Matches 101 - 150 out of 298 < 1 2 3 4 5 6 >


Match Document Document Title
7993626 Methods and compositions for F-18 labeling of proteins, peptides and other molecules  
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. The labeled molecules may be peptides or...
7972588 Radiolabelling methods  
The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a...
7968081 Peptide for diagnosing, preventing and treating atherosclerosis and uses thereof  
A peptide for diagnosing, preventing and treating atherosclerosis, and a use thereof, comprising an amino acid sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 2, and a use thereof. The peptide...
7910059 Methods compositions and kits pertaining to analyte determination  
This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling...
7901667 Bridgehead labelled compounds and methods of using the same  
The present invention relates to compounds having the general formula: Y-L-BFR-X wherein BFR is a bridged fused ring system; Y is a targeting group; L is optionally present and is a linker for...
7887784 1-[(2′-substituted)-piperazin-1′ -yl]-isoquinolines as norepinephrine transporter inhibitor therapeutics and positron emission tomography imaging agents  
Racemic mixtures and enantiomerically pure forms of novel 1-[(2′-substituted)-piperazin-1′-yl]-isoquinolines are norepinephrine (NE) transporter (NET) inhibitor compounds. Compounds of the...
7875258 Technetium-dipyridine complexes, and methods of use thereof  
One aspect of the invention relates to novel complexes of technetium (Tc) with various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a...
7858072 Stilbene derivatives and their use for binding and imaging amyloid plaques  
This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to...
7854920 Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions...
7850948 Radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy  
This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention...
7851496 Ionic liquid type crown ether derivatives, method for preparing the same and method for isolating metal ions using the same  
Disclosed relates to an ionic liquid type crown ether derivative, expressed by Chemical Formula 1 below, for isolating metal ions, a method for preparing the same and a method for isolating...
7846419 Method for producing radioactive isotopes for positron emission tomography  
A method for producing radioactive isotopes for positron emission tomography is provided. The method includes generating radioactive isotopes by the acceleration of a projectile in a linear...
7842278 Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof  
The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or...
7842279 F-18 peptides for pre targeted positron emission tomography imaging  
F-18 radiolabeled peptides are prepared by reacting a peptide comprising a hydroxylamine, a thiosemicarbazide, a hydrazine or a free amine group with 4-[18F]Fluorobenzaldehyde. Specific,...
7837981 Methods for imaging soluble A-beta  
Provided herein are agents that bind to soluble beta-amyloid. Also provided are in vivo and in vitro methods for detecting soluble beta-amyloid in a sample that may include brain tissue.
7837982 Imaging agents  
The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged...
7824660 Nanotubes for cancer therapy and diagnostics  
The present invention provides a novel approach to cancer therapy and diagnostics that utilizes nanotubes and other similar nanostructures as both an indirect source of radiation therapy (BNCT),...
7820144 Receptor selective cannabimimetic aminoalkylindoles  
Disclosed are cannabimimetic aminoalkylindole compounds and methods for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoids. The disclosed compounds may...
7815894 Compounds, compositions and methods for medical imaging of neuropsychiatric disorders  
Compounds, compositions and methods for the diagnosis of Alzheimer's disease. Synthesized Glycerophosphocholine (GPC) may be used as a diagnostic aid to measure progression of Alzheimer's disease....
7807135 Stilbene derivatives and their use for binding and imaging amyloid plaques  
This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to...
7794691 Radionuclides for medical use  
Methods of using Th-226 or mother radionuclides thereof, namely U-230 or Th-226, in medicine. These radionuclides are particularly appropriate for the treatment of human and/or non-human mammals,...
7790142 Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid  
The present invention relates to novel modified fatty acid analogs, where a positron or gamma-emitting label is placed at a position on a fatty acid backbone and an organic substituent is...
7790141 Radio-opaque compounds, compositions containing same and methods of their synthesis and use  
Radio-opaque biodegradable compositions are formed by modifying terminal groups of synthetic and natural biodegradable polymers such as polylactones with iodinated moieties. The biodegradable...
7785566 Pharmaceutical compounds  
The invention comprises pharmaceuticals of formula (I) Z-(L)n-V, wherein V denotes a peptide, L denotes an optional linker, Z denotes a group that optionally can carry an imaging moiety M, n...
7771706 Method for monitoring protein translation  
Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline...
7763234 Pharmaceutical compounds  
A pharmaceutical of the general formula Z—(L)n-V, wherein V denotes an amino acid sequence X1-X2-Val-Tyr-Ile-His-Pro-X8-X9-X10; L denotes a bond or a linker; Z denotes a group that optionally can...
