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8795656 Methods of treating rheumatoid arthritis by administering an anti-IL3 antibody  
The use of an IL-3 inhibitor for prophylactic treatment of rheumatoid arthritis, for treatment of rheumatoid arthritis in an early stage, during early phases of exacerbation, or as maintenance...
8795668 Methods for treating pulmonary fibrosis  
Methods and compositions for the treatment of fibrosing diseases are described. More specifically, the invention demonstrates that inhibiting or otherwise decreasing the activity of CCL21 either...
8790882 Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using elisa assays  
The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic...
8790649 EGFR-binding molecules and immunoconjugates thereof  
Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to EGFR are provided. Methods of using the agents, antibodies, or immunoconjugates, such as...
8790645 Pharmaceutical composition comprising a bispecific antibody for EpCAM  
The present invention provides a pharmaceutical composition comprising a bispecific single chain antibody construct. Said bispecific single chain antibody construct is characterized to comprise or...
8791242 Canine thymic stromal lymphopoietin protein and uses thereof to treat allergic symptoms  
The present invention discloses a canine TSLP protein and a nucleic acid that encodes that protein. Peptide fragments of the protein that comprise specific epitopes of the canine TSLP protein are...
8785599 FcγRIIB—specific antibodies and methods of use thereof  
The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than the antibodies or fragments thereof bind...
8785139 Modification-dependent activity assays  
Disclosed herein are methods, systems and kits to measure the presence and/or activity of recombinant polypeptides comprising a modification.
8784772 Urothelial differentiation of urothelial carcinoma: a bladder cancer stem cell model  
The present invention provides a method of treating cancer in a patient (e.g., a human patient) in need thereof, the method comprising administering a therapeutically effective regimen, the...
8784822 Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis  
A method for treating renal failure associated with advanced stage renal disease includes administering a soluble cytokine receptor to one or more of tumor necrosis factor alpha, interferon gamma...
8784806 Screening method  
This invention relates to a novel screening method that identifies simple molecular markers that are predictive of whether a particular disease condition is responsive to a specific treatment....
8784808 FcγRIIB specific antibodies and methods of use thereof  
The present invention relates to antibodies or fragments thereof that bind FcγRIIB with greater affinity than said antibodies or fragments binds FcγRIIA. The invention encompasses the use of such...
8784807 Method of inhibiting regulatory T-cell activity by administering an antibody that inhibits interleukin 35  
Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective...
8784814 Method for inhibiting binding to B-cell receptor  
The invention provides an isolated protein which is a member of the TNF ligand superfamily and comprises: i) a polypeptide having the amino acid sequence of figure (1); or ii) a variant of the...
8784818 Anti-VEGFR-3 antibody compositions  
The present invention provides anti-VEGFR-3 monoclonal antibodies, pharmaceutical compositions containing said antibodies and uses of said antibodies in the treatment of disease.
8784809 Vascular endothelial growth factor 2  
Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions...
8784890 Methods for producing ECM-based biomaterials  
A method for forming an extracellular matrix material (ECM) material includes providing at least an ECM composition containing ECM particles varying in their capacity for migration through a fluid...
8778339 Combination of FcγRIIB-specific antibodies and CD20-specific antibodies and methods of use thereof  
The present invention relates to methods of treatment, prevention, management or amelioration of one or more symptoms of diseases or disorders associated with CD20 expression that encompass...
8779098 B7-H3L cell surface antigen and antibodies that bind thereto  
The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of monoclonal antibodies that bind to antigen...
8778342 Antibody therapy  
The present invention provides a composition comprising naked humanized, chimeric, and human anti-CEA antibodies and a therapeutic agent, which is useful for treatment of CEA expressing cancers...
8778615 Methods and compositions for diagnosis and prognosis of renal injury and renal failure  
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal...
8778345 Anti-CD40 antibodies  
The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and...
8778344 Method of treating atopic dermatitis with antibody to zcytor17 ligand  
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for...
8771968 Biomarker for osteoarthritis and/or other ageing-related diseases, and use thereof  
The invention relates to the identification of a biomarker whose abundance in biological sample is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has...
8771969 Peptide antibody depletion and its application to mass spectrometry sample preparation  
The present invention relates, e.g., to a method for pre-processing a sample for mass spectral analysis, comprising cleaving proteins in the sample to peptides and immunodepleting highly abundant...
8771695 Antibodies directed to HER-3 and uses thereof  
The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding...
