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7514079 |
Antibodies that specifically bind to neurokinin B
The present invention relates to antibodies and related molecules that specifically bind to neurokinin B. Such antibodies have uses, for example, in the prevention and treatment of cancer as well...
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7514081 |
Methods of inhibiting an immune response with anti-human endokine alpha antibodies
The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha...
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7510840 |
Method of inhibiting growth or survival of a cell by providing an anti-108P5H8 antibody
A novel gene (designated 108P5H8) and its encoded protein, and variants thereof, are described wherein 108P5H8 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
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7510707 |
PAR, a novel marker gene for breast and prostate cancers
The present invention relates to a gene selectively expressed in malignant cells and associated with the development of androgen resistance in prostate cancer. Levels of the gene, termed “PAR”...
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7510715 |
Protozoan derived compositions and methods of use thereof
The instant invention relates to methods for treating a subject suffering from or susceptible to an autoimmune disease or disorder, or a disease or disorder having an autoimmune component,...
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7511122 |
Humanized and chimeric antibodies specific for lipoteichoic acid of GRAM positive bacteria
The present invention encompasses monoclonal and chimeric antibodies that bind to lipoteichoic acid of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis...
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7510708 |
Disruption of the REG pathway
Disruption of the Reg signalling pathway permits spontaneous and therapeutic induction of pro-apoptotic signals to be more effective. Disruption can be accomplished by means of antibodies,...
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7507408 |
Anti hepatitis C virus antibody and uses thereof
Described are novel antibodies specifically recognizing conformation dependent epitopes of HCV glycoprotein E2 and that are capable aof neutralizing the binding of E2 protein onto susceptible...
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7504104 |
Human CDR-grafted antibody and antibody fragment thereof
A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood...
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7501121 |
IL-13 binding agents
Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
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7498027 |
Methods of treatment using human tumor necrosis factor receptor TR17 antibodies
The present invention relates to a novel protein, TR17, which is a member of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided...
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7498419 |
Crystals and structure of domain III of West Nile Virus envelope protein in association with a Fab fragment of a neutralizing antibody
The present invention provides crystalline forms of domain III of the West Nile Virus (“WNV”) envelope protein in complex with a Fab fragment of a neutralizing antibody, methods of obtaining...
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7494653 |
Method and compositions for immunization with the Pseudomonas V antigen
A method of inhibiting, moderating or diagnosing Pseudomonas aeruginosa infection is disclosed. In one embodiment, this method comprises inoculating a patient with an effective amount of PcrV...
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7494647 |
Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody
A humanized antibody against tissue factor (TF), comprising: A: a humanized H chain comprising (1) a H chain V region comprising the H chain CDRs of a mouse monoclonal antibody against TF and the...
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7495085 |
Antibodies against human or mouse IL-21 receptor
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The antibodies can act as antagonists...
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7494655 |
Immunizing composition and method for inducing an immune response against the β-secretase cleavage site of amyloid precursor protein
The present invention is directed to an immunizing composition containing an antigenic product such as a multiple antigen peptide system (MAPS) or a filamentous bacteriophage displaying an AβPP...
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7491391 |
Anti-IL-23 antibodies, compositions, methods and uses
An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using...
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7491392 |
Antibodies to human IL-1β
An IL-1β binding molecule, in particular an antibody to human IL-1β, especially a human antibody to human IL-1β is provided, wherein the CDRs of the heavy and light chains have amino acid...
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7488476 |
B-cell epitope peptides of HSP 65, DNA encoding said peptides, antibodies directed against said peptides and the different uses thereof in the treatment of inflammatory and autoimmune diseases
B-cell epitope peptides of HSP 65, particularly the peptides comprising the amino acid sequence substantially as denoted by SEQ ID: Nos. 1-5 and their biologically functional homologues and...
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7485459 |
Human neuronal attachment factor-1 antibodies
A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such...
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7485301 |
Methods of treating inflammatory disease using antibodies which bind GPR-9-6
The invention relates to an antibody or antigen-binding fragment thereof which binds to the CC chemokine receptor GPR-9-6 and blocks the binding of a ligand (e.g., TECK) to the receptor. The...
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7481999 |
Compounds and methods for modulating OB-cadherin-mediated function
Compositions and methods for modulating OB-cadherin-mediated functions are provided. The compositions and methods employ OB-cadherin modulating agents which generally comprise one or more of: (a) a...
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7473766 |
PAK4-related antibodies
This invention provides an isolated mammalian nucleic acid molecule encoding a PAK4 serine/threonine kinase. This invention provides an isolated nucleic acid molecule encoding a mutant homolog of...
