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8658164 Methods and materials for the diagnosis of prostate cancers  
Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including detecting the levels of expression of multiple polypeptide biomarkers in a biological sample...
8658167 Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis  
Provided are methodology, compositions and kits to prevent and treat diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, using processed lysyl oxidase or lysyl...
8658168 Compositions and methods for homoconjugates of antibodies which induce growth arrest of apoptosis of tumor cells  
This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The...
8658165 Method of treating aberrant mucus production in respiratory disease  
The present invention relates to modulators of the Neuregulin (NRG) family, particularly NRG1 and more particularly NRG1β, and most particularly NRG1β1. The present invention also relates to the u...
8658166 Methods and materials for the diagnosis of prostate cancers  
Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including detecting the levels of expression of multiple polypeptide biomarkers in a biological sample...
8658771 Humanized antibodies against human interferon-alpha  
The present invention provides humanized anti-human IFN-α monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ...
8658380 Diagnostic and therapeutic target  
The present invention relates to an in vitro method for assessing the risk that a subject suffers from a cancer, comprising measuring the expression level of Proline/arginine-rich end leucine...
8652474 Composition comprising antibody that binds to domain II of HER2 and acidic variants thereof  
A composition comprising a main species HER2 antibody that binds to domain II of HER2 and acidic variants thereof is described. Pharmaceutical formulations comprising the composition, and...
8652465 Methods and compositions for the treatment of persistent infections  
The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and...
8652790 Conformational entropy in molecular recognition  
The present invention provides methods for the determination of the degree of molecular recognition of a protein with a ligand, including a first protein with a second protein. The methods may...
8652466 Methods for the treatment of disease using immunoglobulins having Fc regions with altered affinities for FcγRactivating and FcγRinhibiting  
The present invention relates to methods of treating or preventing cancer and other diseases using molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies),...
8652468 Methods of binding TNF-α using anti-TNF-α antibody fragment-polymer conjugates  
Described are conjugates formed by an antibody fragment covalently attached to a nonproteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugates...
8652789 Diagnosis and prognosis of dipeptidyl peptidase-associated disease states  
A method is provided for the diagnosis or prognosis of a disease state, involving the measurement of a parameter of discriminated dipeptidyl dipeptidases from a patient sample, and the correlation...
8652469 M-CSF-specific monoclonal antibody and uses thereof  
M-CSF-specific RX1-based or RX-I derived antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of...
8652467 Dek protein compositions and methods of using the same  
The present invention relates to DEK protein compositions (e.g., antibodies, small molecule inhibitors, siRNAs) and methods of using the same. In particular, the present invention provides...
8652476 Pharmaceutical composition for treating ischemic events  
Methods and pharmaceutical compositions for treating severe ischemic events including cerebral infarction, cardiac infarction, or pulmonary embolism, comprising a thrombolytic intervention...
8647625 Anti-CD154 antibodies  
The present invention provides peptides, and fragments thereof, and antibodies, or fragments thereof comprising the same, wherein the peptide comprises at least one amino acid substitution compared...
8647626 Compositions comprising TNF-specific antibodies for oral delivery  
In accordance with the invention, the development and use of antibodies within the digestive tract is provided. Antibodies are described that are used to treat disorders associated with altered...
8647624 Treatment of immune disorders with anti-CD70 antibody  
Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as...
8647636 Low antigen-dose immunization utilizing overlapping peptides for maximizing T-helper cell 1 (Th1) immunity against a pathogen  
Disclosed are compositions, kits, and methods for inducing an immune response against disease. The dosage of antigen contained or utilized in the presently disclosed compositions, kits, and methods...
8642032 Method for screening of patient to be administered with pharmaceutical agent comprising anti-cancer antibody as active ingredient  
The present invention provides a method for screening a patient to be administered with a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient, said method...
8642036 Treatment with anti-ErbB2 antibodies  
The present invention concerns the treatment of disorders characterized by the overexpression of ErbB2. More specifically, the invention concerns the treatment of human patients susceptible to or...
8642031 Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof  
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may...
8642033 Methods for inducing in vivo tolerance  
The present invention encompasses methods for inducing in vivo tolerance to a foreign tissue.
8642039 Method of treating a staphylococcus infection in a patient having a low-level pathogenic Pseudomonas aeruginosa infection  
This invention provides methods of treating patients having a Staphylococcus infection where the patient also has a low level of Pseudomonas aeruginosa. The methods comprise administering an...
