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7381407 |
Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods...
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7371534 |
Sensitive intracellular calcium assay
A sensitive intracellular calcium assay is disclosed comprising conveniently a reagent comprised of a dye precursor capable of entering cells and being hydrolyzed to a dye, whereby the dye...
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7368098 |
Use of biomolecular targets in the treatment and visualization of tumors
The present invention relates to the use of a protein that is differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as a biomolecular target for tumor...
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7361336 |
Methods of cancer therapy targeted against a cancer stem line
Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous...
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7351398 |
Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic thioether.
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7351397 |
Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy chromans
Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic 6-hydroxy-chroman derivative.
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7329400 |
Generator for rhenium-188
Radioisotope generators comprising inorganic layered hydroxide composition, such as magnesium aluminates and lithium aluminates. These inorganic layered hydroxides form anion exchange materials...
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7326402 |
Method of diagnosing, monitoring, staging, imaging and treating cancer
The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating cancer.
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7312461 |
Laparoscopic tumor therapy using high energy electron irradiation
A laparoscopic tumor therapy method and an articulated electron beam transport system are provided for use with a high power, long focus electron source for tumor therapy. The high power, long...
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7306782 |
Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases
The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide...
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7300644 |
Targeted combination immunotherapy
The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities,...
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7288534 |
Sphingomyelin enhancement of tumor therapy
Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing...
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7279150 |
Chelating agents with lipophilic carriers
Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the...
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7252961 |
Competitive immunoassay using complexed analyte derivatives
The invention relates to a method for the detection of an analyte in a competitive immunoassay in the presence of an analyte derivative and first and second receptor molecules, and to a kit for...
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7252815 |
Pathological tissue detection and treatment employing targeted benzoindole optical agents
Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor...
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7235239 |
Antibodies to a chemokine expressed in inflamed adenoid
The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for...
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7229604 |
Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
The invention provides, in a general sense, a new labeling strategy employing 99m Tc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99m Tc for...
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7229603 |
Stablilized and lyophilized radiopharmaceutical agents
A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a...
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7220399 |
Alpha or beta emitters attached to fragments in radioimmunotherapy
The present invention relates to radioimmunoconjugates useful in targeted radioimmunotherapy and methods of treating a patient using radioimmunoconjugates. The radioimmunoconjugates of the present...
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7214658 |
Method of delivering a TNF antagonist to the brain of a human by perispinal administration without direct intrathecal injection
The present invention provides specific methods of using and administering etanercept to improve cognitive function in a human, for both the treatment and prevention of cognitive impairment, or,...
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7201890 |
Intraoperative, intravascular and endoscopic tumor and lesion detection, biopsy and therapy
Methods are provided for close-range intraoperative, endoscopic and intravascular detection and treatment of lesions, including tumors and non-malignant lesions. The methods use antibody fragments...
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7195750 |
Clinical parameters for determining hematologic toxicity prior to radioimmunotherapy
New clinical parameters are reported which may serve as predictors of the hematological toxicity associated with therapeutic radiolabeled antibodies, particularly those antibodies which target...
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7135296 |
Elemental analysis of tagged biologically active materials
Improved methods for the detection and quantitation of labeled biological materials in a sample using elemental spectroscopic detection are described. Element-labeled biologically active materials,...
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7125541 |
Combined methods for tumor vasculature targeting and tumor treatment with radiotherapy
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects,...
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7112317 |
Combined methods and compositions for tumor vasculature targeting and tumor treatment
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects,...
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7105149 |
Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/myeloma
This invention provides an isolated nucleic acid molecule which encodes immunoglobulin receptor, Immunoglobulin superfamily Receptor Translocation Associated, IRTA, protein. Provided too, are the...
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7097985 |
Antibodies to human chemokine beta-9
Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for...
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7094404 |
Method for treating malignancy and autoimmune disorders in humans using tac antibodies
The present invention relates to a method for treating conditions associated with elevated levels of Tac-positive cells, including malignancy and autoimmune disorders and for preventing allograft...
