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8557245 Methods for treating bone cancer by administering a nerve growth factor antagonist antibody  
The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth...
8557967 Anti-interferon-α antibodies  
The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention f...
8557244 Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody  
This invention concerns methods for the treatment of intermediate and high-grade non-Hodgkins lymphomas, comprising the administration of anti-CD20 monoclonal antibodies and fragments thereof....
8557240 Method for the treatment of inflammatory disorders  
A method for the treatment of inflammatory disorders is disclosed, particularly the treatment of arthritis. The method comprises the administration of a function blocking antibody which is capable...
8557239 Methods for treating psoriasis using antibodies that bind to the P40 subunit of IL-12 and/or IL-23  
The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.
8557238 EG-VEGF nucleic acids and polypeptides and methods of use  
The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells...
8551476 SP35 antibodies and uses thereof  
Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination (Negative Regulator). Molecules that block endogenous Sp35...
8552157 c-Kit antibodies and uses thereof  
This invention is directed to antibodies that specifically bind to an extracellular domain of human c-Kit, pharmaceutical compositions comprising these antibodies, and their use in treating cancer.
8551477 Methods of treating OX40 mediated recall immune responses using OX40L antibodies and agents useful for identifying same  
T cell memory can persist in the absence of antigen. However, some memory cells by default are subject to signals accompanying periodic antigen exposure. OX40 is essential to the extent and...
8552154 Anti-PD-L1 antibodies and uses therefor  
The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing,...
8551485 Anti-CD40 antibodies and methods of inhibiting proliferation of CD40 expressing cells  
The present invention describes humanized antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters...
8551489 Methods for the treatment of cancers  
Methods for the treatment of cancers involving dysregulation of thromboxane receptor β (TP-β) are provided, including in certain aspects methods for diagnosing such cancers. Specific cancers i...
8551719 Endotoxin detection method  
The invention relates to a method for detecting endotoxins in a sample.
8545839 Anti-c-Met antibody  
The invention relates to a novel antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine kinase activity of said receptor both in...
8546093 Detection method for methicillin resistant staphylococcus aureus  
The present invention relates to an antibody against a protein specifically expressed in methicillin-resistant strains of Staphylococcus aureus (MRSA), and a method and a kit for detecting MRSA....
8545848 Human cytomegalovirus neutralising antibodies and use thereof  
The invention relates to neutralizing antibodies which are specific for human cytomegalovirus and bind with high affinity as well as immortalized B cells that produce such antibodies. The invention...
8545838 Compositions and methods for cancer immunotherapy  
Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a liver-expressed chemokine (LEC). In one embodiment, the cancer targeting molecule is an antibody that...
8546331 Modulation of pathogenic CD14+/CD16+ monocytes  
The invention is based on the discovery that interleukin-1 alpha (IL-1alpha) is expressed on the proinflammatory CD14+CD16+ monocyte subset. Importantly, since IL-1alpha appears to be almost...
8546538 Lymphoid chemokines in the diagnosis, monitoring and treatment of inflammatory disease  
Experimental autoimmune encephalomyelitis (EAE) is a Th1-mediated autoimmune disease of the central nervous system that is widely used as an animal model of multiple sclerosis (MS). In this study...
8541179 Immunodetection assay for Mycobacterium tuberculosis complex  
The present invention provides a method for specifically detecting a Mycobacterium tuberculosis complex-specific secretory protein MPT64 antigen in a biological sample, whereby diagnosis of...
8540995 Monoclonal antibodies specific to the fusion peptide from hemagglutinin from influenza A viruses and uses thereof  
This invention relates to methods and products for the diagnosis, surveillance, prevention, and treatment of influenza A virus infections in animals and humans. More particularly, the invention...
8541006 Methods and devices for the detection of biofilm  
The present invention provides methods and kits for biofilm detection.
8540988 Antibodies that bind polypeptides involved in the process of bone remodeling  
This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling, variants and derivatives of the polynucleotides and corresponding...
8540989 Compositions and methods for treating and diagnosing cancer  
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in...
8540986 Toll-like receptor 3 antagonists  
Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
8540987 Composition for neutralizing botulinus toxin type-A, and human anti-botulinus toxin type-A antibody  
Provided herein is a means which is effective for botulism diseases and the prevention of the botulism diseases. Specifically provided is a plurality of human anti-botulinum toxin type-A antibodies...
8540993 Methods of treatment using IL-18 receptor antigen binding proteins  
Provided herein are IL-18 receptor antigen binding proteins and polynucleotides encoding the same. Expression vectors and host cells comprising the same for production of the antigen binding...
