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7384623 |
High energy phototherapeutic agents
High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive...
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7374765 |
Methods and compositions for diagnosis and treatment of iron misregulation diseases
Methods and compositions are provided for the diagnosis and treatment of iron misregulation diseases, including HFE polypeptides, agonists, and antagonists, and transferrin receptor agonists and...
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7312461 |
Laparoscopic tumor therapy using high energy electron irradiation
A laparoscopic tumor therapy method and an articulated electron beam transport system are provided for use with a high power, long focus electron source for tumor therapy. The high power, long...
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7201890 |
Intraoperative, intravascular and endoscopic tumor and lesion detection, biopsy and therapy
Methods are provided for close-range intraoperative, endoscopic and intravascular detection and treatment of lesions, including tumors and non-malignant lesions. The methods use antibody fragments...
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7045503 |
Radiometal-binding peptide analogues
Novel metal binding ligands are disclosed that may be coupled to peptides for use in methods of diagnosis and therapy. Peptides containing the ligands are produced using a method wherein ligand...
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7022483 |
Methods for identifying and isolating antigen-specific T cells
The present invention is directed to methods for the identification and isolation of antigen-specific T cells using a novel class of artificial antigen presenting cells. The resulting T cells may...
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6913767 |
Compositions for microencapsulation of antigens for use as vaccines
Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided...
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6709652 |
Pretargeting methods and compounds
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for...
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6676622 |
Extracorporeal affinity adsorption methods for the treatment of atherosclerosis, cancer, degenerative and autoimmune diseases
Extracorporeal affinity adsorption treatments which are aimed at the substantial removal of two or more compounds that are etiological in the pathogenesis of diseases in man provide effective...
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6635234 |
Preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning
Processes for the preparation, prepared solutions, and the use of radium-223 for the treatment of calcified tumors, bone tumors, treatment of bones, bone surfaces and soft tissues is described.
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6632615 |
Method for isolating a target biological material, capture phase, detecting phase and reagent containing them
The invention concerns a method for isolating a target biological material contained in a sample, which consists in providing a capture phase comprising an organic molecule having at least a...
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6576239 |
Angiogenic homing molecules and conjugates derived therefrom
The present invention provides tumor homing molecules, which selectively home to a tumor. The invention also provides methods of using a tumor homing molecule to target an agent such as a drug to a...
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6569112 |
Extracorporeal affinity adsorption device
Extracorporeal affinity adsorption treatments which are aimed at the substantial removal of two or more compounds that are etiological in the pathogenesis of diseases in man provide effective...
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6468503 |
Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic precipitates in the cancer
A method for the treatment of cancer is disclosed which is capable of directing supra-lethal doses of radiation, called Hot-Spots, virtually exclusively to the cancer. The present invention...
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6375927 |
Methods of radiotherapy using biomodulators
Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue...
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6299860 |
Method for viewing diseased tissue located within a body cavity
Methods are provided for in vivo detection of tissue associated with a disease state in a subject, such as tissue located in a body opening. In the invention method, the subject is administered a...
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6265187 |
Recombinant endotoxin-neutralizing proteins
In general, the invention features a recombinant endotoxin-neutralizing polypeptide (RENP) characterized by (i) an amino acid sequence, (ii) an amino acid sequence and structure that facilitates...
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6248304 |
Scintigraphic imaging agents
This invention provides scintigraphic imaging agents and reagents for preparing said agents, methods for radiolabeling said reagents and kits containing non-radioactive reagents and other...
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6193948 |
Antigen recognized by patients with antibody associated paraneoplastic sensory neuronopathy, DNA encoding same and uses thereof
An isolated nucleic acid sequence encoding Hu paraneoplastic antigenic polypeptide is provided by this invention. This invention also provides a purified Hu antigenic polypeptide and compositions...
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6165988 |
Medicament in particulate form
The medicament in particulate form has one or more anionic or partially anionic active substances bound to a carrier material. The carrier material includes particulate copolymer or homopolymer of...
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6126916 |
Radiometal-binding peptide analogues
Novel metal binding ligands are disclosed that may be coupled to peptides for use in methods of diagnosis and therapy. Peptides containing the ligands are produced using a method wherein ligand...
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6033644 |
Biomodulators as universal imaging agents
Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue...
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5965131 |
Delivery of diagnostic and therapeutic agents to a target site
An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the...
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5965106 |
In vivo binding pair pretargeting
A method for in-vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in...
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5906807 |
Method of MRI using biomodulators
Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue...
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5814295 |
Determination of lymph nodes enriched in tumor reactive cells their proliferation and their use in adoptive cellular therapy
The present invention is directed to a method for reliably determining lymph nodes enriched in tumor reactive cells, e.g., CD4+tumor-specific lymphocytes. This method includes the steps of...
