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8741287 PlGF-1 assay and kits and components thereof  
The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of...
8741289 Siglec 15 antibodies in treating bone loss-related disease  
Novel antibodies and antigen binding fragments that specifically binds to Sιglec-15 are described herein. In some embodiments, the antibodies or antigen binding fragments may block the biological ...
8741292 Proteins and methods for modulating cell activity  
The present invention relates to a novel gene encoding a protein termed Coiled Coil Domain Containing 95 (CCDC95) or a peptide fragments thereof. The present invention also relates to the use of...
8741288 Protein markers for detecting liver cancer and method for identifying the markers thereof  
The present invention relates to the diagnosis of liver cancer. It discloses the use of protein ERBB3 and protein IGFBP2 in the diagnosis of liver cancer. It relates to a method for diagnosis of...
8741586 Antibodies against HER2 truncated variant CTF-611  
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognise an epitope of the...
8741260 Fusion proteins for delivery of GDNF to the CNS  
The invention provides compositions, methods, and kits for increasing transport of GDNF across the blood brain barrier while allowing its activity to remain substantially intact. The GDNF is...
8742075 Monoclonal antibodies against ANGPTL3  
Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid...
8734789 Targets for regulation of angiogenesis  
The present invention relates to the identification of polynucleotides and polypeptides having increased expression in tumor blood vessels. The invention further relates to the use of the...
8734792 Reagents and treatment methods for autoimmune diseases  
The invention concerns treatment methods using anti-CD22 monoclonal antibodies with unique physiologic properties. In particular, the invention concerns methods for the treatment of B-cell...
8734801 Anti-IL13 antibodies and uses thereof  
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize...
8734791 Optimized fc variants and methods for their generation  
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
8734788 Composition and method for treatment of reperfusion injury and tissue damage  
The present invention provides compounds and methods for the treatment and prophylaxis of ischemia reperfusion injury. In particular the invention provides compounds which function to suppress...
8734802 Methods of treating vasomotor symptoms using antibodies  
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot...
8734790 Anti-TLR4 antibodies and methods of use thereof  
This invention relates generally to antibodies that specifically bind Toll-like Receptor 4 (TLR-4), and to methods of using the anti-TLR4 antibodies as therapeutics and to methods of using the...
8734800 Subtypes of humanized antibody against interleukin-6 receptor  
An antibody subtype (1) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which one C-terminal of the heavy chain is Pro-NH2 (447), and an antibody...
8734797 Anti-IL13 antibodies and uses thereof  
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize...
8734798 Function modifying NAv 1.7 antibodies  
A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions...
8729234 Method for simultaneously detecting an antigen of, and an antibody, against, an infectious microorganism  
The invention relates to a method for detecting, in vitro, an infection with a microorganism, such as the hepatitis C virus, in a biological sample, by simultaneously detecting an antigen of this...
8728525 Protein microspheres retaining pharmacokinetic and pharmacodynamic properties  
The present disclosure relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active...
8728468 Treatments for cancer  
The present invention provides methods for reducing tumor survival, expansion, and metastasis. In particular, the invention provides methods for reducing melanoma tumor survival, expansion, and...
8728471 Antibody therapy for treatment of diseases associated with gluten intolerance  
The present invention includes a pharmaceutical compositions and methods for treating diseases associated with gluten intolerance in a patient, comprising: administering to the patient an effective...
8728473 Methods of preventing or treating pain using anti-NGF antibodies  
Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect...
8728539 Method of enhancing intestinal pinocytosis of immunoglobulins in postnatal domestic mammals  
Disclosed is a method of enhancing absorption (pinocytosis efficiecy) of immunoglobulins administered to postnatal domestic mammals (e.g., bovine) by using selenium. As an example of a selenium...
8728469 Method of treating rheumatoid arthritis using anti-IL-20 antibodies  
A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its...
8728523 Transdiscal administration of specific inhibitors of pro-inflammatory cytokines  
The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
8728438 Coronin 1 modulators for the treatment of autoimmune and lymphoproliferative disorders and mycobacterial infections  
The invention relates to the treatment of mycobacterial infections, autoimmune disorders, lymphoproliferative disorders and induction of immunosuppression following transplantation using coronin 1...
8722051 Tweak receptor  
The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening...
