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5167948 |
Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
The invention relates to a diagnostic or radiotherapeutic composition, comprising a hydrogen containing compound in addition to a pharmaceutically acceptable formulation means and optionally an...
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5164175 |
Diagnostic aid containing an organ-specific substance labeled with technetium-99m
The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ specific substance, or an organ-specific substance which has...
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5112595 |
99MTC(III) myocardial imaging agents and method of use
A myocardial imaging agent for use in humans comprising a Tc(III) complex ligated in a planar position by a tetradentate ligand having incorporated therein four hard atoms and two furanone rings...
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5104638 |
Method of making a radiopharmaceutical complex from a kit
The present invention relates to novel technetium-99m complexes and to methods of preparing the complexes. The present invention further relates to radiopharmaceutical compositions comprising the...
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5066478 |
Radio labeled organic amine phosphonic acid complexes for the treatment of calcific tumors
Particle-emitting radionuclides, e.g. Gd-159, Ho-166, Lu-177 and Yb-175, have been complexed with organic aminoalkylenephosphonic acids wherein the nitrogen and phosphorus are interconnected by an...
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5064633 |
Macrocyclic aminophosphonic acid complexes, their formulations and use
Particle emitting radionuclides, e.g. X-90, have been complexed with certain macrocyclic aminophosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or...
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5059412 |
Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
Particle emitting radionuclides, e.g. Samarium-153, have been complexed with certain macrocyclic aminophosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or...
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5049372 |
Anticancer activities in a host by increasing blood and plasma adenosine 5'-triphosphate (ATP) levels
Growth of tumor cells in a host is arrested by the generation of elevated blood and plasma levels of adenosine 5'-triphosphate in said host. These elevated levels can be achieved, for instance, by...
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5037631 |
Technetium-99M complex for examinating the renal function
The present invention relates to novel technetium-99m complexes and to methods of preparaing the complexes. The present invention further relates to radiopharmaceutical compositions comprising the...
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5021235 |
Preparation of rhenium phosphonate therapeutic agents for bone cancer without purification
The process of the present invention includes preparing a first aqueous solution of rhenium in the form of radioactive perrhenate, wherein the concentration of rhenium in said solution is within...
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5006329 |
Radioactive tagged compounds and method for the treatment of metastatic bone cancer
Organophosphonates such as methylene diphosphonates and analogs thereof are tagged with chromium-51 for the treatment of bone cancer without causing damage to bone marrow. The chromium-51...
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5002754 |
Technetium (III/II) imaging agents
A ligated technetium (III/II) complex is useful as a brain perfusion imaging agent. The complex has a technetium (III/II) center surrounded by six ligating moieties. The complex preferably has a...
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4976950 |
Bone marrow suppressing agents
The invention concerns a method for suppressing bone marrow which comprises administering to a mammal at least one bone marrow suppressing complex of a radionuclide selected from the group...
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4957728 |
Kit for preparing Tc (III)-99m myocardial imaging agents that are effective in humans
A myocardial imaging agent for humans is a technetium(III) complex ligated in the planar positions by a tetradentate ligand such as (acac) 2 en and in the axial positions by an ether containing...
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4935222 |
Procedure for isolating and purifying radioactive ligated rhenium pharmaceuticals and use thereof and kit
A sterile pyrogen free Re 196 or Re 188 radiopharmaceutical is prepared by reducing radioactive perrhenate in the presence of a bone seeking ligand to form a solution including complexed...
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4917879 |
99MTC(III) myocardial imaging agents that are effective in humans
A myocardial imaging agent for humans is a technetium(III) complex ligated in the planar positions by a tetradentate ligand such as (acac) 2 en and in the axial positions by an ether containing...
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4910012 |
Products containing Tc-99-m-ωalkylphosphinico-1-hydroxyalkane-1,1-diphosphonates for bone scintigraphy and a process for the preparation of these products
Tc-99m products containing at least one compound of the formula I ##STR1## in which R is a methyl, ethyl or propyl group and n represents a number from 1 to 6, or the physiologically tolerated...