8642068 Bioabsorbable medical device with coating  
A biodegradable, bioabsorbable medical device with a coating for capturing progenitor endothelial cells in vivo and delivering a therapeutic agent at the site of implantation. The coating on the...
8642357 Semaphorin 7A plays a critical role in TGF-β1-induced pulmonary fibrosis and alveolar destruction  
The present invention provides methods of treating a subject diagnosed with, or at risk for developing, pathogenic fibrosis, particularly pulmonary fibrosis. The method of the invention comprises...
8637014 Antibodies to OX-2/CD200 and uses thereof in inhibiting immune responses  
This disclosure provides methods and compositions for inhibiting immune responses. The disclosure also provides methods and compositions for inhibiting graft rejection and promoting or prolonging...
8637028 Adjuvant incorporation in immunonanotherapeutics  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...
8637645 H5 subtype-specific binding proteins useful for H5 avian influenza diagnosis and surveillance  
The invention provides monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes of avian influenza virus (“AIV”). The monoclonal ant...
8637032 Antagonist anti-CD40 monoclonal antibodies and methods for their use  
Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically...
8637015 Methods of antagonizing signal transduction in dorsal root ganglion cells  
Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include...
8637011 Modulation of NKG2D  
The present invention relates to methods and compositions for treating and/or preventing inflammation associated with viral infection and solid organ transplant rejection. In particular, the...
8637644 H5 subtype-specific binding proteins useful for H5 avian influenza diagnosis and surveillance  
The invention provides monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes of avian influenza virus (“AIV”). The monoclonal ant...
8637469 Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors  
The invention describes a method of treating upper airway disease by administering a composition of one or more proinflammatory cytokine inhibitors sufficient to inhibit inflammation in the upper...
8637030 Combination pharmaceutical composition and methods of treating functional diseases or conditions of gastrointestinal tract  
The present invention provides a combination pharmaceutical composition comprising a) an activated-potentiated form of an antibody to a S-100 protein, b) an activated-potentiated form of an...
8637013 Treatment of drug-related side effect and tissue damage by targeting the CD24-HMGB1-Siglec10 axis  
The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24...
8637018 Humanized anti-IL-18 antibodies  
The present invention discloses humanised anti-IL-18 antibodies, methods of manufacture, and methods of treatment with said antibodies. Further disclosed are screening methods using for example...
8637012 Genetic products differentially expressed in tumors and the use thereof  
The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the invention also...
8632772 Methods of treating multiple myeloma using combination therapies based on anti-CS1 antibodies  
Compositions and methods for treating MM are provided herein.
8632773 Antibody composition with altered Fab sialylation  
The present invention relates to a population of antibodies enriched from an antibody preparation, wherein the enriched population of antibodies has an altered amount of sialylation in the Fab...
8632776 Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for Parkinson's disease, dementia with lewy bodies and other α-synucleinopathies  
Antibodies and fragments thereof have high affinity for human α-synuclein protofibrils and low binding of α-synuclein monomers, wherein the antibodies or fragments have specified Complementarity D...
8633301 Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine  
Pharmaceutical composition comprising an antibody specifically recognizing CD38 and vincristine.
8628772 Surface protein (HBsAg) variant of the hepatitis B virus  
The invention relates to sequences of a novel variant of the Hepatitis B surface antigen (HBsAg) and to methods for detecting, in patient samples, nucleic acids, antigens, and antibodies directed...
8628778 Humanized monoclonal antibodies to hepatocyte growth factor  
The present invention is directed toward a humanized neutralizing monoclonal antibody to hepatocyte growth factor, a pharmaceutical composition comprising same, and methods of treatment comprising...
8628771 CA IX-specific inhibitors  
Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Screening assays are provided for identifying compounds,...
8628774 Compositions and methods for treating and diagnosing cancer  
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in...
8629250 Hepcidin, hepcidin antagonists and methods of use  
The invention relates to purified, correctly folded hepcidin, antibodies that bind hepcidin, and methods of making and using such materials. Also provide are methods of treated hepcidin-related...
8628773 Antigen binding proteins  
Antigen binding proteins, such as antibodies, that interact with Epidermal Growth Factor Receptor (EGFR) are described. Methods of treating cancers and other diseases by administering a...
8623354 Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment  
The present invention relates generally to treatment and prophylactic protocols for cellular diseases or disorders, such as diseases and disorders associated with abnormal cellular proliferation....