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7235644 |
Vaccine against Gram-negative bacterial infections
A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a...
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7235380 |
CDR-grafted anti-tissue factor antibodies and methods of use thereof
The present invention provides CDR-grafted antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced...
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7232568 |
Compositions and methods for treating hyperimmune response in the eye
The present invention comprises and utilizes methods and compositions for treating hyperimmune reactions in the eye. Compositions comprising antibodies to gamma interferon alone and in combination...
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7230087 |
P. aeruginosa mucoid exopolysaccharide specific binding peptides
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for...
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7230082 |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7229772 |
Detection of apoptotic products
The present invention concerns a method for the determination of apoptotic products in samples taken from patients in which apoptosis is induced as a result of disease or therapy, which is...
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7229618 |
Crystals and structure of Synagis Fab
The present invention provides crystalline forms and three-dimensional atomic structure coordinates of Synagis Fab. The present invention further provides methods of using such three-dimensional...
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7229763 |
Assay system using labeled oligonucleotides
The present invention provides a useful system for assays that comprises a solid support, a plurality of capture oligonucleotides immobilized onto the solid support, and complementary...
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7226593 |
Methods of treating cachexia with chimeric anti-TNF antibodies
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α(TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7226590 |
Antimicrobial composition
This invention provides novel Streptococcus salivarius, compositions containing same, and use of S. salivarius strains as antimicrobial agents. The strains are bacterial inhibitors with respect...
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7223842 |
Detection of proteins whose absence is associated with a neoplasm
This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in...
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7223396 |
Methods of treatment of fistulas in Crohn's disease with anti-TNF antibodies
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7220409 |
Stabilization of immunoglobulins at low pH
The present invention provides a method of stabilizing immunoglobulins in a solution having a pH below 4 by adding cereals or hydrolysed cereal products in an amount sufficient to prevent...
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7217416 |
Use of gamma globulin for the topical treatment of lesions of dermatitis
The use of G class immunoglobulins, particularly immunoglobulins for intravenous use or for intramuscular use to produce a medicine for the local therapeutic treatment of dermatitis, particularly...
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7214375 |
Methods of decreasing the accumulation of extracellular matrix associated with glomerulonephritis with anti-TGF-β-specific antibodies
The present invention provides a method for treating or arresting the progress of pathologies characterized by an accumulation of extracellular matrix components by providing an agent to suppress...
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7214376 |
Methods of inhibiting TNFα in patients with neoplastic disease
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7211256 |
Plasmodium falciparum antigens inducing protective antibodies
The present invention relates, in part, to a purified polyclonal or monoclonal antibody which recognizes an epitope of a protein of 48,000 dalton, where the protein recognizes is a surface protein...
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7211251 |
Antibodies to transferrin receptor-like proteins
The present invention provides isolated nucleic acids encoding TfR2 polypeptides, or fragments thereof, and isolated TfR2 polypeptides encoded thereby. Further provided are vectors containing the...
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7211401 |
Method for the detection of prion diseases
The invention provides methods for the detection of prion diseases, such as scrapie of sheep, bovine spongiform encephalopathy of cattle, Creutzfeld-Jacob disease of man, whereby aberrant proteins...
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7211254 |
Methods for treating ICACC protein associated diseases
A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy,...
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7208162 |
Combination therapy of respiratory diseases using antibodies and anti-inflammatory agents
Therapeutically effective anti-viral compositions, useful especially against respiratory diseases caused or mediated by respiratory syncytial virus (RSV) are disclosed, wherein said compositions...
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7208152 |
Antibodies for “Bonzo” chemokine receptor and therapeutic uses thereof
The invention relates to an antibody or antigen-binding fragment thereof which binds to the CXC chemokine receptor Bonzo (also referred to as STRL33, TYMSTR, HBMBU14 and CXCR6) and blocks the...
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RE39586 |
Human monoclonal antibody against Hepatitis B virus surface antigen (HBVSAG)
Disclosed is a hybridoma cell line which produces human antibodies capable of binding to the hepatitis B virus surface antigen (HBVsAg), as well as antibodies produced by the cell line. Also...
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7208167 |
Treatment of hepatitis C with thymosin and peptide combination therapy
A method and pharmaceutical combination for treating hepatitis C by administering to a hepatitis C patient an effective amount of at least one alpha thymosin peptide, in combination with...
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7204982 |
Compositions and methods for treatment and detection of multiple cancers
The invention provides a method for inhibiting proliferation of cancer cells, as well as methods for detecting and treating various cancers, including cancer of the brain, lung, breast, prostate...
