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7381400 |
Injection of a radioactive dye for sentinel lymph node identification
A one-step procedure for sentinel lymph node identification and biopsy using a single compound, a radiolabeled, low molecular weight dye (e.g., 125 I-labeled methylene blue). This radiolabled dye...
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7378079 |
Agents for imaging and diagnostic methods using them
The present invention provides novel compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their plasma membrane, while binding to a lesser...
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7351401 |
Thioflavin derivatives for use in the antemortem diagnosis of Alzheimers disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
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7351398 |
Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic thioether.
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7351397 |
Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy chromans
Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic 6-hydroxy-chroman derivative.
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7341709 |
Compositions for labeling β-amyloid plaques and neurofibrillary tangles
Compositions useful for labeling β-amyloid plaques and neurofibrillary tangles are provided. The compositions comprises compounds of formula (I):
wherein R 1 is selected from the group...
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7338652 |
Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents
New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such...
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7335347 |
Methods for purifying radiolabelled compounds
One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a...
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7332149 |
Vitronectin receptor antagonist pharmaceuticals
The present invention describes novel compounds of the formula:
(Q) d —L n —C h ,
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7329401 |
Cyclooxygenase-2 selective agents useful as imaging probes and related methods
This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2...
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7314609 |
Stereoisomers of fatty acid analogs for diagnostic imaging
The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a...
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7306785 |
Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety...
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7273601 |
Preparation of radiolabelled haloaromatics via polymer-bound intermediates
According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate...
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7270800 |
Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
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7265199 |
Poly-tri-fluoro-ethoxypolyphosphazene coverings and films
The present invention relates to an anti-thrombogenic, physically well-tolerated polymer and its use for manufacturing sheaths and films as a component of therapeutic devices for preventing...
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7238339 |
Bifunctional chelating compounds containing hydroxamic acid residues
New types of hydroxamic acid-based bifunctional chelators are provided. These chelators are designed to chelate metal ions that can be detected either by their paramagnetic or radioactive...
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7229603 |
Stablilized and lyophilized radiopharmaceutical agents
A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a...
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7195751 |
Compositions and kits pertaining to analyte determination
This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The...
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7194360 |
Method of determining radioactive nuclides
A method of simply and quickly determining α-ray releasing nuclides having long half-life without carrying out a chemical separation is provided. By inputting a data of pulses incident to an...
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7179445 |
Cobalamin conjugates useful as imaging and therapeutic agents
The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis.
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7175830 |
Imaging of drug accumulation as a guide to antitumor therapy
The use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labeled anticancer drug to a patient and imaging at least a part of the patient...
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7172749 |
Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy
Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and...
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7169377 |
Radioligands for the TRP-M8 receptor and methods therewith
One embodiment of the invention is a composition that comprises a radioactive [ 18 F], [ 123 I], [ 125 I], or [ 131 I]-N-radiohaloaryl-alkylcarboxamide molecule. The composition binds to the...
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7160537 |
Method for preparing radiolabeled thymidine having low chromophoric byproducts
The invention is a method and related precursor for preparing 18 F-FLT. The precursor has a butoxycarbonyl protecting group at the 5′-position that results in low amounts of chromophoric...
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7141234 |
Imaging of drug accumulation as a guide to antitumor therapy
The present invention describes the use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labelled anticancer drug to a patient and imaging at...
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7125683 |
Preparations for diagnosis extrapancreatic secretory function
A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into...
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7118730 |
Quinoline derivative as diagnostic probe for disease with tau protein accumulation
The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits...
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7115249 |
Solid-phase electrophilic fluorination
The invention relates to compounds of formula (I); wherein R 1 and R 2 independently selected from C 1-6 alkyl; P 1 , P 2 , P 3 , and P 4 are each independently hydrogen or a protecting group;...
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7112318 |
Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts
The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with 18 F for non-invasive assessment of ΔΨm, lipophilic ammonium cation analogs of the PhCs, and methods of...
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7090828 |
Vitronectin receptor antagonist pharmaceuticals
The present invention describes novel compounds of the formula:
(Q) d -L n -C h ,
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7060251 |
Imaging agents for early detection and monitoring of cardiovascular plaque
The invention provides imaging agents comprising a label in association with a plaque specific targeting molecule. Methods for using the imaging agents to diagnose or monitor plaque formation and...
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7037487 |
Method for diagnosing lactose intolerance and diagnostic kit for performing the method
The method for diagnosing lactose intolerance in patients by the oral administration of defined amounts of lactose, followed by assaying metabolites of lactose, is performed in a way where the...
