Matches 51 - 100 out of 193 < 1 2 3 4 >
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6632418 Radioligands and their use for identifying potassium channel modulators  
The present invention relates to novel radioligands and test methods using those radioligands in screening compounds.
6589504 Compounds and methods for diagnosing and treating amyloid-related conditions  
The invention provides methods for diagnosing and treating amyloid-related conditions and compounds useful for the same. The invention provides for detecting, imaging, monitoring, diagnosing, and...
6572823 Apparatus and method for reconstituting a solution  
An apparatus and method are provided for handling a solution. The apparatus comprises a housing and a vial assembly positioned within an enclosure of the housing. The vial assembly maintains at...
6565829 5-arylsulfonyl indoles useful for treating disease  
The invention provides derivatives of 5-arylsulfonyl indole and 5-arylsulfonyl indoline compounds which may be in the form of pharmaceutical acceptable salts or compositions that are useful in...
6562319 Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy  
Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and...
6537522 Neuroprobes for mapping monoamine reuptake sites  
Iodinated neuroprobes for mapping monoamine reuptake sites in the brain, and particularly iodinated neuroprobes that can also serve as radiotracers for use in single-photon emission computed...
6517811 Compounds for cancer imaging and therapy  
The present invention relates to a class of compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, prostate carcinomas, breast carcinomas,...
6509003 Reagents for the determination of cerebral regional acetylcholinesterase activity  
The present invention relates to N-alkylpiperidine derivatives represented by general formula (1) or (2); wherein R 1 represents optionally fluorinated lower alkyl; R 2 represents lower alkyl;...
6506364 Radioiodinated sulfonated phenols for the study of renal function  
The present invention concerns the use of a radioiodinated phenolic compound of the formula wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged...
6491893 Compounds for targeting and imaging infection and inflammation  
The present invention provides novel agents for specifically targeting and detecting or treating focal sites of infection or inflammation in a subject.
6447748 Benzamide compounds for cancer imaging and therapy  
The present invention relates to a class of compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, prostate carcinomas, breast carcinomas,...
6447747 Process for the preparation of radiopharmaceuticals  
Process for the preparation of radiohalogenated radiopharmaceuticals by an electrophillic substitution, preferably halogenodestannylation reactions, by the reaction of an organometallic substituted...
6416735 Ligands for α-7 nicotinic acetylcholine receptors based on methyllcaconitine  
Ligands for nAChRs are provided based on various derivatives of methyllycaconitine (MLA) such as radiolabeled MLA, and MLA containing a fluorimetric marker group and their use in imaging for...
6399042 4-fluoroalkyl-3-halophenyl nortropanes  
A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes family are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These...
6379649 Imidazo(1,2-a)pyridines as peripheral benzodiazepine receptor binding agents  
The invention provides imidazo [1,2-a] pyridines of formula (1), wherein Y is selected from F, Cl, Br, I, OH, SH, NH 2 , CN and COOH; Z is selected from N(R 3 )C(O)R 4 and C(O)NR 3 R 4 ; R 1 , R 2...
6376534 Compounds useful in pain management  
Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel...
6365125 Process for the production of radioiodinated neuroreceptor agents  
The present invention is related to process for producing radioiodinate neuroreceptor agents with improves yields. In said process the trialkyltin group of the precursor of the neuroreceptor agent...
6358492 Dopamine transporter imaging ligand  
The 3α isomer of RTI-55, RTI-352, is an effective in vivo binding ligand that reflects greater selectivity for the dopamine transporter than is observed with RTI-55. In addition, there is also a...
6359006 Amphiphilic fluorine derivatives with telomeric structures; preparation procedure and biomedical applications  
New fluorinated derivatives useful as surfactants or in the transport of drug or markers, or in drug targeting, and preparations containing the derivatives, for medical, cosmetic and veterinary...
6344179 Fluoralkenyl nortropanes  
Provided are compounds of the following formula: wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or...
6331287 2'-deoxy-2'-fluoro-d-arabinofuranosyl pyrimidine nucleoside  
The nucleoside analog 2'-fluoro-5-methyl-1-β-D-arabinofuranosyluracil (FMAU) has been found to have an especially desirable combination of properties for use as an imaging agent, including in...
6331286 Methods for high energy phototherapeutics  
Methods of treating and imaging diseased tissue having the steps of administering a radiosensitizer agent proximate to or into the diseased tissue; and treating the diseased tissue with x-rays or...
6315979 Radioiodinated sulfonated phenols for brachytherapy  
The present invention concerns the use of a radioiodinated phenolic compound of the formula ##STR1## wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or...
6238644 Method for treating and/or imaging breast cancer using radioactive iodide  
The instant invention utilizes the preferential uptake of iodine by mammary cells in general, and neoplastic mammary cells in particular to promote the concentration of radioactive iodine in...
6224849 Alkylaminobenzothiazole and-benzoxazole derivatives  
The present invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is O...
6217845 Protein labelling  
Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a...
6180083 Tropane derivatives useable in particular for in vivo detection of dopamine transporters  
The present invention relates to tropane derivatives having particular use for the in vivo detection of dopamine transporters. These derivatives meet the formula ##STR1## in which R 1 is I or Sn...