7736625 Light stabilized in vivo stain composition and method of manufacture  
Photochemical demethylation reactions in solutions of thiazine dyes, in which the dye molecules act as both sensitizer and substrate, are reduced by quenching triple-state dye molecules, returning...
7727511 Agents for imaging soluble a-beta  
Provided herein are agents that bind to soluble beta-amyloid. Also provided are in vivo and in vitro methods for detecting soluble beta-amyloid in a sample that may include brain tissue.
7713962 Neurofibrillary labels  
A method for determining the Braak stage of neurofibrillary degeneration associated with a tauopathy in a subject having neurofibrillary degeneration is disclosed. The method comprises the steps...
7700075 Virtual colonoscopy with radiolabeled phospholipid ether analogs  
The present invention provides agents and methods for dual modality virtual colonoscopy that gives both anatomical and functional information using hybrid CT/PET scanning. In preferred...
7670591 Heteroaryl substituted benzoxazoles  
The present invention relates to novel heteroaryl substituted benzoxazole derivatives and therapeutic uses for such compounds, having the structural formula (Ia) below: and to their...
7662360 Conjugates of N-hydroxypropymethacrylamide-methacrylate copolymer with nuclide activation agent and/or anti-cancer compounds  
The present invention relates to new anti-cancer compounds and in particular to new compounds for use in nuclide activation therapy, such as neutron capture therapy. Specifically this invention...
7658910 Preparation of radiolabelled haloaromatics via polymer-bound intermediates  
According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate...
7622102 Method for monitoring early treatment response  
Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline...
7611693 Mechanism-based targeted pancreatic beta cell imaging and therapy  
Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.
7608240 Nanotubes for cancer therapy and diagnostics  
The present invention provides a novel approach to cancer therapy and diagnostics that utilizes nanotubes and other similar nanostructures as both an indirect source of radiation therapy (BNCT),...
7597876 Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules  
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. In particular embodiments, the labeled...
7575738 Heat shock protein as a targeting agent for endothelium-specific in vivo transduction  
The present invention relates to the use of Heat Shock Proteins and fragments thereof as targeting ligand. The Heat Shock Protein may be labeled with imaging agents that are capable of binding...
7572598 Preparation comprising albumin esterified with a labeled substance for diagnosis of pancreatic exocrine function  
A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates...
7563433 Methods and compositions for F-18 labeling of proteins, peptides and other molecules  
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. In particular embodiments, the labeled...
7560096 Diagnostic procedures using direct injection of gaseous hyperpolarized 129Xe and associated systems and products  
A method of screening for pulmonary embolism uses gaseous phase polarized 129Xe which is injected directly into the vasculature of a subject. The gaseous 129Xe can be delivered in a controlled...
7560095 Cancer specific monoclonal antibodies  
Novel monoclonal antibodies and binding fragments thereof specific to human breast cancer, lung cancer, colon cancer and other cancers. The monoclonal antibody does not bind to the cell surface of...
7550272 Method for diagnosis of pancreatic exocrine function  
A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates...
7534418 Imaging agents  
The present invention provides novel compounds that find use as imaging agents within nuclear medicine applications (e.g., PET imaging and SPECT imaging). The present invention also provides...
7514068 Biphenyl-pyrazolecarboxamide compounds  
The present invention relates to biphenyl-pyrazole compounds and in particular biphenyl-pyrazolecarboxamides. The invention further provides compositions comprising a compound of this invention...
7488466 Preparation for determining pyrimidine metabolic capacity  
The present invention provide a method for measuring and assessing the capacity in an individual subject to metabolize a variety of fluorouracil drugs, such as 5-fluorouracil, which are degraded...
7485283 Contrast agents for myocardial perfusion imaging  
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds...
7449170 Materials and methods for controlling isotope effects during fractionation of analytes  
Compositions and methods for controlling or eliminating isotope effects during fractionation of chemically equivalent but isotopically distinct compounds. Isotope coding agents contain heavy...
7438891 Imaging agents for early detection and monitoring of cardiovascular plaque  
The present invention relates in part to a method of imaging cardiovascular plaque formation in a mammal comprising administering to the mammal an effective amount of 18F-2-fluorodeoxy-D-glucose...
7427389 Diagnostic agents for positron emission imaging using radiolabeled halogenated xanthenes  
New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such...

Matches 101 - 150 out of 298 < 1 2 3 4 5 6 >