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7608259 |
Methods of cancer diagnosis and therapy targeted against a cancer stem line
Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous...
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7608696 |
IBC-1 (invasive breast cancer-1), a putative oncogene amplified in breast cancer
This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of...
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7608246 |
Apolipoprotein E as an adjuvant for lipid antigens
The present invention is directed to pharmaceutical compositions that contain a combination of apolipoprotein E and an antigenic lipid. The compositions may be administered to a subject for the...
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7608263 |
RG1 antibodies and uses thereof
The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and...
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RE40948 |
APC antibodies
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous...
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7608260 |
Stabilized immunoglobulins
The present invention provides stabilized immunoglobulin molecules that have increased storage stability and/or in vivo half-lives due to the mutation of one or more amino acids that would...
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7608404 |
Disease determination method, data generation method for disease determination and data generation system for disease determination
Supernatant of the urinary sample (SP 1 ) was mixed with an acid or alkali and heated (SP 2 ) and the sample for fluorescence assay was prepared after adjusting its acidity to alkaline (SP 3 )....
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7608405 |
Method of selectively assaying adiponectin multimers
Methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of...
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7604953 |
Bioamplification for microbial sensor signal transduction
A process of detection of the causative agent of Johne's disease ( Mycobacterium avium subsp. paratuberculosis ) (MAP) by detecting shedding of surface protein of MAP. A preferred way is use of...
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7604801 |
Methods for detecting parvovirus infections
The present invention provides a method for diagnosing a subject suffering a pathological condition characterized by parvovirus infection by detecting the presence of IgE anti-Parvovirus B 19...
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7604800 |
Anti-PSGL-1 antibodies
Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of...
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7605233 |
Tumour necrosis factor binding ligands
The present invention relates to ligands which bind to human tumour necrosis factor alpha (TNF) in a manner such that upon binding of these ligands to TNF the biological activity of TNF is...
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7601348 |
Method of examining colon cancer and colon adenoma
The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at...
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7601350 |
Antibodies that bind M. tuberculosis polypeptides
Purified antibodies that bind to M. tuberculosis ERP protein are disclosed. In one embodiment, a purified antibody, which binds specifically with a polypeptide comprising SEQ ID NO: 39 or SEQ ID...
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7601349 |
GIPs, a family of polypeptides with transcription factor activity that interact with Goodpasture antigen binding protein
The present invention provides isolated GPBP-interacting 90 and 130 kDa polypeptides, and portions thereof (GIP90/130 polypeptides), antibodies to the GIP90/130 polypeptides, and pharmaceutical...
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7601357 |
Targeting of long chain triacylglycerol hydrolase gene for tuberculosis treatment
Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or...
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7601352 |
Monoclonal antibodies and antigen binding fragments thereof capable of binding TrkA and inhibiting the functional activation of TrkA
Monoclonal antibodies, synthetic and biotechnological derivatives thereof (ScFv or others) are able to recognize the NGF high affinity receptor, TrkA, and act as NGF-antagonist molecules....
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7597888 |
Glycoprotein VI and uses thereof
The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The...
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7598046 |
Use of prion conversion modulating agents
The use of Apolipoprotein B, Apolipoprotein E, fragments and mimetics thereof is provided for diagnostic, detection, prognostic and therapeutic applications In prion diseases. More specifically,...
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7597896 |
Composition comprising a protein encoded by a modified ERP gene of Mycobacterium
The invention concerns Mycobacterium strains whereof the erp gene is modified and a vaccine composition containing same. The modification of the erp gene decreases the virulence and the...
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7597891 |
Synthesis of human secretory IgA for the treatment of Clostridium difficile associated diseases
A composition for treating a subject is provided. The composition includes dimeric or polymeric secretory IgA therapeutic. Formulating agents are mixed with the dimeric or polymeric secretory IgA...
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7597893 |
Human monoclonal antibody specific lipopolysaccharides (LPS) of serotype IATS 06 of Pseudomonas aeruginosa
The present application relates to a human monoclonal antibody specific for the serotype IATS 06 of P. aeruginosa , a hybridoma producing it, nucleic acids encoding it, and host cells transfected...
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7597887 |
KIM-1 antagonists and use to modulate immune system
The use of KIM-1 antagonists to inhibit signaling between a T cell and a second cell, e.g., an antigen-presenting cell, is disclosed. Such inhibition is useful for treatment of diseases including...
