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7387776 |
Human monoclonal antibodies against CD30
Isolated human monoclonal antibodies which bind to CD30 (e.g., human CD30) are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of...
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7378092 |
Immunogenic compositions for induction of anti-tumor immunity
The invention relates to methods of inducing an anti-tumor immunity and/or inducing an immune responses to p53 in mammals. The methods comprise administering to a mammal an effective amount of at...
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7364734 |
Treatment of LFA-1 associated disorders with increasing doses of LFA-1 antagonist
A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need thereof, comprising...
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7332582 |
Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation...
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7323171 |
Methods of treating skin conditions using inhibitors of the CD2/LFA-3 interaction
Methods of using inhibitors of the CD2/LFA-3 interaction in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in...
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7311910 |
Methods for treating cancer and infectious disease by blocking CTLA4-B7 interactions
The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing...
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7309489 |
Mouse CD40 ligand-specific antibodies and hybridomas
There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human...
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7291331 |
Methods of treating OX40 medicated recall immune responses
T cell memory can persist in the absence of antigen. However, some memory cells by default are subject to signals accompanying periodic antigen exposure. OX40 is essential to the extent and...
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7288638 |
Fully human antibodies against human 4-1BB
Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody....
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7273609 |
Methods for treating autoimmune and chronic inflammatory conditions using antagonists of CD30 or CD30L
The invention provides methods of treating autoimmune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of...
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7259247 |
Anti-human T-cell costimulating polypeptide monoclonal antibodies
A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the...
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7250167 |
Method of treatment with anti-CD2 antibody LO-CD2b
A monoclonal antibody which binds to baboon and human CD2, and in particular LO-CD2b antibody. The antibody may be employed to prevent and inhibit an immune response in human patients, such as when...
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7232888 |
Antibodies against tumor surface antigens
The present invention relates to improved antibodies against tumor surface antigens and their use in the treatment of tumors. Of particular interest are highly stable, humanized, high affinity...
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7229628 |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is...
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7223395 |
Blocking leukocyte emigration and inflammation by interfering with CD99/HEC2
The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to...
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7169389 |
Human CD154 binding molecules and treatment methods
A CD154 binding molecule, in particular an antibody to human CD154, especially a human antibody to human CD154 is provided, wherein the CDRs of the heavy chain and light chain have amino acid...
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7166283 |
Methods of treating an inflammatory disorder and prohibiting proliferation, cytokine production, and signal transduction with antibody against costimulatory signal transduction molecule AILIM
Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal...
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7157086 |
Treatment for inflammatory bowel disease with α4-specific antibodies
The present invention disclosed recombinant anti-VLA-4 antibody molecules, including humanized recombinant anti-VLA-4 antibody molecules. These antibodies are useful in the treatment of specific...
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7147851 |
Humanized immunoglobulin reactive with α4β7 integrin
The present invention relates to humanized immunoglobulins having binding specificity for α4β7 integrin, comprising an antigen binding region of nonhuman origin (e.g., rodent) and at least a...
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7138119 |
Compositions and methods for inhibition of HIV-1 infection
This invention provides a composition which comprises an admixture of three compounds, wherein: (a) one compound is an antibody which binds to a CCR5 receptor; (b) one compound retards attachment...
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7132099 |
Methods of modulating T lymphocyte costimulation with an antibody to an 8F4 polypeptide
A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the...
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7125551 |
Methods for treatment of asthmatic disorders using a monoclonal antibody to 8F4 polypeptide
The present invention relates to methods and compositions for the prevention and treatment and prevention of immune system disorders, including cancer, AIDS, asthmatic disorders, autoimmune...
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7122187 |
Treating autoimmune diseases with humanized anti-CD40L antibody
The present invention is directed to humanized antibodies which bind human gp39 and their use as therapeutic agents. These humanized antibodies are especially useful for treatment of autoimmune...
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7122183 |
Methods for treating autoimmune and chronic inflammatory conditions using antagonists of CD30 or CD30L
The invention provides methods of treating autoimmune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of...
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7112327 |
Inhibition of complement activation
The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as...
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7094404 |
Method for treating malignancy and autoimmune disorders in humans using tac antibodies
The present invention relates to a method for treating conditions associated with elevated levels of Tac-positive cells, including malignancy and autoimmune disorders and for preventing allograft...
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7090841 |
Use of CD63 inhibitors
The invention provides a method of decreasing human immunodeficiency virus entry into cells, the method comprising decreasing levels of functional CD63 present with the human immunodeficiency virus...
