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9028800 Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules  
The present application discloses compositions and methods of synthesis and use of 18F or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to...
9023317 Polymer precursors of radiolabeled compounds, and methods of making and using the same  
One aspect of the present invention relates to novel compounds that can be used to prepare radiolabeled compounds in an effective manner. A second aspect of the present invention relates to a...
9005577 Substrate based PET imaging agents  
The present application is directed to radiolabeled imaging agents comprising a radiolabel, and a substrate, pharmaceutical compositions comprising radiolabeled imaging agents, and methods of...
8945510 Radiolabeled glutaminyl cyclase (QC) inhibitors and uses of same  
Radiolabeled glutaminylcyclase (QC) inhibitors as imaging agents, in particular, but not exclusively, as medical imaging agents for the detection of neurological disorders; and pharmaceutical...
8916132 Benzimidazole-derived compounds use as markers in the case of neurodegenerative diseases  
Use of benzimidazole-derived compounds of formula (I) according to the following structure, wherein x is a heteroatom selected from N, S, O, P, SO, SO2 and SO3, preferably from N, S and SO3 and...
8916131 Radiopharmaceutical composition  
The present invention relates to radiopharmaceuticals and in particular to a radiopharmaceutical composition comprising a compound of Formula (I): and polysorbate as an excipient. The...
8911707 Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions...
8906392 Nanocluster compositions and methods  
Compositions, methods of making, and methods of using nanoclusters in which the nanoclusters comprise a plurality of nanoparticles having a core of nanoparticles arranged such that the surfaces of...
8889100 Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules  
The present application discloses compositions and methods of synthesis and use of 18F- or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to...
8877159 Phospholipid analogs as diapeutic agents and methods thereof  
The present invention provides methods and uses of phospholipid ether analogs as diagnostic and therapeutic agents for numerous cancers.
8877160 Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof  
The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting...
8858911 Phosphodiesterase 1-targeting tracers and methods  
Tracers targeting phosphodiesterase 1 for use in gamma radiation detection-based diagnostic techniques, particularly gamma-emitter labeled tracers for SPECT and positron emitter-labeled...
8846000 Radiolabeled PDE10 inhibitors  
The present invention is directed to radiolabeled pyrimidinone compounds of general structural formula I which are useful as radiotracers for quantitative imaging of PDE10 in mammals.
8834841 Imaging agents  
The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged...
8834843 Imaging method  
The present invention relates to a method useful in facilitating the identification of fibrogenesis in a subject. The method of the invention is particularly useful when applied as part of a...
8808665 In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents  
The present application discloses compositions and methods of synthesis and use involving click chemistry reactions for in vivo or in vitro formation of therapeutic and/or diagnostic complexes....
8802053 Radio-methyl vorozole and methods for making and using the same  
Radiotracer vorozole compounds for in vivo and in vitro assaying, studying and imaging cytochrome P450 aromatase enzymes in humans, animals, and tissues and methods for making and using the same...
8795629 Radio-methyl vorozole and methods for making and using the same  
Radiotracer vorozole compounds for in vivo and in vitro assaying, studying and imaging cytochrome P450 aromatase enzymes in humans, animals, and tissues and methods for making and using the same...
8778305 PSMA-binding agents and uses thereof  
Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds,...
8778304 TSPO-targeting compounds and uses thereof  
Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.
8778303 99mTc-labeled 19 amino acid containing peptide for use as phosphatidylethanolamine binding molecular probe and radiopharmaceutical  
The invention encompasses radiopharmaceutical compounds that can be used in imaging cell death associated with either apoptosis or necrosis. Phosphatidylethanolamine (PtdE) is externalized to the...
8758726 Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules  
The present application discloses compositions and methods of synthesis and use of 18F or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to...
8753605 Imaging probes, methods of making imaging probes, and methods of imaging  
In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of detecting the...
8741261 Methods for carbon isotope labeling synthesis by transition metal-promoted carbonylation via isocyanate using azides and carbon-isotope monoxide  
Methods and reagents for transition metal-promoted carbonylation via isocyanate using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled compounds are useful...
8709382 Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules  
The present application discloses compositions and methods of synthesis and use of 18F- or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to...
