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7368112 |
S. aureus fibrinogen binding protein gene
The isolation of genes and proteins from Staphylococcus aureus is provided, and the nucleic acids coding for specific regions of the S. aureus CIfA protein are described. The nucleic acids...
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7364738 |
Monoclonal antibodies to the CLFA protein and method of use in treating infections
Monoclonal antibodies which can bind to the ClfA protein and which are generated from binding subdomains or active fragments of the ClfA protein from Staphylococcus aureus , including the active...
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7316910 |
Rapid test for hemolytic streptococcus
A reagent for the detection of an extracellular enzymatically active protein produced by a beta-hemolytic streptococcus bacteria found in a host biological fluid includes a proteinaceous substrate...
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7279162 |
Isolated broadly reactive opsonic immunoglobulin for treating a pathogenic coagulase-negative staphylococcus infection
The invention describes the identification, making, and isolation of immunoglobulin and antigen useful for preventing, diagnosing, and treating staphylococcal infections. The invention further...
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7241592 |
Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use
Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross...
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7238351 |
Immunogen adherence inhibitor directed to lactic acid producing organisms and method of making and using it
The method of producing a microbial adherence inhibitor for administration to food animals to control the incidents of acidosis in food animals by preventing the adherence of colony-forming lactic...
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7226590 |
Antimicrobial composition
This invention provides novel Streptococcus salivarius, compositions containing same, and use of S. salivarius strains as antimicrobial agents. The strains are bacterial inhibitors with respect...
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7195763 |
Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences...
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7189404 |
Strain selection of pneumococcal surface proteins
The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the...
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7160990 |
Antibodies to a fibrinogen binding protein of staphylococcus epidermidis
A new fibrinogen binding protein or polypeptide originating from coagulase negative staphylococci, biotechnological methods for producing the protein or polypeptide having fibrinogen binding...
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7115264 |
Monoclonal antibodies to the fibronectin binding protein and method of use in treating or preventing infections
Monoclonal antibodies which can bind to the Fnbp protein of Staphylococcus aureus and which are generated from a peptide from the D2 region of fibronectin binding protein B (Fnbp) of S. aureus ...
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7087228 |
Preventing tooth decay and infective endocarditis using natural oligopeptides
The present invention provides compositions, medicaments, and methods for the treatment or prophylaxis of conditions associated with the binding of Streptococcus mutans to teeth. Specifically,...
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7067135 |
Methods and compositions for the treatment and prevention of Staphylococcus aureus infections
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, Staphylococcus spp., particularly S. aureus.
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7063980 |
Pretreatment kit for saliva and pretreatment method for saliva
A pretreatment kit and a pretreatment kit for saliva in identification and quantitative determination of mutans streptococci by immunochromatography utilizing an antigen-antibody reaction, which...
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7056510 |
Streptococcus pneumoniae SP036 polynucleotides, polypeptides, antigens and vaccines
The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneunoniae. The invention further relates to isolated nucleic acid molecules...
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7045132 |
Streptococcus pneumoniae 37-kDa surface adhesin a protein
The invention provides a nucleic acid encoding the 37-kDa protein from Streptococcus pneumoniae . Also provided are isolated nucleic acids comprising a unique fragment of at least 10 nucleotides...
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7045131 |
Staphylococcal immunotherapeutics via donor selection and donor stimulation
A method and composition for the passive immunization of patients infected with or susceptible to infection from Staphylococcus bacteria such as S. aureus and S. epidermidis infection is...
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7030101 |
Compositions of β-glucans and specific antibodies
Compositions and kits comprising combinations of β-glucans and specific immunoglobulins are disclosed. The compositions and kits are useful in methods of preventing or treating infection by a...
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7018986 |
Use of beta glucans for the treatment of osteoporosis and other diseases of bone resorption
The invention provides methods of using beta glucans to treat conditions associated with bone loss or low bone density as well as methods for promoting bone growth in situations where enhanced bone...
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7015007 |
Capsular polysaccharide adhesin antigen, preparation, purification and use
A substantially pure capsular exopolysaccharide adhesin of coagulase-negative staphylococcal strains, and a gonoral method to prepare such adhesins, are described. Vaccines composed of such...
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6908619 |
Camp factor of streptococcus uberis
The CAMP factor gene of Streptococcus uberis ( S. uberis ) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the...
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6841154 |
Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and Staphylococcus aureus
Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis ...
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6803035 |
Anti-diarrheal and method for using the same
A food product and method for treating and preventing diarrhea in a subject animal suffering from or susceptible to diarrhea. The method comprises administering an egg product to the subject animal...
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6790661 |
System for detecting bacteria in blood, blood products, and fluids of tissues
The invention provides methods for screening for the presence of a clinically relevant amount of bacteria in donor blood or a blood product from a donor mammal, particularly blood or a blood...
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6790446 |
Campylobacter vaccine
The present invention relates to vaccines comprising antiserum raised against a flagellaless Campylobacter strain for the prevention of Campylobacter colonization in animals. The invention also...
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6767536 |
Recombinant Staphylococcus thioredoxin reductase and inhibitors thereof useful as antimicrobial agents
Isolated and purified Staphylococcus thioredoxin reductases (TrxB) are provided. Polynucleotides encoding the TrxBs, vectors and host cells containing such polynucleotides are also provided. In...
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6686169 |
Reagent for the detection of Staphylococcus aureus by agglutination
Reagents and methods for the detection of Staphylococcus aureus are provided. The reagents contain an antibody that binds to a capsular polysaccharide of type 5 of Staphylococcus aureus , and...
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6663862 |
Reagents for detection and purification of antibody fragments
An isolated B1 domain polypeptide of bacterial Protein G which binds a Fab fragment of an IgG but substantially does not bind a Fc fragment of an IgG. Methods for the detection and purification of...
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6632432 |
Directed human immune globulin for the prevention and treatment of staphylococcal infections
This invention is directed to a Directed Human Immunoglobulin and compositions thereof for preventing or treating staphylococcal infections such as S. epidermidis.
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6592876 |
Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products
PspAs, portions thereof, DNA therefor, and immunological compositions, primers and probes based thereon are disclosed claimed.
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6537559 |
Staphylococcus aureus antigen-containing whole cell vaccine
A negatively-charged S. aureus antigen contains β-hexosamine as a major carbohydrate component. S. aureus strains that carry the antigen account for nearly all of the clinically significant...
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6355625 |
Compositions of β-glucans and specific IGIV
Compositions and kits comprising combinations of β-glucans and specific immunoglobulins are disclosed. The compositions and kits are useful in methods of preventing or treating infection by a...
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6322788 |
Anti-bacterial antibodies and methods of use
Compositions containing a purified antibody having both an antigen-binding portion specific for a bacterial antigen and a constant region that does not bind bacterial Fc-binding proteins are...
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6288214 |
Collagen binding protein compositions and methods of use
Disclosed are the cna gene and cna-derived nucleic acid segments from Staphylococcus aureus, and DNA segments encoding cna from related bacteria. Also disclosed are Col binding protein (CBP)...
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6274144 |
Method for generating antibodies to saccharide fragments
A method for depolymerizing polysaccharides containing into saccharide fragments using ozonolysis is described.
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6231857 |
Antibodies to S. mutans and uses thereof
The invention describes three monoclonal IgG antibodies, referred to as SWLA1, SWLA2, and SWLA3, which appear to recognize a species-specific lipooligosaccharide or lipopolysaccharide on the cell...
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6197299 |
Antibody conjugates
A soluble antibody conjugate comprising an antibody linked to a structure which is recognized by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the...
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6030835 |
Methods and composition for identifying group a streptococcus
Methods and compositions are provided for identifying a group A Streptococcus in any of a variety of physiological samples, such as blood, saliva, throat swabs, cerebrospinal fluid, brocheolar...
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5961975 |
Type I surface antigen associated with staphylococcus epidermidis
A process is disclosed for culturing clinical Staphylococcus epidermidis cells that reproducibly enables identification of a limited number of predominant serotypes. Two predominant serotypes...
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5955089 |
Strain selection of pneumococcal surface proteins
The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the...
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5858363 |
Target specific antibody-superantigen conjugates and their preparation
A soluble antibody conjugate comprising an antibody linked to a structure which is recognizable by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the...
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5856202 |
Method for determining antistreptolysin O antibody
A method for immunologically determining antistreptolysin O antibody comprises contacting a test sample solution containing antistreptolysin O antibody with a binding agent to selectively bind the...
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5770208 |
Staphylococcus aureus B-linked hexosamine antigen
A negatively-charged S. aureus antigen contains β-hexosamine as a major carbohydrate component. S. aureus strains that carry the antigen account for nearly all of the clinically significant...
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5721339 |
Gamma antigen of pathogenic group B streptococci
The subject invention concerns a novel in vitro process for identifying and quantifying native antigens on potentially pathogenic group B streptococci bacteria present in a clinical specimen. The...
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5718899 |
Method and compositions for direct concentrated delivery of passive immunity
Compositions containing a high concentration of the full repertoire of immunoglobulins, including IgA, IgM and IgG, are used to combat infections from microorganisms and viruses at a wound,...
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5707627 |
Methods and compositions for the direct concentrated delivery of passive immunity
Compositions containing a high concentration of the full repertoire of immunoglobulins, including IgA, IgM and IgG, are used to combat infections from microorganisms and viruses at a wound,...
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5700465 |
Bovine serum and bovine IgG as preventives and therapeutives for bovine mastitis
Immunoglobulin G-2 (IgG2), e g. bovine IgG2, and its reaction with neutrophils can be used to enhance the neutrophil's functional status in host animal defense against bacterial infections.
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5681565 |
Methods and compositions for passive immunotherapy
The direct, concentrated local delivery of antibodies, and pooled human immunoglobulins in particular, to tissue surfaces (e.g., wounds, burns, etc.), and biomaterial implant surfaces significantly...
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5585098 |
Oral administration of chicken yolk immunoglobulins to lower somatic cell count in the milk of lactating ruminants
A method for lowering somatic cell count in the milk of a lactating ruminant is disclosed. IgY antibodies are first obtained from the egg of a hen which has been actively immunized against one or...
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5571511 |
Broadly reactive opsonic antibodies that react with common staphylococcal antigens
The invention relates to the identification, making, and isolation of immunoglobulin and antigen that is useful to prevent, diagnose, or treat Staphylococcus infections. The invention further...
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