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7384977 |
Water soluble paclitaxel prodrugs
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or...
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7381399 |
Technetium-dipyridine complexes, and methods of use thereof
One aspect of the invention relates to novel complexes of technetium (Tc) with various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a...
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7374765 |
Methods and compositions for diagnosis and treatment of iron misregulation diseases
Methods and compositions are provided for the diagnosis and treatment of iron misregulation diseases, including HFE polypeptides, agonists, and antagonists, and transferrin receptor agonists and...
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7371364 |
Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy
The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf; SEQ ID NO. 3) NIR imaging...
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7368474 |
Radiofluorination methods
The present invention relates to methods and reagents for [ 18 F]-fluorination, particularly of peptides. The resultant 18 F-labelled compounds are useful as radiopharmaceuticals, specifically for...
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7364719 |
Vasoregulating compounds and methods of their use
Methods and compounds are described for regulating blood pressure in a subject. Specific embodiments are methods for reversing vasodilation of blood vessels, by administering to a subject a...
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7357915 |
Method of imaging cell death in vivo
A method of imaging apoptosis in vivo, using radiolabeled annexin, is described.
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7351398 |
Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic thioether.
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7351397 |
Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy chromans
Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic 6-hydroxy-chroman derivative.
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RE40059 |
Sensitive substance encapsulation
A process for stabilizing a sensitive substance; (a) plating a sensitive substance onto a solid carrier under a controlled atmosphere to reduce loss of the sensitive substance; (b) encapsulating...
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7320783 |
Methods and compositions for the enhancement of wound healing
The present invention relates to methods and compositions for wound healing, and in particular, methods and compositions to promote and enhance wound healing. In particular, the present invention...
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7312461 |
Laparoscopic tumor therapy using high energy electron irradiation
A laparoscopic tumor therapy method and an articulated electron beam transport system are provided for use with a high power, long focus electron source for tumor therapy. The high power, long...
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7311892 |
Multidrug multiligand conjugates for targeted drug delivery
Described is a multi drug multiligand conjugate for targeted drug delivery. The MDML conjugate contains a plurality of tripartite molecules linked to a central scaffold moiety, with each tripartite...
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7306784 |
Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant...
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7303871 |
Enzyme treatment of foodstuffs for Celiac Sprue
Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of...
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7279149 |
Amino acid composition with increased blood brain barrier permeability
An amino acid composition with improved blood brain barrier permeability comprising an amino acid polymer, wherein the amino acid comprises at least one asparagyl-4-aminobutane or...
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7261875 |
Dendritic poly (amino acid) carriers and methods of use
The present invention concerns a design for dendritic poly(amino acid) polymer carriers, also known as nonlinear polymers, and their applications. These dendritic poly(amino acid) carriers have...
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7244411 |
Method of selective peptide isolation for the identification and quantitative analysis of proteins in complex mixtures
The present invention describes a method of selective peptide isolation for the identification and quantitative analysis of proteins in complex mixture. The method comprises the selective isolation...
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7238341 |
Peptide-based multimeric targeted contrast agents
Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
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7238340 |
Monoamine, diamide, thiol-containing metal chelating agents
Therapeutically active thiazole derivatives of formula (I) wherein R 1 -R 2 , X and X′ as are defined in the specification, processes for the preparation thereof, the use thereof in therapy,...
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7229620 |
Method for radiolabeling antibodies with yttrium-90
Methods and kits for radiolabeling proteins, peptides and ligands with radiolytic isotopes, particularly yttrium-90, are disclosed, whereby sufficient purity, specific activity and binding affinity...
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7229604 |
Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
The invention provides, in a general sense, a new labeling strategy employing 99m Tc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99m Tc for...
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7226577 |
Gastrin releasing peptide compounds
New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N-O-P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not),...
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7223735 |
Abuse resistant lysine amphetamine compounds
The present invention describes compounds, compositions and methods of using the same comprising lysine covalently attached to amphetamine. These compounds and compositions are useful for reducing...
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7220827 |
Compound binding to leukocytes and medicinal composition containing the compound in labeled state as the active ingredient
A compound that comprises Met-Leu-Phe or Nle-Leu-Phe serving as the leukocyte-binding site of a formyl peptide receptor (FPR), a binding part comprising Ser or Thr that increases the binding ratio...
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7220399 |
Alpha or beta emitters attached to fragments in radioimmunotherapy
The present invention relates to radioimmunoconjugates useful in targeted radioimmunotherapy and methods of treating a patient using radioimmunoconjugates. The radioimmunoconjugates of the present...