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5756685 |
Protein conjugate containing metal radionuclide labeled proteins
Protein, ligand and anti-ligand conjugated chelated metal radionuclides are provided for use in vivo. Intermediates are provided for preparing the compositions efficiently.
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5707603 |
Pyridine complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions
The invention provides targeting radioactive immunoreagents comprising a metal radionuclide ion, a complexing agent having structure A-I, as defined in the specification, and an immunoreactive...
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5660811 |
Isotopic tracer composition and method for making and using same
An isotopic tracer composition and methods of making and using same for radiological evaluation of body functions and diseases in a subject and for radiological therapy. The isotopic tracer...
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5474904 |
Methods of imaging cancer cells using modified C-reactive protein
The invention provides a method of treating cancer in a mammal comprising administering to the mammal an effective amount of modified C-reactive protein ("mCRP"). The invention also provides a...
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5431899 |
Rotavirus VP6 as a diagnostic and targeting agent
Advantage is taken of the ability of rotaviral VP6 protein to home to macrophage and monocytes to provide label to these cells in either an in vitro or in vivo environment. Further, the ability to...
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5256395 |
Affinity enhancement immunological reagents for in vivo detection and killing of specific target cells
Immunological reagents, consisting of a) antibody or fragment conjugates having both an anti-cell specificity and an anti-hapten specificity, and b) synthetic tracers containing at least two hapten...
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4863713 |
Method and system for administering therapeutic and diagnostic agents
A method and system for localizing a diagnostic or therapeutic agent to an internal target site. The system includes (1) an epitopic compound, (2) a binding protein which is effective to bind...
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4783313 |
Enhancing body defense mechanisms
Disclosed is a method of providing immuno-prophylaxis as well as malignant tumor immuno-therapy by administering a malignant-tumor-immunization and recession-provoking antigenic agent of malignant...
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4767609 |
Therapeutic and diagnostic processes using isotope transfer to chelator-target recognition molecule conjugate
A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially...
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4705677 |
Immunization
Disclosed is a method of providing immuno-prophylaxis as well as malignant tumor immuno-therapy by administering a malignant-tumor-immunization and recession-provoking antigenic agent of malignant...
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4430318 |
Immunoassay utilizing .sup.125 I Protein A
An improved method for the preparation of 125 I-labelled Protein A ( 125 I PA) of high specific and functional activity. 125 I PA has been used in combination with purified rabbit IgG...
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4425320 |
Method and apparatus for carrying out solid phase in vitro diagnostic assays
A fluid receptacle is provided with a retainer on the inner surface thereof for confining at least the reactive portion of a coated insert matrix within the receptacle during inversion thereof. The...
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4421735 |
Radiolabeled diagnostic compositions and method for making the same
Protein molecules are covalently bonded to a chelating agent which in turn binds a radioactive molecule. Prior to binding, the radioactive molecule is reduced with dithionite ion and then mixed...
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4415546 |
Biologically active analogs of ACTH and radioimmuno assay therefor
A fully steroidogenically active analog of ACTH is disclosed. The analog differs from natural ACTH in that phenylalanine replaces tyrosine in the second position on the peptide chain; and...
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4376760 |
Tridecapeptide
The tridecapeptide of the formula H-Met-Ser-Tyr-Asn-Leu-Leu-Gly-Phe-Leu-Gln-Arg-Ser-Ser-OH and the use thereof as a hapten, tracer or antibody.
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4356165 |
Bupropion radioimmunoassay, and kit
A radioimmunoassay proceedure has been discovered for bupropion [(±)-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1##...
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4340581 |
Process for the immunological determination of basal membrane material and new basal membrane suitable therefor
This invention relates to a process for the immunological determination of asal membrane material in body fluids and provides new basal membrane fragments suitable for such determination, and a...
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4318899 |
Encainide assay method
A reliable and sensitive immunoassay for encainide in biological fluids including a novel hapten required for antigen synthesis and an immunologically homologous labeled tracer is provided.
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4273756 |
Immunoassay for class specific antibodies
The present invention encompasses a method for determining a class specific antibody to an antigen comprising: (a) binding an antibody for a specific immunoglobulin class to a solid support to...
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4146603 |
Tumor specific glycoproteins and method for detecting tumorigenic cancers
A new class of glycoproteins has been found to be produced by human cancer cells and is not produced by normal cells and said glycoprotein is present in the sera of cancer patients. This tumor...
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4136160 |
Specific assay for active demyelinization
A specific test for active demyelinzation is based on a discovery that free myelin basic protein can be detected in cerebrospinal fluid by the use of a radioimmunoassay, and that the level of basic...
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4107284 |
Radioimmunoassay procedure using a stabilized complex
An improved radioimmunoassay procedure involves the use of a stabilized complex of labelled antigen and antibody which has an extended shelf life as compared to the same complex absent the...
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