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8460890 Detection and measurement of blood-feeding activity  
This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive...
8460662 Compositions and methods relating to anti-IGF-1 receptor antibodies  
The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric...
8460663 Stabilized liquid anti-RSV antibody formulations  
The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which ...
8460667 EPHA2 receptor antagonist antibodies  
Antagonistic antibodies that specifically bind to and inhibit Class A Eph receptors are provided. Also provided are cytotoxic conjugates, pharmaceutical compositions and kits comprising these...
8460886 Use of an efficacy marker for optimizing therapeutic efficacy of an anti-human PD-1 antibody on cancers  
A purpose of the present invention is to provide a method capable of more effectively prescribing an anti-human PD-1 antibody for anti-cancer therapy, a method for estimating or optimizing...
8460658 Method of treating cancer and/or cellular proliferative conditions and agents targeting hyaluronan anabolism useful for same  
The present invention relates generally to the modulation of hyaluronan (HA) synthesis and degradation. The present invention further contemplates modulation of cellular proliferation, useful in...
8460660 Anti-mesothelin antibodies  
The present invention provides monoclonal anti-mesothelin antibodies and antibody fragments and methods for their use. The antibodies can be completely human.
8460669 Compositions and methods for identifying response targets and treating flavivirus infection responses  
Cellular receptors are identified that induce plasma leakage and other negative effects when infected with flaviviruses, such as dengue virus or Japanese encephamyelitis virus. Using fusion...
8454961 Alpha-4-beta-7 heterodimer specific antagonist antibody  
There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.
8455623 Compositions and methods for diagnosing and treating cancer  
Isolated antibodies that specifically bind the human MET Receptor and inhibit MET signaling are described. Also described are methods of treating cancer, the methods comprising administering a...
8454955 Methods for treating allergic airway inflammation, airway hypersensitivity, and eosinophilia  
The invention provides a method of screening a therapeutic agent for allergic airway inflammation and/or airway hypersensitivity, comprising using an IL-17RB positive NKT cell, as well as a...
8454959 Compositions monovalent for CD28 binding and methods of use  
Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or...
8454954 Treatment of synucleinopathies  
This invention relates generally to treating synucleinopathies in subjects that are not clinically diagnosed with a lysosomal storage disease, as well as associated methods of making medicaments...
8455622 Variant target binding agents and uses thereof  
The present invention provides variant target binding agents and methods relating to the use of such binding agents for the prophylaxis or treatment of cancers and immunological disorders. The...
8454956 Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies  
The invention features methods and compositions for preventing or treating rheumatoid arthritis and osteoporosis by administering an antagonist of IL-20. The IL-20 antagonist may be an anti-IL-20...
8454958 Methods for detecting and inhibiting angiogenesis  
The present invention provides methods for reducing or inhibiting angiogenesis in a tissue, by contacting α5β1 integrin in the tissue with an agent that interferes with specific binding of the α...
8454952 Augmentation of endothelial thromboresistance  
Stretch-induced increased hemodynamic load adversely affects endothelial cell function and is an important contributor to thromboembolus formation in heart failure, valvular heart disease, atrial...
8454962 Alpha-4-beta-7 heterodimer specific antagonist antibody  
There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.
8454953 Methods for reducing allergies caused by environmental allergens  
Compositions suitable for reducing symptoms of an allergic response to environmental allergens comprising molecules that specifically inhibit the ability of the allergen to bind to mast cells in an...
8454957 Methods for treating coagulation disorders  
The invention is directed to methods for treating coagulation disorders, in particular, hemophilia. Such methods utilize novel compositions including Amnion-derived Multipotent Progenitor cells...
8449875 Targeting pseudotyped retroviral vectors  
The present invention provides targeted lentiviral vectors that are psuedotyped with mutated Sindbis envelopes. For example, mutations in the Sindbis E2 protein are used to alter viral titer,...
8449882 Anti-EPHA2 antibody  
Problem to Be Solved It is intended to provide an antibody having an inhibitory activity against cell malignant transformation and/or tumor cell growth, etc.SolutionThe present invention provides...
8449881 Anti-α-enolase I antibodies for diagnosis and treatment of α-enolase I-associated diseases  
The invention relates to antibodies against α-enolase I, their pharmaceutical compositions and diagnosis and treatment uses. Particularly, the invention provides polyclonal anti-α-enolase I a...
8449883 Compositions and methods for the diagnosis and treatment of tumor  
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
8449863 Stabilized uncoated particles of reversed liquid crystalline phase materials  
Uncoated particles of reversed cubic phase or reversed hexagonal phase material containing an active disposed within are provided. The uncoated particles have an ionic charge that is sufficient to...
