Matches 101 - 150 out of 193 < 1 2 3 4 >
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5780008 Polyhdric phenol compounds  
The invention relates to polyhydric phenol compounds of the general formula ##STR1## wherein R is a hydrogen atom or a saccharide moiety; A and B are hydrogen atoms or form together a C--C bond;...
5770180 Bridge-substituted tropanes for methods of imaging and therapy  
Disclosed are bridge-substituted analogs of tropanes and benztropines as well as methods for: imaging of cocaine receptors; treatment of cocaine abuse; and imaging and treatment of Parkinson's...
5756068 Methods of radioimaging and radiochemotherapy using phenolic thioeter amines and acyl derivatives thereof  
Compounds useful in radioimaging and radiochemotherapy as it particularly relates to the treatment and location of malignant melanomas and other pigmenting disorders, as well as novel acyl...
5756066 Iodine-containing peptides  
Iodine-containing peptides of general formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 , a, m and q have the meanings indicated in the description, agents containing these compounds, the use of...
5753701 N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters as novel safe agents for water disinfection  
The present invention relates to N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters, and their use as agents for water disinfection and as mild oxidizing agents for the...
5750089 Halogenated neuroprobe for mapping monoamine reuptake sites  
An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein R= ##STR2## wherein n=2-8; R'=C w H 2w +1 wherein w=0-6 and C...
5744121 Serotonin (5-HT.sub.1A) receptor ligands and imaging agents  
Compounds such as 4-(s'-methoxy)phenyl- 2'-N-2"-pyridinyl)-p-iodobenzamido! ethylpiperazine have affinity and specificity for serotonin 5-HT 1A receptors.
5741476 Polyhydric phenol compounds  
The invention relates to polyhydric phenol compounds of the general formula ##STR1## wherein R is a hydrogen atom or a saccharide moiety; A and B are hydrogen atoms or form together a C--C bond;...
5725838 Radiolabeled D4 receptor ligands  
Herein described are radiolabeled compounds and their precursors useful to image D4 receptors in vivo, of the formula: ##STR1## wherein R is selected from iodo, tri(loweralkyl)tin and a...
5723103 Substituted benzamides and radioligand analogs and methods of use  
This invention provides compounds of the formula I ##STR1## wherein, R 1 , R 2 , and R 3 are independently a first halogen atom,! fluorine, chlorine, bromine, iodine, alkyl, alkenyl, alkynyl,...
5700446 Synthesis of ferrocenyl phenyltropane analogs and their radio-transformation to technetium neuroprobes for mapping monoamine reuptake sites  
Neuroprobes that include rhenium, manganese, and technetium for use in mapping monoamine reuptake sites are disclosed. Non-radioactive tricarbonylrheniumcyclopentadienyl (TRCp) or non-radioactive...
5698179 Iodinated neuroprobe for mapping monoamine reuptake sites  
An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein: R=aryl, substituted aryl, heterocyclic, CO(CH 2 ) n Y, (CH 2...
5690906 Dopamine D-3 and serotonin (5-HT.sub.1A) receptor ligands and imaging agents  
Tetralin derivatives, such as 7-hydroxy-2-(N-n-propyl-N-3 '-iodo-2'-propenyl)-amino!tetralin and 8-hydroxy-2-(N-n-propyl-N-3 '-iodo-2'-propenyl)amino-tetralin, are disclosed which have affinity and...
5667764 Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles  
Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a...
5643550 Method of treating colorectal carcinoma lesion and composition for use therein  
This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface...
5622685 Polyether-substituted porphyrin anti-tumor agents  
Tumor-active or tumor-diagnostic substances having preferred accumulation in the tumor, which are characterized in that they have at least two phenolic hydroxyl and/or amino groups, at least...
5609848 Radiohalogenated small molecules for protein labeling  
Haloaryl compounds are lithiated and thereafter metalated with one of the following organometallic groups: Sn(n--Bu) 3 or SnMe 3 . The resulting aryltin compound can be transmetalated in...