8541029 Article and method for focused delivery of therapeutic and/or diagnostic materials  
A microfiber extrudate and delivery process includes a bio-compatible polymer matrix forming a body of the microfiber extrudate, an exogenously excitable material arranged within the body, and an...
8535684 Methods of inhibiting HIV infectivity  
A method for identifying host genes and encoded proteins for potential targets for therapeutic intervention employs a Gene Search Vector that is either lentivirus or MMLV-based, and can be used to...
8535665 Process for identification of molecular mimicry and the uses thereof  
The present invention discloses a process for simple and rapid detection and identification of molecular mimicry or mimic antigens or molecules existing in/on humans, animals and plants. The...
8535666 Antibody (11C7) anti Nogo-A and its pharmaceutical use  
This invention relates to molecules, such as for example monoclonal antibodies or Fab fragments thereof, which are capable of binding to the human NogoA polypeptide or human NiG or human NiG- or...
8535664 Method of treating a pathological syndrome and a pharmaceutical agent  
The application relates to a pharmaceutical agent comprising homeopathically activated form of antibodies to a pharmaceutically active small molecule, which activated form is obtained by repeated...
8535676 Antibody therapy  
The present invention provides a composition comprising naked humanized, chimeric, and human anti-CEA antibodies and a therapeutic agent, which is useful for treatment of CEA expressing cancers and...
8535725 Porous-wall hollow glass microspheres as carriers for biomolecules  
The present invention includes compositions of porous-wall hollow glass microspheres and one or more biomolecules, wherein the one or more biomolecules are positioned within a void location within...
8529894 Methods of reducing inflammation in cardiomyopathy  
The invention pertains to methods of treating cardiovascular disease by modulating inflammatory and immunoregulatory responses associated with such pathological conditions. Embodiments of the...
8529900 Methods for the treatment, the prognostic assessment and the staging of non-small cell lung cancer  
The present invention relates to methods for the treatment, the prognosis and the diagnosis of non-small cell lung cancer.
8529891 Inhibitors of extracellular HSP90  
The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention...
8530414 Antibodies to PCSK9 and uses thereof  
The present invention relates to antibodies to proprotein convertase subtilisin/kexin type 9 (PCSK9), or antigen-binding fragments thereof, compositions comprising such PCSK9 antibodies or...
8529893 Methods for treating IFN-γ mediated diseases using human anti-IFN-γ neutralizing antibodies as selective IFN-gamma pathway inhibitors  
This invention provides antibodies that interact with or bind to human interferon-gamma (IFN-γ) and methods for treating IFN-γ mediated diseases by administering a pharmaceutically effective a...
8530627 FcγRIIB specific antibodies and methods of use thereof  
The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind F...
8529892 Diagnostic and treatment methods for characterizing bacterial microbiota in skin conditions  
The present invention relates to methods for characterization of bacterial skin microbiota to provide diagnostic, therapeutic, and preventive measures for alleviating skin conditions. In certain...
8529901 Composition of a first non-labeled monoclonal antibody binding to a tumor antigen and a non-cross reactive second monoclonal antibody labeled with a NIR fluorescence label  
This invention relates to a composition of a non-labeled monoclonal antibody binding to a tumor antigen and a second monoclonal antibody labeled with a NIR fluorescence label, binding to the same...
8529897 Inflammation-regulating compositions and methods  
The various embodiments provide a composition that provides local control over inflammation. The composition localizes the activities of the cytokine-neutralizing antibodies to the site of...
8524228 Netrin-1 compositions and methods of use thereof  
Methods and compositions for male or female contraception are provided. The compositions include an effective amount of netrin-1 to reduce or inhibit sperm concentration in semen of males or to...
8524229 Medicament and a method for regulation of the vascular tone  
The method of treatment for diseases accompanied by disturbances of the vascular tone utilizes the use of ultra low doses of antibodies to a protein or a peptide involved in the vascular tone...
8524227 Anti-IL-TIF antibodies  
The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes...
8524667 Methods of treating gout using IL-1BETA antibodies  
This invention relates to a novel use of IL-1β-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1β ligan...
8524865 Antibodies and immunoconjugates and uses therefor  
Anti-CD22 antibodies and immunoconjugates thereof are provided. Methods of using anti-CD22 antibodies and immunoconjugates thereof are provided.
8524235 Method for treating coronary artery disease using antibody binding human protein tyrosine phosphatase beta(HPTPbeta)  
Antibodies and antigen binding fragments thereof that bind to human protein tyrosine phosphatase beta (HPTPβ), and uses thereof.
8524236 Methods of antagonizing the binding of CD40 to CD40L with CD40L-specific monovalent polypeptides in autoimmune individuals  
The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential...