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5514363 |
Method for radiolabeling antibody fragments
A protein containing at least one pendant sulfhydryl group is directly radiolabeled with a radiometal which binds tightly to sulfhydryl groups, using one or more pendant sulfhydryl groups on the...
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5482698 |
Detection and therapy of lesions with biotin/avidin polymer conjugates
Methods of detecting and/or treating lesions in a patient are provided. The methods are an improvement over known methods comprising the steps of (a) parenterally injecting a subject with a...
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5433940 |
Inhibitors of thrombin
This invention relates to novel biologically active molecules which bind to and inhibit thrombin. Specifically, these molecules are characterized by a thrombin anion-binding exosite association...
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5422090 |
Human PAI-2
Minactivin (also known as Plasminogen Activator Inhibitor-2 [PAI-2]), a protein inactivator of urokinase-type plasminogen activator, has been shown to be a natural inactivator of this plasminogen...
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5403573 |
Radiolabeled protein composition and method for radiation synovectomy
A radiolabeled protein composition adapted for radiation therapy which comprises a radioisotope and a protein material containing about 6 or more percent amino acids which have a...
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5395608 |
Triamine chelants, their derivatives, complexes and conjugates
A group of functionalized triamine chelants and their derivatives that form complexes with radioactive metal ions are disclosed. The complexes can be covalently attached to a protein or an antibody...
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5395609 |
Synthetic peptides for use in tumor detection
Radioactively labelled peptides comprising oligopeptides of from 3 to 10 peptide units and containing the sequence RGD and particularly the oligopeptides RGDSY and RGDFY, are disclosed as in vivo...
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5387409 |
Boronic acid adducts of rhenium dioxime and technetium-99m dioxime complexes containing a biochemically active group
Boronic acid adducts of technetium-99m and radioactive rhenium dioxime complexes, each of which include biochemically active groups, are useful as diagnostic and therapeutic agents, respectively.
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5384113 |
Stabilizers to prevent autoradiolysis of radiolabeled peptides and proteins
Gentisic acid and its derivatives substantially inhibit peptide autoradiolysis. Gentisic acid or its derivatives may also be used in combination with other stabilizers such as inositol and ascorbic...
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5380646 |
Thrombus detection using radiolabelled disintegrins
Radiolabelled polypeptides derived from the Viperidae disintegrins are provided as well as a method for the detection of venous and arterial thrombi, pulmonary emboli and tumors or abscesses that...
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5376356 |
Imaging tissue sites of inflammation
The present invention involves a method of imaging tissue sites of inflammation which takes advantage of the up-regulation of surface antigenic markers on leukocytes upon activation thereof. A...
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5346670 |
Phthalocyanine and tetrabenztriazaporphyrin reagents
Red-shifted, water-soluble, fluorescent, monomerically-tetherable derivatives having the formula: ##STR1## wherein, M represents either H 2 or is selected from among the following metals:...
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5326551 |
Nuclear imaging uses of radio-labelled atrial natriuretic factor
Uptake, binding, and/or displacement of atrial natriuretic factor in a target organ of a mammal can be quantified by nuclear imaging. A diagnostically effective amount of a radio-labelled mammalian...
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5310536 |
Ligands for improving metal chelate formation kinetics
Amide-thiolate ligands having improved metal chelate formation kinetics are disclosed. The ligands include a tertiary amine strategically located to facilitate rapid formation of an...
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5308604 |
Conjugates for tumor localization and/or tumor therapy
The invention relates to conjugates composed of a) at least one polyalcohol or a derivatized polyalcohol, b) at least one active agent, c) at least one linker and d) a protein, wherein...
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5286850 |
Antibody DTPA-type ligand conjugates
The subject matter of the present invention relates to bifunctional cyclohexyl DPTA ligands and methods for utilizing these compounds. Antibody DTPA-type ligand conjugates are also provided.
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5279812 |
Radiolabeled anticoagulant peptides
This invention relates to the usage of anticoagulant peptide derivatives that are iodinated.
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5277892 |
In vivo lymphocyte tagging
Methods and reagents for the in vivo tagging of leukocytes, and in particular lymphocytes with a leukostimulatory agent and a linked medically useful metal ion, including a radioisotope, and...
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5277893 |
Direct radiolabeling of substrates containing monosulfides or disulfide bonds with radionuclides
Proteins containing one or more disulfide bonds are radiolabeled with radionuclides of technetium or rhenium for use in diagnosis and treatment of a variety of pathologic conditions. Radiolabeling...
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5270030 |
Fibrin binding domain polypeptide and method of producing
This invention provides an imaging agent which comprises a polypeptide labeled with an imageable marker, such polypeptide having an amino acid sequence substantially present in the fibrin binding...
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5245018 |
Process for preparing a radiopharmaceutical composition
A process for preparing a radiopharmaceutical composition comprising a technetium 99m chelate complex, comprises the steps of: (1) mixing (a) HSCH 2 CO--NHCH 2 CO--NHCH 2 CO--NHCH 2 COOH...
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5240693 |
Image enhancement by coadministration of biomodulators and structurally modified imaging agents
Biomodulators can be administered together with an agent such as a drug or an imaging agent (specific or non-specific) structurally modified to take advantage of perturbations of cell...
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5230883 |
Method for localization and treatment of tumors using polylysine complexes
Improved methods of selectively localizing, imaging and/or treating tumors, which have a net negative charge, employ novel compositions containing non-immunogenic complexes having a net positive...
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5223242 |
Negatively charged specific affinity reagents
An in vivo imaging or therapeutic method including administering to a mammal a specific affinity reagent including a physiologically compatible polymer bonded to one or more specific affinity...
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5219555 |
Method for labeling proteins with technetium or rhenium
The invention relates to a method for labeling substances with--in particular radioactive--technetium or rhenium isotopes with the aid of N-substituted or C-substituted macrocyclic amine...
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5217705 |
Method of diagnosing blood clots using fibrin-binding proteins
A fibrin-binding protein such as t-PA is labeled with a detectable substance, such as a radionuclide, and administered to a patient for diagnosis of blood clots and for monitoring the dissolution...
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5198424 |
Functionally active selectin-derived peptides
Peptides derived from three regions of the lectin binding region of GMP-140 have been found to selectively interact with "selectins", including GMP-140, ELAM-1, and lymphocyte homing receptor. The...
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5183653 |
Boronic acid adducts of metal dioxime complexes useful in labelling proteins and other amine-containing compounds
Boronic acid adducts of metal dioxime complexes are useful as reagents for labeling proteins and other amine-containing compounds.
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5180816 |
One vial method for labeling protein/linker conjugates with technetium-99M
A one vial method for labeling a protein, such as an antibody or antibody fragment, with a radiometal such as Tc-99m or a rhenium isotope, is disclosed. The method comprises contacting in a single...
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5171563 |
Cleavable linkers for the reduction of non-target organ retention of immunoconjugates
A process for reducing the non-target organ accumulation of immunoconjugates administered in vivo during therapeutic or diagnostic procedures involves the use of immunoconjugates comprising linkers...
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5169933 |
Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable...
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5167948 |
Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
The invention relates to a diagnostic or radiotherapeutic composition, comprising a hydrogen containing compound in addition to a pharmaceutically acceptable formulation means and optionally an...
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5164175 |
Diagnostic aid containing an organ-specific substance labeled with technetium-99m
The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ specific substance, or an organ-specific substance which has...
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5162505 |
Proteins modified with positively charged carriers and compositions prepared therefrom
Protein conjugates comprising a protein covalently linked to at least one positively charged agent, so that the protein conjugate has an overall net positive charge in aqueous conditions at...
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5133956 |
Radiolabeled metal-binding protein for the treatment of arthritis
Radioactive high molecular weight metal-binding protein compositions and a method for therapeutic radiation treatment including the treatment of rheumatoid arthritis comprising injection of a...
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5126122 |
Radiolabeled hyaluronectin composition for the diagnosis and/or treatment of cancer
This composition is made up of an injectable aqueous solution of a glycoprotein, hyalurenectin, onto which a radioactive element is bound.
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5098996 |
Process for introducing fluorine into biologically active materials
Radioactive fluorine can be easily introduced into biologically active molecules containing amino groups. A p-bromomethyl benzoyl group is coupled to the amino group of the biologically active...
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5096696 |
Binding of radiolabeled albumin fragments to fibrin clots
Compositions and methods useful in the diagnosis and treatment of vascular disorders in mammals is disclosed. Intact serum albumin is fragmented by a cleaving agent and thereafter albumin fragments...
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5094848 |
Cleavable diphosphate and amidated diphosphate linkers
The specificity of a pharmaceutical agent for a given site of action is increased by covalently bonding the agent via a diphosphate or amidated diphosphate bond to a targeting moiety, preferably a...
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5053216 |
Radioactive Jomol, its derivatives, processes for the production of these compounds, their use and product
The invention relates to radioactively tagged Jomol, and its derivatives, diagnostic compositions, and pharmaceutical preparations containing such Jomol or its derivatives, as well as to products...
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5000935 |
Treatment method utilizing transferrin-radioiodine conjugate
Conjugates of transferrin with a radioactive isotope of iodine are utilized to treat cancer in animals.
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4992255 |
Capillary depletion method for quantifying transcytosis through the blood-brain barrier
A method for quantifying transcytosis through the blood-brain barier by infusing a perfusate into the brain of a living mammal. The perfusate includes a radio-labelled test compound and a...
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4937067 |
Method and means for detection of adrenal metabolic activity
The metabolic activity of the adrenal gland can be monitored by intravenously injecting an infusate composed of low density lipoproteins labelled with a radioisotope that is suitable for...
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4895714 |
Radioiodinated apotransferrin for use in tumor diagnosis, imaging, localization or treatment
Conjugates of apotransferrin labelled with radioactive iodine are set forth along with a method of tumor imaging, diagnosis and localization using the radioiodinated apotransferrin.
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4885153 |
Radiohalogenated for proteins
Haloaryl compounds bearing a defined functional group or precursor are metalated with either Sn(n-Bu) 3 or SnMe 3 . The resulting aryltin compound may be transmetalated in site-specific reaction...
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4885151 |
Diagnostic aid for the scintigraphic visualization of malignant tumors comprising the substance obtained from enzymatic processing of murein using hen's eggwhite lysozyme
A diagnostic aid for the scintigraphic visualization of malignant tumors which contains a radionuclide which is bonded by means of a complex-forming agent to the substance obtained by the enzymatic...
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4855353 |
High molecular compounds having amino groups, and their utilization
A radioactive diagnostic or therapeutic agent, which comprises a metallic element-labeled high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino...
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4851209 |
Diagnostic procedures using radio labeled sucralfate and derivatives or precursors thereof
A novel diagnostic procedure for the in vivo clinical evaluation of gastrointestinal ulcer disease and other diseases associated with loss of mucosal integrity in humans which comprises the oral...
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4783313 |
Enhancing body defense mechanisms
Disclosed is a method of providing immuno-prophylaxis as well as malignant tumor immuno-therapy by administering a malignant-tumor-immunization and recession-provoking antigenic agent of malignant...
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4767609 |
Therapeutic and diagnostic processes using isotope transfer to chelator-target recognition molecule conjugate
A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially...
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