5601801 Radiolabelled angiotensin converting enzyme inhibitors  
Angiotensin convening enzyme (ACE) inhibitors can be labelled with Iodine-123, Iodine-125, Iodine-127 or Iodine-131, useful to image the kidneys and lungs for diagnosis and treatment of diseases...
5569447 Stannylated 3-quinuclidinyl benzilates and methods of preparing radiohalogenated derivatives  
The present invention provides stannylated 3-quinuclidinyl benzilate compounds and a method of synthesizing *AQNB by iodinating such stannylated 3-quinuclidinyl benzilate compounds. The iodination...
5565185 Process for the preparation of radiolabeled meta-halobenzylguanidine  
The present invention provides a no-carrier-added synthesis of radiolabeled meta-halobenzylguanidine by halodestannylation which comprises reacting a meta-trialkylstannylbenzylguanidine with a...
5480631 Radioiodinated benzamines and method of their use as radioimaging  
Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medicine as imaging agents to detect, visualize, and analyze the distribution and...
5407653 Evaluation of the multidrug resistance phenotype  
The present invention relates to methods for detecting the multidrug resistance phenotype in vivo and in vitro. The invention particularly relates to methods of diagnosing the multidrug resistance...
5407658 Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport  
Analogs of cytochalasin B are used as radiopharmaceuticals to provide an image for the nuclear imaging of glucose transport across cell membranes. Like cytochalasin B, the analogs bind specifically...
5401490 Markers of tissue hypoxia  
Novel nucleosides are provided having at least one hydrogen or hydroxide substitutent replaced by a γ-emitting halogen. Methods of preparation of these nucleosides are provided and also a novel...
5372813 Substituted 6-nitroquipazines, methods of preparation, and methods of use  
Disclosed is a substituted 6-nitroquipazine of the formula ##STR1## wherein R 1 , R 2 , R 3 , and R 4 are each selected from the group consisting of H, Fl, CL, Br, I, CF 3 , CH 2 CH 2 F, CH 3 ,...
5358712 Radiopharmaceutical agents for the detection of Alzheimer's disease  
Novel anticholinergics which are related to vesamicol are particularly useful when radiolabeled for evaluating cholinergic innervation in the living human brain. The cholinergic deficit in the...
5336483 Radiolabeled n-substituted-6-iodo-3,14-dihydroxy-4, 5α-epoxymorphinans, intermediates for producing the same, and a process for the preparation and methods of detecting opioid receptors  
The present invention is directed to radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans, intermediates for producing the same, and a process for the preparation and methods of...
5334369 Platelet receptor antagonists useful in detecting intravascular platelet aggregation  
This invention provides novel compounds used in a method of determining platelet deposition. These compounds include 123 I-SAP and analogues. Also provided is a method of determining platelet...
5324502 Radiopharmaceuticals for imaging the heart  
Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts...
5320825 Serotonin reuptake inhibitors for S.P.E.C.T. imaging  
Disclosed are novel compounds for CNS neurotransmitter systems, especially for the neurotransmitter serotonin, which have the formula ##STR1## where each of U, V, W, X, Y and Z is independently...
5306482 Radiopharmaceutical bacteriostats  
Benzalkonium chloride and benzethorium chloride are each useful in radiopharmaceutical preparations (optionally in the presence of a polymyxin or a polymyxin derivative) as bacteriostatic agents...
5302700 Radiohalogenation conjugate technology  
Compounds of the formulae, ##STR1## are provided where L is a linking group of the formula, ##STR2## is --Sn(n--C 4 H 9 ) 3 or --Sn(CH 3 ) 3 , HgCl or --N 2 + ; R is hydrogen, methyl, mono-, di-...
5242680 Thiol-reactive maleimido-based radiolabeling reagents  
Novel thiol-reactive maleimido-based radiolabeling reagents are disclosed which are useful for binding and receptor studies and assays. The reagents are also useful as diagnostic imaging agents,...
5232684 Labelled resiniferatoxin, compositions thereof, and methods for using the same  
The present invention relates to labelled resiniferatoxin and congeners thereof. Preferably, the labelled compounds of the invention are radio or fluorescently labelled. The invention is further...