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7087395 |
Vitamin D assay
The present invention features a kit and a method of using the kit for determining a concentration of a vitamin D component. The kit comprises a releasing composition and a detecting composition....
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7067110 |
Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen...
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7067109 |
Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids
Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor...
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7060272 |
Death domain containing receptor-4 agonist antibodies and methods
The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid...
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7056680 |
Antibodies to claudin-50 polypeptide
The sequence of a cDNA encoding Claudin-50 and sequence of Claudin-50 protein are disclosed. The cDNA can be used to express the protein or portions thereof or to obtain antibodies capable of...
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7045127 |
Human anti-epidermal growth factor receptor single-chain antibodies
Human anti-epidermal growth factor receptor (EGFR) single-chain antibodies (scFvs) were isolated from a human IgM phage display library using purified epidermal growth factor receptor as antigen....
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7029652 |
Method of treating tumors
A method of treating tumors, such as prostate tumors, breast tumors, non-Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an...
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7026456 |
Antibodies against human IL-12
The present invention relates to novel p75 heterodimer specific anti-human IL-12 antibodies that are characterized by a higher potency and greater efficacy in neutralizing human IL-12 bioactivity...
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7014838 |
Use of biomolecular targets in the treatment and visualization of brain tumors
The present invention relates to the use of proteins that are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor...
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7011816 |
Labeling targeting agents with gallium-68 and gallium-67
A method and compositions are described for labeling a targeting agent with Ga-68, in which eluate from an acid-eluted Ge-68/Ga-68 generator is combined with a macrocycle-containing targetable...
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6953567 |
Fluorination of proteins and peptides for F-18 positron emission tomography
Thiol-containing peptides can be radiolabeled with fluorine-18 (F-18) by reacting a peptide comprising a free thiol group with an F-18-bound labelling reagent which also has a group that is...
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6919067 |
Compositions comprising a tissue glue and therapeutic agents
The present invention concerns compositions comprising a radiotherapeutic agent, or an agent which can be converted to a radiotherapeutic, and a tissue glue. The compositions of the present...
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6893625 |
Chimeric antibody with specificity to human B cell surface antigen
A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production,...
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6863887 |
Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis
The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered...
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6846476 |
Treatment of B-cell associated diseases
Treatment of B-cell associated diseases including autoimmune and B-cell malignancies such as leukemias, lymphomas, using the combination of an anti-CD20 antibody, preferably RITUXAN® and a...
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6835370 |
Diagnosis and treatment of malignant neoplasms
The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an...
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6827925 |
Specific binding proteins including antibodies which bind to the necrotic center of tumors, and uses thereof
Specific binding members, based on the third CDR of the antibody NHS76 (SEQ ID NO: 2) are provided, together with their use in methods of treatment and diagnosis.
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6790661 |
System for detecting bacteria in blood, blood products, and fluids of tissues
The invention provides methods for screening for the presence of a clinically relevant amount of bacteria in donor blood or a blood product from a donor mammal, particularly blood or a blood...
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6773928 |
Compositions and methods for enhancing bioassay performance
Compositions of matter and methods for enhancing bioassay performance are disclosed. More particularly, the composition of matter comprises a molecularly compact polymer-ligand conjugate capable of...
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6760612 |
Method for detecting lymphoid tissue in tumor progression
A method is provided for detecting lymphoid tissues containing shed tumor antigen in an individual. A detector molecule, with binding specificity for shed tumor antigen, is administered to an...
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6743411 |
Extracorporal system for treating disease with radionucleotides
A composition of matter comprises a pathogen-targeting organic moiety which is conjugated to a radioisotope which has a half-life of less than 100 days. The composition can be synthesized by...
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6740304 |
Receptor binding conjugates
The present invention relates to a receptor binding conjugate which consists of an antibody, a radionuclide and folate or a folate derivative, wherein or not the conjugate possesses dual binding...
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