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7128908 |
Methods for treating systemic lupus erythematosus using anti-TNF antibodies and fragments thereof
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7129207 |
Human K+ ion channel and therapeutic applications thereof
The present invention relates to a novel human K + ion channel, to nucleic acid molecules encoding the same and to vectors comprising said nucleic acid molecules. The invention additionally...
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7128907 |
Methods of treating crohn's disease with anti-TNF antibodies
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7128906 |
T1 receptor-like ligand II and uses thereof
The present invention relates to a novel T1 Receptor (T1R)-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like...
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7128905 |
Method of treating graft versus host disease by administration of a Fas antagonist
The present invention is drawn to methods of preventing and treating diseases wherein the involvement of apoptosis has been indicated.
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7125551 |
Methods for treatment of asthmatic disorders using a monoclonal antibody to 8F4 polypeptide
The present invention relates to methods and compositions for the prevention and treatment and prevention of immune system disorders, including cancer, AIDS, asthmatic disorders, autoimmune...
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7125696 |
Method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent
A invention concerns a novel method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent, and polypeptides obtainable by said method. The invention also concerns...
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7122637 |
Polypeptide variants with altered effector function
The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function...
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7122188 |
Antibodies which bind with proteins of human immunodeficiency virus type 1 (HIV-1), and immune complexes comprising proteins of HIV-1
This invention provides antibodies which bind with p12 and p18 proteins of a human immunodeficiency virus type 1 (HIV-1), antibodies which bind with immune complexes comprising p12 or p18 proteins...
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7122639 |
Chemokine alpha-2 antibodies
Human chemokine Alpha-2-polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are...
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7122187 |
Treating autoimmune diseases with humanized anti-CD40L antibody
The present invention is directed to humanized antibodies which bind human gp39 and their use as therapeutic agents. These humanized antibodies are especially useful for treatment of autoimmune...
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7122186 |
Human serine protease
The present invention relates to a new member of the serine protease family, Ztryp3. Members of this family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis,...
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7122196 |
Compounds and methods for diagnosis of tuberculosis
Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins,...
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7118744 |
Immunogenic compositions for induction of anti-tumor immunity
The invention relates to the use of an immunogen selected from the group consisting of
(i) an anti-p53 mAb; (ii) a fragment of an anti-p53 mAb; (iii) a peptide based on a CDR of the heavy or...
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7118749 |
Transferrin receptor genes
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic...
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7118890 |
Antibodies to vertebrate delta proteins and fragments
The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In...
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7119172 |
P. aeruginosa mucoid exopolysaccharide specific binding peptides
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for...
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7118741 |
Transepithelial transport of molecular species
There is disclosed a synthetic cross-linker protein capable of binding a molecule or macromolecular species to a transcytosis receptor for transport of the molecule or macromolecule species across...
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7118742 |
Ligand for herpes simplex virus entry mediator and methods of use
A novel polypeptide ligand, p30, or LIGHT, for herpes virus entry mediator, HVEM, is provided. LIGHT is useful for modulating immune responses and in inhibiting infection and/or subsequent...
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7115263 |
Compositions and methods for treating hyperimmune response in the eye
The present invention comprises and utilizes methods and compositions for treating hyperimmune reactions in the eye. Compositions comprising antibodies to gamma interferon alone and in combination...
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7115264 |
Monoclonal antibodies to the fibronectin binding protein and method of use in treating or preventing infections
Monoclonal antibodies which can bind to the Fnbp protein of Staphylococcus aureus and which are generated from a peptide from the D2 region of fibronectin binding protein B (Fnbp) of S. aureus ...
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7115379 |
Anti-mammalian CX3C cytokine antibodies
Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using...
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7115262 |
Chimeric protein for prevention and treatment of HIV infection
This invention relates to bispecific fusion proteins effective in viral neutralization. More specifically, such proteins have two different binding domains, an inducing-binding domain and an...
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7115723 |
Humanized antibody specific for surface antigen pre-S1 of HBV and preparation method thereof
The present invention relates to humanized antibodies specific for HBV surface antigen pre-S1, which show binding affinity similar to mouse monoclonal antibody and which show remarkably reduced...
