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6953843 |
Antibodies and fragments thereof to MDL-1 protein
The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells,...
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6951923 |
Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof
This invention provides for antibodies directed to OLD-35 protein, the product of the OLD-35 gene, which displays enhanced expression during cellular senescence and terminal cell differentiation.
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6949246 |
Compounds and methods for diagnosis of tuberculosis
Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins,...
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6949360 |
DNA coding for human cell surface antigen
DNAs coding for human cell surface antigen (Fas or Fas antigen), vectors for expressing for said DNAs and transformants transfected with said vector are proveded. Fas is a polypeptide that exists...
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6942865 |
Methods and reagents to detect and characterize norwalk and related viruses
Double-stranded cDNA was synthesized from nucleic acid extracted from Norwalk virus purified from stool specimens of volunteers. One clone was isolated from a cDNA library constructed in a pUC-13...
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6939544 |
Antibodies against mouse pituitary tumor transforming gene carboxy-terminal (PTTG-C) peptides
Disclosed are isolated antibodies that specifically bind a murine pituitary tumor transforming gene carboxy-terminal (PTTG-C) peptide. The inventive antibodies are useful in assays to determine...
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6936248 |
Methods of inhibiting GPR-9-6 function
The invention relates to an antibody or antigen-binding fragment thereof which binds to the CC chemokine receptor GPR-9-6 and blocks the binding of a ligand (e.g., TECK) to the receptor. The...
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6936247 |
Filariid anti-P22U antibodies
The present invention relates to isolated parasitic helminth nucleic acid sequences capable of hybridizing, under stringent conditions, to at least a portion of D. immitis nucleic acid sequence...
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6921809 |
Monoclonal antibody to the stabilizer peptide of the P64K antigen of Neisseria meningitidis
The present invention related to biotechnology and genetic engineering, particularly the expression of proteins of viral origin in microorganisms through their fusion by applying recombinant DNA...
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6919077 |
LFA-1 alpha subunit antibodies and methods of use
Antibodies useful for and methods of treating LFA-1 alpha subunit associated physiological conditions and diseases treatable with an antibody that binds LFA-1 alpha subunit, such as HIV, are provided.
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6905685 |
Methods of using antibodies to human receptor protein 4-1BB
Disclosed herein are the methods of using the H4-1BB protein, ligands to this protein, and various mAbs either directed against H4-1BB or other molecules that can be used therapeutically. The...
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6902734 |
Anti-IL-12 antibodies and compositions thereof
The present invention relates to at least one anti-IL-12 antibody, including isolated nucleic acids that encode at least one anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or...
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6899878 |
Antibodies to interleukin-1 receptor intracellular ligand proteins
Antibodies to IL-1-R intracellular ligand proteins are disclosed. The antibodies arc useful for inhibiting the binding between IL-1-R and IL-1-R intracellular ligand proteins.
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6887481 |
Bacterial-derived molecules and therapeutic and diagnostic uses therefor
The present invention relates generally to molecules derived from a Mycobacterium species and recombinant, synthetic, derivative, homologue and analogue forms of said molecules. The molecules of...
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6887468 |
Antibody kits for selectively inhibiting VEGF
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
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6881405 |
Reagents and methods for inducing an immune response to prostate specific antigen
The invention is an apparatus and method for the treatment of prostate cancer, and involves administering an antibody that specifically binds with prostate antigen.
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6881408 |
Immunoadsorber for use in sepsis therapy
The invention relates to immunoadsorbers for use in sepsis therapy, in particular for removal of complement factors and lipopolysaccharides (LPS) and, if need be, further sepsis mediators such as...
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6863887 |
Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis
The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered...
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6863889 |
Polynucleotides and proteins encoded thereby
The present invention provides novel isolated SECX polynucleotides and the membrane-associated or selected polypeptides encoded by the SECX polynucleotides. Also provided are the antibodies that...
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6861228 |
Modulating Robo: ligand interactions
Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for...
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6849418 |
Diagnosis of spongiform or de-myelinating disease
Disclosed are a method and a corresponding kit for detecting multiple sclerosis, Creutzfeld-Jakob disease, and/or spongiform encephalopathy in mammals. The method includes the step of testing a...
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6849413 |
PGRP-L polynucleotides, polypeptides, and antibodies
The present invention relates to novel human and murine proteins called PGRP-L, and isolated polynucleotides encoding these proteins. Also provided are vectors, host cells, antibodies, and...
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6843990 |
Monoclonal antibodies for the detection of decoy receptor 3, hybridomas producing said antibodies and uses thereof
The invention provides monoclonal antibodies against decoy receptor 3 (DcR3), hybridomas producing said antibodies, kits containing said monoclonal antibodies and uses of the hybridomas, antibodies...
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6835380 |
Antibodies against rat pituitary tumor transforming gene carboxy-terminal (PTTG-C) peptides
Disclosed are isolated antibodies that specifically bind a rat pituitary tumor transforming gene carboxy-terminal peptide (PTTG-C). These antibodies are believed to be particularly useful in...
