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8758750 Synergistic anti-CD47 therapy for hematologic cancers  
Methods are provided for treatment of hematologic cancers, particularly lymphomas and leukemias, including without limitation myelogenous and lymphocytic leukemias. A combination of antibodies...
8758755 Stem cell fusion model of carcinogenesis  
Methods for modeling cancer cell migration, screening drugs for effects on tumor cell migration, and detecting the potential for tumor cell migration relating to the fusion of a bone marrow derived...
8758749 Biological materials and uses thereof  
The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell...
8754031 Use of prolactin receptor antagonists in combination with an agent that inactivates the HER2/neu signaling pathway  
The present invention describes compositions and methods for inhibiting cell proliferation comprising a prolactin receptor antagonist and an agent that inactivates the HER2/neu signaling pathway,...
8753633 Human antibodies that bind human TNFα  
Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd...
8754195 Antibody formulations  
The present invention relates to formulations comprising sucrose, and methods of making such formulations, wherein the sucrose content promotes the reduction or elimination of the reversible...
8753635 Monoclonal antibodies to anthrax protective antigen  
The characterization and isolation of F20G75, F20G76 and F20G77, anti-PA monoclonal antibodies which also have neutralizing activities is described. The monoclonal antibodies may be used as a...
8753625 Use of complement inhibitors to treat ocular diseases  
The present invention relates to the treatment of ocular diseases and conditions by administering a complement pathway inhibitor, particularly an alternative pathway inhibitor. Ocular diseases...
8753628 Optimized Fc variants  
The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized ...
8753627 Anti-activin a antibodies and uses thereof  
The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human,...
8753839 Compositions and methods for crystallizing antibodies  
The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an...
8747854 Methods of treating moderate to severe hidradenitis suppurativa with anti-TNF-alpha antibodies  
The invention provides methods, uses and compositions for the treatment of hidradenitis suppurativa. The invention describes methods and uses for treating hidradenitis suppurativa, wherein a TNFα ...
8747844 Methods of treating pain  
The invention relates to methods for treating pain disorders including neuropathic and inflammatory pain and to methods to reduce or eliminate nociceptive tolerance induced by opiate analgesic use...
8748173 Monoclonal antibodies specific for anthrax spores and peptides derived from the antibodies thereof  
The present invention provides monoclonal antibodies which are highly specific for Bacillus spores. Also provided are peptides derived from those monoclonal antibodies. Both the antibodies and...
8747870 Polymeric compositions and methods of making and using thereof  
Described herein are polymeric compositions that comprise at least one polymer residue and at least one crosslinking moiety, wherein the polymer residue is crosslinked by the crosslinking moiety...
8747857 Calicheamicin derivative-carrier conjugates  
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate...
8747845 Methods of treatment by administering antibodies that bind colony stimulating factor 1 receptor (CSF1R)  
Antibodies that bind CSF1R are provided. Antibody heavy chains and light chains that are capable of forming antibodies that bind CSF1R are also provided. Polynucleotides encoding antibodies to...
8748384 Modulation of activity of proneurotrophins  
The present invention provides agents for inhibiting binding of a pro-neurotrophin to a Vps1 Op-domain receptor, in particular the binding of a pro-NGF or a pro-BDNF to a Sortilin receptor. The...
8747856 Antigen binding fragments of an antibody for use in treating or diagnosing ocular diseases  
The present invention relates to the use of a fully human antigen binding fragment of an antibody for the manufacture of a medicament for the treatment or diagnosis of an ocular disease upon...
8747852 Methods of treating pterygium  
Methods for treating pterygium recurrence following pterygiectomy, and for treating keloid recurrence, following surgical removal of the keloid, are disclosed. The methods include administering an...
8747846 Compositions and methods for immunization against drug resistant Acinetobacter baumannii  
The present invention provides vaccine compositions comprising OmpA, or antigenic fragments thereof, and related methods of active immunization against A. baumannii infection. The invention also...
8747843 Method of treatment and bioassay involving macrophage migration inhibitory factor (MIF) as cardiac-derived myocardial depressant factor  
One embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount of at least one anti-MIF antibody; and at least one...
8748581 Anti-IL-6R polypeptides and pharmaceutical compositions thereof  
The present invention relates to amino acid sequences that are directed against/and or that can specifically bind Interleukin-6 Receptor (IL-6R) with improved affinity and/or avidity, and/or that...