8450464 Human monoclonal antibodies that bind CXCR4  
The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the...
8444970 Compositions and methods for treating ocular diseases and conditions  
The present invention relates to compositions and methods for prevention and treatment of diseases and conditions, particularly ocular diseases and conditions, characterized by aberrant...
8445444 Compositions and methods for diagnosing, treating, and preventing prostate conditions  
Disclosed are compositions and methods for diagnosing, preventing, and treating prostate cancer and prostate intraepithelial neoplasia (PIN).
8444975 Method for inhibiting bone resorption  
This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling; variants and derivatives of the polynucleotides and corresponding...
8445021 Functionalized magnetic nanoparticles and methods of use thereof  
The present disclosure provides compositions comprising 2-deoxyglucose-functionalized magnetic nanoparticles. The compositions are useful in various applications, which are also provided.
8444973 Anti-CD19 antibodies and uses in B cell disorders  
The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies and...
8444980 Therapeutic use of anti-CS1 antibodies  
The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such...
8444972 Antitumor antibodies, proteins, and uses thereof  
Antibodies that bind to a 40 kDa protein which is expressed on tumors, but is not expressed on normal adult hemopoietic cells are disclosed. Also disclosed are methods for production and the use of...
8444976 Antigen binding polypeptides  
The invention relates to a platform technology for production of antigen binding polypeptides having specificity for a desired target antigen which is based on the conventional antibody repertoire...
8444981 Alpha-4 beta-7 heterodimer specific antagonist antibody  
There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.
8444979 Antibodies that inhibit TSLP activity  
The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
8444974 Use of antibodies for the vaccination against cancer  
Described is the use of antibodies which are directed against human cellular membrane antigens for the vaccination against cancer diseases.
8444971 OVR110 antibody compositions and methods of use  
Isolated antibodies and antigen binding fragments thereof directed against Ovr110 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided....
8445645 Identification and engineering of antibodies with variant Fc regions and methods of using same  
The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises...
8440185 Compositions and methods for the treatment of immunologic disorders  
Compositions and methods for preventing, reducing or inhibiting immunologic disorders are provided. Suitable compositions include one or more LIGHT-HVEM antagonists. LIGHT-HVEM antagonists include...
8440194 Methods using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias  
Methods of treating, preventing or managing leukemias are disclosed. The methods encompass the administration of an immunomodulatory compound of the invention known as Revlimid® or lenalidomide. ...
8440186 P2X7 epitopes  
The invention relates to purinergic (P2X) receptors, more specifically to P2X7 receptors, the generation of antibodies and the use of antibodies and immunogens that are capable of selectively...
8440187 Use application of sugar chain-recognizing receptor  
Provided are a novel means for regulating inflammatory reactions by regulating the signaling in inflammatory responses caused by non-homeostatic cell death, specifically an anti-inflammatory agent...
8440188 Therapeutic and diagnostic anti-HSP70 antibodies  
Methods and compositions for the detection, prevention and treatment of infectious diseases, primary and metastatic neoplastic diseases, including, but not limited to human sarcomas and carcinomas...
8440189 Antagonists of TWEAK and of TWEAK receptor and their use to treat immunological disorders  
The present invention relates to reagents which modify the activity of TWEAK and their use as therapeutic agents for the treatment of immunological disorders.
8435948 Methods for inhibiting osteoclastic bone resorption and bone loss comprising administration of an anti-FSH or anti-FSHR antibody  
The invention discloses compositions and methods for decreasing osteoclast which are useful for the treatment of a variety of bone loss disorders.
8435512 Anti-properdin antibodies  
A method of inhibiting alternative complement pathway activation in a mammal includes administering an amount of an antibody and/or fragment thereof that specifically binds to an epitope of the N...
8435510 Platelet derived growth factor receptor supports cytomegalovirus infectivity  
The disclosure relates generally to compositions and methods useful for inhibiting the infection and propagation of viral particles, particularly members of the Herpesviridae family, and more...
8435526 Methods of treating mucositis using anti-TNF antibodies  
In accordance with the invention, the development and use of antibodies within the digestive tract is provided. Antibodies are described that are used to treat disorders associated with altered...
8435514 Method for the treatment of neurodegenerative diseases  
Disclosed are methods for treating neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Alzheimer's Disease, Parkinson's Disease, Myasthenia Gravis, Multifocal Motor Neuropathy,...