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7597886 |
Tumor necrosis factor-gamma
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also...
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7595045 |
Anti-α9 integrin antibody and the use thereof
The present invention provides an anti-mouse α9 integrin antibody, an anti-human α9 integrin antibody, a hybridoma producing any of the antibodies, a method of producing any of the antibodies and...
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7595378 |
Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a...
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7595047 |
Compositions and methods for promoting or inhibiting angiogenesis
Compounds, compositions and methods for promoting or inhibiting angiogenesis, and screening methods for identifying compounds are disclosed. The compounds bind to F1 ATP synthase particularly to...
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7595044 |
Artery-and vein-specific proteins and uses therefor
Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand,...
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7595051 |
Methods of treating neovascular glaucoma, macular degeneration and capillary proliferation with alphavbeta3-specific antibodies
The present invention describes methods for inhibition angiogenesis in tissues using vitronectin α v β 3 antagonists, and particularly for inhibiting angiogenesis in inflamed tissues and in...
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7592430 |
Antibodies to M-CSF
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also...
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7592006 |
Composition comprising the LO-CD2a antibody
The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response...
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7592004 |
Stable lyophilized pharmaceutical formulation of IgG antibodies
This invention is directed to a stable lyophilized pharmaceutical formulation prepared by lyophilizing an aqueous formulation comprising a high concentration, e.g. 50 mg/ml or more, of an IgG...
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7592007 |
Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA-4 specific antibodies
Isolated ligands which bind a molecule expressed on the surface of T cells and induce antigen specific apoptosis in activated T cells are disclosed. Preferably, the T cell surface molecule is CTLA4...
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7589070 |
Surface modification for improving biocompatibility
A therapeutic delivery system efficiently introduces biologically active molecules to mammalian cells without the use of synthetic polymers or biopolymer coatings. Surface modification of a metal...
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7588920 |
Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7589182 |
Anti-sulfotyrosine antibodies
The invention provides anti-sulfotyrosine specific antibodies capable of detecting and isolating polypeptides that are tyrosine-sulfated. The sulfotyrosine antibodies and antibody fragments of the...
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7588760 |
Antagonists specific for denatured collagen and methods of using same
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen but not to native triple...
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7585501 |
Compositions and methods for treating kidney disease
The present invention relates to methods and compositions for the prevention and treatment of renal damage. The invention provides protein-based renal therapeutic agents for administration to...
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7585502 |
Mammalian CX3C chemokine antibodies
Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using...
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7585953 |
Antibodies specific for TAT285-1
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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7585500 |
Fully human monoclonal antibodies to IL-13
The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies...
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7585847 |
Immunostimulatory nucleic acids for the treatment of asthma and allergy
The invention involves administration of an immunostimulatory nucleic acid alone or in combination with an asthma/allergy medicament for the treatment or prevention of asthma and allergy in...
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7585952 |
Human mini-antibody cytotoxic for tumor cells which express the ErbB2 receptor
The invention refers to a fully human miniantibody (scFv), called Erbicin, specific for the receptor ErbB2, with a pharmacological, in particular antitumour, activity. It has been obtained from a...
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7582735 |
Feline immunoglobulin E molecules and related methods
The invention relates to: nucleic acid molecules encoding the light chain and heavy chain of feline immunoglobulin E (IgE), including species-specific regions of feline IgE; proteins encoded by the...
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7582299 |
Cripto-specific antibodies
The invention provides Cripto-specific antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and inhibit Cripto activity are provided. Antibodies...
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7582297 |
Methods of treating respiratory conditions
The present invention provides prophylactic an tehrapeutic protocols desinged to prevent, manage, treat, or ameliorate a respiratory condition or one or more symptoms thereof. In particular, the...
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7582294 |
Medicament for treating prostate diseases
A medicament based on antibodies contains an activated form of ultra-low doses of monoclonal, polyclonal, or natural antibodies to the prostate-specific antigen, the activated form being prepared...
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7582293 |
Anti-PRO6308 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7582295 |
Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy
The invention relates to molecules for treatment and diagnosis of tumors and malignancies, comprising a tumor seeking biomolecule, which is coupled to an intercalating moiety, which is capable of...
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7579320 |
IAP BIR domain binding compounds
Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II
or a salt thereof, in which R 1 , R 2 , R 3 , R 100 , R 200 , R 300 , A, A 1 , BG, Q...
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