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7473422 |
Antibodies to retinoid metabolizing protein
Amino acid sequences and corresponding nucleic acid sequence of retinoid metabolizing protein found in human, mouse and zebrafish are described, as well as methods of using same.
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7473421 |
Humanized anti-CCR2 antibodies and methods of use therefor
The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks...
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7470428 |
Compositions and methods related to TIM-3, a Th1-specific cell surface molecule
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or...
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7468183 |
Antibody immunization therapy for treatment of atherosclerosis
The present invention relates to passive immunization for treating or preventing atherosclerosis using an isolated human antibody directed towards at least one oxidized fragment of apolipoprotein B...
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7455836 |
Method of treatment and agents useful for same
The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the...
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7455837 |
Compositions and methods for the diagnosis and treatment of sepsis
The present invention relates to methods and compositions for the diagnosis and treatment of sepsis. The present invention also provides methods of providing a prognosis to a patient with sepsis....
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7449556 |
Recombinant antibodies against infectious bursal disease virus (ibdv)
The purpose of this project was to isolate recombinant antibodies for diagnosis of very virulent infectious bursal disease virus (vvIBDV) in fixed tissues. Phage-displayed recombinant antibodies,...
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7449185 |
Antibodies to OCIF-binding molecules
The present invention relates to a novel protein which binds to Osteoclastogenesis Inhibitory Factor (OCIF-binding molecule; OBM), a process for preparing the same, DNA encoding said protein, a...
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7446180 |
Conformationally abnormal forms of tau proteins and specific antibodies thereto
Invention relates to antibodies with a specificity to an abnormally truncated form of tau protein which is conformationally different from normal tau and does not bind to normal tau protein,...
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7439324 |
ALS-specific peptide composition
The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion...
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7435413 |
Anti-tissue factor antibodies with enhanced anticoagulant potency
The invention concerns anti-tissue factor (anti-TF) antibodies with enhanced anticoagulant potency, and methods and means for identifying, producing and using such antibodies. The anti-TF...
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7435796 |
Antibodies which bind B7RP1
Novel polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding said polypeptides, and vectors and host cells for expressing...
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7435540 |
PrPSc-selective peptides
The present invention features methods for identifying peptides that selectively bind to PrP Sc or fragments thereof. The invention also features the use of such peptides in screening methods for...
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7432067 |
Methods of detection of MATER protein autoantibodies
Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for...
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7429646 |
Antibodies to human tumor necrosis factor receptor-like 2
The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice...
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7427399 |
Antibodies and related molecules that bind to 161P2F10B proteins
Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is...
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7423125 |
Antibodies to VEGF-C
Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such...
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7419664 |
Method of treatment using antibody to CLCA-1
The invention relates to methods of treating a disease or condition, wherein expression or activity of soluble CLCA1 is up-regulated, by administering inhibitors of soluble CLCA1. The invention...
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7419662 |
Methods of making chemokine alpha 3 antibodies
Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are...
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7417125 |
Antibodies that bind a PRO1158 polypeptide
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7410639 |
Vascular endothelial growth factor D(VEGF-D) antibodies and methods of use
VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as...
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7407655 |
Method of inhibiting leukocytes with human CXC chemokine receptor 3 antibody
The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3...
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7404954 |
Methods of targeting agents to cells expressing the polymeric immunoglobulin receptor
The invention provides compositions and methods for specific binding to a region of the polymeric immunoglobulin receptor (pIgR) of a cell with the provisos that the ligand does not substantially...
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7393529 |
Methods and compositions for inhibiting binding of IgE to a high affinity receptor
The invention provides methods and compositions for inhibiting binding of IgE to a high affinity receptor. The methods and compositions are useful in the treatment of allergic diseases and allergy...
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7390486 |
PRO4381 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7390489 |
Monoclonal antibody selectively recognizing listeria monocytogenes, hybridoma producing the antibody, test kit comprising the antibody and detection method of listeria monocytogenes using the antibody
The present invention relates to a monoclonal antibody binding specifically to the p60 protein of Listeria monocytogenes , a hybridoma cell producing the monoclonal antibody, a test kit comprising...
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7392141 |
Method of preparing a modified granulocyte colony stimulating factor (G-CSF) with reduced immunogenicity
A method of preparing a modified granulocyte colony stimulating factor (G-CSF) protein having reduced immunogenicity relative to human G-CSF comprises the steps of (i) identifying one or more...
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