6165441 Method of diagnosis and photodynamic therapy of tumours  
A method of therapeutical treatment of tumors, by photodynamic therapy comprising administering to a subject in need of said treatment an effective amount of a tumor-localizing photosensitizer...
6162417 Pyrrolo isoquinolines  
Compounds of the formula: ##STR1## wherein X, Y, and R, independently of one another, is each a H; halogen, wherein said halogen is selected from the group consisting of 123 I, 124 I, 125 I, ...
6123917 Method for making cocaine receptor binding ligands and intermediates therefor  
An improved method for preparation of cocaine receptor binding ligands is provided. The method calls for the preparation of the silylaryl intermediate prepared from phenyl trimethylsilane and a...
6066310 Diagnostic and therapeutic method for tumor using radiolabeled avidin  
A method for diagnosis or therapeutics of tumor which is characterized by administering an amount of a glycoprotein having a molecule capable of specifically binding to a lectin to a subject in...
6045773 Method of detecting cyclooxygenase-2  
The invention relates to a method of detecting concentrations of cyclooxygenase-2 in a mammal, the method comprising: administering to the mammal a diagnostically effective amount of a...
6027710 Radiation-protecting agent  
The present invention provides a radiation-protecting agent which protects the active ingredient of radiopharmaceuticals against the radiolysis caused by a reaction of the active ingredient with...
6019957 Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging  
The present invention relates to a radiolabeled non-steroidal compound having the formula: ##STR1## where R 1 , R 2 , and R 3 , are the same or different and are a radioactive or nonradioactive...
6015543 Benzamide compounds containing a heterocyclic ring for tumor imaging and therapy  
The present invention relates to a class of compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, prostate carcinomas, breast carcinomas,...
6015544 Process for producing radiolabelled benzodiazepine receptor agents and composition containing the same  
A process for producing a carrier free radio halogenated 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5,6-dihydro-5-methyl- 6-oxo-4H-imida zo[1,5-a][1,4]-benzodiazepine of formula (II) where R 1 is a...
6013242 Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression  
Biologically active derivatives of the tropane ring system are provided which selectively bind either to the 5-HT or DA reuptake site, leading to compounds which have use for the treatment of...
6004530 Use of metallo-porphyrin conjugates for the detection of biological substances  
The present invention refers to a process for the preparation of an activated metallo-porphyrin derivative and to novel activated metallo-porphyrin derivatives obtainable by said process. Further,...
6001331 Method of imaging amyloid deposits  
The present invention provides a method of imaging amyloid deposits and radiolabeled compounds useful in imaging amyloid deposits. The invention also provides a method of delivering a therapeutic...
5993776 Radiopharmaceutical compositions that include an inclusion complex of a cyclodextrin and a radio-halogenated fatty acid  
The invention relates to radio-pharmaceutical compositions that include an inclusion complex of a cyclodextrin and a radio-halogenated fatty acid. These complexes include a cyclodextrin such as...
5985239 Derivatives of N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters  
The present invention relates to N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters, and their use as agents for water disinfection and as mild oxidizing agents for the...
5976497 Dopamine D4 receptor ligands  
Described herein are D4 receptor-selective compounds of the formula: ##STR1## wherein R 1 is selected from H and an acid labile protecting group; and R 2 and R 3 are independently selected from...
5925332 Radioimaging and radiochemotherapy phenolic thioether amines and acyl derivatives thereof for use in diagnosing and treating pigmentation disorders  
Compounds useful in radioimaging and radiochemotherapy as it particularly relates to the treatment and location of malignant melanomas and other pigmenting disorders, as well as novel acyl...
5919797 Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites  
Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen...
5911970 Methods for cancer imaging and therapy using benzamine compounds  
The present invention relates to a class of compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, prostate carcinomas, breast carcinomas,...
5904915 Method of diagnosing pathological state of tumor cells using a diagnostic agent for glycometabolic function  
A diagnostic agent for glycometabolic function comprising a glucose derivative of the formula (I): ##STR1## wherein R 1 , R 2 , R 3 and R 4 are the same or different and each represents hydrogen...
5888475 Labeled cocaine analogs  
Novel methods for positron emission tomography or single photon emission spectroscopy using tracer compounds having the structure: ##STR1## where X in β configuration is phenyl, naphthyl; 2,3...
5853696 Substituted 2-carboxyalkyl-3(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging agents for neurodegenerative disorders  
Disclosed are certain cocaine analogs useful for imaging of cocaine receptors and dopamine receptors. Also disclosed are analogs useful for imaging diagnostics for Parkinson's disease.
5811073 Method for radioisotopic detection and localization of inflammation in a host  
A method for detecting and localizing the lesions of bacterial and sterile inflammations in a host is disclosed. The method permits in vivo detection and localization of inflammation within 1 to 2...
5795561 Radioiodinated phospholipid ether analogues  
Novel radioiodinated analogues of naturally-occurring phospholipid ethers are tumor-specific and have a triglycerol backbone structure which, in certain embodiments, is substituted at the...
Matches 51 - 100 out of 193 < 1 2 3 4 >