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4898724 |
Organis amine phosphonic acid complexes for the treatment of calcific tumors
Particle-emitting radionuclides, e.g. Samarium-153, have been complexed with organic aminoalkylenephosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or...
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4873074 |
Process for the preparation of stable radiodiagnostic products
Stable injection solutions of radiodiagnostic aids ready for use are obtained by addition to the organ- or tissue-specific carrier, before, during of after the labeling with the pertechnetate, of a...
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4857299 |
Stable radiodiagnostic product
Stable injection solutions of radiodiagnostic aids ready for use are obtained by addition to the organ-or tissue-specific carrier, before, during or after the labeling with the pertechnetate, of a...
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4853209 |
Bone marrow suppressing agents
The invention concerns a method for suppressing bone marrow which comprises administering at least one bone marrow suppressing radionuclide composition selected from the group of radionuclide...
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4842845 |
Radioactive metal chelates for dipyridoxyl phosphate
Radioactive metal ion chelates of N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacet
ic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,
N'-diacetic acids, and...
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4810486 |
Bone-seeking complexes of technetium-99m
A composition for use in the preparation of a bone-scanning agent comprises a mixture of a bis-phosphonic acid of formula (I), wherein R 1 and R 3 may be the same or different group selected from...
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RE32826 |
Cationic technetium complexes useful as radiodiagnostic agents
A cationic lipophilic complex of technetium is disclosed wherein all of the coordination positions of the technetium atom are filled with a neutral donor atom having a pair of electrons available...
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4795626 |
.sup.99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo
A cationic 99m Tc III myocardial imaging agent is disclosed which has a relatively negative redox potential. This prevents in vivo reduction of the Tc(III) to Tc(II). The redox potential of the...
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4781912 |
Cationic complex of technetium-99m.
The invention relates to a cationic complex of technetium-99m with (a) at least one bidendate ligand X having the formula R 1 R 2 ZQZR 3 R 4 where each Z is phosphorus or arsenic, ...
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4707353 |
Radiographic imaging agents
A composition useful for tissue imaging, comprising tin metal or an alloy containing tin and an ascorbate, gentisate or reductate stabilizer. Preferably, such compositions also comprise a...
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4695449 |
Composition and method for treatment of melanomas
A composition and method for the treatment of melanomas in human beings wherein the composition comprises at least one O-phosphorylated derivative of 3-(3,4-dihydroxy)phenylalanine.
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4693884 |
Technetium-99m triphosphonates and tetraphosphonates for the scintigraphic visualization of res-containing organs and lymph vessels, and a process for their preparation
A diagnostic agent for the visualization of RES-containing organs or of lymph vessels, containing 99m Tc triphosphonates or tetraphosphonates in physiologic saline, and a process for their...
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4666698 |
N-(4-aminobenzoyl)-aminodicarboxylic acids for stabilizing technetium.sup.9 9
N-(4-Aminobenzoyl)-aspartic acid and -glutamic acid, their physiologically acceptable salts or their esters are described as stabilizers for Tc 99m injection preparations which contain a tin-II...
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4657755 |
Composition and method for investigating alimentary functions
Enterically administrable diagnostic compositions for investigating alimentary functions comprising multiple units of a size of at the most 5 mm, preferably between 0.5 and 1.3 mm, in particular...
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4642229 |
Bone-seeking complexes of Technetium-99m
A bone-seeking, Technetium-99m-ethylene glycol-1,2-bisphosphonate complex has been found to be useful as a bone-scanning agent. The complex, which is prepared by adding Technetium-99m, as an...
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4606907 |
Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines
New stable complexing agents for radionuclides which are phosphonate derivatives of certain polyamidoamines have been found which are useful in imaging the skeletal system in animals. Even though...
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4582700 |
Products and processes
Novel technetium [99m](I) complexes useful as imaging agents.
