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6747133 |
Antibodies against the tumor suppressor gene ING1
The invention provides novel tumor suppressor genes, methods for making and using these and related tumor suppressor genes and proteins and peptides, and nucleic acids encoding these and related...
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6737058 |
Methods for inhibiting endothelial cell and fibrinogen mediated inflammation using fibrinogen specific antibodies
The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to...
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6730301 |
MCP-1 receptor antibodies
Novel human chemokine receptors, MCP-1RA and MCP-1RB, and processes for producing them are disclosed. The receptors, which are alternately spliced versions of MCP-1 receptor protein may be used in...
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6723319 |
Method of treating inflammatory intestinal diseases containing as the ingredient IL-6 receptors antibodies
A preventive or therapeutic agent for treating bowel disease, including Crohn's disease and ulcerative colitis, where the agent has as an active ingredient an antibody directed against IL-6...
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6723519 |
Compositions and method for determining the presence of rat PTTG peptide in a sample
Polypeptides are expressed by the pituitary-tumor-transforming-gene (PTTG), formerly known as pituitary-tumor-specific-gene (PTSG), and nucleic acids encode them. Examples are the human and rat...
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6719972 |
Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies
Isolated ligands which bind a molecule expressed on the surface of T cells and induce antigen specific apoptosis in activated T cells are disclosed. Preferably, the T cell surface molecule is CTLA4...
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6719975 |
Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin
A method of making antibodies to hirudin by immunizing with an immunogenic composition containing polymerized hirudin monomers in the absence of carrier protein is taught.
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6716967 |
Rupestris stem pitting associated virus nucleic acids, proteins, and their uses
This invention relates to purified monoclonal antibodies that specifically bind to a Rupestris stem pitting associated virus coat protein or coat protein polypeptide, and methods of detecting a...
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6713059 |
Antibodies raised against immunogenic conjugates of gram-negative bacterial autoinducer molecules
The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a...
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6709653 |
Antibodies specific for human inositol monophosphatase H1
Human Inositol Monophosphatase H1 polynucleotide and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for...
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6706266 |
Oncostatin M antagonists
The present invention relates to the use of an antagonist of OSM such as an antibody or small molecule in the manufacture of a medicament for the treatment or prophylaxis of an inflammatory...
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6699678 |
Chlamydia trachomatis specific peptides and their use in diagnostic assays
Disclosed are peptides or a mixture of peptides, or analogs thereof, derived from the variable domains of the Chlamydia trachomatis ( C. trachomatis ) immunodominant major outer membrane protein...
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6699973 |
Antibodies to peptides that target GIT receptors and related methods
The invention provides an antibody or antibody fragment specific to a domain of a GIT targeting agent, such as a polyclonal antibody, monoclonal antibody, chimeric antibody, single chain antibody,...
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6692740 |
ACPL antibodies
The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
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6689360 |
Human B-cell translocation genes-2 and 3 antibodies
The present invention relates to antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3)....
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6689361 |
SPE-4 antibody preparations
This application discloses SPE-4 related peptides, peptide-carrier protein conjugates and fusion proteins, immunogenic compositions, antibodies and methods for characterizing the SPE-4 related...
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6689744 |
Notch receptor agonists and uses
The present invention is directed to methods of alleviating prostate disorders by activation of the Notch1 receptor. Also provided herein are methods for detecting and diagnosing prostate...
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6682896 |
Peptides representing epitopic sites on r-IFN-β, antibodies thereto and uses thereof
The present invention discloses synthetic peptides and antibodies raised thereto wherein the synthetic peptides represent important epitopic sites recognized by monoclonal antibodies which can...
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6680373 |
P2U2 receptor antibodies
A novel subtype of the P 2 -purinergic receptor, referred to as the P 2U2 receptor, is disclosed. This receptor is activated by four of its agonists in the following order of specificity:...
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6677124 |
Monoclonal antibody recognizing C-terminus of hBNP
A hybridoma producing a monoclonal antibody recognizing the C-terminus of human brain natriuretic peptide (hBNP) was cultivated in a medium or the abdominal cavity of a mouse to recover the...
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6676939 |
Methods of modulating IL-174 response
Agonists or antagonists of cytokine designated IL-174, and various methods of their use are provided. In particular, the methods make use of facts that many activities of the IL-174 cytokine are...
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6673344 |
Antibodies to human CKβ-10/MCP-4
Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods...
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6673355 |
Rotavirus enterotoxin NSP4 and methods of using same
The rotavirus nonstructural glycoprotein, NSP4, performs multiple functions in the virus replication cycle, especially during viral morphogenesis. Specifically, NSP4 is an intracellular receptor...
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6660274 |
Surface antigens and proteins useful in compositions for the diagnosis and prevention of lyme disease
A novel isolated Borrielia burgdorferi sensu lato surface antigen is characterized by a relative molecular mass of 39.5 kDa. This antigen is expressed in vitro by spirochetes of a B. burgdorferi...
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6653084 |
Anti-erbB-2 antibodies to human receptor related to but distinct from EGF receptor
The isolation, cloning and characterization of a human gene related to but distinct from the EGF receptor gene has been described. Nucleotide sequence of the gene and amino acid sequence of the...