8709381 Compound containing a carbon or an oxygen isotope, preparation and use thereof, and composition comprising thereof  
The present disclosure relates to a compound comprising at least one of a carbon or an oxygen isotope and a process for preparing the compound. The process comprises irradiating a compound...
8691187 Imaging agents for detecting neurological disorders  
Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins...
8691185 Benzothiazole derivative compounds, compositions and uses  
This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid...
8679452 Miniaturized liquid surface reactions using nanomolar amounts of concentrated [11C]carbon dioxide in a stationary gas-phase  
Methods and reagents for miniaturized carboxylation with carbon-isotope labeled carbon dioxide using Grignard reagents or other organometallic reagents in a closable reaction loop or reactor are...
8668900 Cancer-imaging agent and method of radioimaging using the same  
The cancer-imaging agent and method of radioimaging relates to the use of a radioimaging agent for the imaging increased choline uptake to detect cancerous tissue. The radioimaging agent includes...
8663602 Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems  
The invention enables high-throughput screening of compounds in living systems to detect unanticipated or unintended biological actions. The invention also allows for screening, detection, and...
8658132 Method for production of radiation diagnostic imaging agent  
A method for producing a radioactive diagnostic imaging agent containing a radioactive 18 fluorine-labeled organic compound represented by the following formula (1): as an effective ingredient in...
8658129 Agents and methods for the imaging of myelin basic protein  
The present invention relates to agents capable of binding to myelin basic protein in a subject. Also provided are methods for the detection of myelin-associated neuropathy comprising identifying...
8658131 Compounds comprising 4-benzoylpiperidine as a sigma-1-selective ligand  
Bipiperidinyl compounds and salts thereof are disclosed. The compounds include high affinity ligands for σ1 receptors. Some compounds are also highly selective for σ1 receptor compared to σ2...
8652440 Methods for diagnosing diseases and evaluating treatments therefor using PET  
The present invention relates to methods for determining whether a mammal has a disease, such as diabetes, using PET data analysis techniques. These methods include administering to a mammal a...
8632752 In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents  
The present application discloses compositions and methods of synthesis and use involving click chemistry reactions for in vivo or in vitro formation of therapeutic and/or diagnostic complexes....
8628750 Cancer imaging and treatment  
Provided herein are compounds or conjugates useful for diagnostic imaging and/or therapeutic purposes. Each compound or conjugate comprises a ligand for the chemokine receptor CXCR4 and a...
8617515 Imaging of myelin basic protein  
The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering...
8617518 Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules  
The present application discloses compositions and methods of synthesis and use of 68Ga, 18F or 19F labeled molecules of use in PET or MRI imaging. Preferably, the 18F or 19F is conjugated to a...
8580229 Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies  
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or...
8568689 uPAR-targeting contrast agents  
The invention relates to contrast agents for detection of the Urokinase Plasminogen Activator Receptor (uPAR). More specifically the invention relates to contrast agents comprising a peptidic...
8551448 Rotanone analogs: method of preparation and use  
The present invention provides rotenone analogs and methods of making and using them. Labeled with single photon and positron emitting isotopes, the rotenone analogs of the present invention are...
8545809 Methods and compositions for improved 18F labeling of proteins, peptides and other molecules  
The present application discloses compositions and methods of synthesis and use of 18F or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to...
8546417 Fused and spirocycle compounds and the use thereof  
The invention relates to fused and spirocycle compounds of Formula I: or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1, R2, Q1-Q3, and Z are defined as set forth in...
8540968 Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof  
The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting...
8535641 Phospholipid analogs as diapeutic* agents and methods thereof  
The present invention provides methods and uses of phospholipid ether analogs as diagnostic and therapeutic agents for numerous cancers.
8524193 Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts  
The invention provides lipophilic salts, particularly, lipophilic salts comprising a pharmaceutically acceptable anion and at least one phosphonium or ammonium cation. In certain embodiments, the...
8518371 Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof  
The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or...
8512676 Detection of rate changes in systematic oscillations of metabolic athways by monitoring isotope ratios  
The methods described herein are based on the observation that oscillations in breath isotope ratio data can be used for the purpose of identifying an “unhealthy” state in an organism such as a...
8506932 Tetracyclic indole derivatives as in vivo imaging agents and having peripheralbenzodiazepine receptor affinity (PBR)  
The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging...

Matches 1 - 50 out of 298 1 2 3 4 5 6 >