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6835370 |
Diagnosis and treatment of malignant neoplasms
The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an...
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6833132 |
Method of stimulating epithelial cells using keratinocyte growth factor (KGF) and method of inhibiting KGF activity
Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used sucessfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other...
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6828416 |
Recombinant multivalent malarial vaccine against Plasmodium falciparum
A recombinant protein is provided which comprises peptides derived from different stages in the life cycle of parasite Plasmodium falciparum . The protein is useful as a reagent and, when combined...
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6828425 |
Antibodies that bind human Zven1
The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular...
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6824993 |
Antibodies that bind human prostate specific G-protein receptor HPRAJ70
The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to...
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6825324 |
Antibodies to receptor protein tyrosine kinases
The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver...
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6824774 |
Antibodies that bind neuron restrictive silencer factor proteins
The present invention relates to neuron-restrictive silencer factor proteins, nucleic acids, and antibodies thereto.
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6824775 |
88kDa tumorigenic growth factor and antagonists
This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expressing or action. Antagonists to an 88...
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6822080 |
Human cyclin-dependent kinase-like proteins and methods of using the same
Substantially pure human cyclin-dependent kinase-like proteins PITALRE and PISSLRE and isolated protein complexes that comprise PITALRE or PISSLRE are disclosed. Isolated nucleic acid molecule that...
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6818214 |
Two novel genes from psoriatic epidermis: psoriastatin type I and psoriastatin type II
A method of modulating cell proliferation or apoptosis comprising modulating psoriastatin activity.
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6818215 |
Antibodies to senescent cell-derived inhibiters of DNA synthesis
Polyclonal and monoclonal antibodies that specifically bind senescent cell derived inhibitor protein (SDI-1), cell lines that produce such monoclonal antibodies, and the use of such antibodies are...
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6815169 |
Identification and expression of a novel kinesin motor protein
The invention provides isolated nucleic acid and amino acid sequences of TL-γ, antibodies to TL-γ, methods of screening for TL-γ modulators using biologically active TL-γ, and kits for...
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6814967 |
Antibodies to cortistatin: neuropeptides, compositions and methods
The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with...
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6814965 |
Methods of decreasing ZVEGF3 activity
Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that...
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6808710 |
Downmodulating an immune response with multivalent antibodies to PD-1
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents...
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6805863 |
Methods of modulating immune coagulation
Methods for mediating immune coagulation using novel antibodies and compounds are described. A protein Fgl2 having direct prothrombinase activity has been identified. Inhibitors of Fgl2 are useful...
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6800285 |
Treatment of central nervous system diseases by antibodies against glatiramer acetate
The present invention provides humanized polyclonal and humanized monoclonal antibodies directed against an epitope on glatiramer acetate, also known as Copolymer 1, Copolymer-1, Cop-1 or Cop....
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6793919 |
Methods for treating rheumatoid arthritis using IL-17 antagonists
A method of treating a mammal afflicted with rheumatoid arthritis by administering to the mammal an antibody that binds IL-17R is disclosed.
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6794192 |
Target
The present invention relates to an isolated target sequence. The target sequence is a splice variant of PDE5 called a PDE5 a 1, a component of which is presented as SEQ ID No 1. The identified...
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6783759 |
Compositions and methods for modulating variola virus
Antibodies directed to SPICE which may be used for detection, prevention, and treatment of variola virus are provided. Recombinant SPICE and VCP proteins are also provided which are used for...
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6774219 |
Candida albicans gene, integrin-like protein, antibodies, and methods of use
An isolated and purified DNA molecule encoding Candida albicans protein with integrin-like motifs, the protein itself, antibodies thereto, and methods of use, are provided.
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6767536 |
Recombinant Staphylococcus thioredoxin reductase and inhibitors thereof useful as antimicrobial agents
Isolated and purified Staphylococcus thioredoxin reductases (TrxB) are provided. Polynucleotides encoding the TrxBs, vectors and host cells containing such polynucleotides are also provided. In...
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6761891 |
Medicament for treating a manifested lyme disease
A pharmaceutical composition for treating Lyme disease contains an antibody as an active agent which is specific for the 24 kDa antigen (OspC) of B. burgdorferi , preferably an antibody which is...
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6759519 |
Antibodies to human G-protein chemokine receptor HDGNR10 (CCR5receptor)
Antibodies against human G-protein chemokine receptor polypeptides, the polypeptides themselves, DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant...
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6759044 |
Cryptopain antibodies for prophylaxis, treatment, diagnosis and detection of Cryptosporidium species
Vaccines, antibodies, proteins, DNAs and RNAs for diagnosis, prophylaxis, treatment and detection of Cryptosporidium species or Cryptosporidium species infections. Cryptosporidium species antigen...
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6756035 |
Anti-CCR1 antibodies and methods of use therefor
The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 1 (CCR1) or a portion of the receptor and blocks binding...
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