8722042 Use of ventricular enlargement rate in intravenous immunoglobulin treatment of alzheimer's disease  
The present invention relates to the use of MRI monitoring of ventricular enlargement rate as an objective measure for the purpose of assessing disease progression in patients suffering from...
8722041 Anti-human equilibrative nucleoside transporter 1 (hENT1) antibodies and methods of use thereof  
This invention provides monoclonal antibodies that recognize hENT1. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and/or prophylactic in...
8722613 Methods and compositions for inhibition of nuclear factor kappaB  
A series of p105-based NF-κB super repressors, designated p-105(sr), have been designed. The p105(sr), no longer generates p50 and undergoes signal-induced degradation, effectively inhibiting all ...
8722349 Methods and kit for endometriosis screening  
Methods of screening a bodily sample for endometriosis are provided. The bodily sample is preferably saliva. According to one embodied method, the bodily sample is subjected to a denaturing...
8715620 Treatment of asthma in mammals with clostridia neurotoxins  
A method is disclosed for blocking or reducing physiological reaction in a mammal to the interaction of IgE antibodies present in said mammal upon contact with the corresponding antigen, by the...
8715656 Therapeutic use of specific ligand in MSRV associated diseases  
The present invention deals with a ligand comprising each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ ID...
8716455 Genetic products differentially expressed in tumors and use thereof  
The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and...
8715653 Modulation of Rhamm (CD168) for selective adipose tissue development  
Herein is described the methods and compositions for modulation of Rhamm, also known as CD 186, and its effects on wound repair, muscle differentiation, bone density and adipogeneisis through its...
8715652 Immunoglobulin preparations having increased stability  
The present invention relates to a protein preparation having increased stability, comprising a stabiliser selected from the group consisting of non-polar and basic amino acids and having a pH of...
8715666 Method for the potentiation of opioid analgesics effects on pain  
According to the invention there is provided use of an anti-TrkA antibody capable of inhibiting the binding between NGF and TrkA combined with at least one opioid analgesic for the preparation of a...
8716235 Method for inhibiting metastasis by using anti-CCL3 antibodies  
Methods and compositions are provided for inhibiting metastasis of a tumor in a subject, or of inhibiting progression of a primary tumor in a subject which requires macrophages for progression.
8715654 Methods of modulating the negative chemotaxis of immune cells  
The current invention is directed to methods of inducing migration of an immune cell toward a cancer cell comprising inhibiting the activity of a chemorepellant released from the cancer cell.
8715655 Human anti-α9 integrin antibody  
The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their li...
8715658 Methods for treating conditions mediated by the inflammatory cytokine cascade using GAPDH inhibitors  
The present invention is directed to a method of treating a subject at risk for or having a condition mediated by an inflammatory cytokine cascade comprising administering to the subject an amount...
8716215 Method of treating or preventing tissue deterioration, injury or damage due to a neuro-, muscular- or neuro-muscular-degenerative disease, or restore tissue adversely affected by said disease  
A method of treatment for treating, preventing, inhibiting or reducing tissue deterioration, injury or damage due to a neuro-, muscular- or neuro-muscular-degenerative disease, or for restoring...
8715657 Therapeutic antibodies binding IL12Rβ1  
The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12Rβ2 chain) as well as IL23 r...
8715670 Human monoclonal antibody that specifically binds to VCAM-1 and a composition for treating an inflammatory disease or a cancer comprising the same  
The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the...
8715659 Single domain brain-targeting antibody fragments derived from llama antibodies  
A phage-displayed library of llama single heavy domain antibodies (sdAbs) was enriched for species that selectively bind to and are internalized by human cerebromicrovascular endothelial cells...
8715660 Treatment of angiogenesis disorders  
This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.
8710202 Isolated nucleic acid molecule encoding an antibody that reduces GDF-8 activity  
The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also...
8709413 Treatment of celiac disease with IgA  
A process is provided for inhibiting symptoms of food allergy or food intolerance in a subject that includes the oral administration to the subject suffering from food allergy or food intolerance...
8709409 Method for treating rheumatoid arthritis by administering an anti-IL-6 antibody and methotrexate  
A pharmaceutical composition for the treatment of interleukin-6 (IL-6) related diseases, comprising an interleukin-6 antagonist (IL-6 antagonist) and immunosuppressants. The IL-6 antagonist is...
8709418 Pharmaceutical composition for treating CAPRIN-1 expressing cancer  
According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen...