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9169323 Antibodies against human CSF-1R  
The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
9040043 Monoclonal antibodies against GMF-B antigens, and uses therefor  
The disclosure relates to anti-glial maturation factor beta (“GMF-B”) monoclonal antibodies (mAbs) and fragments thereof, as well as hybridoma lines that secrete antibodies or fragments....
9040049 ADAM-15 antibodies and immunogenic peptides  
The present invention relates to antibodies and antigen-binding fragments thereof, immunogenic peptide(s), and siRNA molecules which are capable of inhibiting neovascularization and/or...
9040044 Compositions and methods for treating and diagnosing cancer  
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in...
9040042 Optimized antibodies that target HM1.24  
The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent...
9040041 Modified FC molecules  
The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding...
9035037 Medical devices  
Medical devices comprising an anti-connexin agent suitable for introduction into a subject.
9035026 Anti-CD16 binding molecules  
The present invention relates to binding molecules that specifically bind to the human Fc gamma receptor expressed on the surface of natural killer (NK) cells and macrophages (i.e. FcγRIIIA), and...
9034324 Anti-BCMA antibodies  
This invention provides antibodies that recognize the B Cell Maturation Antigen (BCMA) and that bind naïve B cells, plasma cells, and/or memory B cells. The invention further provides methods for...
9034585 Diabetes-related biomarkers and methods of use thereof  
The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify...
9034586 Method of detecting pancreatic disease and pancreas testing kit  
A pancreatic disease is tested for with high sensitivity even with simple equipment and a simple procedure. Provided is a method of detecting pancreatic disease including detecting a concentration...
9034334 Protofibril selective antibodies and the use thereof  
The invention relates to an isolated antibody, or fragment thereof, having high affinity for human Aβ protofibrils. The invention further relates to compositions that include the antibody, or a...
9028823 Methods of inducing or enhancing an immune response in a subject by administering agonistic GITR binding antibodies  
The present invention provides binding molecules that specifically bind to GITR, e.g., human GITR (hGITR), on T cells and dendritic cells. Binding molecules of the invention are characterized by...
9028815 Identification and engineering of antibodies with variant FC regions and methods of using same  
The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region...
9028818 Antibodies binding to adrenomedullin receptors and uses thereof as drugs  
The invention relates to antibodies binding to the proteins forming adrenomedullin receptors, and to the uses thereof as a drug.
9029508 Dual variable domain immunoglobulins and uses thereof  
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
9028826 Methods of immune therapy with anti-CD154 antibodies having impaired FcR binding and/or complement binding properties  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune...
9023352 Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein  
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant...
9023349 Compositions and methods for diagnosing and treating an inflammation  
A method of reducing an inflammatory response in a subject is provided. The method comprising providing to a subject in need thereof a therapeutically effective amount of an agent capable of...
9023993 Anti-cancer agent comprising anti-HB-EGF antibody as active ingredient  
A monoclonal antibody having a neutralizing activity on HB-EGF is disclosed. The monoclonal antibody of the present invention is preferably an antibody that does not bind to the HB-EGF protein on...
9023994 Immunoglobulin reduced in thrombogenic agents and preparation thereof  
The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a...
9023356 Treatment method using EGFR antibodies and SRC inhibitors and related formulations  
The present invention relates to the treatment of EGFR-mediated disease, particularly cancer by inhibiting or blocking EGFR and src in combination or simultaneously. The invention relates to...
9023353 Anti-(+)—methamphetamine monoclonal antibodies  
The present invention encompasses compositions and methods for effectively treating at least one symptom or sign of methamphetamine use, or for slowing the rate of (+) methamphetamine entry into...
9023604 Method of reversibly staining a target cell  
The present invention relates to methods of reversibly staining a target cell. The invention also relates to methods of isolating a target cell or a target cell population that is defined by the...
9023359 Targeting rare human PCSK9 variants for cholesterol treatment  
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
9023348 Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof  
A composition-of-matter comprising an antibody or antibody fragment including an antigen-binding region capable of specifically binding an antigen-presenting portion of a complex composed of a...