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7030109 |
1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
The present invention discloses radioligands of 9-arylsulfone of the formula (X)
or a pharmaceutically acceptable salt or enantiomer thereof, which are useful in diagnosing depression, obesity...
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7018614 |
Stabilization of radiopharmaceuticals labeled with 18-F
An 18 F isotope-labeled FDG radiopharmaceutical is stabilized against degradation in radiochemical purity due to radiolysis using selected amounts of ethyl alcohol that depend on the activity...
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7018613 |
Preparations for evaluating eliminative ability of stomach
Preparations whereby reduction or acceleration of the gastric emptying rate can be noninvasively evaluated: and a method of evaluating the gastric emptying rate by using these preparations. Thus,...
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7018610 |
Polymer precursors of radiolabeled compounds, and methods of making and using the same
One aspect of the present invention relates to novel compounds that can be used to prepare radiolabeled compounds in an effective manner. A second aspect of the present invention relates to a...
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7011814 |
Systems, methods and devices for in vivo monitoring of a localized response via a radiolabeled analyte in a subject
Methods, systems, devices and computer program products monitor in vivo detected radiation in a target localized site within a subject, over a selected time period, to do one or more of: (a)...
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6991777 |
Methods for in vivo evaluation of physiological conditions and/or organ or system function including methods to evaluate cardiopulmonary disorders such as chronic heart failure using polarized 129 Xe
In certain embodiments, methods of the present invention obtain NMR spectroscopy signal data that corresponds to the behavior of the polarized 129 Xe at a selected site(s) in selected environments...
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6977068 |
Method for detection of fibrin clots
A method for the detection of fibrin in a source, in particular the in vivo detection of a fibrin in a patient, the method comprising supplying to the source or patient an amount of a detectable...
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6974567 |
Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque
Detectably labeled macrophage scavenger receptor antagonists useful for the diagnosis and monitoring of various cardiovascular diseases including but not limited to atherosclerosis, vulnerable...
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6962687 |
Method and means for detecting inflammatory processes
A method of detecting inflammatory processes comprises (a) administering per-orally or per-rectally a composition comprising a diagnostically effective amount of L-[guanido- 15 N 2 ]-arginine,...
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6932961 |
Oxazinocarbazoles for the treatment of CNS diseases
The present invention provides isotopically labeled oxazinocarbazole derivatives having a ring connecting position 8 (C-8) and position 9 (N-9), and more specifically, provides compounds of formula...
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6911219 |
Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
This relates to partially acetalized polyvinyl alcohol embolization particles suitable for implanting in the human body, to compositions containing those particles, and to methods of making and...
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6902719 |
Reverse isotope dilution assay and lactose intolerance assay
A “reverse isotope dilution assay” herein, wherein a pathway that produces a given metabolite is assayed by diluting a labelled metabolite produced by a second constitutive pathway. In one...
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6893626 |
Compositions for TRP-M8 binding and radioreceptor methods therewith
One embodiment of the invention is a composition that comprises a radioactive 32 P or 33 P phosphine oxide molecule. The said composition is designed to bind to the transient potential...
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6872381 |
Radiopharmaceuticals for diagnosing Alzheimer's disease
This invention is directed to the use of radiopharmaceuticals in diagnosing Alzheimer's disease. In particular the radiopharmaceuticals of the invention are able to pass through the blood-brain...
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6818200 |
Method of using deuterated calcium channel blockers
A method of enhancing the efficiency and increasing the duration of action of drugs (e.g. dihydropyridines and anti-bacterials) and particularly of nifedipine and penicillins wherein one or more...
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6797256 |
Composition for determining pyrimidine metabolizing activity
The present invention provide a method for assessing the sensitivity to a pyrimidine drug such as 5-FU which is degraded in the pyrimidine metabolic pathway, specifically in vivo pyrimidine...
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6764673 |
Synthesis of &lsqb 2H1, 13C&rsqb , &lsqb 2H2, 13C&rsqb and &lsqb 2H3, 13C&rsqb methyl aryl sulfones and sulfoxides
The present invention is directed to labeled compounds, [ 2 H 1 , 13 C], [ 2 H 2 , 13 C] and [ 2 H 3 , 13 C]methyl aryl sulfones and [ 2 H 1 , 13 C], [ 2 H 2 , 13 C] and [ 2 H 3 , 13 C]methyl...
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6749832 |
Labelled ascorbic acid derivatives
Compounds of formula (I) where: X 1 is OH or SH or NH 2 or —L-Z; X 2 and X 3 are the same or different and each is H, C 1-4 alkyl, benzyl a protecting group or —L-Z, X 4 is H or C 1-4 ...
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