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7384977 |
Water soluble paclitaxel prodrugs
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or...
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7384624 |
Oral contrast and method of producing the oral contrast
Oral contrast compositions are used as an aid for CAT scans and are ideally fast-flowing and good tasting for assisting in quick preparation of a patient in today's extremely active and busy...
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7381400 |
Injection of a radioactive dye for sentinel lymph node identification
A one-step procedure for sentinel lymph node identification and biopsy using a single compound, a radiolabeled, low molecular weight dye (e.g., 125 I-labeled methylene blue). This radiolabled dye...
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7381399 |
Technetium-dipyridine complexes, and methods of use thereof
One aspect of the invention relates to novel complexes of technetium (Tc) with various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a...
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7378079 |
Agents for imaging and diagnostic methods using them
The present invention provides novel compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their plasma membrane, while binding to a lesser...
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7378077 |
High dose radionuclide complexes for bone marrow suppression
The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases,...
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7371719 |
Self-assembly of peptide-amphiphile nanofibers under physiological conditions
Peptide amphiphile compounds, compositions and methods for self-assembly or nanofibrous network formation under neutral or physiological conditions.
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7368254 |
Lipid-based systems for targeting diagnostic agents
The invention relates to targeting of diagnostic agents by use of lipid-based compositions. The invention is useful in the diagnosis of various disorders which are associated with or resulting from...
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7364719 |
Vasoregulating compounds and methods of their use
Methods and compounds are described for regulating blood pressure in a subject. Specific embodiments are methods for reversing vasodilation of blood vessels, by administering to a subject a...
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7351401 |
Thioflavin derivatives for use in the antemortem diagnosis of Alzheimers disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
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7351399 |
Prodrugs for phosphorus-containing compounds
Prodrugs of formula I, their uses, their intermediates, and their method of manufacture are described:
and pharmaceutically acceptable prodrugs and salts thereof.
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7351398 |
Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic thioether.
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7351397 |
Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy chromans
Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic 6-hydroxy-chroman derivative.
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7347984 |
Mammalian agmatinase inhibitory substance
The present invention provides for methods and compounds for treating brain trauma and disorders such as: ischemia, stroke, neurodegenerative disorders, opioid addiction, idiopathic pain, epilepsy,...
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7344701 |
Xanthene dyes
The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like....
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7344700 |
Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
Provided is a class of radiolabeled androgen receptor targeting agents (ARTA), useful for prostate cancer imaging and in treating or preventing prostate cancer. The agents define a new-subclass of...
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7341708 |
Methods for producing pure amino acid chelate complexes, and uses thereof
A two-stage method of preparing essentially pure amino acid chelates, wherein the first stage comprises contacting a metal ion from a metal oxide or hydroxide with an amino acid thereby producing a...
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7338652 |
Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents
New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such...
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7335652 |
Neurofibrillary labels
Disclosed are methods for determining the stage of neurofibrillary degeneration associated with a tauopathy in a subject believed to suffer from the disease, by (i) introducing into the subject a...
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7335632 |
Beta-secretase inhibitors and methods of use thereof
The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
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7335347 |
Methods for purifying radiolabelled compounds
One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a...
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7332149 |
Vitronectin receptor antagonist pharmaceuticals
The present invention describes novel compounds of the formula:
(Q) d —L n —C h ,
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7329401 |
Cyclooxygenase-2 selective agents useful as imaging probes and related methods
This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2...
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7320784 |
Immobilized labeling compounds and methods
The invention includes methods and compounds for labelling conjugates with metals which comprise the steps of coupling the conjugate to a support surface; introducing a complex-forming metal to the...
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7320783 |
Methods and compositions for the enhancement of wound healing
The present invention relates to methods and compositions for wound healing, and in particular, methods and compositions to promote and enhance wound healing. In particular, the present invention...
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7314609 |
Stereoisomers of fatty acid analogs for diagnostic imaging
The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a...
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7306786 |
Calcium phosphate cements comprising a water-soluble contrast agent
Methods are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products and include a contrast agent. In the subject methods, dry reactants that include a...
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7306785 |
Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety...
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7306784 |
Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant...
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7303739 |
Prodrugs for liver specific drug delivery
The present invention is directed towards novel cyclic phosph(oramid)ate prodrugs of alcohol-, amine-, and thiol-containing drugs, their preparation, their synthetic intermediates, and their uses....
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7300644 |
Targeted combination immunotherapy
The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities,...
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7294329 |
Poly(vinyl acetal) coatings for implantable medical devices
A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a polyacetal-based polymer.
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7288244 |
Determining vulnerable plaque in blood vessels
The invention is based on the realisation that inflamed plaques in blood vessel walls, which are potentially vulnerable to rupture, can be detected at elevated temperatures which are lower than...
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7279149 |
Amino acid composition with increased blood brain barrier permeability
An amino acid composition with improved blood brain barrier permeability comprising an amino acid polymer, wherein the amino acid comprises at least one asparagyl-4-aminobutane or...
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7273601 |
Preparation of radiolabelled haloaromatics via polymer-bound intermediates
According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate...
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7270800 |
Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
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7268220 |
Bridged aromatic substituted amine ligands with donor atoms
The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of...
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7261876 |
Multivalent constructs for therapeutic and diagnostic applications
The invention provides compositions and methods for therapeutic and diagnostic applications.
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7261875 |
Dendritic poly (amino acid) carriers and methods of use
The present invention concerns a design for dendritic poly(amino acid) polymer carriers, also known as nonlinear polymers, and their applications. These dendritic poly(amino acid) carriers have...
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7252815 |
Pathological tissue detection and treatment employing targeted benzoindole optical agents
Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor...
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7250154 |
Radio-opaque polymeric biomaterials
A radio-opaque dihydroxy compound substituted with at least one bromine or iodine atom. Radio-opaque medical implants and drug delivery devices and methods for therapeutic site-specific or systemic...
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7238341 |
Peptide-based multimeric targeted contrast agents
Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
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7238340 |
Monoamine, diamide, thiol-containing metal chelating agents
Therapeutically active thiazole derivatives of formula (I) wherein R 1 -R 2 , X and X′ as are defined in the specification, processes for the preparation thereof, the use thereof in therapy,...
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7238339 |
Bifunctional chelating compounds containing hydroxamic acid residues
New types of hydroxamic acid-based bifunctional chelators are provided. These chelators are designed to chelate metal ions that can be detected either by their paramagnetic or radioactive...
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7238338 |
System and method for the large scale labeling of compounds with radiohalogens
Disclosed are methods for manufacturing radiohalogen-labeled steroids, nucleosides, nucleotides and proteins, for example, pyrimidines and proteins. Methods according to the example embodiments...
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7229604 |
Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
The invention provides, in a general sense, a new labeling strategy employing 99m Tc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99m Tc for...
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7229603 |
Stablilized and lyophilized radiopharmaceutical agents
A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a...
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7226578 |
Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the...
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7226577 |
Gastrin releasing peptide compounds
New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N-O-P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not),...
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7220753 |
2,7-substituted octahydro-1H-pyrido[1,2-a]pyrazine derivatives as ligands for serotonin receptors
Substituted pyrido[1,2-a]pyrazines of general formula I; wherein Ar and Ar 1 represent various carbocyclic and heterocyclic aromatic rings; A represents O, S, SO, SO 2 , CHOH, C═O, or —(CR 3 R...
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