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6322794 |
Seroreactive epitopes on proteins of human papillomavirus (HPV) 18
The invention relates to seroreactive epitopes on proteins of human papillomavirus HPV18. In addition, the invention relates to peptides which have amino-acid sequences which coincide in whole or...
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6319499 |
Methods for activating an erythropoietin receptor using antibodies
Antibodies and fragments thereof which activate an erythropoietin receptor and stimulate erythropoiesis are described. Also described are hybridoma cell lines which produce the antibodies and...
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6309637 |
Human microfibril-associated glycoprotein 4 splice variant
The invention provides a human microfibril-associated glycoprotein 4 splice variant (MAG4V) and polynucleotides which identify and encode MAG4V. The invention also provides expression vectors, host...
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6307021 |
Human apoptosis regulator
The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors...
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6303121 |
Method of using human receptor protein 4-1BB
Disclosed herein are the methods of using the H4-1BB protein, ligands to this protein, and various mAbs either directed against H4-1BB or other molecules that can be used therapeutically. The...
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6300477 |
Antibodies to human cystatin E
Disclosed are antibodies and antibody fragments that bind to novel human CysE polypeptides. Also provided are methods for producing the antibodies. Also disclosed are methods for utilizing such...
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6299877 |
Type I interferons
The invention concerns a novel human interferon-ε, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-α family...
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6294655 |
Anti-interleukin-1 receptor antagonist antibodies and uses thereof
The present invention provides novel nucleic acids, the novel polypeptide sequences encoded by these nucleic acids and uses thereof. These novel polynucleotide and polypeptide sequences were...
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6290958 |
Anti-flea epoxide hydrolase antibodies and uses thereof
The present invention relates to arthropod epoxide hydrolase proteins; to arthropod epoxide hydrolase nucleic acid molecules, including those that encode such epoxide hydrolase proteins; to...
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6291649 |
Anti-bodies binding adhesin-derived antigens
An antigen which, as its major immunizing component, comprises a determinant of an adhesin polypeptide or an immunogenically active subsequence thereof or a precursor therefor which is convertible...
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6288214 |
Collagen binding protein compositions and methods of use
Disclosed are the cna gene and cna-derived nucleic acid segments from Staphylococcus aureus, and DNA segments encoding cna from related bacteria. Also disclosed are Col binding protein (CBP)...
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6284471 |
Anti-TNFa antibodies and assays employing anti-TNFa antibodies
Anti-TNF antibodies and anti-TNF peptides, specific for tumor necrosis factor (TNF) are useful for in vivo diagnosis and therapy of a number of TNF-mediated pathologies and conditions, as well as...
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6274143 |
Methods of delaying development of HMFG-associated tumors using anti-idiotype antibody 11D10
The present invention provides methods of delaying development of HMFG-associated tumors using the anti-idiotype antibody 11D10, particularly in high-risk individuals having low tumor burden.
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6261559 |
Methods of treating asthma with interleukin-9 antibodies
A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1 (AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 of AAF1....
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6261790 |
Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies
Methods to detect prion or PrP-Sc protein as an indication of transmissible spongiform encephalopathies (TSEs) are described. In one aspect, the invention is directed to monoclonal antibodies that...
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6261806 |
Molecular sequence of swine retrovirus and methods of use
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such...
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6261560 |
Method for inhibiting muscle protein proteolysis with antibodies to interleukin-6 receptor
The present invention provides a muscle protein proteolysis inhibiting agent comprising antibody to Interleukin-6 receptor (IL-6R antibody). Antibodies of animals other than humans such as mice and...
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6248326 |
Regulation of osteoclast formation by inhibition of osteoblastic stem cell factor
The present invention provides an inhibitor of osteoblastic stem cell factor binding and/or activity, for example, an antibody or an antisense oligonucleotide. Also provided are pharmaceutical...
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6248325 |
Glutathione s-transferase
The present invention provides a human glutathione s-transferase (HGST) and polynucleotides which identify and encode HGST. The invention also provides genetically engineered expression vectors and...
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6238666 |
RANTES homolog antibody
The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a human rantes homolog (PTEC). The invention provides for genetically...
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6235883 |
Human monoclonal antibodies to epidermal growth factor receptor
In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucelotide sequences encoding and amino acid...
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6221352 |
Method of preventing the proliferation of Vβ14 or Vβ17-Expressing T cells
The present invention provides vaccines and a means of vaccinating a vertebrate so as to prevent or control specific T cell mediated pathologies, including autoimmune diseases and the unregulated...
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6221353 |
Antibodies Which Bind Mycobacterial Tuberculosis Proteins
Antibodies that bind Mycobacterium tuberculosis 28 kDa proteins and immune complexes between the antibodies and proteins.
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6217865 |
Method of antibody blending for increased efficacy
The invention relates to blending eggs from all egg lots produced over a predetermined time period of the egg laying cycle of immunized avians, to form an antibody-containing substance. The...
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6214343 |
Prevention and treatment of necrotizing enterocolitis
Methods are described for preventing and treating necrotizing enterocolitis in animals, including humans. Antibodies directed to PAF and/or TNF are shown to have a beneficial effect in animal...