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7074406 |
Treating allergic diseases with humanized anti-CD40L antibody
The present invention is directed to humanized antibodies which bind human gp39 and their use as therapeutic agents. These humanized antibodies are especially useful for treatment of autoimmune...
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7070777 |
Method for inhibiting inflammation with an antibody that binds the 5C8 protein
This invention provides for methods of inhibiting inflammation with antibodies that bind the 5c8 protein.
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7070776 |
Methods for blocking binding of CD28 receptor to B7
The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. The invention further provides methods for using antibodies to B7, or fragments thereof, to...
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7060273 |
Methods for inhibiting HIV-1 infection
This invention provides a method of reducing an HIV infected subject's HIV-1 viral load which comprises administering to the subject an effective viral load reducing amount of an antibody which (a)...
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7041289 |
Method for treating established spontaneous auto-immune diseases in mammals
A method of treating spontaneous and ongoing auto-immune diseases in mammals, comprising administering to a mammal, in need of such a treatment, a therapeutically effective amount of one or more...
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7037496 |
Chimeric immunoglobulin for CD4 receptors
Chimeric antibodies for CD4 receptor comprising a variable or antigen binding region of a non-human origin specific for CD4 receptor and a constant region of human origin are disclosed. These...
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7034121 |
Antibodies against CTLA4
The invention provides an antibody-toxic moiety conjugates comprising an antibody that specifically recognizes a molecule expressed on the surface of a T cell which is expressed only on T cells and...
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7029676 |
Methods and compositions for modulating heterotypic E-cadherin interactions with T lymphocytes
The present invention relates to methods and compositions for modulating the heterotypic adhesion between E-cadherin expressing cells and T lymphocytes. Monoclonal antibodies which specifically...
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7011833 |
Enhancing immune responses with B7-1 or B7-2 in the absence of a crosslinking agent
Methods of enhancing immune responses in which soluble forms of costimulatory molecules, e.g., B7 molecules, are administered to augment immune responses to antigens, e.g., to tumor cells and...
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6994853 |
Time-staggered utilization of tumor cells in combination with intact antibodies for immunization
The invention relates to the time-staggered utilization of tumor cells in combination with intact, preferably heterologous antibodies for the immunization of humans and animals.
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6991790 |
Antibody formulation
A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of antibody not subjected to prior lyophilization, a buffer maintaining the pH in the range from about 4.5...
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6989145 |
Recombinant antibody and antibody fragment
A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment...
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6972126 |
Methods for using resonance energy transfer-based assay of HIV-1 envelope glycoprotein-mediated membrane fusion, and kits for practicing same
This invention provides: agents determined to be capable of specifically inhibiting the fusion of a macrophage-tropic primary isolate of HIV-1 to a CD4 + cell, but not a T cell-tropic isolate of...
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6955811 |
Methods of inhibiting immune response suppression by administering antibodies to OX-2
Methods and compositions for regulating immunity are disclosed. For enhancing an immune response, agents that inhibit OX-2 are administered. Such methods are useful in treating cancer. For...
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6919077 |
LFA-1 alpha subunit antibodies and methods of use
Antibodies useful for and methods of treating LFA-1 alpha subunit associated physiological conditions and diseases treatable with an antibody that binds LFA-1 alpha subunit, such as HIV, are provided.
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6916475 |
Anti-idiotypic antibody and its use in regulating the composition of T cell lymphocytes
The present invention provides an anti-idiotypic antibody having specific reactivity with an idiotope common to more than one type of anti-HIV-1 antibody, and having no specific reactivity with...
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6881406 |
Modulation of systemic memory T cell trafficking
Methods are provided to specifically modulate the trafficking of systemic memory T cells, particularly CD4+ T cells, without affecting naive T cells or intestinal memory T cells. It is shown that...
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6858204 |
Compositions and methods for the therapy and diagnosis of lung cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic...
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6852320 |
T cell inhibitory receptor compositions and uses thereof
The invention relates to compositions which bind T cell inhibitory receptor molecules and modulate T cell activity, and methods of using such compositions. Such compositions include biliary...
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6849258 |
LO-CD2a antibody and uses thereof for inhibiting T cell activation and proliferation
The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response...
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6821516 |
Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
The invention relates to macrophages which have at least one of the following properties: their cytotoxic activity without IFN-γ is increased by about 20 to 30% with respect to standard...
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6808710 |
Downmodulating an immune response with multivalent antibodies to PD-1
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents...
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6805865 |
Compositions and methods for treating cancer and hyperproliferative disorders
Compositions and methods effective for eliciting an immune response for inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related...
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