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7115261 |
Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies
The invention teaches methods for treating tumors and tumor metastases in a mammal comprising administering, to a mammal in need of treatment, a therapeutic amount of an antagonist sufficient to...
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7115716 |
Tumor specific monoclonal antibodies
The invention provides tumor-specific human monoclonal antibodies and functional fragments. Also provided are nucleic acids encoding tumor-specific human monoclonal antibodies and functional...
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7115268 |
Peptides useful for reducing symptoms of toxic shock syndrome and septic shock
This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates...
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7112326 |
Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically...
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7112661 |
Variable heavy chain and variable light chain regions of antibodies to human platelet glycoprotein Ib alpha
The present invention is directed to a method of selecting a clone that binds to human platelet glycoprotein Ib alpha using a human variable heavy chain and variable light chain immunoglobulin...
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7112327 |
Inhibition of complement activation
The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as...
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7108853 |
Surface protein of Leptospira
The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
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7109301 |
Tenascin-C isoform as marker for neoplasias
Diagnostic method for the identification of human neoplasias based on the determination of the CTN-C isoform of TN-C, fragments antibodies and their conjugates used in said method, and their...
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7108852 |
Methods of treating inflammation using antibodies to M-CSF
A hematopoetic factor called “colony stimulating factor” (CSF) is capable of synergizing the attracting capabilities of chemokines and of inducing the accumulation and/or activation in vitro...
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7108986 |
Glypican-1 in human breast cancer
Glycosylphosphatidylinositol-(GPI-) anchored HSPG glypican-1 is strongly expressed in human breast and pancreatic cancer—both by the cancer cells and in the case of pancreatic cancer the adjacent...
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7108854 |
Surface proteins of Leptospira
The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
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7105158 |
Methods of administering microencapsulated materials for immune modulated diseases
Compositions useful in treating immune modulated disease comprising an anticytokine antibody or immune active drug capable of modifying cytokine activity or modulating the immune system...
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7105159 |
Antibodies to prostate-specific membrane antigen
This invention provides purified antibodies to the outer membrane domain of prostate-specific membrane (PSM) antigen, compositions of matter comprising PSM antigen antibodies conjugated to a...
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7105170 |
Latent human tuberculosis model, diagnostic antigens, and methods of use
Provided herein is an in vitro granuloma model and methods of its use. Methods of detecting and/or diagnosing latent tuberculosis in a subject are also provided, as are latency-specific antigens...
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7101549 |
Glycoprotein VI and uses thereof
The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The...
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7101962 |
Antibodies of the P2Y10 receptor useful in altering T lymphocyte function
The present invention relates to modulators of P2Y10. Various modulators are disclosed, including an antibody that binds specifically to P2Y10. The present invention also relates to methods of...
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7101547 |
Method for the prevention and treatment of diseases caused by an inflammatory response mediated by endogenous substance P by using anti-substance P antibodies
The present invention provides methods for preventing or treating a disease in a subject which is caused by an inflammatory response to a disease or syndrome which is mediated by endogenous...
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7101978 |
TNF-α binding molecules
The present invention relates to TNF-α binding molecules and nucleic acid sequences encoding TNF-α binding molecules. In particular, the present invention relates to TNF-α binding molecules with...
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7101548 |
Functional role of adrenomedullin (AM) and the gene-related product (PAMP) in human pathology and physiology
The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving...
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7101550 |
PD-1, a receptor for B7-4, and uses therefor
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents...
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7101557 |
Combined tissue factor methods for coagulation and tumor treatment
The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic...
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7097834 |
Osteoprotegerin binding proteins
A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the...
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7097846 |
35 kD tumor associated protein antigen: uses and methods of detection
This invention provides the isolation and characterization of a tumor associated antigen which can be used for immunodiagnosis, immunoprognosis, and therapy of human cancer. The antigen is a...
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7097835 |
Immunoselective targeting agents and methods of use thereof
The present invention provides immunoselective targeting agents that bind to transporters that are transiently accessible on the surface of neuronal cells, and that deliver compounds selectively to...
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7097836 |
Method for increasing the efficacy of anti-tumor agents by anti-endoglin antibody
The present invention provides a method for enhancing the efficacy of chemotherapeutic agents for therapy of cancer and other angiogenesis-associated diseases such as rheumatoid arthritis. The...
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7097840 |
Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention...
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