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6994852 |
Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5
Antibodies directed against an antigenic determinant of high molecular weight kininogen domain 5, particularly a determinant located in the region formed by light chain amino acids Gly(440) to...
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6994853 |
Time-staggered utilization of tumor cells in combination with intact antibodies for immunization
The invention relates to the time-staggered utilization of tumor cells in combination with intact, preferably heterologous antibodies for the immunization of humans and animals.
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6982252 |
Inhibition of vacuolar proton ATPase activity and/or the modulation of acidic organelle function sensitizes cells to radiation, chemotherapy and biological agents
The present invention relates to methods and compositions for inhibiting cell survival and/or promoting cell death following exposure to cytotoxic agents and stress such as radiation or...
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RE38916 |
APC Antibodies
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous...
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6969518 |
Compositions and methods for the therapy and diagnosis of breast cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic...
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6949245 |
Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
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6927203 |
Treatment of metastatic disease
The present invention is directed to compounds and methods for the treatment of metastatic disease. The compounds of this invention have specificity for EphA2, an epithelial cell tyrosine kinase...
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6926896 |
Monoclonal antibodies (MAbs) against tumor-associated antigens, the preparation and use thereof
The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these...
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6924361 |
Phosphopeptide-specific antibodies that are activity specific; methods of production and antibody uses
This invention relates to growth regulatory proteins expressed in various disease states, especially receptor tyrosine kinases and similar growth factor receptors. Prior to the Applicants...
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6905685 |
Methods of using antibodies to human receptor protein 4-1BB
Disclosed herein are the methods of using the H4-1BB protein, ligands to this protein, and various mAbs either directed against H4-1BB or other molecules that can be used therapeutically. The...
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6893638 |
Methods for treating b cell lymphoma using CD80-specific antibodies
The present invention relates to methods for treating B cell lymphoma using CD80-specific antibodies.
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6881405 |
Reagents and methods for inducing an immune response to prostate specific antigen
The invention is an apparatus and method for the treatment of prostate cancer, and involves administering an antibody that specifically binds with prostate antigen.
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6843990 |
Monoclonal antibodies for the detection of decoy receptor 3, hybridomas producing said antibodies and uses thereof
The invention provides monoclonal antibodies against decoy receptor 3 (DcR3), hybridomas producing said antibodies, kits containing said monoclonal antibodies and uses of the hybridomas, antibodies...
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6835370 |
Diagnosis and treatment of malignant neoplasms
The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an...
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6828425 |
Antibodies that bind human Zven1
The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular...
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6824993 |
Antibodies that bind human prostate specific G-protein receptor HPRAJ70
The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to...
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6824775 |
88kDa tumorigenic growth factor and antagonists
This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expressing or action. Antagonists to an 88...
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6821516 |
Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
The invention relates to macrophages which have at least one of the following properties: their cytotoxic activity without IFN-γ is increased by about 20 to 30% with respect to standard...
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6821515 |
Protein formulation
A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for...
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6822080 |
Human cyclin-dependent kinase-like proteins and methods of using the same
Substantially pure human cyclin-dependent kinase-like proteins PITALRE and PISSLRE and isolated protein complexes that comprise PITALRE or PISSLRE are disclosed. Isolated nucleic acid molecule that...
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6787153 |
Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane
A human monoclonal antibody specifically binding to a surface antigen of cancer cell membrane, an isolated DNA encoding the antibody, and a hybridoma producing the antibody. An anti-cancer...
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6764679 |
Antibodies to DcR3 Polypeptide, a TNFR Homolog
A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
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6759043 |
Monoclonal antibodies having property of causing apoptosis
It is the objective and purpose of the present invention to provide a monoclonal antibody having the property of causing apoptosis on myeloid cells. This invention relates to a monoclonal antibody...
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6753154 |
Human AZU-1 gene, variants thereof and expressed gene products
A human AZU-1 gene, mutants, variants and fragments thereof. Protein products encoded by the AZU-1 gene and homologs encoded by the variants of AZU-1 gene acting as tumor suppressors or markers of...
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6747133 |
Antibodies against the tumor suppressor gene ING1
The invention provides novel tumor suppressor genes, methods for making and using these and related tumor suppressor genes and proteins and peptides, and nucleic acids encoding these and related...
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6737511 |
Receptor-mediated uptake of an extracellular BCL-xL fusion protein inhibits apoptosis
Apoptosis-modifying fusion polypeptides, and the corresponding nucleic acid molecules, are disclosed. Pharmaceutical compositions comprising these polypeptides, and the use of these polypeptides to...
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6689360 |
Human B-cell translocation genes-2 and 3 antibodies
The present invention relates to antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3)....
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6689744 |
Notch receptor agonists and uses
The present invention is directed to methods of alleviating prostate disorders by activation of the Notch1 receptor. Also provided herein are methods for detecting and diagnosing prostate...
