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7351399 |
Prodrugs for phosphorus-containing compounds
Prodrugs of formula I, their uses, their intermediates, and their method of manufacture are described:
and pharmaceutically acceptable prodrugs and salts thereof.
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7194360 |
Method of determining radioactive nuclides
A method of simply and quickly determining α-ray releasing nuclides having long half-life without carrying out a chemical separation is provided. By inputting a data of pulses incident to an...
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7115579 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
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7112318 |
Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts
The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with 18 F for non-invasive assessment of ΔΨm, lipophilic ammonium cation analogs of the PhCs, and methods of...
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7105495 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
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7037486 |
Labelled phosphoinositides and analogues
The present invention provides novel compounds comprising cellular phosphoinositides and analogues tagged with stable or radioactive isotopes. The present invention also provides novel methods for...
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7018612 |
Method of preparing a radioactive rhenium complex solution
The invention relates to a method of preparing a solution of a radioactive rhenium complex, by reacting at elevated temperature a radioactive perrhenate in a substantially aqueous solution with a...
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6899864 |
Morpholino imaging and therapy
The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate...
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6896871 |
Biphosphonate conjugates and methods of making and using the same
The present invention is directed to particular bisphosphonate compounds, and in particular, to bisphosphonate conjugates that are useful in the treatment of soft tissues surrounding bone and...
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6869589 |
Cryptate compounds and methods for diagnosis and therapy
The present invention relates to cryptate compounds useful as chelating agents. In particular, the present invention relates to functionalized derivatives of certain cryptate compounds. These...
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6780397 |
Biomolecule conjugation strategy using novel water-soluble phosphine-based chelating agents
This invention describes a novel strategy to produce phosphine-functionalized biomolecules (e.g. peptides or proteins) for potential use in the design and development of site-specific...
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6776977 |
Polypodal chelants for metallopharmaceuticals
Tripodal polyaminophosphonate chelants are disclosed, as well as chelates of the chelants with metal ions to form radiopharmaceutical and radioactive, MRI and X-ray or CT imaging compounds and...
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6607710 |
Bisphosphonic acid derivative and compound thereof labeled with radioactive nuclide
An object of the present invention is to provide a bisphosphonic acid derivative and said bisphosphonic acid derivative being labeled with a radioactive nuclide, which has properties of rapid...
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6548042 |
Bis-phosphonate compounds
The present invention provides a pharmaceutical compound, or pharmaceutically acceptable salt thereof, for use in medicine, wherein said compound is of formula I wherein R is a pharmaceutically...
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6440386 |
Stabilized radiophosphate-labeled proteins
A radiotherapeutic agent comprising a 32 P or 33 P radiolabeled protein selected from the group consisting of: wherein X is an targeting peptide, Y is a phosphorylation peptide, L is a...
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6299857 |
Cardiovascular and thrombus imaging agents, methods and kits
The invention provides cardiovascular imaging agents comprising a radionuclide in association with a nucleotide polyphosphate targeting molecule. Methods for using the cardiovascular imaging agents...
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6287536 |
Two-step pretargeting methods using improved bidtin-active agent conjugates
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for...
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6270745 |
Radioactive transition metal nitride heterocomplex
The present invention provides a single radioactive transition metal nitride heterocomplex which permits labeling of a physiologically active substance such as a peptide, hormone or the like...
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6149889 |
Radioactive particles and methods for preparing same
A nuclear medical drug for localize radiotheraphy of a tumor and methods for its preparation. The drug includes a radioactive ceramic or glass particle having biocompatiblity. Ceramic or glass...
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6054115 |
Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same
A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or...
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5976492 |
Radioactive phosphorus labeled proteins for targeted radiotherapy
32 P- and 33 P-labeled proteins which are useful for radiotherapy are prepared by stably linking 32 P- or 33 P-containing molecules to targeting proteins in such a way that the targeting...
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5948386 |
Conjugate and method for forming aminomethyl phosphorus conjugates
A method of forming phosphine-amine conjugates includes reacting a hydroxymethyl phosphine group of an amine-free first molecule with at least one free amine group of a second molecule to...
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5876693 |
Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals
A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises a functionalized hydroxyalkyl phosphine ligand and a metal combined with the ligand.
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5874059 |
Microemulsions labelled with radioactivity used as means for targeting neoplastic cells
The present invention relates to a method for diagnosing neoplasms by means of injecting radioactively-labelled microemulsions into the blood circulation so as to localize neoplastic cells. This...
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5872107 |
Treatment of urogenital cancer with boron neutron capture therapy
Methods and compositions for treating urogenital tumors, and in particular, cancer of the prostate, bladder, and kidney, with BCNT, are disclosed. Any boron-containing compound that is sufficiently...
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5795561 |
Radioiodinated phospholipid ether analogues
Novel radioiodinated analogues of naturally-occurring phospholipid ethers are tumor-specific and have a triglycerol backbone structure which, in certain embodiments, is substituted at the...
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5762907 |
Frozen radiopharmaceutical formulations
Radiopharmaceutical formulations for complexes comprising at least one radionuclide complexed with a ligand, or its physiologically-acceptable salts thereof, especially 153 ...
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5762906 |
Further improvements relating to radiolabelling of proteins
A structurally modified protein is provided that will bind to a tumor-associated structure wherein the amino group in at least one basic amino acid in the binding protein is structurally modified...