9017670 Anti-Tie2 antibodies and uses thereof  
The present invention provides antibodies that bind to Tie2 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to...
9017678 Method of treating rheumatoid arthritis using antibody to IL6R  
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
9017668 High affinity human antibodies to human cytomegalovirus (CMV) gB protein  
Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high...
9017955 Fibrinogen assay  
The present invention is directed to a method of detecting intact fibrinogen, comprising the steps of: a) providing a sample containing at least some fibrinogen optionally converted at least in...
9017672 Hexon Tat-PTD modified adenovirus and uses thereof  
The invention provides a hexon Tat-PTD modified adenovirus, a gene delivery vector based on the modified adenovirus that enhances gene delivery efficiency, and an oncolytic agent based on the...
9017682 Treatment of neuroinflammatory conditions using antibodies directed against MCAM  
Methods, uses, agents and compositions useful for the diagnosis, prevention and/or treatment of inflammatory conditions, such as neuroinflammatory conditions such as multiple sclerosis, and for...
9017671 Method of treating cancer with a pharmaceutical formulation comprising a HER2 antibody  
The present application describes antibody formulations, including monoclonal antibodies formulated in histidine-acetate buffer, as well as a formulation comprising an antibody that binds to...
9017669 Anti-CDH3 antibodies and uses thereof  
The present invention relates to anti-CDH3 antibodies, which can be labeled with a radioisotope. Moreover, the present invention provides methods and pharmaceutical compositions that comprise an...
9017685 Pathway for Th-17 cell development and methods utilizing same  
The present disclosure demonstrates for the first time that Th-17 cells are the product of a distinct CD4+ T cell lineage with unique developmental and functional characteristics. The...
9011913 Use of functionalized magnetic nanoparticles in cancer detection and treatment  
The present invention provides methods of detecting a cancer cell in an individual, methods of grading a cancer, and methods of treating a cancer. The methods involve use of functionalized...
9011847 Anti-FAP antibodies and methods of use  
The invention provides antibodies against Fibroblast Activation Protein (FAP) and methods of using the same.
9011848 Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof  
Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid...
9011864 Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates  
Disclosed are methods, compositions and kits for improving targeting, in particular tumor targeting, of immunoconjugates. The method and composition relies on the sequestration of non-target cells...
9011861 Therapeutic compositions for the treatment of dry eye disease  
Described herein are materials and methods for treating dry eye disease in a subject.
9011859 Methods for treating TWEAK-related conditions  
The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage...
9011850 Method of stabilizing antibody and stabilized solution-type antibody preparation  
The present invention provides a method of suppressing the formation of a soluble association of an antibody in a solution; a method of suppressing the formation of a chemically degraded product...
9011856 Antibodies specific for sclerostin and methods for increasing bone mineralization  
Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by...
9011849 Ameliorating or therapeutic agent for chronic prostatitis, interstitial cystitis and/or urination disorders  
The purpose of the present invention is to provide a medicinal agent which is useful for amelioration or treatment of chronic prostatitis, interstitial cystitis and/or urination disorders. The...
9012160 Monitoring skin metabolism products for evaluating burn injury  
The present invention relates to methods and kits for evaluating the severity of a burn injury, which are based on the detection in a clinical fluid sample of skin metabolism products, such as...
9011854 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Anti-DLL3 antibody drug conjugates and methods of use
 
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
9005621 Human binding molecules capable of binding to and neutralizing influenza B viruses and uses thereof  
Described are binding molecules, such as human monoclonal antibodies, that bind to hemagglutinin of influenza B viruses, and have a broad neutralizing activity against such influenza viruses....
9005612 Binding domain-immunoglobulin fusion proteins  
The invention relates to novel binding domain immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region...
9005611 Protein formulation  
A composition comprises a biological molecule that is susceptible to aggregation, dimerization or hydrolysis, wherein the ionic strength is less than 40 mM.
9005620 Compounds  
Binding members, e.g. human antibody molecules, which bind interleukin-6 (IL-6) and neutralize its biological effects. Use of binding members for IL-6 in medical treatment e.g. for treating...