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7214662 |
Injectable solution of an LHRH antagonist
An aqueous injectable soution of an LHRH antagonist, such as Cetrorelix, in an organic, pharmaceutically acceptable acid, such as gluconic acid.
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7208466 |
Use of a lectin or conjugates for modulation of c-fibre activity
The present invention relates to the treatment of pain and to compounds that modulate C-fibre activity. In particular, the present invention relates to the use of a lectin in the manufacture of a...
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7204972 |
Annexin derivatives with endogenous chelation sites
Modified annexins having an N-terminal chelation site comprising an amino acid extension are disclosed. The amino acid extension includes an amino acid sequence X 1 -Gly-X 2 , where X 1 and X 2 ...
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7202216 |
Drug therapy for celiac sprue
Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an...
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7201890 |
Intraoperative, intravascular and endoscopic tumor and lesion detection, biopsy and therapy
Methods are provided for close-range intraoperative, endoscopic and intravascular detection and treatment of lesions, including tumors and non-malignant lesions. The methods use antibody fragments...
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7196063 |
Peptides and pharmaceutical compositions comprising same
The present invention relates to an NST500 compound of general formula (I): comprising the following components: X 1 —X 2 —{(X 3 ) a /X 4 /X 5 }—X 6 , wherein: X 1 stands for a saturated or...
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7194360 |
Method of determining radioactive nuclides
A method of simply and quickly determining α-ray releasing nuclides having long half-life without carrying out a chemical separation is provided. By inputting a data of pulses incident to an...
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7192922 |
Method of treating left ventricular dysfunction
A method of treating a patient having heart failure due to LV systolic dysfunction with an LV ejection fraction less than 40%. The method includes the steps of administering to a patient in need...
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7186414 |
Compounds and compositions for delivering active agents
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7179785 |
Compounds that bind to p185 and methods of using the same
Novels peptides and pharmaceutical compositions comprising the same are disclosed. Conjugated compositions peptides linked to detectable agents and/or cytotoxic agents. are disclosed. Method of...
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7179446 |
Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
The present invention describes a method of concurrent imaging in a mammal comprising:
a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging...
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7179445 |
Cobalamin conjugates useful as imaging and therapeutic agents
The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis.
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7176008 |
Process for producing activated thrombin-activatable fibrinolysis inhibitor
The invention is a process for purifying TAFIa from a serum sample in the presence of a reversible inhibitor of TAFIa. The invention is also a method of measuring the activity of TAFIa in the...
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7160536 |
Radiolabelled metal transport proteins as imaging agents
A 99mc Tc labeled metal transport protein, products and uses thereof in imaging and especially detecting the presence of high energy/iron uptake tissues such as a tumour within a mammalian body...
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7153490 |
Liposomes encapsulating anticancer drugs and use thereof in the treatment of malignant tumors
Liposomes encapsulating anticancerous drugs and the use thereof in the treatment of malignant tumors. The liposomes are coated with a lipopeptide composed of three substructures: a lipid fragment,...
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7147838 |
Gastrin receptor-avid peptide conjugates
A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin...
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7147837 |
Bioactivated diagnostic imaging constrast agents
The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow...
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7138105 |
Compositions for delivery of therapeutics and other materials, and methods of making and using the same
In part, the present invention is directed to compositions comprising a carrier with a metal binding domain, a metal ion, and an active agent.
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7138104 |
Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
The present invention describes a method of concurrent imaging in a mammal comprising:
a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging...
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7138103 |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable...
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7119069 |
Human kininogen D3 domain polypeptide as an anti-angiogenic and anti-tumor agent
Human kininogen domain 3 (HK-D3) polypeptides and biologically active variants and derivatives of HK-D3 are anti-angiogenic. These molecules are used to inhibit angiogenesis or treat a disease or...
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7118745 |
Engineering antibodies that bind irreversibly
The present invention provides a mutant antibody comprising a reactive site not present in the wild-type of the antibody and a complementarity-determining region that specifically binds to a metal...
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7115248 |
Radiolabeled annexins
Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.
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7097824 |
Tuftsin metallopeptide analogs and uses thereof
Tuftsin receptor-specific peptides, peptidomimetics and peptide-like constructs are provided, particularly for use in biological, pharmaceutical and radiopharmaceutical applications, in which the...
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