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5981477 |
Peptide-metal chelate conjugates
This invention relates to diagnostic and radiodiagnostic agents, including radiolabeled scintigraphic imaging agents, and therapeutic and radiotherapeutic agents. The invention provides such agents...
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5980861 |
Chelator compositions and methods of synthesis thereof
Compositions of radiolabeled nucleic acids and methods for synthesis and use thereof are disclosed.
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5981504 |
Genetic induction of receptors for targeted radiotherapy
The present invention provides a method to achieve radioisotopic localization at tumor sites, i.e., a method of enhancing radiolabeled ligand localization to a tumor in an individual in need of...
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5976496 |
Labeled somatostatin analogs for imaging cardiovascular disease
The present invention provides methods and kits for detecting cardiovascular disease in a living mammal, using a labeled form of a somatostatin analog. The methods and kits of the invention provide...
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5976493 |
Metabolically cleavable dendrimeric polychelants
The invention provides polychelant compounds which are useful for example in diagnostic imaging procedures and which are degradable in vivo to release excretable fragments. Such compounds...
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5976495 |
Peptide derived radionuclide chelators
For use in imaging sites of diagnostic interest within the body, the present invention provides radionuclide chelators of formula (I), wherein X is a linear or branched, saturated or unsaturated C...
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5972890 |
Synthetic peptides for arterial imaging
Vascular disease including asymptomatic atherosclerosis can be diagnosed by administering a synthetic peptide or peptide analog having an affinity for, and propensity to accumulate at, a site of...
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5968478 |
N- methyl piperazine compounds having dopamine receptor affinity
Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein X 1 is selected from CH 2 , NH, O and S; X 2 -- is selected from CH=, CH 2 --, and N=; R 1 to...
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5968476 |
Technetium-99m labeled peptides for thrombus imaging
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to specific binding peptides, methods and kits for making such peptides,...
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5968477 |
Radiolabeled annexin conjugates with hexose and a chelator
Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.
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5965131 |
Delivery of diagnostic and therapeutic agents to a target site
An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the...
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5961954 |
Chealators of type XN.sub.1 S.sub.1 X.sup.1 for radioactive isotopes, their metal complexes and their diagnostic and therapeutical uses
This invention relates to new bifunctional chelating agents with intermittent chalcogen atoms, pharmaceuticals containing these compounds, their use in radiodiagnostics and radiotherapy, and...
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5958374 |
Method for preparing radionuclide-labeled chelating agent-ligand complexes
Radionuclide-labeled chelating agent-ligand complexes that are useful in medical diagnosis or therapy are prepared by reacting a radionuclide, such as 90 Y or 111 In, with a polyfunctional...
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5955055 |
Synthetic peptides for arterial imaging at vascular imaging sites
Vascular disease including asymptomatic atherosclerosis can be diagnosed by administering a synthetic peptide or peptide analog having an affinity for, and propensity to accumulate at, a site of...
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5955437 |
Use of an anticoagulant as a diagnostic agent
Detectably labelled annexines and compositions thereof are disclosed. Also disclosed are methods for diagnosing a disruption or activation of the hemostatic system or a prothrombotic state in an...
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5955426 |
Cyclic hexapeptide somatostatin analogues
This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, and radiodiagnostic reagents and peptides. Specifically, the invention relates to...
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5948386 |
Conjugate and method for forming aminomethyl phosphorus conjugates
A method of forming phosphine-amine conjugates includes reacting a hydroxymethyl phosphine group of an amine-free first molecule with at least one free amine group of a second molecule to...
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5942210 |
Methods for lyoprotecting a macromolecule using tricine
This invention relates to lyoprotection agents for protecting macromolecules during lyophilization or freeze-drying. In particular, methods for use of these lyoprotectants in conjugate formulations...
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5932188 |
Therapeutic and diagnostic imaging compositions and methods
This invention provides therapeutic and diagnostic imaging compositions and methods featuring a polymer comprising units containing a poly(alkylene oxide) moiety linked to the residue of a...
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5932189 |
Cyclic peptide somatostatin analogs
This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, and radiodiagnostic reagents and peptides. Specifically, the invention relates to...
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5922301 |
Radiolabelled amino acid formulations stored in an unfrozen state
Additives are proposed for compositions comprising radiolabelled organic compounds e.g. 32P-labelled nucleotides. Stabilisers are selected from tryptophan, para-aminobenzoate, indoleacetate and the...
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5902566 |
Process for producing yttrium-90-labelled protein substrate
A process for the production of yttrium-90, generated by radioactive decay of strontium-90, by means of a generator including a column containing strontium-90 adsorbed on a cation-exchange resin,...
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5891418 |
Peptide-metal ion pharmaceutical constructs and applications
A peptide is provided for use as a diagnostic imaging, radiotherapeutic, or therapeutic agent, which peptide has a conformationally constrained global secondary structure obtained upon complexing...
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5888474 |
Technetium-99m labeled peptides for GPIIb/IIIa ligands useful for thrombus imaging
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to specific binding peptides, methods and kits for making such peptides,...