5227152 Radiopharmaceutical bacteriostats  
Benzalkonium chloride and benzethonium chloride are each useful in radiopharmaceutical preparations as bacteriostatic agents which are compatible with anti-oxidants.
5219548 High affinity halogenated-tamoxifen derivatives and uses thereof  
Applicants describe the synthesis of fluorotamoxifen and iodotamoxifen analogs with the halogen atom positioned on the aliphatic chain of the tamoxifen molecule. The halogenated-tamoxifen...
5219556 Stabilized therapeutic radiopharmaceutical complexes  
A method of preparing a stable, therapeutic radiopharmaceutical composition comprised of an alpha- or beta-emitting radionuclide and a ligand by lyophilizing a solution of the complex. The...
5192525 High affinity tamoxifen derivatives and uses thereof  
The synthesis of tamoxifen derivatives, most particularly halo, haloalkyl and hydroxy tamoxifen derivatives, wherein the native tamoxifen molecule includes a substituted chemical group positioned...
5186921 Dopamine receptor ligands and image agents  
Novel CNS dopamine D-2 receptors, such as the compound 5-iodo-7-N-[(1-ethyl-2-pyrrolidinyl)methyl]carboxamide-2,3-d ihydrobenzofur an, are disclosed. These compounds are useful as imaging agents...
5167948 Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound  
The invention relates to a diagnostic or radiotherapeutic composition, comprising a hydrogen containing compound in addition to a pharmaceutically acceptable formulation means and optionally an...
5154913 Radioiodinated benzamines method of their use as radioimaging agents  
Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medicine as imaging agents to detect, visualize, and analyze the distribution and...
5130117 Radiohalogenated benzazepine derivatives and method of imaging dopamine receptors therewith  
Novel CNS dopamine D-1 receptors, such as the compound (±)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-(4'-[ 125 I]iodophenyl)-1H-3-benzazepine-7-ol, are disclosed. These compounds are useful as...
5128118 Cocaine receptor binding ligands  
3β-[4-iodophenyl]-tropan-2β-carboxylic acid methyl ester tartrate is a high affinity binding ligand for neurotransmitters in mammalian brains. It and its congeners may be employed for imaging and...
5116614 Jomol derivatives as agents for the use in malignant tumors and lowered immune defenses  
The invention relates to Jomol, processes for its production of Nocardia opaca cells (DSM 43202 or ATCC 21953, respectively), its derivatives, diagnostic compositions, and pharmaceutical...
5104637 Radio labeled dihematophorphyrin ether and its use in detecting and treating neoplastic tissue  
Radiolabeled dihematoporphyrin ether having the following general formula ##STR1## wherein at least one of R 1 -R 6 is a moiety labeled with a radionuclide imaging agent is useful in providing a...
5096695 Radioiodine benzodiazepines as brain imaging agents  
Radioiodine 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazep ine derivatives and their use as brain imaging agents.
5077035 Radioiodinated benzovesamicol analogs for cholinergic nerve mapping  
Radioiodinated benzovesamicol analogs which selectively localize in presynaptic cholinergic neurons of the general formula: ##STR1## where X is selected from the group consisting of H, OH, NH 2 ,...
5039511 Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor  
The presence and location of amyloid deposits in an organ or body area of a patient is effected by intravenous administration of novel radioactive iodine-labeled amyloid binding compounds and...
5021220 Kit for preparing radiodiagnostic examination compositions  
The invention relates to a method of preparing a chlorinated, brominated, radiobrominated, iodinated and/or radio-iodinated aromatic or heteroaromatic compound, in which the (hetero)aromatic...
4994258 Gamma emitting, CCK-A antagonists for pancreatic imaging  
Novel radiolabeled cholecystokinin-A (CCK-A) antagonists have been developed which, after intravenous injection, localize in the pancreas as a result of specific binding to CCK-A receptors. These...
Matches 101 - 150 out of 193 < 1 2 3 4 >