Patents in Class 424/142.100

Matches 1 - 50 out of 299

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Match	Document	Document Title
1	7632926	Humanized monoclonal antibodies to hepatocyte growth factor The present invention is directed toward a humanized neutralizing monoclonal antibody to hepatocyte growth factor, a pharmaceutical composition comprising same, and methods of treatment comprising...
2	7632925	Antibodies that bind human 17-A1/EpCAM tumor antigen The present invention provides an anti-human antibody or fragment thereof that is low or not immunogenic in humans. In particular, the antibodies or fragments are directed to human tumor antigens,...
3	7628988	Methods and compositions for treating type 1 diabetes The invention features methods for increasing or maintaining the number of functional cells of a predetermined type, for example, insulin producing cells of the pancreas, blood cells, spleen cells,...
4	7618631	Treatment with anti-ErbB2 antibodies and EGFR-targeted drugs The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and EGFR-targeted drugs.
5	7615214	Anti-human VEGF receptor Flt-1 monoclonal antibody The present invention provides an antibody or peptide which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and...
6	7615215	Anti-human VEGF receptor Flt-1 monoclonal antibody The present invention provides an antibody or peptide which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and...
7	7615383	Methods for treating neuropathy by agonist anti-trk-C monoclonal antibodies The invention concerns agonist anti-trkC monoclonal antibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such...
8	7612179	antibodies binding to a C-terminal fragment of apoliopoprotein E A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the...
9	7611706	RG1 antibodies and uses thereof The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and...
10	7608696	IBC-1 (invasive breast cancer-1), a putative oncogene amplified in breast cancer This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of...
11	7608263	RG1 antibodies and uses thereof The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and...
12	7605238	Human CTLA-4 antibodies and their uses The present invention provides human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
13	7601353	Peptide-based passive immunization therapy for treatment of atherosclerosis The present invention relates to passive immunization for treating or preventing atherosclerosis using an isolated human antibody directed towards at least one oxidized fragment of apolipoprotein B...
14	7601352	Monoclonal antibodies and antigen binding fragments thereof capable of binding TrkA and inhibiting the functional activation of TrkA Monoclonal antibodies, synthetic and biotechnological derivatives thereof (ScFv or others) are able to recognize the NGF high affinity receptor, TrkA, and act as NGF-antagonist molecules....
15	7601818	Human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions...
16	7597888	Glycoprotein VI and uses thereof The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The...
17	7597889	Binding molecules derived from immunoglobulins which do not trigger complement mediated lysis Disclosed are binding molecules which are recombinant polypeptides containing: (i) a binding domain capable of binding a target molecule, and (ii) an effector domain having an amino acid sequence...
18	7597893	Human monoclonal antibody specific lipopolysaccharides (LPS) of serotype IATS 06 of Pseudomonas aeruginosa The present application relates to a human monoclonal antibody specific for the serotype IATS 06 of P. aeruginosa , a hybridoma producing it, nucleic acids encoding it, and host cells transfected...
19	7597886	Tumor necrosis factor-gamma Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also...
20	7595046	Treatment of cancer using anti-Apo-2 antibodies Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also...
21	7595048	Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1 Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of the immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them,...
22	7588761	Human antibodies that bind human TNFα Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., K d...
23	7585500	Fully human monoclonal antibodies to IL-13 The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies...
24	7585504	High affinity antibodies against HMGB1 and methods of use thereof Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The...
25	7578999	Antibodies specific for sclerostin A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In...
26	7579446	Binding molecules capable of neutralizing rabies virus and uses thereof The invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding...
27	7566772	Antibodies against interleukin-1β Antibodies directed to the antigen IL-1β and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen IL-1β. Nucleotide sequences encoding,...
28	7563874	Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof...
29	RE40831	Human monoclonal antibodies to the hepatitis B surface antigen Disclosed is a process for obtaining hybridoma cell lines which produce human antibodies capable of binding to the hepatitis B virus surface antigen (HBVsAg), as well as the hybridoma cell lines,...
30	7553485	Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor (IGF-IR) and/or the insulin/IGF-I hybrid receptor (hybrid-R)...
31	7553486	Anti-VEGF treatment for radiation-induced vasculopathy An anti-VEGF method for treating undesirable conditions resulting from radiation-induced vasculopathy. In a specific application, the method is applied to these undesirable conditions found in an eye.
32	7550568	Monoclonal antibodies to human high molecular weight-melanoma associated antigen The present invention provides monoclonal antibodies that react against high molecular weight melanoma-associated antigen. These antibodies may be used for diagnostic and/or therapeutic purposes.
33	7541031	Methods for treating rheumatoid arthritis using human antibodies that bind human TNFα Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., K d...
34	7534427	Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins The invention is directed to a method for treating a treating and diagnosing a B cell-related disease, T cell-related disease or an autoimmune disease in a mammal by concurrently or sequentially...
35	7531168	Method for downmodulating immune response in type I diabetes The instant invention provides compositions and methods for downmodulation of immune responses, e.g., autoimmune responses. For example, methods of downmodulating an immune response using agents...
36	7531633	Staphylococcus antibodies A negatively-charged Staphylococcus antigen contains amino acids and a N-acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of ...
37	7531169	High affinity anti-human IgE antibodies The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and...
38	7527790	Methods of reducing bone absorption comprising administering an antibody that binds OBM Novel proteins and polypeptides binding to osteoclastogenesis inhibitory factor (OCIF) (OCIF-binding molecules, OBMs) and nucleic acids encoding these proteins and polypeptides are provided....
39	7524501	Methods of treating an injury to, or disorder of, the eye involving photoreceptor proliferation by administering VEGF2 antibodies The present invention is directed to VEGF-2 polynucleotides and polypeptides and methods of using such polynucleotides and polypeptides. In particular, provided are methods of treating retinal...
40	7524496	*WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST* Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant,...
41	7524497	Antibodies to PRO 1120 polypeptide The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
42	7521051	Methods of upmodulating adaptive immune response using anti-PD-1 antibodies This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those...
43	7517524	Immunointeractive molecules The present invention relates generally to immunointeractive molecules and more particularly antibodies which bind to vascular endothelial growth factor-B (VEGF-B) or its functional or structural...
44	7507408	Anti hepatitis C virus antibody and uses thereof Described are novel antibodies specifically recognizing conformation dependent epitopes of HCV glycoprotein E2 and that are capable aof neutralizing the binding of E2 protein onto susceptible...
45	7504105	Treatment using antibodies to cytokine receptor common gamma chain like The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide...
46	7501247	Method of treating skin inflammation Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17 and/or IL-23.
47	7498030	Treatment with anti-ErbB2 antibodies and anti-hormonal compounds The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and anti-hormonal compounds, such as anti-estrogens.
48	7491516	Dual specificity antibodies and methods of making and using Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or...
49	7488486	Pharmaceutical compositions and articles of manufacture useful in reversal of a clinical epiosode of an incurable disease and methods of use thereof A method of reversing a clinical episode of a disease which is generally considered incurable in a subject. The method includes providing an immune-globulin preparation containing a detectable...
50	7488802	Antibodies against PD-1 This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those...

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