8771685 Anti-BV8 antibodies and uses thereof  
The present invention concerns antibodies to Bv8 and the uses of same.
8771698 Modulation of UL24 interactions with protein targets and uses thereof for inhibition of herpesvirus infection  
Methods and uses for the treatment of herpesvirus infection based on the inhibition of the interaction between herpesvirus UL24 and non-muscle myosin type IIa (NM2a) are described.
8771691 Methods for the treatment and the prognostic assessment of malignant pleural mesothelioma  
The present invention relates to methods for the treatment and the prognostic assessment of malignant pleural mesothelioma.
8774488 Method and device for identification of nucleated red blood cells from a maternal blood sample  
A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and...
8765126 Methods of treating complications and disorders associated with G-CSF administration  
The present embodiments relate to novel uses of MPO inhibitors and inhibitors of MPO and E-selectin binding. In some embodiments, methods are provided for treating G-CSF-induced vascular...
8765131 Methods of inhibiting alternative pathway complement activation with anti-factor D antibodies  
The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as...
8765127 Methods of preventing ischemia/reperfusion damage to kidney using antibodies that bind BMP-1 isoforms  
Uses of BMP-1 isoforms for diagnosing and treating defects and disorders of bone and soft tissues are described. Also described is a newly isolated variant of the BMP-1 isoform BMP-1-3.
8765122 Nanosphere/microsphere delivery system for the treatment of spinal cord injury  
A formulation including injectable biodegradable nanospheres and/or microspheres as a delivery system for chondroitinase ABC (cABC) or a functional derivative of cABC to treat acute and chronic...
8765125 Methods of treating autoimmune diseases with Dll4 antagonists  
The present invention provides methods of treating a disease or disorder, in which increasing the number of regulatory T cell (Treg) is beneficial, by administering to a subject suffering from...
8765133 Method of producing anti-CD166 antibody in ostrich  
Disclosed is an antibody produced using an ostrich. Also disclosed is a method for producing the antibody. By using an ostrich, it becomes possible to produce antibodies (particularly antibodies...
8765663 Methods for increasing adiponectin  
In certain aspects, the present invention provides compositions and methods for increasing adiponectin in a patient in need thereof by administering an antagonist of an ActRIIB signaling pathway....
8765916 ERG monoclonal antibodies  
Monoclonal antibodies, or antigen-binding fragments thereof, that bind to ERG, and more specifically, to an epitope formed by amino acids 42-66 of ERG3 are disclosed. The monoclonal antibodies can...
8765132 Human cytomegalovirus neutralizing antibodies and use thereof  
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or...
8765385 Method of detection of neutralizing anti-actriib antibodies  
The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to ActRIIB and uses for same.
8765124 Stabilized preparation containing protein  
Protein formulations containing a poloxamer as a surfactant, and methods for maintaining the biological activity in protein formulations without adding an antioxidant and for inhibiting the...
8758747 Stable lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies  
The invention concerns lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies which contain a sugar or an amino sugar, an amino acid and a surfactant as stabilizers. In...
8758748 Anti-angiogenic therapy  
The present invention provides novel monoclonal antibodies directed to PlGF and fragments and derivatives thereof, more particularly to humanized antibodies and fragments thereof for use in the...
8758752 RS7 antibodies  
This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more...
8758753 Ganglioside associated recombinant antibodies and the use thereof in the treatment of tumors  
The present invention is related to the obtaining of modified antibodies by means of DNA recombinant technology from the murine monoclonal antibody P3 (MAb P3), produced by the hybridoma cell line...
8758750 Synergistic anti-CD47 therapy for hematologic cancers  
Methods are provided for treatment of hematologic cancers, particularly lymphomas and leukemias, including without limitation myelogenous and lymphocytic leukemias. A combination of antibodies...
8758755 Stem cell fusion model of carcinogenesis  
Methods for modeling cancer cell migration, screening drugs for effects on tumor cell migration, and detecting the potential for tumor cell migration relating to the fusion of a bone marrow...
8758749 Biological materials and uses thereof  
The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell...
8754031 Use of prolactin receptor antagonists in combination with an agent that inactivates the HER2/neu signaling pathway  
The present invention describes compositions and methods for inhibiting cell proliferation comprising a prolactin receptor antagonist and an agent that inactivates the HER2/neu signaling pathway,...
8753633 Human antibodies that bind human TNFα  
Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g.,...