8741876 Therapeutic agent for ulcerative colitis  
A method for treating a patient having ulcerative colitis, by administering a drug which containing an effective amount of tetracyclines is provided. The drug may also contain penicillins and/or...
8741287 PlGF-1 assay and kits and components thereof  
The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of...
8741289 Siglec 15 antibodies in treating bone loss-related disease  
Novel antibodies and antigen binding fragments that specifically binds to Sιglec-15 are described herein. In some embodiments, the antibodies or antigen binding fragments may block the biological ...
8741292 Proteins and methods for modulating cell activity  
The present invention relates to a novel gene encoding a protein termed Coiled Coil Domain Containing 95 (CCDC95) or a peptide fragments thereof. The present invention also relates to the use of...
8741288 Protein markers for detecting liver cancer and method for identifying the markers thereof  
The present invention relates to the diagnosis of liver cancer. It discloses the use of protein ERBB3 and protein IGFBP2 in the diagnosis of liver cancer. It relates to a method for diagnosis of...
8741586 Antibodies against HER2 truncated variant CTF-611  
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognise an epitope of the...
8741260 Fusion proteins for delivery of GDNF to the CNS  
The invention provides compositions, methods, and kits for increasing transport of GDNF across the blood brain barrier while allowing its activity to remain substantially intact. The GDNF is...
8742075 Monoclonal antibodies against ANGPTL3  
Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid...
8734789 Targets for regulation of angiogenesis  
The present invention relates to the identification of polynucleotides and polypeptides having increased expression in tumor blood vessels. The invention further relates to the use of the...
8734792 Reagents and treatment methods for autoimmune diseases  
The invention concerns treatment methods using anti-CD22 monoclonal antibodies with unique physiologic properties. In particular, the invention concerns methods for the treatment of B-cell...
8734801 Anti-IL13 antibodies and uses thereof  
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize...
8734791 Optimized fc variants and methods for their generation  
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
8734788 Composition and method for treatment of reperfusion injury and tissue damage  
The present invention provides compounds and methods for the treatment and prophylaxis of ischemia reperfusion injury. In particular the invention provides compounds which function to suppress...
8734802 Methods of treating vasomotor symptoms using antibodies  
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot...
8734790 Anti-TLR4 antibodies and methods of use thereof  
This invention relates generally to antibodies that specifically bind Toll-like Receptor 4 (TLR-4), and to methods of using the anti-TLR4 antibodies as therapeutics and to methods of using the...
8734800 Subtypes of humanized antibody against interleukin-6 receptor  
An antibody subtype (1) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which one C-terminal of the heavy chain is Pro-NH2 (447), and an antibody...
8734797 Anti-IL13 antibodies and uses thereof  
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize...
8734798 Function modifying NAv 1.7 antibodies  
A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions...
8729234 Method for simultaneously detecting an antigen of, and an antibody, against, an infectious microorganism  
The invention relates to a method for detecting, in vitro, an infection with a microorganism, such as the hepatitis C virus, in a biological sample, by simultaneously detecting an antigen of this...
8728525 Protein microspheres retaining pharmacokinetic and pharmacodynamic properties  
The present disclosure relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active...
8728468 Treatments for cancer  
The present invention provides methods for reducing tumor survival, expansion, and metastasis. In particular, the invention provides methods for reducing melanoma tumor survival, expansion, and...
8728471 Antibody therapy for treatment of diseases associated with gluten intolerance  
The present invention includes a pharmaceutical compositions and methods for treating diseases associated with gluten intolerance in a patient, comprising: administering to the patient an effective...
8728473 Methods of preventing or treating pain using anti-NGF antibodies  
Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect...
8728539 Method of enhancing intestinal pinocytosis of immunoglobulins in postnatal domestic mammals  
Disclosed is a method of enhancing absorption (pinocytosis efficiecy) of immunoglobulins administered to postnatal domestic mammals (e.g., bovine) by using selenium. As an example of a selenium...
8728469 Method of treating rheumatoid arthritis using anti-IL-20 antibodies  
A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its...
8728523 Transdiscal administration of specific inhibitors of pro-inflammatory cytokines  
The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
8728438 Coronin 1 modulators for the treatment of autoimmune and lymphoproliferative disorders and mycobacterial infections  
The invention relates to the treatment of mycobacterial infections, autoimmune disorders, lymphoproliferative disorders and induction of immunosuppression following transplantation using coronin 1...