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7384623 |
High energy phototherapeutic agents
High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive...
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7381400 |
Injection of a radioactive dye for sentinel lymph node identification
A one-step procedure for sentinel lymph node identification and biopsy using a single compound, a radiolabeled, low molecular weight dye (e.g., 125 I-labeled methylene blue). This radiolabled dye...
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7378079 |
Agents for imaging and diagnostic methods using them
The present invention provides novel compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their plasma membrane, while binding to a lesser...
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7351401 |
Thioflavin derivatives for use in the antemortem diagnosis of Alzheimers disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
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7351398 |
Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic thioether.
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7351397 |
Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy chromans
Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic 6-hydroxy-chroman derivative.
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7338652 |
Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents
New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such...
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7329401 |
Cyclooxygenase-2 selective agents useful as imaging probes and related methods
This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2...
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7326403 |
Radioactive iodine-labeled compound
A radioactive iodine-labeled compound represented by the following formula (I):
wherein X represents a radioactive iodine atom which may substitute at an arbitrary position on the benzene ring...
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7314609 |
Stereoisomers of fatty acid analogs for diagnostic imaging
The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a...
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7312461 |
Laparoscopic tumor therapy using high energy electron irradiation
A laparoscopic tumor therapy method and an articulated electron beam transport system are provided for use with a high power, long focus electron source for tumor therapy. The high power, long...
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7273601 |
Preparation of radiolabelled haloaromatics via polymer-bound intermediates
According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate...
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7270800 |
Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
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7220730 |
Cancer specific radiolabeled conjugates regulated by the cell cycle for the treatment and diagnosis of cancer
Radiolabeled conjugates are disclosed which have a component that is effective to target tumor cells, which cells selectively take up and degrade the conjugate, thereby delivering to the tumor cell...
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7195751 |
Compositions and kits pertaining to analyte determination
This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The...
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7194360 |
Method of determining radioactive nuclides
A method of simply and quickly determining α-ray releasing nuclides having long half-life without carrying out a chemical separation is provided. By inputting a data of pulses incident to an...
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7172749 |
Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy
Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and...
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7169377 |
Radioligands for the TRP-M8 receptor and methods therewith
One embodiment of the invention is a composition that comprises a radioactive [ 18 F], [ 123 I], [ 125 I], or [ 131 I]-N-radiohaloaryl-alkylcarboxamide molecule. The composition binds to the...
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7118731 |
Drugs for the diagnosis of tissue reproductive activity or the treatment of proliferative diseases
An agent which comprises, as an active ingredient, a radiolabeled compound as represented by the following formula or a pharmaceutically acceptable salt thereof:
wherein R 1 denotes hydrogen,...
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7115249 |
Solid-phase electrophilic fluorination
The invention relates to compounds of formula (I); wherein R 1 and R 2 independently selected from C 1-6 alkyl; P 1 , P 2 , P 3 , and P 4 are each independently hydrogen or a protecting group;...
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7112318 |
Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts
The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with 18 F for non-invasive assessment of ΔΨm, lipophilic ammonium cation analogs of the PhCs, and methods of...
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7060251 |
Imaging agents for early detection and monitoring of cardiovascular plaque
The invention provides imaging agents comprising a label in association with a plaque specific targeting molecule. Methods for using the imaging agents to diagnose or monitor plaque formation and...
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7045115 |
Drugs for the diagnosis of tissue-reproductive activity or the treatment of proliferative diseases
An agent which comprises, as an active ingredient, a radiolabeled compound as represented by the following formula or a pharmaceutically acceptable salt thereof:
wherein R 1 denotes hydrogen,...
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7018610 |
Polymer precursors of radiolabeled compounds, and methods of making and using the same
One aspect of the present invention relates to novel compounds that can be used to prepare radiolabeled compounds in an effective manner. A second aspect of the present invention relates to a...
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6991776 |
Intracorporeal medicaments for high energy phototherapeutic treatment of disease
New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described,...
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6974567 |
Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque
Detectably labeled macrophage scavenger receptor antagonists useful for the diagnosis and monitoring of various cardiovascular diseases including but not limited to atherosclerosis, vulnerable...
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6951640 |
Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy
The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula
which selectively accumulate in neoplastic tissue within...
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6911219 |
Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
This relates to partially acetalized polyvinyl alcohol embolization particles suitable for implanting in the human body, to compositions containing those particles, and to methods of making and...
