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7504104 |
Human CDR-grafted antibody and antibody fragment thereof
A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood...
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7504101 |
Methods for enhancing antigen-specific immune response using antibodies that bind OX-40
Compositions and methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the surface of T-cells are disclosed, comprising administering to the mammal a...
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7501119 |
Methods and molecules for modulating an immune response
A molecule capable of potentiating immune responses and modifying existing states of immune responsiveness is described. Also described are compositions containing the molecule, as well as methods...
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7501498 |
Alpha-fetoprotein Immu31 antibodies and fusion proteins
The present invention provides humanized, chimeric and human anti-alpha-fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as...
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7501247 |
Method of treating skin inflammation
Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17 and/or IL-23.
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7501118 |
Human gene relating to respiratory diseases and obesity
This invention relates to isolated nucleic acids comprising genes of human chromosome 20p13-p12 and the proteins encoded by these genes. Expression vectors and host cells containing such genes or...
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7501494 |
Designed deimmunized monoclonal antibodies for protection against HIV exposure and treatment of HIV infection
This invention is directed to deimmunized antibodies that are useful as immunotherapeutic drugs against Human Immunodeficiency Virus (HIV) and CD4-mediated autoimmune disorders. More specifically,...
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7501124 |
Methods of inducing T-cell non-responsiveness with anti-gp39 24-31 antibodies
Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which...
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7501122 |
Treatment with anti-ErbB2 antibody combinations
The present application describes methods for treating ErbB-expressing cancer with anti-ErbB2 antibody combinations.
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7498028 |
Preparation of spheres for diagnostic tests
The invention relates to surfactant-free reagent spheres useful for biological tests particularly those involving antigen/antibody reactions.
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7498032 |
Methods for treating immune disorders or cancer with anti-CD40 antibodies
The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the...
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7498030 |
Treatment with anti-ErbB2 antibodies and anti-hormonal compounds
The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and anti-hormonal compounds, such as anti-estrogens.
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7498035 |
Compounds of hydrophilic polymer-polycarboxyl oligopeptide and medicines, medical composite comprising above compound and use of above compound in medicines
The present invention relates to a conjugate of hydrophilic polymer-multicarboxyl oligopeptide and drug molecule of the following formula:
wherein: P is a hydrophilic polymer; m is an integer...
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7498304 |
Angiogenesis-modulating compositions and uses
Hedgehog agonists and antagonists can be used to regulate angiogenesis, and to prevent angiogenesis driven pathologies. Furthermore, hedgehog agonists and antagonists have utility in modulating...
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7494653 |
Method and compositions for immunization with the Pseudomonas V antigen
A method of inhibiting, moderating or diagnosing Pseudomonas aeruginosa infection is disclosed. In one embodiment, this method comprises inoculating a patient with an effective amount of PcrV...
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7494646 |
Antibodies and molecules derived therefrom that bind to STEAP-1 proteins
Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is...
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7494655 |
Immunizing composition and method for inducing an immune response against the β-secretase cleavage site of amyloid precursor protein
The present invention is directed to an immunizing composition containing an antigenic product such as a multiple antigen peptide system (MAPS) or a filamentous bacteriophage displaying an AβPP...
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7495083 |
PRO940 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7494651 |
TGF-β binding antibodies
The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are...
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7491389 |
Modulating angiogenesis
Hemangioblasts in adult bone marrow participate in new blood vessel formation. By modulating the differentiation of hemangioblasts into blood vessel cells, angiogenesis in a particular tissue can...
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7491390 |
Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders
Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as...
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7491516 |
Dual specificity antibodies and methods of making and using
Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or...
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7491393 |
Methods of inhibiting IL-2 production by T cells by administering 7C10 and 16C10 CD80-specific antibodies
The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and...
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7488476 |
B-cell epitope peptides of HSP 65, DNA encoding said peptides, antibodies directed against said peptides and the different uses thereof in the treatment of inflammatory and autoimmune diseases
B-cell epitope peptides of HSP 65, particularly the peptides comprising the amino acid sequence substantially as denoted by SEQ ID: Nos. 1-5 and their biologically functional homologues and...
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7488806 |
Human antibodies to human delta like ligand 4
An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDll4) and blocks hDll4 binding to a Notch receptor. The human anti-hDll4...
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7488802 |
Antibodies against PD-1
This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those...
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7485302 |
Treatment with anti-ErbB2 antibodies and chemotherapeutic agents
The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and chemotherapeutic agents.