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4582698 |
Process for imaging cardiac infarcts
The imaging of cardiac infarcts with complexed radioactive metals is improved by employing as the complexing agent a compound of the formula ##STR1## wherein substituents A, B, X and Y are each...
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4533541 |
Tin-117m-labeled stannic (Sn.sup.4+) chelates
The radiopharmaceutical reagents of this invention and the class of Tin-117m radiopharmaceuticals are therapeutic and diagnostic agents that incorporate gamma-emitting nuclides that localize in...
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4528177 |
Imaging agents and method
Radioiodine containing phenylbutylammonium salts are valuable imaging agents, particularly for the heart.
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4515767 |
Radioactive metals complexed with phosphonate derivatives of dicyclopentadienebis(methylamine)
Complexes of radionuclides with a compound of the formula ##STR1## wherein substituents A, B, X and Y are each independently selected from radicals including hydrogen, hydroxyalkyl (wherein the...
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4515766 |
Labeled phosphonic acid compositions for investigations of in vivo deposits of calcium
The composition and methodology associated with the formulation of a halogenated phosphonic acid labeled in the ring moiety are disclosed having the formula: ##STR1## wherein R 1 is aryl and is...
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4510125 |
Process for making lyophilized radiographic imaging kit
A process for making a lyophilized composition useful for skeletal imaging whereby an aqueous solution containing an ascorbate, gentisate, or reductate stabilizer is contacted with tin metal or an...
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4504463 |
Process for making a lyophilized product for use in skeletal imaging
A process for making a lyophilized composition, useful for skeletal imaging, containing diphosphonates, stannous reductant, and optionally, a gentisate stabilizer. The process comprises (1)...
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4455291 |
Accelerators for forming cationic technetium complexes useful as radiodiagnostic agents
A composition for preparing cationic lipophilic technetium complexes is described. The composition comprises an admixture of (a) an accelerator compound selected from the group of water-soluble...
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4451450 |
Cationic compounds useful for making radiodiagnostic agents
A normally solid, hydrophilic compound capable of binding with Tc-99m to form a cationic complex is provided. The compound has a formula selected from: ##STR1## wherein: R, R', R", R 1 , R 2 , R 3...
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4451451 |
Radiopharmaceutical composition based on technetium-99m and reagent for making it
Radiopharmaceutical compositions containing complexes of technetium-99m with a complexing agent are prone to time and activity-related decomposition and formation of pertechnetate. Stabilizing...
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4446123 |
Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations
Process of radioimaging the myocardium of mammals using intravenous injection of radiolabeled lipophilic cations of quaternary ammonium, quaternary phosphonium or quaternary arsonium compounds of...
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4440738 |
Stable radiographic imaging agents
Stable compositions, useful as technetium-99m-based imaging agents, comprise reductic acid or certain structurally-related compounds in combination with a pertechnetate reductant or dissolved in...
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4439413 |
Radioactive diagnostic agent for bone scanning and non-radioactive carrier therefor
A radioactive diagnostic agent for bone scanning, which comprises 99m Tc and a non-radioactive carrier comprising (A) at least one chosen from methanehydroxydiphosphonic acid and their salts and...
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4427647 |
Method and reagent for making a radiopharmaceutical composition based on pertechnetate
A method of making a radiopharmaceutical composition by mixing an aqueous solution of pertechnetate with a reducing agent comprising tin metal or stannous ion to reduce the pertechnetate and a...
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4419339 |
Formulation and method of making cationic lipophilic complexes
A method for the preparation of a technetium-99m complex having the formula [(L) 2 99m Tc(X) 2 ] ♁X .crclbar ., which comprises adding technetium-99m to a complex having the formula [(L) 2 ...
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4411881 |
Composition and method for stabilizing radiolabeled compounds using thiocarbonylated diethylenetriamines
A stabilized composition comprising a solution of a radiolabeled compound and a diethylenetriamine is described. Preferred diethylenetriamines include, N,N-bis(2-aminoethyl) dithiocarbamic acid,...
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