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6379699 |
Liposome having attached target-binding moiety and artherosclerotic plaque interacting moiety
Complexes are prepared containing two or more different effector molecules joined to each other by a joining component. One effector molecule is a binding molecule such as an antibody or Fc...
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6372216 |
Method of producing specific immunoglobin to block HCV infection
A drug which protects individuals against hepatitis C virus (HCV) is made of HCV hyperimmune globulins, which guarantee a substantial hyperimmunity against HCV thanks to a substantial...
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6365156 |
Method for improving the half-life of soluble viral-specific ligands on mucosal membranes
This invention relates to methods of increasing the half-life of a viral-specific ligand on a mucosal membrane by modifying the viral-specific ligand to bind the bacteria colonized on the mucosal...
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6291239 |
Monoclonal antibody
A monoclonal antibody (FE8) against human complement receptor type 2 CR2, CD21) which is able to substantially remove C3-derived fragments already attached to CR2, in particular C3dg from CR2 at...
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6261806 |
Molecular sequence of swine retrovirus and methods of use
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such...
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6228361 |
IgG-1 human monoclonal antibody reactive with an HIV-1 antigen and methods of use
The present invention provides a human-mouse myeloma analog, designated HMMA 2.11TG/O, which has been deposited with the American Type Culture Collection (ATCC) under Accession Number HB 9583. The...
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6187309 |
Method for treatment of symptoms of central nervous system disorders
The present invention provides a method for treating the symptoms of autism comprising the step of administering an effective amount of anti-rubeola antibody.
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6156314 |
Chimeric infectious bursal disease virus cDNA clones, expression products and vaccines based thereon
Chimeric cDNA for the expression of immunogenic polypeptides include the genetic epitopic determinants for a base infectious bursal disease virus strain and at least one other infectious bursal...
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RE36866 |
Anti-aids immunotoxins
The present invention provides a novel anti-AIDS immunotoxin. The immunotoxin comprises a toxin chemically conjugated to a monoclonal antibody directed against viral reverse transcriptase. Also...
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6099840 |
Hepatitis B vaccine
A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a...
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6093548 |
Detection and quantitation of MN-specific antibodies.
A new gene--MN--and proteins/polypeptides encoded therefrom are disclosed. Recombinant nucleic acid molecules for expressing MN proteins/polypeptides and recombinant proteins are provided....
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6071516 |
Treatment of Post-Polio Syndrome with gamma-globulin
A method for treating a patient suffering from Post-Polio Syndrome (PPS) comprises the intravenous, intramuscular or subcutaneous administration of a pharmacologically effective amount of an...
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6051226 |
MN-specific antibodies and their use in cancer treatment
A new gene--MN--and proteins/polypeptides encoded therefrom are disclosed. Recombinant nucleic acid molecules for expressing MN proteins/polypeptides and fusion proteins are provided. Expression of...
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6004768 |
Biosensors, extracorporeal devices and methods for detecting substances using crosslinked protein crystals
Proteins such as enzymes and antibodies are immobilized by crosslinking crystals of the proteins such as microcrystals having a cross-section of 10 -1 mm or less with a multifunctional...
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5997861 |
Antiviral supramolecules containing target-binding molecules and therapeutic molecules bound to spectrin
Complexes are prepared containing two or more different effector molecules joined to each other by a joining component. One effector molecule is a binding molecule such as an antibody or Fc...
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5919461 |
Nonpathogenic infectious bursal disease virus and vaccine
An Infectious Bursal Disease Virus of the Delaware Variant E type having the characteristics of being able to grow on both VERO cells and CEF cells, reacting with monoclonal antibody BK9 produced...
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5916754 |
Bayou hantavirus and related methods
The present invention relates to the discovery and isolation of a novel hantavirus designated the Bayou hantavirus. In particular, the present invention relates to nucleic acids of the newly...