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6211340 |
δ-sarcoglycan antibodies
Disclosed herein is a substantially pure nucleic acid sequence encoding a mammalian 35 kDa non-dystrophin component (δ-sarcoglycan) of the dystrophin-glycoprotein complex. Also disclosed are the...
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6207154 |
Methods of treatment using antagonists of cytokine synthesis inhibitory factor
Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines...
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6197937 |
Modified low density lipoprotein receptor
The present invention provides a DNA sequence essentially encoding a mammalian vascular endothelial receptor for modified low-density lipoprotein. The sequence is set forth in the Sequence No. 1, 2...
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6193965 |
Oncoprotein kinase
An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD or 55 kD as determined by reducing SDS-PAGE, having serine and theonine kinase activity, phosphorylating the c-Jun...
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6184359 |
Antibodies to epithelium-derived T-cell factor
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for...
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6184357 |
Prostate-specific kallikrein
The present invention provides a human prostate-specific kallikrein (HPSK) and polynucleotides which identify and encode HPSK. The invention also provides genetically engineered expression vectors...
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6180102 |
Monoclonal antibody to human Mx protein MxA
This invention provides a monoclonal antibody which recognizes an epitope corresponding to amino acids 10 to 220, amino acids 221 to 297, or amino acids 469 to 662, counting from the N-terminus of...
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6177078 |
Monoclonal antibody antagonists to IL-3
Anti IL-3 Receptor alpha chain monoclonal antibody (MoAb) is the product of a hybridoma cell line designated 7G3. The MoAb acts as an antagonist to IL-3 in vitro activity. The MoAb binds to the N...
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6171782 |
Antibody compositions to HCV and uses thereof
A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B...
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6172199 |
Human ubiquitin-conjugating enzyme
The present invention provides a polynucleotide (ubcp) which identifies and encodes a novel ubiquitin-conjugating enzyme (UBCP). The invention provides for genetically engineered expression vectors...
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6171587 |
Antibodies to tissue factor inhibitor
A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined. Antibodies having a...
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6168791 |
Antibodies that bind immunomodulators
This invention relates to a polypeptide other than human interleukin (10) which has at least one of the following properties: a) induces inhibition of spontaneous IL-8 production by human...
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6165465 |
Immunologic enhancement of the somatogenic effect of somatotropin with an antibody
The present invention is directed to antibodies, in particular monoclonal antibodies, of porcine somatotropin (pST). When these antibodies are administered together with pST, the growth of...
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6165735 |
Parasitic helminth asparaginase proteins, nucleic acid molecules, and uses thereof
The present invention relates to: parasitic helminth asparaginase proteins; parasitic helminth asparaginase nucleic acid molecules, including those that encode such asparaginase proteins;...
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6156314 |
Chimeric infectious bursal disease virus cDNA clones, expression products and vaccines based thereon
Chimeric cDNA for the expression of immunogenic polypeptides include the genetic epitopic determinants for a base infectious bursal disease virus strain and at least one other infectious bursal...
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6156315 |
Method for inhibiting the binding of low density lipoprotein to blood vessel matrix
This invention also provides a method of treating atherosclerosis in a subject, comprising administering to the subject an effective amount of a substance capable of binding to the amino-terminal...
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6143874 |
Antibodies to the neurotrophic factor NNT-1
Disclosed are nucleic acids encoding novel neurotrophic factors, designated NNT-1. Also disclosed are amino acid sequences for NNT-1 polypeptides, methods for preparing NNT-1 polypeptides, and...
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6143273 |
Therapeutic composition containing antibodies to soluble polypeptide fractions of LAG-3 protein
Soluble polypeptide fraction consisting of all or part of one at least one of the four immunoglobulin-type extracellular LAG-3 protein domains (amino acids 1-159, 160-230, 240-330 and 331-412 of...
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6139839 |
Control of infectious microorganisms by modulation of chorionic gonadotropin-related protein activity
A method of controlling, in a warm-blooded animal, an infectious microorganism expressing a chorionic gonadotropin-like growth-regulating protein comprises modulating the activity of the protein by...
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6133426 |
Humanized anti-IL-8 monoclonal antibodies
Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed...
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6132719 |
Monoclonal antibody and method of immunological analysis of e-D-dimer and e-DD/E complex
A monoclonal antibody which specifically reacts with D-monomer produced by digesting human fibrinogen with granulocyte elastase and D-domain containing digestion products produced by digesting...
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6130050 |
Method for detection of growth differentiation factor-12 polypeptide
Growth differentiation factor-12 (GDF-12) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-12...
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6117981 |
Hybridomas for lung cancer marker and monoclonal antibodies thereof
Hybridomas secreting monoclonal antibodies specific for an epitope found in the amino acids of LCGA associated with non-small cell lung carcinoma protein have been found. The monoclonal antibodies...
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6114143 |
Anti-HIV monoclonal antibody
A monoclonal antibody useful for clinical application which recognizes the conserved region of V3-PND region of glycoprotein antigen having a molecular weight of about 1.2×10 5 daltons (gp120) on...
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6110722 |
F.sub.0 ATP synthase subunit
The present invention provides a human ATP synthase subunit (ASYS) and polynucleotides which encode ASYS. The invention also provides expression vectors, host cells, agonists, antisense molecules,...
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