, and preferably whole unfractionated honey. A...
|
|
|
4911910 |
Purified equine immunologlobulins and method of use thereof
Equine immunoglobulins are recovered from the pass-through fraction of a QAE column loaded with equine serum in an acidic buffer. The recovered antibodies are electrophoretically free of...
|
|
|
4550019 |
Manufacture and use of fowl egg antibodies
Immunological preparations are prepared by immunizing hens with an immunogen having a molecular or particle weight of at least 30,000, to a stage of hyper-immunization at which there occurs a...
|
|
|
4499073 |
Intravenously injectable immune serum globulin
A composition is disclosed which comprises a solution in a pharmaceutically acceptable carrier of an immune serum globulin, said solution having an ionic strength and a pH to maintain the monomer...
|
|
|
3903262 |
Pharmaceutical compositions comprising intravenously injectable modified serum globulin, its production and use
A pharmaceutical composition comprising, in a pharmaceutically acceptable aqueous carrier adapted for intravenous administration, an intravenously injectable, substantially pure modified immune...
|
|
|
3626057 |
METHOD OF PRODUCING TETANUS ANTITOXIN
A method of producing tetanus antitoxin from the milk system of a cow by hyperimmunization of cows, which are free from Brucellosis and Tuberculosis, with tetanus toxoid and subsequently with...
|
|
|
3415804 |
Fractionation of mixtures of proteinaceous substances using polyethylene glycol
|
|
|
3175947 |
Human serum tetanus antitoxin titer production
|
|
|
2957808 |
Process for the isolation of diagnostic and immunizing proteinaceous materials
|
|
|
2793203 |
Process of preparing stable, highly purified gamma globulin preparations
|