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6673562 |
Differential immunoassay
The invention provides assay methods and kits that in general measure the level of a first analyte in a sample reduced by the level of a second analyte present in the same sample. In one...
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6673341 |
Methods of inhibiting proliferative diseases by inhibiting TGF-β-mediated angiogenesis
Disclosed are methods of inhibiting proliferative diseases characterized by TGF-β-mediated angiogenesis.
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6652853 |
Method for treating cancer using A33 specific antibodies and chemotherapeutic agents
This invention relates to a combination of immunotherapy and chemotherapy to promote tumor regression by treating a patient in need thereof with a combination of a humanized antibody that binds to...
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6653084 |
Anti-erbB-2 antibodies to human receptor related to but distinct from EGF receptor
The isolation, cloning and characterization of a human gene related to but distinct from the EGF receptor gene has been described. Nucleotide sequence of the gene and amino acid sequence of the...
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6638505 |
Antibodies to aglyco products and methods of use
Glycoconjugates, therapeutic compositions containing the glycoconjugates and therapeutic methods of using the glycoconjugates are disclosed. In particular, peptide constituents of aglyco 10B, which...
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6616926 |
Methods of modulating lipid metabolism and storage
Anti-hedgehog antibodies directed at blocking the binding of hedgehog to its receptor patched-1, will impair lipid metabolism and storage. This invention presents methods for the treatment of a...
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6602501 |
C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof
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6596277 |
Methods of decreasing cell adhesion
The present invention provides substantially pure integrins containing a novel β subunit designated as β 6 . The novel β 6 subunit forms heterodimers with α V and α F . Methods of...
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6596276 |
Method for inhibiting tumor angiogenesis in a living subject
The present invention provides a method for inhibiting tumor angiogenesis in a living subject. The method relies upon tumor angiogenesis mediated by vascular endothelial growth factor and specified...
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6572856 |
Methods for the prevention and treatment of cancer using anti-C3b(i) antibodies
The present invention relates to the treatment and prevention of cancer, viral infections and microbial infections by the administration of anti-C3b(i) antibodies. The present invention also...
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6548062 |
Method of treating cancer with anti-neurotrophin agents
A method of treating or preventing cancer by administering to a mammal a therapeutically effective amount of at least one anti-neurotrophin agent is described. The anti-neurotrophin agent is...
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6528269 |
Immunological agents specific for prion protein (PRP)
The present invention is directed to a panel of monoclonal antibodies (Mabs) specific for murine prion protein PrP c . These Mabs can be applied to immunoblotting, cell surface immunofluorescent...
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RE38008 |
Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof
Methods for improved targeting of antibody, antibody fragments, peptides hormones, steroid hormones and conjugates thereof are disclosed. Enhanced delivery to target cells of antibodies or...
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6495137 |
Humanized anti-tag-72 monoclonal antibodies using human subgroup 4 kappa light chains
Novel composite and humanized anti-TAG-72 monoclonal antibodies, antibody fragments, and derivatives thereof using human subgroup IV kappa light chain framework regions.
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6491914 |
Anti-idiotypic monoclonal antibodies, their use in the active immunotherapy of malignant tumors, and compositions including the anti-idiotypic monoclonal antibodies
An anti-idiotypic monoclonal antibody that is specific against the N-glycolyl residues of gangliosides, particularly those expressed by cancer cells. The monoclonal antibody is useful as an...
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6468547 |
Enhancement of tumor cell chemosensitivity and radiosensitivity using single chain secretory antibodies
The present invention provides a method of enhancing the chemosensitivity and radiosensitivity of a neoplastic cell expressing an oncoprotein that stimulates proliferation of the cell, comprising...
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6468529 |
Hepatocyte growth factor receptor antagonists and uses thereof
Hepatocyte growth factor (HGF) receptor antagonists are provided. The HGF receptor antagonists include HGF receptor antibodies and fragments thereof. The HGF receptor antagonists can be employed to...
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6455040 |
Tumor necrosis factor receptor 5
The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic...
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6447776 |
Mutations of E cadherin as a basis for the diagnosis and therapy of human malignant tumors
The present invention describes monoclonal antibodies which are useful for the specific detection of diffuse gastric carcinoma. Further embodiments describe therapeutic and diagnostic means for the...
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6440416 |
Vaccines against cancer and infectious diseases
A method of stimulating an immune response in a human against malignant cells or an infectious agent comprises the step of administering to the human an immunogenic amount of a primate...
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6423313 |
Inhibition of tumor growth by blockade of the protein C system
Compositions, and methods of use thereof, for the inhibition of tumor growth and killing of solid tumors wherein the active agent is a compound blocking the Protein C system, preferably...
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6406693 |
Cancer treatment methods using antibodies to aminophospholipids
Disclosed are the surprising discoveries that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are stable and specific markers accessible on the luminal surface of tumor...
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