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6596850 |
Anti-αv3β3 recombinant human antibodies, nucleic acids encoding same
The invention provides a LM609 grafted antibody comprising one or more CDRs having at least one amino acid substitution, where the LM609 grafted antibody has α v β 3 binding activity. Nucleic...
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6596277 |
Methods of decreasing cell adhesion
The present invention provides substantially pure integrins containing a novel β subunit designated as β 6 . The novel β 6 subunit forms heterodimers with α V and α F . Methods of...
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6596848 |
Antibodies to NIMA interacting proteins
A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA...
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6592868 |
Methods for treating autoimmune diseases with 5C8-specific antibodies
This invention provides methods of treating autoimmune diseases, including those selected from the group consisting of rheumatoid arthritis, Myasthenia gravis, systemic lupus erythematosus, Graves'...
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6590079 |
Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same
The invention provides a Vitaxin antibody and a LM609 grafted antibody exhibiting selective binding affinity to α v β 3 . The Vitaxin antibody consists of at least one Vitaxin heavy chain...
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6576236 |
Methods for stimulating T cell responses by manipulating a common cytokine receptor &ggr chain
When stimulated through the T cell receptor(TCR)/CD3 complex without requisite costimulation through the CD28/B7 interaction, T cells enter a state of antigen specific unresponsiveness or anergy....
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6572856 |
Methods for the prevention and treatment of cancer using anti-C3b(i) antibodies
The present invention relates to the treatment and prevention of cancer, viral infections and microbial infections by the administration of anti-C3b(i) antibodies. The present invention also...
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6569431 |
Recombinant antibody fragments as autoantibody antagonists
The invention provides methods and compositions for inhibiting autoantibody binding in demyelinating disease such as multiple sclerosis. The compositions comprise immunoglobulin CDR3 sequences...
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6562949 |
Antibodies to viral encoded semaphorin protein receptor polypeptides
The invention is directed to VESPR polypeptides as a purified and isolated protein, the DNA encoding the VESPR polypeptide, host cells transfected with cDNAs encoding VESPR, and methods for...
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6558961 |
Immunodiagnostics using particle delivery methods
Methods for assessing immunocompetence, cellular or humoral immunity, antigen exposure, or allergic conditions in an individual by accelerating diagnostic particles into a target skin site in the...
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6555111 |
Method of inhibiting the cytocidal effect of TNF with TNF receptor-specific antibodies
Antibodies to Tumor Necrosis Factor receptors (TNF-Rs) which inhibit the cytocidal effect of TNF but not its binding to the TNF-Rs, and ligands interacting with other receptors of the TNF/NGF...
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6551599 |
Monoclonal antibodies against campylobacter jejuni and campylobacter coli outer membrane antigens
The present invention is directed to a method of producing monoclonal antibodies that are highly specific for (1) unique epitopes of Campylobacter jejuni (Cj) only and (2) epitopes conserved...
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6548061 |
Immunological composition and its method of use to transiently disrupt mammalian central nervous system myelin to promote neuronal regeneration
Novel compositions are described comprising the combined administration of serum complement proteins with complement-fixing antibodies. The antibodies specifically bind to one or more epitopes of...
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6545128 |
Anti-bax inhibitor protein antibodies
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid...
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6534058 |
Anti-C5 monoclonal antibodies
The invention relates to C5 inhibitors, which inhibit type II endothelial cell activation, wherein the inhibition is manifested by the suppression of E-selectin. These inhibitors are useful in...
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6534057 |
Method increasing the delayed-type hypersensitivity response by infusing LFA-1-specific antibodies
Methods for treating and inhibiting disease and symptoms associated with the human immunodeficiency virus (HIV) are provided. The method includes transforming the human immunodeficiency virus (HIV)...
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6528061 |
Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions
A purified immunogenic polypeptide comprises an epitope unit recognized by a protective monoclonal antibody having a high affinity and a high specificity for a surface polysaccharide of a...
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6528055 |
Methods of administering antibodies that specifically bind ACT-4-L-h-1 ligand
The invention provides ligands and fragments thereof to a receptor on the surface of activated CD4 + T-cells. An exemplary ligand is designated ACT-4-L-h-1. Preferred fragments include purified...
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6528625 |
Anti-CCR5 antibodies and kits comprising same
The present invention relates to an antibody or functional portion thereof which binds to a mammalian (e.g., human) chemokine receptor 5 protein (CKR-5 or CCR5) or portion of the receptor. The...
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6528493 |
Screening methods for identifying modulators of proliferation and differentiation of bone cells
The present application relates to a compositions comprising a compound which modulates the activity of T1-M protein, the use of compounds which modulate the activity of T1-M protein, and an in...
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6528269 |
Immunological agents specific for prion protein (PRP)
The present invention is directed to a panel of monoclonal antibodies (Mabs) specific for murine prion protein PrP c . These Mabs can be applied to immunoblotting, cell surface immunofluorescent...
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RE38008 |
Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof
Methods for improved targeting of antibody, antibody fragments, peptides hormones, steroid hormones and conjugates thereof are disclosed. Enhanced delivery to target cells of antibodies or...
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6517845 |
Mycobacterium tuberculosis superoxide dismutase
The invention relates to Mycobacterium tuberculosis superoxide dismutase antibodies, methods of using them for detection of M. tuberculosis , methods of testing for an inhibitor of an M....
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6514497 |
Inhibition of LERK-2-mediated cell adhesion
Methods of modulating LERK-2-mediated cell adhesion, as well as methods of modulating angiogenesis and inflammation are described. Also described are agents such as antibodies which can modulate...