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7485299 |
Serpentine transmembrane antigens expressed in human cancers and uses thereof
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate...
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7485298 |
Diagnosis and treatment of human dormancy-related sequellae
New methods for diagnosis and treatment of human dormancy syndrome-related sequellae are provided. Human dormancy syndrome (HDS) is characterized by elevated serum ratio of rT3/fT3 compared to a...
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7485297 |
Method of inhibition of vascular development using an antibody
Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that...
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7485296 |
PSCA: prostate stem cell antigen and uses thereof in pancreatic cancer
The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade...
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7485616 |
Methods of investigating, diagnosing, and treating amyloidosis
The present invention provides a therapeutic method for removing amyloid fibrils from a patient. The present invention also provides a transgenic animal that develops systemic AA amyloidosis within...
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7485456 |
Modulators of TNF receptor associated factor (TRAF), their preparation and use
A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives...
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7482434 |
Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof
Embodiments of the invention described herein relate to antibodies directed to the antigen monocyte chemo-attractant protein-1 (MCP-1) and uses of such antibodies. In particular, in accordance with...
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7482003 |
Treatment for asthma with α4-specific antibodies
The present invention disclosed recombinant anti-VLA-4 antibody molecules, including humanized recombinant anti-VLA-4 antibody molecules. These antibodies are useful in the treatment of specific...
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7482005 |
Methods of treating diseases with anti-VEGF antibodies
The present invention provides monoclonal antibodies, and portions thereof, which are capable of specifically binding to human vascular endothelial cell growth factor (hVEGF) or hVEGF-related...
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7482007 |
Methods of inhibiting angiogenesis to treat cancer with alphavbeta3-specific antibodies
The present invention describes methods for inhibition angiogenesis in tissues using vitronectin α v β 3 antagonists, and particularly for inhibiting angiogenesis in inflamed tissues and in...
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7481999 |
Compounds and methods for modulating OB-cadherin-mediated function
Compositions and methods for modulating OB-cadherin-mediated functions are provided. The compositions and methods employ OB-cadherin modulating agents which generally comprise one or more of: (a) a...
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7479544 |
Anti-PRO87299 antibodies
The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease.
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7479271 |
Humanized anti-ghrelin antibodies
Humanized antibodies, or antigen-binding portions thereof, that preferentially bind acylated ghrelin with respect to unacylated ghrelin, are disclosed. These molecules have high affinity and a slow...
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7476385 |
Methods of inhibiting IgE responses to thymus-dependent antigens with the anti-gp39 antibody MR1
Methods of suppressing a humoral immune response to a thymus-dependent (TD) antigen are disclosed. The methods involve administering to a subject a TD antigen with an antagonist of a molecule which...
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7470774 |
Anti-pro1477 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7470772 |
Antibody that specifically binds to Chemerin receptor ligand precursor
The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the...
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7470428 |
Compositions and methods related to TIM-3, a Th1-specific cell surface molecule
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or...
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7468183 |
Antibody immunization therapy for treatment of atherosclerosis
The present invention relates to passive immunization for treating or preventing atherosclerosis using an isolated human antibody directed towards at least one oxidized fragment of apolipoprotein B...
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7465446 |
Surrogate therapeutic endpoint for anti-CTLA4-based immunotherapy of disease
The present invention provides a method of treatment using human sequence antibodies against human CTLA-4. In particular, methods of treating cancer are provided.
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7465445 |
Methods of preventing or treating graft versus host reaction by administering an antibody or portion thereof that binds to AILIM
An antibody against AILIM (alternatively called JTT-1 antigen, JTT-2 antigen, ICOS and 8F4) was found to have a significant therapeutic effect on arthrosis, for example, rheumatoid arthritis and...
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7465444 |
Methods of suppressing or treating an inflammatory bowel disease by administering an antibody or portion thereof that binds to AILIM
Antibodies against AILIM (also called ICOS and 8F4) were found to significantly suppress the onset of inflammatory bowel diseases (especially Crohn's disease and colitis (ulcerative colitis and...
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7465790 |
Therapeutic antibodies
A pharmaceutical comprising a therapeutic protein that binds to a therapeutic target, the protein being modified with a compound that inhibits binding of the protein to the therapeutic target, the...
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7462352 |
Methods of treatng B-cell diseases using humanized anti-CD19 antibodies
The present invention provides humanized, chimeric and human anti-CD19 antibodies, anti-CD19 antibody fusion proteins, and fragments thereof that bind to a human B cell marker. Such antibodies,...
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