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6645492 |
Methods of treating asthma with interleukin-9 receptor antibodies
A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1 (AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 ...
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6645491 |
Method for treating inflammatory conditions using an antibody to MIP-3α
Agonists or antagonists of MIP-3α, and various methods of use in dermatological and related applications are provided. In particular, the method makes use of fact that the MIP-3α chemokine is...
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6638505 |
Antibodies to aglyco products and methods of use
Glycoconjugates, therapeutic compositions containing the glycoconjugates and therapeutic methods of using the glycoconjugates are disclosed. In particular, peptide constituents of aglyco 10B, which...
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6638507 |
Mammalian proteases; related reagents
Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related...
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6635251 |
Eotaxin-specific antibodies
A chemoattractant protein called “eotaxin” is capable of attracting eosinophils and of inducing eosinophil accumulation and/or activation in vitro and in vivo. Various types of agents that...
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6630143 |
Antibodies against flt3 ligand
Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is...
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6630141 |
Isolated antibody that binds to an Ikaros polypeptide
Purified DNA including a sequence encoding an Ikaros protein.
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6630144 |
Monoclonal antibodies to Ebola glycoprotein
In this application are described Ebola GP monoclonal antibodies and epitopes recognized by these monoclonal antibodies. Also provided are mixtures of antibodies of the present invention, as well...
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6623737 |
Antibodies to intimin-like proteins of E. coli
The invention is related to antibodies, particularly monoclonal antibodies, which recognize particularly epitopes of the intimin protein of enteropathogenic E. coli and enterohemorrhagic E. coli...
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6623738 |
Semaphorin receptors
The invention provides methods and compositions relating to two classes of semaphorin receptors, SR1 and SR2. The polypeptides may be produced recombinantly from transformed host cells from the...
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6620590 |
Diagnosis of pre-eclampsia
A method for diagnosis of pre-eclampsia is disclosed, which comprises measuring the hormone inhibin A in a biological sample such as maternal serum. The method allows non-invasive, early diagnosis...
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6610288 |
Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function
Isolated porcine hepatocytes, isolated populations of such hepatocytes and methods for using the hepatocytes to treat subjects with disorders characterized by insufficient liver function are...
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6610297 |
Peptide immunogens for vaccination against and treatment of allergy
Disclosed are compositions for treating allergies that include either BSW17 mimotope peptides or antibodies raised against BSW17 mimotope peptides. Also disclosed are methods for the treatment of...
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6610834 |
Human IgM antibodies to chemokine receptors
Human sera from normal (i.e., non-HIV infected) individuals contain certain IgM autoantibodies reactive to chemokine and other lymphocyte-surface receptors. A subset of these IgM autoantibodies...
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6610303 |
Papilloma viruses, products for the detection thereof as well as for treating diseases caused by them
This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein and a papilloma virus genome, respectively. In addition, this invention concerns proteins coded by the...
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6605279 |
Therapeutic compositions for inhibiting the interactions of B7-1 and B7-2 with their natural ligands
Disclosed is a composition for inhibiting the interactions of B7-1 and B7-2 with their natural ligands. Such compositions comprise an antibody specific for B7-2 and an antibody specific for B7-1,...
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6602501 |
C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof
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6596852 |
Antibodies that bind the cytokine designated LERK-5
LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the...
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6596277 |
Methods of decreasing cell adhesion
The present invention provides substantially pure integrins containing a novel β subunit designated as β 6 . The novel β 6 subunit forms heterodimers with α V and α F . Methods of...
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6596276 |
Method for inhibiting tumor angiogenesis in a living subject
The present invention provides a method for inhibiting tumor angiogenesis in a living subject. The method relies upon tumor angiogenesis mediated by vascular endothelial growth factor and specified...
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6589534 |
Hepatitis B virus binding proteins and uses thereof
An isolated nucleic acid, a recombinant protein encoded thereby and uses thereof. The isolated nucleic acid including (a) a polynucleotide at least 60% identical to SEQ ID NOs:1, 3, 5 or portions...
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6569996 |
Antibody that specifically binds to the cadherin-5 cell adhesion recognition sequence
Modulating agents for inhibiting or enhancing nonclassical cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: (a) a peptide sequence that is at least 50%...
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6565848 |
Cadherin-like asymmetry protein-1, and methods for its use
The present invention relates to molecules involved in cell-cell interactions in the immune system. In particular, the invention relates to a cell surface protein which contains certain classical...
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6562949 |
Antibodies to viral encoded semaphorin protein receptor polypeptides
The invention is directed to VESPR polypeptides as a purified and isolated protein, the DNA encoding the VESPR polypeptide, host cells transfected with cDNAs encoding VESPR, and methods for...
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6555111 |
Method of inhibiting the cytocidal effect of TNF with TNF receptor-specific antibodies
Antibodies to Tumor Necrosis Factor receptors (TNF-Rs) which inhibit the cytocidal effect of TNF but not its binding to the TNF-Rs, and ligands interacting with other receptors of the TNF/NGF...
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