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6891024 |
Monoclonal antibodies to Sarcocystis neurona and uses therefor
The present invention is directed to particular monoclonal antibodies that find use in the identification and purification of Sarcocystis neurona and related antigens. In particular, these...
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6887481 |
Bacterial-derived molecules and therapeutic and diagnostic uses therefor
The present invention relates generally to molecules derived from a Mycobacterium species and recombinant, synthetic, derivative, homologue and analogue forms of said molecules. The molecules of...
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6887473 |
Inhibition of angiogenesis in disease states with an anti-αvβ3 monoclonal antibody
The present invention describes methods for inhibition angiogenesis in tissues using vitronectin α v β 3 antagonists, and particularly for inhibiting angiogenesis in inflamed tissues and in...
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6884418 |
Use of ligand-mimicking agents and anti-neoplastic drugs in cancer therapy
This invention is directed toward novel synergistic combinations of ligand-mimicking agents specific to the c-erbB-2 protein and anti-neoplastic drugs or agents, which can be used to treat a...
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6881405 |
Reagents and methods for inducing an immune response to prostate specific antigen
The invention is an apparatus and method for the treatment of prostate cancer, and involves administering an antibody that specifically binds with prostate antigen.
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6881407 |
Method for treating hepatitis
Hepatitis can be treated by administering to a patient in need thereof an effective amount of a compound that neutralizes the effects of secreted TNFalpha. Two types of these compounds are...
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6881406 |
Modulation of systemic memory T cell trafficking
Methods are provided to specifically modulate the trafficking of systemic memory T cells, particularly CD4+ T cells, without affecting naive T cells or intestinal memory T cells. It is shown that...
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6875432 |
Reduced-viscosity concentrated protein formulations
The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method...
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6872392 |
Humanized antibodies
Chimeric human antibody expression vectors are constructed by inserting the heavy chain variable region-encoding cDNA and antibody light chain variable region-encoding cDNA isolated from hybridomas...
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6869605 |
BAFF, inhibitors thereof and their use in the modulation of B-cell response
The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists.
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6863890 |
Treatment of AIDS with antibodies to gamma interferon, alpha interferon and TNF-alpha
The present disclosure concerns the treatment of a patient with autoimmune disease, including AIDS, by neutralizing, removing or inhibiting different types of interferons, tumor necrosis factor,...
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6861510 |
Immunogenic compositions against gastrin peptides
Immmunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies...
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6861055 |
Human GDP-mannose 4,6-dehydratase
The invention provides a novel GDP-mannose 4,6-dehydratase.
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6849413 |
PGRP-L polynucleotides, polypeptides, and antibodies
The present invention relates to novel human and murine proteins called PGRP-L, and isolated polynucleotides encoding these proteins. Also provided are vectors, host cells, antibodies, and...
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6849258 |
LO-CD2a antibody and uses thereof for inhibiting T cell activation and proliferation
The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response...
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6843990 |
Monoclonal antibodies for the detection of decoy receptor 3, hybridomas producing said antibodies and uses thereof
The invention provides monoclonal antibodies against decoy receptor 3 (DcR3), hybridomas producing said antibodies, kits containing said monoclonal antibodies and uses of the hybridomas, antibodies...
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6843989 |
Methods for the treatment and prevention of cancer using anti-CD40 antibodies
The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the...
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6841152 |
Methods for protecting against autoimmune diabetes
Methods are provided for preventing the development of autoimmune diseases in susceptible subjects and for prolonging acceptance of tissue transplants by administration of an agonist of the T cell...
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6835380 |
Antibodies against rat pituitary tumor transforming gene carboxy-terminal (PTTG-C) peptides
Disclosed are isolated antibodies that specifically bind a rat pituitary tumor transforming gene carboxy-terminal peptide (PTTG-C). These antibodies are believed to be particularly useful in...
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6835370 |
Diagnosis and treatment of malignant neoplasms
The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an...
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6833132 |
Method of stimulating epithelial cells using keratinocyte growth factor (KGF) and method of inhibiting KGF activity
Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used sucessfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other...
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6830751 |
Use of IL-12 antagonists in the treatment of rheumatoid arthritis
Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one...
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6824779 |
Methods for inhibiting the interaction of B7-2 with its natural ligand
The present invention relates to, inter alia, methods for inhibiting the interaction of the B-lymphocyte antigen, B7-2, with its natural ligand on the surface of an immune cell are disclosed. The...
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6824993 |
Antibodies that bind human prostate specific G-protein receptor HPRAJ70
The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to...
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6821516 |
Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
The invention relates to macrophages which have at least one of the following properties: their cytotoxic activity without IFN-γ is increased by about 20 to 30% with respect to standard...
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6822080 |
Human cyclin-dependent kinase-like proteins and methods of using the same
Substantially pure human cyclin-dependent kinase-like proteins PITALRE and PISSLRE and isolated protein complexes that comprise PITALRE or PISSLRE are disclosed. Isolated nucleic acid molecule that...