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5888970 |
Technetium-99m labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents
The present invention describes novel radiopharmaceuticals of formula (I): ##STR1## wherein J, K, L, and M, are amino acids or derivatives thereof and R', R 1 , R 2 and n are as defined herein,...
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5879656 |
Methods of treating metastatic colorectal cancer with ST receptor binding compounds
Conjugated compounds which comprises an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier or...
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5871711 |
Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to...
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5871937 |
Acute phase protein modulating endotoxic activity of lipopolysaccharides, assay methods and polypeptides
A lipopolysaccharide binding protein is disclosed as are an assay method, polypeptides and antibodies related to that binding protein. The binding protein: (a) is present in impure form in acute...
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5871710 |
Graft co-polymer adducts of platinum (II) compounds
A biocompatible graft co-polymer adduct including a polymeric carrier, a protective chain linked to the polymeric carrier, a reporter group linked to the carrier or to the carrier and the...
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5861139 |
Direct labeling of peptides with metal ions
Proteins containing one or more disulfide bonds or monosulfides are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of pathologic conditions. Labeling is...
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5851797 |
Tie ligand-3, methods of making and uses thereof
The present invention provides for an isolated nucleic acid molecule encoding TIE ligand-3. In addition, the invention provides for a receptorbody which specifically binds TIE ligand-3. The...
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5843396 |
Method for stabilizing radiolabeled organic compounds by adding a separate stabilizing compound
A stabilized composition comprising an organic compound labeled with a β-emitting radionuclide and a stabilizing effective amount of a non-radiolabeled stabilizing compound selected from the group...
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5837218 |
Non-receptor cell mediated imaging agents
Detectably labelled non-receptor mediated cell-associating compounds are provided for use in the diagnostic imaging of target sites in a mammal. Cell-associating compounds may be directly labelled,...
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5833942 |
Technetium-99m labeled somatostatin-derived peptides for imaging and therapeutic uses
This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to...
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5830431 |
Radiolabeled peptide compositions for site-specific targeting
This invention relates to radiolabeled peptide compositions for radiopharmaceutical use and, more specifically, to radiolabeled peptides for diagnostic or therapeutic use having an unmodified...
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5827498 |
Tumor affinity peptide, and radioactive diagnostic agent and radioactive therapeutic agent containing the peptide
A peptide having affinity with tumor or a salt thereof, which comprises an amino acid sequence containing 20 or less amino acid residues, said amino acid sequence being described as X 1 ...
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5820845 |
Somatostatin-derived peptides for imaging and therapeutic uses
This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to...
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5814297 |
Technetium-99m labeled peptides for imaging having a single thiol containing moiety
The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides...
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5807537 |
Technetium-99m labeled peptides for imaging comprising a single thiol moiety
The invention elates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides...
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5804158 |
Sequestered imaging agents
Compounds useful for high resolution diagnostic imaging incorporate an imaging agent having a chelator that is linked by a metal-cleavable bond to a ligand that has affinity for a site removed from...
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5804157 |
Peptide compositions and method of radiolabeling
This invention relates to radiolabeled peptide compositions for radiopharmaceutical use and, more specifically, to radiolabeled peptides for diagnostic or therapeutic use having an unmodified...
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5800802 |
Chelator IDAC-2
A method for removing unbound labeling reagent from a composition comprising bound and unbound labeling reagents in which a chelator-matrix conjugate capable of binding unbound labeling reagent is...
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5792444 |
Labeled chemotactic peptides to image focal sites of infection or inflammation
The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a...
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5785948 |
Metal chelate forming peptides and use thereof represented by three amino acid sequences
The invention provides, inter alia, metal radionuclide-labelled reagent comprising a metal radionuclide coordinated with a metal chelate forming peptide having an amino acid sequence of three amino...
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5783171 |
Radionuclide metal N.sub.2 S.sub.2 chelates substituted with glucose and biotin moieties
Chelating compounds of specified structure are useful for radiolabeling targeting proteins such as antibodies as well as proteinaceous and non-proteinaceous ligands and anti-ligands. The...
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5762906 |
Further improvements relating to radiolabelling of proteins
A structurally modified protein is provided that will bind to a tumor-associated structure wherein the amino group in at least one basic amino acid in the binding protein is structurally modified...
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5759517 |
Hemoglobins as drug delivery agents
A tracer, such as a radioisotope, is conjugated to a hemoglobin-like protein, such as normal hemoglobin, for use as an in vitro diagnostic imaging agent.
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5759515 |
Polyvalent peptide pharmaceutical applications
High affinity linked, branched or linear repeat peptides containing two or more biological-function domains and at least one medically useful metal ion-binding domain are labeled with medically...
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5759516 |
Peptide-metal ion pharmaceutical preparation
Peptides containing a biological-function domain and a medically useful metal ion-binding domain are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of...
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5756065 |
Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
A group conjugates having a functionalized polyaminocarboxylate chelant that form complexes with rare earth-type metal ions, covalently attached to an antibody or antibody fragment, can be used for...
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