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5728369 |
Radioactive phosphorus labeling of proteins for targeted radiotherapy
32 P- and 33 P-labeled proteins which are useful for radiotherapy are prepared by stably linking 32 P- or 33 P- containing molecules to targeting proteins in such a way that the targeting...
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5662882 |
Radiopharmaceutical formulations having non-stannous reductants
The present invention relates to novel radiopharmaceutical imaging agents having non-stannous reductants. The present invention further relates to kits for forming radiopharmaceutical imaging...
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5635158 |
Peptides modified by the phosphine group for marking with 99M TC and 186-188 RE or paramagnetic agents
The peptides described are modified with the phosphine group and are useful for marking with 99m Tc and 186 -188 Re or paramagnetic agents for use in diagnosis and radiotherapy; in particular...
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5605672 |
Blood pool imaging composition and method of its use
The invention features a method of blood pool imaging which utilizes an imaging agent which can be easily labelled with a radioactive isotope and injected into a patient. The imaging agent is a...
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5601800 |
New multifunctional ligands for potential use in the design therapeutic or diagnostic radiopharmaceutical imaging agents
A class of diagnostic and therapeutic compounds derived from phosphinimines that include ligands containing either a single phosphinimine functionality or both a phosphinimine group and a phosphine...
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5462724 |
Sensitizing agents for use in boron neutron capture therapy
Compounds of formula I and II ##STR1## in which B contains a carboranyl group and one of R 3 and R 4 is a carboranyl group or a boronic acid or ester are useful sensitizing agents for boron...
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5417959 |
Functionalized aza-crytand ligands for diagnostic imaging applications
The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein V is CR 1 or N; W is CR 2 or N; R 1 and R 2 may be the...
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5356787 |
Method of identifying compounds that modulate myocardial calcium-independent phospholipase A.sub.2 activity
A method of identifying compounds that modulate the activity of myocardial calcium-independent phospholipase A 2 is disclosed. In a test assay of the method of the invention, myocardial...
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5306482 |
Radiopharmaceutical bacteriostats
Benzalkonium chloride and benzethorium chloride are each useful in radiopharmaceutical preparations (optionally in the presence of a polymyxin or a polymyxin derivative) as bacteriostatic agents...
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5300279 |
Organic amine phosphonic acid complexes for the treatment of calcific tumors
Particle-emitting radionuclides, e.g. Gd-159, Ho-166, Lu-177 and Yb-175, have been complexed with organic aminoalkylenephosphonic acids. These complexes have been found useful in compositions for...
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5227152 |
Radiopharmaceutical bacteriostats
Benzalkonium chloride and benzethonium chloride are each useful in radiopharmaceutical preparations as bacteriostatic agents which are compatible with anti-oxidants.
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5219556 |
Stabilized therapeutic radiopharmaceutical complexes
A method of preparing a stable, therapeutic radiopharmaceutical composition comprised of an alpha- or beta-emitting radionuclide and a ligand by lyophilizing a solution of the complex. The...
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5202109 |
Conjugates for bone imaging and bone cancer therapy
The present invention provides conjugates formed from calcified tissues targeting agents and radiolabeled compounds. One such conjugate comprises a chelate and a targeting agent that is capable of...
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5192526 |
Kit for preparation of rhenium therapeutic agents for bone cancer without purification
The process of the present invention includes preparing a first aqueous solution of rhenium in the form of radioactive perrhenate, wherein the concentration of rhenium in said solution is within...
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5190742 |
Device and method for carrying out a plurality of sequential transformations of a substrate
A device or kit having inlet means for introducing within the kit a first reagent, includes a substrate and at least a second reagent in the form of microcapsules adapted to release, according to a...
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5167948 |
Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
The invention relates to a diagnostic or radiotherapeutic composition, comprising a hydrogen containing compound in addition to a pharmaceutically acceptable formulation means and optionally an...
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5167947 |
Enhancement of absorption of radioprotective drugs
The present invention provides a pharmaceutical composition for enhancing gastrointestinal tract absorption of a radioprotective drug comprising a therapeutically effective dosage amount of a...
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5164175 |
Diagnostic aid containing an organ-specific substance labeled with technetium-99m
The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ specific substance, or an organ-specific substance which has...
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5112595 |
99MTC(III) myocardial imaging agents and method of use
A myocardial imaging agent for use in humans comprising a Tc(III) complex ligated in a planar position by a tetradentate ligand having incorporated therein four hard atoms and two furanone rings...
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5104638 |
Method of making a radiopharmaceutical complex from a kit
The present invention relates to novel technetium-99m complexes and to methods of preparing the complexes. The present invention further relates to radiopharmaceutical compositions comprising the...
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5066478 |
Radio labeled organic amine phosphonic acid complexes for the treatment of calcific tumors
Particle-emitting radionuclides, e.g. Gd-159, Ho-166, Lu-177 and Yb-175, have been complexed with organic aminoalkylenephosphonic acids wherein the nitrogen and phosphorus are interconnected by an...
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5064633 |
Macrocyclic aminophosphonic acid complexes, their formulations and use
Particle emitting radionuclides, e.g. X-90, have been complexed with certain macrocyclic aminophosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or...
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