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7205390 |
Enzyme
A substantially pure 3-phosphoinositide dependent protein kinase that phosphorylates and activates protein kinase Bα. A recombinant polynucleotide encoding a protein kinase as defined. Uses of the...
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7205162 |
Artificial antibodies, method of producing the same and use thereof
Artificial antibodies or antibody mimics are described. They consist of polymers that carry specific binding sites mimicking the properties of antibodies. There is also described a method for...
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7204985 |
Methods of treating disseminated intravascular coagulation by multiple administration of anti-TNF antibodies
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7198788 |
Anti-CD26 monoclonal antibodies as therapy for diseases associated with cells expressing CD26.
Therapeutic methods comprising administering anti-CD26 antibodies for the prevention and treatment of cancers and immune diseases associated with expressing CD26 are provided. The invention...
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7198787 |
Method of killing target cells in harvested cell populations with one or more immuno-toxins
A method for killing unwanted target cells in a cell population comprising nucleated cells harvested from peripheral blood, or CD-34+ or similar early progenitor cells selected from the above...
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7198789 |
Methods and compositions for modulating interleukin-21 receptor activity
Methods and compositions for modulating interleukin-21 (IL-21)/IL-21 receptor (MU-1) activity using agonists or antagonists of IL-21 or IL-21 receptor (“IL-21R” or “MU-1”), are disclosed....
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7195926 |
Antibodies to a cathepsin C homolog
The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for...
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7195750 |
Clinical parameters for determining hematologic toxicity prior to radioimmunotherapy
New clinical parameters are reported which may serve as predictors of the hematological toxicity associated with therapeutic radiolabeled antibodies, particularly those antibodies which target...
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7196175 |
Antibodies to JTT-1 protein and cells secreting such antibodies
Novel cell surface molecules recognized by monoclonal antibodies against a cell surface molecule of lymphocytic cells that play an important role in autoimmune diseases and allergic diseases have...
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7195760 |
Anti-pro363 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7195763 |
Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences...
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7192585 |
CD80 specific antibodies
The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and...
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7192721 |
Universal rapid test and method for detection of tuberculosis in multiple host species
A universal test apparatus for detecting tuberculosis (TB) in any of many different species of non-primate mammals is provided. The universal test apparatus includes a test site having a...
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7192584 |
Methods of treating psoriasis with anti-TNF antibodies
The invention relates to anti-TNF antibodies, fragments, regions and derivatives thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in methods of treating...
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7192586 |
Methods and compositions for treating or preventing skin disorders using binding agents specific for prostate specific membrane antigen
Methods and compositions for treating, preventing, or diagnosing epidermal or dermal disorders, e.g., psoriasis, are disclosed. The methods and compositions of the invention use binding agents,...
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7192917 |
Antagonists of HMG1 for treating inflammatory conditions
There is disclosed a pharmaceutical composition and method for treating sepsis, including, septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount...
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7189395 |
Complexes of immunoglobulins and polysaccharides for oral and transmucosal absorption
The present invention relates to complexes consisting of immunoglobulins and polysaccharides for oral and transmucosal use. The polysaccharides comprised in the complexes according to the...
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7189816 |
Compounds
An antibody, or a derivate or a fragment thereof, having a binding structure for a target structure is described. The antibody is displayed in, and on the cell surface of, human gastrointestinal...
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7182933 |
Targeting drug/gene carriers to irradiated tissue
The present invention provides a biomolecular carrier of pharmaceuticals, comprising: a biomolecule carrier bearing molecules that bind to a cellular adhesion molecule expressed on endothelial...
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7179464 |
Method of treatment by administering an antibody to human interleukin-5 receptor α chain
The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor α chain. The invention also provides hybridomas and...
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7179466 |
Methods of treating rheumatoid arthritis by multiple administration of anti-TNF antibodies
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7179462 |
α (2) macroglobulin receptor as a heat shock protein receptor and uses thereof
The present invention relates to the use of alpha (2) macroglobulin (“α2M”) receptor as a heat shock protein receptor, cells that express the α2M receptor bound to an HSP, and antibodies and...
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7179463 |
Treatment of alzheimer's disease
A method for the treatment of Alzheimer's disease in a subject having or suspected of having Alzheimer's disease by administering to the subject a therapeutically effective amount of an antibody...
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7175988 |
Human G-protein Chemokine Receptor (CCR5) HDGNR10
The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed...
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7175847 |
Treating intestinal inflammation with anti-CD80 antibodies that do not inhibit CD80 binding to CTLA-4
The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and...
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