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5911987 |
Cell surface protein and effector cell bonding reagent
The present invention relates to a bonding reagent, which is characterized in that it comprises a first bonding component specific for the hemagglutinin-neuraminidase molecule of a Newcastle...
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5871996 |
Retrovirus agents MSRV1 and MSRV2 associated with multiple sclerosis
Composition including two pathogenic and/or infective agents associated with multiple sclerosis, namely a first agent which consists of a human virus possessing reverse transcriptase activity and...
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5861500 |
Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin 6 (IL-6) and uses thereof
This invention provides an isolated DNA molecule which encodes interleukin 6 (IL-6) of Kaposi's sarcoma-associated herpesvirus. Antisense oligonucleotide molecules are also provided.
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5854418 |
Kaposi's sarcoma-associated herpesvirus (KSHV) viral macrophage inflammatory protein-1α II (vMIP-1α II) and uses thereof
This invention provides an isolated DNA molecule which encodes viral macrophage inflammatory protein-1α II (vMIP-1α II). Antisense and oligonucleotide molecules are also provided.
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5849296 |
Crosslinked protein crystals
A protein such as an enzyme or antibody is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent. The crosslinked protein crystals may be lyophilized for...
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5830641 |
In vitro diagnostic assays for the detection of HIV-1 or HIV-2 employing viral-specific antigens and antibodies
The invention relates to a new class of retroviruses, designated by HIV-2, of which samples have been deposited to the ECACC under numbers 87.01.1001 and 87.01.1002 and to the NCIB under numbers...
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5824307 |
Human-murine chimeric antibodies against respiratory syncytial virus
This invention relates to a human antibody which contains the one CDR from each variable heavy and variable light chain of at least one murine monoclonal antibody, against respiratory syncytial...
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5807840 |
Method for treating canine distemper
The present invention discloses a method for treating patients having the CDV associated symptoms or animals carrying or infected by the canine distemper virus (CDV) or having antibodies against...
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5807551 |
Method to provide artificial passive immunity in birds
The invention provides methods for inducing long-term passive immunity in birds, through administration of superconcentrated antibodies to hatching eggs or to post-hatch birds. The...
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5795578 |
Vaccine against equine herpesvirus type 1
The present invention is directed to a gene encoding an envelope glycoprotein of equine herpesvirus type 1 (EHV-1), the glycoprotein D (gD) gene, its gene product and antibodies directed against gD...
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5785968 |
Anti-feline calicivirus recombinant antibody and gene fragment encoding the same
Anti-FCV (feline calicivirus) feline-type recombinant antibody effective for treatment, prevention and diagnosis of FCV infection and a gene fragment useful for preparation of said antibody are...
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5780028 |
Method of obtaining immunoglobulins from colostrum and their use in pharmaceutical composition
A pharmaceutical composition consisting, of nontoxic components wherein the nontoxic components comprise a core element comprising an antibody which binds to an antigen wherein the core element is...
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5759545 |
Method for the treatment of HIV-I infection
A method for the treatment of the AIDS virus in a mammal, which method comprises administering to the mammal having the AIDS virus a therapeutic, effective amount of a human antispermatozoal...
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5683865 |
Method for diagnosis of mystery swine disease
The method of diagnosis of Mystery Swine Disease (MSD) is carried out with polyclonal or monoclonal antibody sera. Either the antibody sera or the biopsied tissue homogenate may be immobilized by...
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5643571 |
Method for controlling infectious diseases in fish and other aquatic lifeforms in a closed culture system
A method for controlling infectious diseases in fish and other aquatic lifeforms, regardless of their developmental stage. The method of controlling pathogenic organisms detrimental to aquatic...
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5582827 |
Process of screening plasma samples for effective antibody titers against respiratory viruses
A process for identifying plasma samples containing effective antibody titers for the treatment and/or prophylaxis of infections caused by a respiratory virus. The process comprises contacting a...