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6818213 |
Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor...
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6818215 |
Antibodies to senescent cell-derived inhibiters of DNA synthesis
Polyclonal and monoclonal antibodies that specifically bind senescent cell derived inhibitor protein (SDI-1), cell lines that produce such monoclonal antibodies, and the use of such antibodies are...
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6814965 |
Methods of decreasing ZVEGF3 activity
Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that...
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6808710 |
Downmodulating an immune response with multivalent antibodies to PD-1
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents...
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6803039 |
Human monoclonal antibody against a costimulatory signal transduction molecule AILIM
Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal...
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6800285 |
Treatment of central nervous system diseases by antibodies against glatiramer acetate
The present invention provides humanized polyclonal and humanized monoclonal antibodies directed against an epitope on glatiramer acetate, also known as Copolymer 1, Copolymer-1, Cop-1 or Cop....
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6793920 |
Antithrombotic agent and anti-von willebrand factor monoclonal antibody
A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet...
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6777222 |
Antibodies to cryptosporidium
A method of producing IgG1 subclass antibodies reactive to the surface of Crystosporidium oocysts , the method comprising: (a) separating at least a protion of the Cryptosporidium oocyst wall from...
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6774219 |
Candida albicans gene, integrin-like protein, antibodies, and methods of use
An isolated and purified DNA molecule encoding Candida albicans protein with integrin-like motifs, the protein itself, antibodies thereto, and methods of use, are provided.
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6770279 |
TNFα antagonists and cyclosporin in therapy of rheumatoid arthritis
A method for treating rheumatoid arthritis using a TNFα antagonist in combination with cyclosporin or analog thereof is disclosed.
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6767540 |
Use of antagonists of plasminogen activator inhibitor-1 (PAI-1) for the treatment of asthma and chronic obstructive pulmonary disease
The invention relates to methods for treatment of asthma and chronic obstructive pulmonary disease (COPD) by administration of antagonists to plasminogen activator inhibitor type-1 (PAI-1)....
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6767541 |
HER-2/neu overexpression abrogates growth inhibitory pathways
The present invention provides methods for obtaining genetic profiles of cancer cells in order to assess the status of a cancer in an individual. In addition, the present invention provides methods...
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6764679 |
Antibodies to DcR3 Polypeptide, a TNFR Homolog
A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
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6764681 |
Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
Methods of using inhibitors of the CD2/LFA-3 interaction in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in...
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6761891 |
Medicament for treating a manifested lyme disease
A pharmaceutical composition for treating Lyme disease contains an antibody as an active agent which is specific for the 24 kDa antigen (OspC) of B. burgdorferi , preferably an antibody which is...
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6759043 |
Monoclonal antibodies having property of causing apoptosis
It is the objective and purpose of the present invention to provide a monoclonal antibody having the property of causing apoptosis on myeloid cells. This invention relates to a monoclonal antibody...
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6759519 |
Antibodies to human G-protein chemokine receptor HDGNR10 (CCR5receptor)
Antibodies against human G-protein chemokine receptor polypeptides, the polypeptides themselves, DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant...
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6759044 |
Cryptopain antibodies for prophylaxis, treatment, diagnosis and detection of Cryptosporidium species
Vaccines, antibodies, proteins, DNAs and RNAs for diagnosis, prophylaxis, treatment and detection of Cryptosporidium species or Cryptosporidium species infections. Cryptosporidium species antigen...
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6749852 |
Method for preventing and inhibiting human HLA alloimmune response to platelet transfusion
The present invention relates to a method for preventing HLA alloimmune response to platelet transfusion. The method comprises the step of presensitizing platelets with at least one monoclonal HLA...
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6747133 |
Antibodies against the tumor suppressor gene ING1
The invention provides novel tumor suppressor genes, methods for making and using these and related tumor suppressor genes and proteins and peptides, and nucleic acids encoding these and related...
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6746673 |
Pharmaceutical compositions containing anti-Fas antibody
A pharmaceutical composition containing an anti-human Fas antibody having apoptosis inducing activity and a compound having a folate antagonist activity or a dihydrofolate reductase inhibiting...
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6737058 |
Methods for inhibiting endothelial cell and fibrinogen mediated inflammation using fibrinogen specific antibodies
The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to...
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6737059 |
Methods of inhibiting inflammatory processes and alleviating symptoms associated with multiple sclerosis
Disclosed are methods for the alleviation of symptoms associated with inflammatory disease states, and more particularly to the inhibition of inflammatory disease processes associated with the...
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6737511 |
Receptor-mediated uptake of an extracellular BCL-xL fusion protein inhibits apoptosis
Apoptosis-modifying fusion polypeptides, and the corresponding nucleic acid molecules, are disclosed. Pharmaceutical compositions comprising these polypeptides, and the use of these polypeptides to...
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