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6511665 |
Antibodies to interleukin-1 receptors
The present invention provides monoclonal antibodies and binding proteins which specifically bind to the IL-1 receptor. Also provided are methods for detecting IL-1 receptors on cells, and for...
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6511664 |
Intercellular adhesion molecule—2 and its binding ligands
The present invention relates to intercellular adhesion molecules (ICAM-2) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as...
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6509319 |
EDTA and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections
A pharmaceutical composition comprising at least one antifungal agent and at least one chelator, and a method for administering the pharmaceutical composition to a patient having a fungal...
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6506383 |
Methods of suppressing immune responses to transplanted tissues and organs with gp39-specific antibodies
The present invention is directed to humanized antibodies which bind human gp39 and their use as therapeutic agents. These humanized antibodies are especially useful for treatment of autoimmune...
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6506382 |
Method for inhibiting reperfusion injury using antibodies to P-selectin glycoprotein ligand
P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of [ 3...
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6504013 |
Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody
The present invention provides methods and compositions for decreasing IgE levels in dogs. The methods and compositions are useful for treating allergic symptoms in dogs. The invention may comprise...
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6503509 |
Method for receptor desensitization
Particular members of the multisubunit immune recognition receptor (MIRR) family of receptors, specifically, the B cell antigen receptor (BCR), the pre-B cell receptor (pre-BCR), the pro-B cell...
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6498237 |
Tumor necrosis factor antibodies
The present invention relates to ligands which bind to human tumour necrosis factor alpha (TNF) in a manner such that upon binding of these ligands to TNF the biological activity of TNF is...
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6497878 |
Treatment of cerebral disorders by inhibition of IL-8 binding to receptor
Methods and compositions for treating or preventing cerebral stroke, cerebral infarction, cerebral edema, reperfusion injury and increased cerebral vascular permeability which employ an agent that...
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6491914 |
Anti-idiotypic monoclonal antibodies, their use in the active immunotherapy of malignant tumors, and compositions including the anti-idiotypic monoclonal antibodies
An anti-idiotypic monoclonal antibody that is specific against the N-glycolyl residues of gangliosides, particularly those expressed by cancer cells. The monoclonal antibody is useful as an...
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6485970 |
Immunointeractive antibody
The present invention relates generally to immunointeractive molecules and their use inter alia in the detection and/or purification of T-cell antigen binding molecules (TABMs). The ability to...
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6482408 |
Fibroblast growth factor 15 antibodies
The present invention relates to antibodies directed to the human protein called Fibroblast Growth Factor 15.
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6468531 |
Method of promoting cellular function
The present invention relates, in general, to a method of producing a therapeutic effect and, in particular, to a method of using antibodies to promote cellular function, to antibodies suitable for...
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6468547 |
Enhancement of tumor cell chemosensitivity and radiosensitivity using single chain secretory antibodies
The present invention provides a method of enhancing the chemosensitivity and radiosensitivity of a neoplastic cell expressing an oncoprotein that stimulates proliferation of the cell, comprising...
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6468529 |
Hepatocyte growth factor receptor antagonists and uses thereof
Hepatocyte growth factor (HGF) receptor antagonists are provided. The HGF receptor antagonists include HGF receptor antibodies and fragments thereof. The HGF receptor antagonists can be employed to...
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6468532 |
Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates
Provided are methods for treating inflammatory diseases in a patient comprising administering to the patient an effective amount of a conjugate consisting essentially of one or more antibody...
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6458354 |
Molecular complexes which modify immune responses
Extracellular domains of transmembrane heterodimeric proteins, particularly T cell receptor and major histocompatibility complex proteins, can be covalently linked to the heavy and light chains of...
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6458355 |
Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
Provided are methods for treating inflammatory diseases in a patient comprising administering to the patient an effective amount of a conjugate consisting essentially of one or more antibody...
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6455042 |
Method of treating ulcerative colitis or crohn's disease by administering an antibody toαEβ7 integrin
The present invention relates to a method for treating an autoimmune disease, such ulcerative coliteis or crohns disease characterized by lymphocyte accumulation at epithelial sites. The method...
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6451311 |
Anti-procalcitonin antibodies and the preparation and use thereof
The invention relates to anti-procalcitonin antibodies, their preparation and use, in particular in therapy and diagnostics. The antibodies comprise binding to procalcitonin but not to free...
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6451310 |
Method for inhibiting an allergic response with a 5c8-specific antibody
This invention provides a method of inhibiting an allergic response in a subject by inhibiting T cell activation of B cells, wherein said method comprises administering to the subject an antibody...
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6451981 |
Antibodies against lymphocyte-associated cell surface protein LAM-1
Human lymphocyte-associated cell surface protein LAM-1, which includes domains homologous with binding domains of animal lectins, growth factors, and C3/C4 binding proteins, and the cDNA encoding...
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6448021 |
Method of inhibiting cell function associated with CCR2 by anti-CCR2 amino-terminal domain antibodies
The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding...
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6447776 |
Mutations of E cadherin as a basis for the diagnosis and therapy of human malignant tumors
The present invention describes monoclonal antibodies which are useful for the specific detection of diffuse gastric carcinoma. Further embodiments describe therapeutic and diagnostic means for the...
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6444206 |
Methods and compositions for inhibiting CD14 mediated cell activation
This invention provides hybridoma cell lines producing monoclonal antibodies which inhibit CD14 mediated cell activation. Monoclonal antibodies produced by these cell lines also are provided. The...
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6440418 |
Methods of treating autoimmune diseases with gp39-specific antibodies
The present invention is directed to humanized antibodies which bind human gp39 and their use as therapeutic agents. These humanized antibodies are especially useful for treatment of autoimmune...
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