Sign up


Match Document Document Title
8470318 Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods  
The invention provides a polypeptide containing at least one IgG Fc region, wherein said at least one IgG Fc region is glycosylated with at least one galactose moiety connected to a respective...
8470330 PSMA antibodies and uses thereof  
The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using...
8470979 Humanized antibody molecules specific for IL-31  
The invention provides humanized mouse anti-human IL-31 antibodies and antibody fragments that are capable of binding IL-31 and thereby neutralizing, inhibiting, limiting, or reducing the...
8465738 Use of vascular endothelial growth factor receptor 1+ cells in treating and monitoring cancer and in screening for chemotherapeutics  
The present invention is directed to a method of inhibiting tumor formation in a cancer patient at a site remote from sites of prior tumor formation and to a method of preventing metastases. These...
8465931 Therapeutic and diagnostic methods and compositions targeting 4Ig-B7-H3 and its counterpart NK cell receptor  
The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The...
8465739 Stable aqueous pharmaceutical formulations of daclizumab antibodies  
This invention is directed to a stable liquid pharmaceutical formulation comprising a high concentration, e.g. 50 mg/ml or more, of antibody in about 20-60 mM succinate buffer or 30-70 mM histidine...
8465740 Regulatory T cell mediator proteins and uses thereof  
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A ...
8465737 Three-dimensional structure of complement receptor type 2 and uses thereof  
Disclosed is a crystalline human CR2 protein in complex with C3d, and the three dimensional structure of the crystalline complex. Also disclosed are methods of use of the structure, particularly...
8460661 Methods of using antibodies that bind the glutamate ligand binding region of Notch1  
Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of...
8460657 Modulation of the TrpV: Vps10p receptor system for the treatment of pain  
This invention relates to the use of an agent capable of binding and thus inhibit formation of a binary Vps10p-domain receptor:TrpV receptor complex, and/or formation of a further ternary...
8461304 Antibodies  
The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of...
8460659 Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases  
Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
8460890 Detection and measurement of blood-feeding activity  
This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive...
8460662 Compositions and methods relating to anti-IGF-1 receptor antibodies  
The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric...
8460663 Stabilized liquid anti-RSV antibody formulations  
The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which ...
8460667 EPHA2 receptor antagonist antibodies  
Antagonistic antibodies that specifically bind to and inhibit Class A Eph receptors are provided. Also provided are cytotoxic conjugates, pharmaceutical compositions and kits comprising these...
8460886 Use of an efficacy marker for optimizing therapeutic efficacy of an anti-human PD-1 antibody on cancers  
A purpose of the present invention is to provide a method capable of more effectively prescribing an anti-human PD-1 antibody for anti-cancer therapy, a method for estimating or optimizing...
8460658 Method of treating cancer and/or cellular proliferative conditions and agents targeting hyaluronan anabolism useful for same  
The present invention relates generally to the modulation of hyaluronan (HA) synthesis and degradation. The present invention further contemplates modulation of cellular proliferation, useful in...
8460660 Anti-mesothelin antibodies  
The present invention provides monoclonal anti-mesothelin antibodies and antibody fragments and methods for their use. The antibodies can be completely human.
8460669 Compositions and methods for identifying response targets and treating flavivirus infection responses  
Cellular receptors are identified that induce plasma leakage and other negative effects when infected with flaviviruses, such as dengue virus or Japanese encephamyelitis virus. Using fusion...
8454961 Alpha-4-beta-7 heterodimer specific antagonist antibody  
There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.
8455623 Compositions and methods for diagnosing and treating cancer  
Isolated antibodies that specifically bind the human MET Receptor and inhibit MET signaling are described. Also described are methods of treating cancer, the methods comprising administering a...
8454955 Methods for treating allergic airway inflammation, airway hypersensitivity, and eosinophilia  
The invention provides a method of screening a therapeutic agent for allergic airway inflammation and/or airway hypersensitivity, comprising using an IL-17RB positive NKT cell, as well as a...
8454959 Compositions monovalent for CD28 binding and methods of use  
Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or...
8454954 Treatment of synucleinopathies  
This invention relates generally to treating synucleinopathies in subjects that are not clinically diagnosed with a lysosomal storage disease, as well as associated methods of making medicaments...