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5545550 |
Human virus associated with chronic fatigue immune deficiency syndrome and assay therefore
A method for the detection of the presence or absence of antibodies which bind to antigens of an NMA virus Deficiency is disclosed. This method comprises contacting a solution containing antigens...
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5545403 |
Method for treating a mammal by administering a CHO-glycosylated antibody
The invention relates to a CHO cell-line capable of producing antibody, the cell-line having been co-transfected with a vector capable of expressing the light chain of the antibody and a vector...
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5521291 |
Conjugates for introducing nucleic acid into higher eucaryotic cells
Conjugates in which a virus is bound via an antibody to a substance having an affinity for nucleic acid, for transporting gene constructs into higher eucaryotic cells. Complexes of the conjugates...
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5464936 |
Compositions for identification of papillomavirus replication inhibitors
Medicaments, and methods of identifying the same, are described that are useful for treating papillomavirus diseases that have the characteristics of preventing, interfering with, or reversing the...
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5143727 |
Method for preventing diarrhea
A therapeutic agent which is milk collected from a milk animal which has been immunized by a virus or viruses capable of growing in the digestive tract can be used to prevent a disease such as...
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4911910 |
Purified equine immunologlobulins and method of use thereof
Equine immunoglobulins are recovered from the pass-through fraction of a QAE column loaded with equine serum in an acidic buffer. The recovered antibodies are electrophoretically free of...
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4800078 |
Immunotherapeutic method of treating respiratory disease by intranasal administration of Igb
A new immunotherapeutic method of treating lower respiratory tract infection caused by respiratory syncytial virus (RSV) is disclosed. The method employs topical application of RSV antibodies into...
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4756907 |
Active/passive immunization of the internal female reproductive organs
Antibody or antigen containing microparticles for the active or passive immunization of the internal female reproductive organs, comprising: microparticles of an antigen or antibody incorporated in...
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4719290 |
Composition of intravenous immune globulin
An intravenous immune globulin preparation having at least 99% pure globulin protein and an anticomplement activity of less than 0.10 C'50 units/mg IgG prepared by: precipitating impurities from...
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4717766 |
Method of preparing high titer anti-respiratory syncytial virus intravenous immune globulin
Normal plasma from donors who have not necessarily been vaccinated with a respiratory syncytial virus vaccine can be screened for higher than normal titers of naturally occurring antibody to...
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4717564 |
High titer varicella-zoster immune globulin for intravenous administration
Normal plasma from donors who have not been vaccinated with a varicella-zoster vaccine can be screened for higher than normal titers of naturally occurring antibody to varicella-zoster virus. Those...
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4699789 |
Viral free semen and methods of producing the same
The elimination or reduction of viral contamination of semen used for artificial insemination by incorporating with the semen a diluent or extender containing antibodies for the particular virus or...
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4692331 |
Gamma-globulin preparation for intravenous administration
A dry γ-globulin preparation capable of intravenous injection which is obtainable by polyethylene glycol fractionation of plasma is improved in its water-solubility and stability against increase...
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4659563 |
High titer anti-respiratory syncytial virus intravenous immune globulin
Normal plasma from donors who have not necessarily been vaccinated with a respiratory syncytial virus vaccine can be screened for higher than normal titers of naturally occurring antibody to...
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4625015 |
Broad spectrum influenza antisera
Antisera against synthetic peptides which neutralize influenza viruses of differing hemagglutinin subtypes, provide protection against infection by influenza virus and methods of preparing the same...
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4617379 |
High titer cytomegalovirus immune serum globulin
Normal plasma from donors who have not been vaccinated with a cytomegalovirus vaccine can be screened for higher than normal titers of naturally occurring antibody to cytomegalovirus. Those plasmas...
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4550019 |
Manufacture and use of fowl egg antibodies
Immunological preparations are prepared by immunizing hens with an immunogen having a molecular or particle weight of at least 30,000, to a stage of hyper-immunization at which there occurs a...
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