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6872381 |
Radiopharmaceuticals for diagnosing Alzheimer's disease
This invention is directed to the use of radiopharmaceuticals in diagnosing Alzheimer's disease. In particular the radiopharmaceuticals of the invention are able to pass through the blood-brain...
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6861044 |
Radioiodinated sulfonated phenols and process therefore
The present invention concerns the use of a radioiodinated phenolic compound of the formula
wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively...
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6843979 |
4-haloethenylphenyl tropane:serotonin transporter imaging agents
A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes and 4-haloethenylphenyl tropane families are described as diagnostic and therapeutic agents for diseases associated with...
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6824760 |
Imaging agents, precursors thereof and methods of manufacture
Compounds of formula (I) and (II): wherein groups R 1 , R 2 , RE, PG 1 and PG 2 have the definitions provided in the specification, methods of manufacture and methods of use.
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6749832 |
Labelled ascorbic acid derivatives
Compounds of formula (I) where: X 1 is OH or SH or NH 2 or —L-Z; X 2 and X 3 are the same or different and each is H, C 1-4 alkyl, benzyl a protecting group or —L-Z, X 4 is H or C 1-4 ...
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6749830 |
Method for the synthesis of radiolabeled compounds
The present invention relates to a new method for radiolabeling chemical compounds. The new method attains the goals of simplicity, high radiochemical yields, speed, versatility, and automation. An...
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6740304 |
Receptor binding conjugates
The present invention relates to a receptor binding conjugate which consists of an antibody, a radionuclide and folate or a folate derivative, wherein or not the conjugate possesses dual binding...
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6699675 |
Marker for inflammatory conditions
Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
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6696089 |
Nanogel networks including polyion polymer fragments and biological agent compositions thereof
The present invention relates to nanogel networks having at least one cross-linked polyionic polymer fragment and at least one nonionic water-soluble polymer fragment, and compositions thereof,...
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6676925 |
Sigma-2 receptors as biomarkers of tumor cell proliferation
Detectably-labeled compounds of formula (I) wherein A,B,C,D,E,F,R,X,Y and Z have any of the meanings given in the specification, and their pharmaceutically acceptable salts, are useful in...
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6660530 |
Methods for labeling β-amyloid plaques and neurofibrillary tangles
A method for labeling β-amyloid plaques and neurofibrillary tangles in vivo and in vitro, comprises contacting a compound of formula (I): with mammalian tissue. In formula (I), R 1 is selected...
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6632418 |
Radioligands and their use for identifying potassium channel modulators
The present invention relates to novel radioligands and test methods using those radioligands in screening compounds.
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6589504 |
Compounds and methods for diagnosing and treating amyloid-related conditions
The invention provides methods for diagnosing and treating amyloid-related conditions and compounds useful for the same. The invention provides for detecting, imaging, monitoring, diagnosing, and...
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6572823 |
Apparatus and method for reconstituting a solution
An apparatus and method are provided for handling a solution. The apparatus comprises a housing and a vial assembly positioned within an enclosure of the housing. The vial assembly maintains at...
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6565829 |
5-arylsulfonyl indoles useful for treating disease
The invention provides derivatives of 5-arylsulfonyl indole and 5-arylsulfonyl indoline compounds which may be in the form of pharmaceutical acceptable salts or compositions that are useful in...
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6562319 |
Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy
Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and...
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6537522 |
Neuroprobes for mapping monoamine reuptake sites
Iodinated neuroprobes for mapping monoamine reuptake sites in the brain, and particularly iodinated neuroprobes that can also serve as radiotracers for use in single-photon emission computed...
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6517811 |
Compounds for cancer imaging and therapy
The present invention relates to a class of compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, prostate carcinomas, breast carcinomas,...
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6509003 |
Reagents for the determination of cerebral regional acetylcholinesterase activity
The present invention relates to N-alkylpiperidine derivatives represented by general formula (1) or (2); wherein R 1 represents optionally fluorinated lower alkyl; R 2 represents lower alkyl;...
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6506364 |
Radioiodinated sulfonated phenols for the study of renal function
The present invention concerns the use of a radioiodinated phenolic compound of the formula wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged...
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6491893 |
Compounds for targeting and imaging infection and inflammation
The present invention provides novel agents for specifically targeting and detecting or treating focal sites of infection or inflammation in a subject.
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6447748 |
Benzamide compounds for cancer imaging and therapy
The present invention relates to a class of compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, prostate carcinomas, breast carcinomas,...
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