8455622 Variant target binding agents and uses thereof  
The present invention provides variant target binding agents and methods relating to the use of such binding agents for the prophylaxis or treatment of cancers and immunological disorders. The...
8454956 Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies  
The invention features methods and compositions for preventing or treating rheumatoid arthritis and osteoporosis by administering an antagonist of IL-20. The IL-20 antagonist may be an anti-IL-20...
8454958 Methods for detecting and inhibiting angiogenesis  
The present invention provides methods for reducing or inhibiting angiogenesis in a tissue, by contacting α5β1 integrin in the tissue with an agent that interferes with specific binding of the α...
8454952 Augmentation of endothelial thromboresistance  
Stretch-induced increased hemodynamic load adversely affects endothelial cell function and is an important contributor to thromboembolus formation in heart failure, valvular heart disease, atrial...
8454962 Alpha-4-beta-7 heterodimer specific antagonist antibody  
There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.
8454953 Methods for reducing allergies caused by environmental allergens  
Compositions suitable for reducing symptoms of an allergic response to environmental allergens comprising molecules that specifically inhibit the ability of the allergen to bind to mast cells in an...
8454957 Methods for treating coagulation disorders  
The invention is directed to methods for treating coagulation disorders, in particular, hemophilia. Such methods utilize novel compositions including Amnion-derived Multipotent Progenitor cells...
8449875 Targeting pseudotyped retroviral vectors  
The present invention provides targeted lentiviral vectors that are psuedotyped with mutated Sindbis envelopes. For example, mutations in the Sindbis E2 protein are used to alter viral titer,...
8449882 Anti-EPHA2 antibody  
Problem to Be Solved It is intended to provide an antibody having an inhibitory activity against cell malignant transformation and/or tumor cell growth, etc.SolutionThe present invention provides...
8449881 Anti-α-enolase I antibodies for diagnosis and treatment of α-enolase I-associated diseases  
The invention relates to antibodies against α-enolase I, their pharmaceutical compositions and diagnosis and treatment uses. Particularly, the invention provides polyclonal anti-α-enolase I a...
8449883 Compositions and methods for the diagnosis and treatment of tumor  
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
8449863 Stabilized uncoated particles of reversed liquid crystalline phase materials  
Uncoated particles of reversed cubic phase or reversed hexagonal phase material containing an active disposed within are provided. The uncoated particles have an ionic charge that is sufficient to...
8450464 Human monoclonal antibodies that bind CXCR4  
The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the...
8444970 Compositions and methods for treating ocular diseases and conditions  
The present invention relates to compositions and methods for prevention and treatment of diseases and conditions, particularly ocular diseases and conditions, characterized by aberrant...
8445444 Compositions and methods for diagnosing, treating, and preventing prostate conditions  
Disclosed are compositions and methods for diagnosing, preventing, and treating prostate cancer and prostate intraepithelial neoplasia (PIN).
8444975 Method for inhibiting bone resorption  
This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling; variants and derivatives of the polynucleotides and corresponding...
8445021 Functionalized magnetic nanoparticles and methods of use thereof  
The present disclosure provides compositions comprising 2-deoxyglucose-functionalized magnetic nanoparticles. The compositions are useful in various applications, which are also provided.
8444973 Anti-CD19 antibodies and uses in B cell disorders  
The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies and...
8444980 Therapeutic use of anti-CS1 antibodies  
The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such...
8444972 Antitumor antibodies, proteins, and uses thereof  
Antibodies that bind to a 40 kDa protein which is expressed on tumors, but is not expressed on normal adult hemopoietic cells are disclosed. Also disclosed are methods for production and the use of...
8444976 Antigen binding polypeptides  
The invention relates to a platform technology for production of antigen binding polypeptides having specificity for a desired target antigen which is based on the conventional antibody repertoire...
8444981 Alpha-4 beta-7 heterodimer specific antagonist antibody  
There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.
8444979 Antibodies that inhibit TSLP activity  
The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
8444974 Use of antibodies for the vaccination against cancer  
Described is the use of antibodies which are directed against human cellular membrane antigens for the vaccination against cancer diseases.
8444971 OVR110 antibody compositions and methods of use  
Isolated antibodies and antigen binding fragments thereof directed against Ovr110 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided....