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7344701 |
Xanthene dyes
The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like....
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7332181 |
Composition for managing diabetes, obesity, and hyperlipidemia and associated methods
A nutritional supplement includes a first formulation including minerals: chromium polynicotinate, magnesium glycinate, manganese sulfate, selenium, vanadyl sulfate, zinc gluconate, copper...
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RE40059 |
Sensitive substance encapsulation
A process for stabilizing a sensitive substance; (a) plating a sensitive substance onto a solid carrier under a controlled atmosphere to reduce loss of the sensitive substance; (b) encapsulating...
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7314609 |
Stereoisomers of fatty acid analogs for diagnostic imaging
The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a...
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7238338 |
System and method for the large scale labeling of compounds with radiohalogens
Disclosed are methods for manufacturing radiohalogen-labeled steroids, nucleosides, nucleotides and proteins, for example, pyrimidines and proteins. Methods according to the example embodiments...
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7229636 |
Cyanocobalamin low viscosity aqueous formulations for intranasal delivery
A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has...
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7220730 |
Cancer specific radiolabeled conjugates regulated by the cell cycle for the treatment and diagnosis of cancer
Radiolabeled conjugates are disclosed which have a component that is effective to target tumor cells, which cells selectively take up and degrade the conjugate, thereby delivering to the tumor cell...
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7194360 |
Method of determining radioactive nuclides
A method of simply and quickly determining α-ray releasing nuclides having long half-life without carrying out a chemical separation is provided. By inputting a data of pulses incident to an...
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7179445 |
Cobalamin conjugates useful as imaging and therapeutic agents
The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis.
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7141233 |
Radionuclide labeling of vitamin B12 and coenzymes thereof
A compound useful for in vivo imaging of organs and tumors is provided of formula:
wherein
is a cobalamin,
is derived from a corrin carboxylic acid group of said cobalamin, Y is a...
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7129219 |
Immunoeffector compounds
This invention provides compounds containing a 2-deoxy-2-amino-β-D-glucopyranose (glucosamine) glycosidically linked to a cyclic aminoalkyl (aglycon) group. The invention further provides methods...
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7128893 |
Vitamin-targeted imaging agents
The invention relates to compounds and methods for targeting radionuclide-based imaging agents to cells having receptors for a vitamin, or vitamin receptor binding derivative or analog thereof, by...
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7118731 |
Drugs for the diagnosis of tissue reproductive activity or the treatment of proliferative diseases
An agent which comprises, as an active ingredient, a radiolabeled compound as represented by the following formula or a pharmaceutically acceptable salt thereof:
wherein R 1 denotes hydrogen,...
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7115579 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
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7115248 |
Radiolabeled annexins
Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.
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7105495 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
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7045115 |
Drugs for the diagnosis of tissue-reproductive activity or the treatment of proliferative diseases
An agent which comprises, as an active ingredient, a radiolabeled compound as represented by the following formula or a pharmaceutically acceptable salt thereof:
wherein R 1 denotes hydrogen,...
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7037487 |
Method for diagnosing lactose intolerance and diagnostic kit for performing the method
The method for diagnosing lactose intolerance in patients by the oral administration of defined amounts of lactose, followed by assaying metabolites of lactose, is performed in a way where the...
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7018614 |
Stabilization of radiopharmaceuticals labeled with 18-F
An 18 F isotope-labeled FDG radiopharmaceutical is stabilized against degradation in radiochemical purity due to radiolysis using selected amounts of ethyl alcohol that depend on the activity...
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6989140 |
Methods for cancer imaging
Methods are provided for cancer and pre-cancer detection by increased uptake of fluorophore glucose or deoxyglucose conjugates in cancerous and pre-cancerous cells relative to normal cells.
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6962784 |
Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a VEGF...
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6962686 |
Cell-specific gene delivery vehicles
A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic...
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6958140 |
Methods of imaging and targeting vasculature
Methods for imaging and targeting tumor vasculature are provided. Specifically, the methods for imaging and targeting tumor vasculature relate to using ephrin-B2 to image developing tumor...
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6913743 |
Near infrared imaging agent
This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific...
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6911434 |
Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ cyclic AGPs for...
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6902719 |
Reverse isotope dilution assay and lactose intolerance assay
A “reverse isotope dilution assay” herein, wherein a pathway that produces a given metabolite is assayed by diluting a labelled metabolite produced by a second constitutive pathway. In one...
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6709652 |
Pretargeting methods and compounds
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for...
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6641797 |
Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
Perfluoroalkyl-containing complexes with sugar radicals of general formula I in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH...
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6635234 |
Preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning
Processes for the preparation, prepared solutions, and the use of radium-223 for the treatment of calcified tumors, bone tumors, treatment of bones, bone surfaces and soft tissues is described.
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6613305 |
Radionuclide labeling of vitamin B12 and coenzymes thereof
A compound useful for in vivo imaging of organs and tumors is provided of formula: wherein is a cobalamin, is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking...
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6582918 |
Platelet derived growth factor (PDGF) nucleic acid ligand complexes
This invention discloses a method for preparing a complex comprised of a PDGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a PDGF...
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6569403 |
Determining effects of external stimuli on the brain using PET
A method of evaluating the effects of administering an external stimuli or treatment such as a psychoactive compound, a drug, or an environmental influence like temperature, noise, vibration, light...
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6548043 |
Measurement of gastric emptying
A meat-free, algae-free, standardized, test meal kit used in the measurement of delayed gastric emptying is provided. The kit contains at least a standardized test meal dry mix and tracer. A method...
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6537522 |
Neuroprobes for mapping monoamine reuptake sites
Iodinated neuroprobes for mapping monoamine reuptake sites in the brain, and particularly iodinated neuroprobes that can also serve as radiotracers for use in single-photon emission computed...
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6537521 |
Polymeric contrast agents for characterizing tumor angiogenesis in medicalimaging
In a method for characterizing the angiogenesis status of a tumor in a living subject, timed magnetic resonance images of the subject into whom a reptating polymer contrast agent containing...
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6534038 |
Ternary ligand complexes useful as radiopharmaceuticals
This invention relates to novel highly functionalized phosphine ligands as ancillary ligands in radiopharmaceuticals. Also, this invention provides radiopharmaceuticals comprised of highly...
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6409987 |
Targeted agents useful for diagnostic and therapeutic applications
A selectively targeted agent comprising a dermatan sulfate having more than about 25% repeating L-iduronic acid→4,6-di-O-sulfated N-acetyl-D-galactosamine disaccharide units that is covalently...
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6395256 |
Adenosine detection in small samples
The invention relates to a method for detecting adenosine with the inactive S-adenosyl homocysteine hydrolase's enzyme which selectively and only binds adenosine with high affinity. The inventive...
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6355609 |
Methods for stabilizing liquid nutritional products and products so stabilized
Nutritional solutions and methods of making same are disclosed. The solutions include protein, lipid, and a carbohydrate source including high amylose starch and guar gum.
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6348492 |
Oxetanone derivatives
This invention relates to novel oxetanone derivative compounds and processes for producing such derivatives that are useful as lipase inhibitors. Further the invention relates to processes for...
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6331287 |
2'-deoxy-2'-fluoro-d-arabinofuranosyl pyrimidine nucleoside
The nucleoside analog 2'-fluoro-5-methyl-1-β-D-arabinofuranosyluracil (FMAU) has been found to have an especially desirable combination of properties for use as an imaging agent, including in...
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6306587 |
Template-directed photoligation
Methods, apparatus and compositions are presented for ligating ligands together which bind to a common receptor. One embodiment includes polynucleotide probes having photoreactive functional...
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6303100 |
Methods for inhibiting the formation of potential endoleaks associated with endovascular repair of abdominal aortic aneurysms
Disclosed are methods for inhibiting the formation of potential endoleaks associated with endovascular repair of abdominal aortic aneurysms which comprise the in situ embolization of blood vessels...
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6299857 |
Cardiovascular and thrombus imaging agents, methods and kits
The invention provides cardiovascular imaging agents comprising a radionuclide in association with a nucleotide polyphosphate targeting molecule. Methods for using the cardiovascular imaging agents...
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6287536 |
Two-step pretargeting methods using improved bidtin-active agent conjugates
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for...
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6284220 |
Noninvasive imaging of nucleic acid vectors
Nucleic acid-imaging compositions and methods for noninvasive imaging of a nucleic acid introduced into somatic tissues of an animal or human are disclosed. The noninvasive imaging enables...
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6280740 |
Formulations of recombinant papillomavirus vaccines
Vaccine formulations comprising recombinant early (E) and late (L) proteins of papillomavirus and oxidized mannan as well as methods of making and using the formulations are provided.
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6270745 |
Radioactive transition metal nitride heterocomplex
The present invention provides a single radioactive transition metal nitride heterocomplex which permits labeling of a physiologically active substance such as a peptide, hormone or the like...
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6268351 |
Methods for inducing proliferation in auditory receptor epithelium
The present invention provides novel methods for stimulating proliferation in auditory receptor epithelium. Administration of agents that activate cAMP production result in demonstrable...
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6245316 |
Enhancement of delivery of radioimaging and radioprotective agents
A radioimaging material or a radioprotective material is attached to a carbohydrate which is capable of binding to or penetrating a cell. The carbohydrate material can be preferentially taken up by...
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