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8192742 |
Method of inhibiting complement activation with human anti-factor C3 antibodies and use thereof
A method of inhibiting complement activation mediated by C3b inhibitors in a subject includes administering a C3B inhibitor to the subject to inhibit at least one of C3b binding to factors B and...
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8192738 |
Targeted antibodies directed to DLL4
The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described...
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8192741 |
Method of treating rheumatoid arthritis with an anti-IL-6R antibody
The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6...
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8192740 |
Pharmaceutical composition comprising anti-GRP78 antibody as active ingredient
An object of the present invention is to provide novel pharmaceutical compositions using anti-GRP78 antibodies. More particularly, the present invention provides a novel method of cancer treatment...
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8192735 |
Method for modulating appetite
Method of modulating appetite and/or body weight in a subject by administering to the subject an effective amount of a MIC-1 modulating agent. The agent is selected from (i) MIC-1 inhibiting agents...
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8192736 |
Remedy for endometriosis
The present invention provides a therapeutic agent for endometriosis comprising an interleukin-5 antagonist as an active ingredient.
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8187594 |
Transferrin receptor antibodies
The invention provides further characterization of the disease and cancer-associated antigen, transferrin receptor. The invention also provides a novel family of antibodies that bind to the...
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8188237 |
Binding domain-immunoglobulin fusion proteins
The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region...
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8187604 |
Methods of treating with anti-factor D antibodies
The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the...
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8187595 |
Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor-I
The present invention provides αVβ3 integrin cysteine loop domain agonists and antagonists (including peptide agonists and antagonists and analogs thereof), along with methods of using the same.
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8188231 |
Optimized FC variants
The present invention relates to optimized Fc variants, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
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8187596 |
Method of treating asthma or allergy by administering an IL-33 receptor antibody
Provided herein are methods of modulating IL-33 activity, e.g., for the purpose of treating immune diseases and conditions, as well as methods of screening for compounds capable antagonizing IL-33...
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8188058 |
Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4-associated disorders
The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic sepsis...
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8187598 |
Methods of treating cancer by administering antibodies to CD200
Methods and compositions for regulating immunity are disclosed. For enhancing an immune response, agents that inhibit OX-2 are administered. Such methods are useful in treating cancer. For...
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8187603 |
Antibodies to human IL-22
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22...
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8188234 |
1D05 PCSK9 antagonists
Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present des...
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8188233 |
1B20 PCSK9 antagonists
Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present des...
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8187597 |
Combination therapy for the treatment of ocular neovascular disorders
The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The...
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8187593 |
FcγRIIB specific antibodies and methods of use thereof
The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind F...
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8187599 |
Compositions and methods for suppressing fibrocytes
The present invention relates to the ability of anti-FcγR antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety ...
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8182809 |
Methods for treating cancer by inhibiting MIC shedding
Described herein are compositions and methods for treating cancer, comprising administering to an individual having cancer an agent to prevent MIC shedding (initiated at the alpha-3 ectodomain of...
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8182817 |
Antibodies to human IL-22
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22...
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8182810 |
IL-B30 antibodies
Purified genes encoding cytokine referred to as interleukin-B30 (IL-B30) from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this...
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8185209 |
Methods to extend vision to infrared wavelengths
In a method for visualizing an object under conditions of low ambient light, the object to be visualized is exposed to incident electromagnetic radiation having a wavelength greater than what can...
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8182818 |
Methods of using anti-TNF antibodies for treating radiation damage to the digestive tract
In accordance with the invention, the development and use of antibodies within the digestive tract is provided. Antibodies are described that are used to treat disorders associated with altered...
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8182811 |
Antibodies to CXCL13
The present invention relates to binding members, especially antibody molecules, for CXCL13. The binding members are useful for the treatment of disorders associated with CXCL13, including...
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8178091 |
Compositions and methods for the treatment of respiratory disorders
Methods and compositions are provided for the treatment of acute lung injury and pulmonary fibrosis by administering inhibitors of IGF-1R signaling activity.
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8178094 |
Methods for inhibiting tumor growth or reducing metastatic burden in a subject by administering FDF03 antibodies
The present invention relates to methods for identifying and using modulators of FDF03 biological activity in vitro and in vivo that are useful in the treatment of cancer.
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8178093 |
Method for treating infectious disease using monoclonal antibodies
The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcγ receptors and having a particular glycan ...
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8178092 |
Methods of treating psoriasis by administration of antibodies to the p40 subunit of IL-12 and/or IL-23
The invention provides a method of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.
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8178097 |
Methods of treatment utilizing binding proteins of the interleukin-21 receptor
The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods...
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8173130 |
Antibodies against flagellin and uses thereof
The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including,...
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8173122 |
Methods of treatment using antibodies to neutrokine-alpha
The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In...
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8173375 |
Rabbit monoclonal antibodies to hepatitis B surface antigens and methods of using the same
Reagents, methods and immunodiagnostic test kits for the accurate detection of hepatitis B virus (HBV) infection are disclosed. The methods and kits employ novel rabbit monoclonal antibodies...
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8173424 |
Internalizing ErbB2 antibodies
This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the...
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8173123 |
Methods of treating colitis involving IL-13 and NK-T cells
Method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity (FIG. 3)....
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8173124 |
Method to treat using antagonistic anti-hTNFSF13b human antibodies
Human monoclonal antibodies that specifically bind to TNFSF13b polypeptides are disclosed. These antibodies have high affinity for hTNFSF13b (e.g., KD=10−8 M or less), a slow off rate for T...
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8173125 |
Wise/Sost nucleic acid sequences and amino acid sequences
The present invention relates to nucleic acid sequences and amino acid sequences which influence bone deposition, the Wnt pathway, ocular development, tooth development, and may bind to LRP. The...
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8168199 |
Dipeptidyl peptidase IV inhibitors for the treatment of schizophrenia and depression
A method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression, insomnia, schizophrenia, epilepsy,...
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8168181 |
Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling; variants and derivatives of the polynucleotides and corresponding...
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8168182 |
Method for treating erectile dysfunction
A medicament based on antibodies contains an activated form of ultra-low doses of monoclonal, polyclonal, or natural antibodies to endothelial nitric oxide synthase (NO synthase), the activated...
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8168180 |
Methods and compositions for modulating angiogenesis
Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue...
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8168186 |
Therapeutic using a bispecific antibody
Multivalent, multispecific molecules having at least one specificity for a pathogen and at least one specificity for the HLA class II invariant chain (Ii) are administered to induce clearance of...
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8168164 |
Targeted conjugates and radiation
The invention relates to a method for enhancing an endogenous immune response-mediated elimination of a population of cancer cells in a host. The method comprises the steps of administering to the...
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8168179 |
Treatment method using anti-PD-L1 antibody
Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative...
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8168178 |
Methods and compositions for regulating lymphocyte activity
The present application is directed to the discovery that hedgehog gene products, and signal transduction pathways involving hedgehog, are involved in maturation of T lymphocytes. The invention...
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8163281 |
Treatment of drug-related side effect and tissue damage by targeting the CD24-HMGB1-Siglec10 axis
The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24...
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8163279 |
IL3Rα antibody conjugates and uses thereof
The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3Rα) chain, and compositions comprising such antibodies. The present invention provides methods for ...
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8163882 |
Polypeptide variants with altered effector function
The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function...
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8163280 |
Antibodies to c-Met
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit...
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