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5738836 |
Composition for stabilizing radiolabeled organic compounds
A stabilized composition comprising an organic compound labeled with a β-emitting radionuclide and a stabilizing effective amount of a non-radiolabeled stabilizing compound selected from the group...
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5736346 |
Induction of the acrosome reaction to evaluate the fertilization capability of mammalian sperm using a dendrimer sugar conjugate
A method of evaluating the in vitro or in vivo fertilization capability of a given sperm sample. The method involves the steps of capacitating a sample of mammalian sperm cells followed by...
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5730981 |
Monoclonal anti-ganglioside antibody and its preparation
The invention relates to monoclonal antibodies of high avidity, which react specifically with the gangliosides GD3 and GQ1b, and to their use for detecting melanomas and other tumors or tissues...
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5728369 |
Radioactive phosphorus labeling of proteins for targeted radiotherapy
32 P- and 33 P-labeled proteins which are useful for radiotherapy are prepared by stably linking 32 P- or 33 P- containing molecules to targeting proteins in such a way that the targeting...
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5723102 |
Process for the preparation of an organ-specific substance labeled with technetium-99m
The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ-specific substance, or an organ-specific substance which has...
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5716595 |
Intraperative, intravascular and endoscopic tumor and lesion detection and therapy with monovalent antibody fragments
Methods are provided for close-range intraoperative, endoscopic and intravascular detection and treatment of lesions, including tumors and non-malignant lesions. The methods use agents labeled with...
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5714149 |
Crosslinked antibodies and processes for their preparation
Cross-linked antibody conjugates are described which have at least one interchain bridge containing a reporter or effector molecule. The bridge may be the residue of a homo-or heterofunctional...
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5714166 |
Bioactive and/or targeted dendrimer conjugates
Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response...
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5690903 |
Loading and conjugating cavity biostructures
Methods for the preparation and use of a biological delivery system are disclosed. The method of preparation includes the loading of a non-biological material into a biostructure having a...
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5683674 |
Antibody against human mucin core protein and method of preparing and using same
Antibodies which bind to the core protein of the human polymorphic epithelial mucin glycoprotein are useful in the diagnosis of cancer.
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5679318 |
Stable therapeutic radionuclide compositions and methods for preparation thereof
Stable therapeutic radionuclide compositions comprising, for example, 186 Re, 188 Re and 131 I stably bound to a proteinaceous targeting moiety and suitable for human in vivo administration...
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5670132 |
Modified radioantibody fragments for reduced renal uptake
PEG-modified-Tc-99m-radiolabeled antibody fragments are useful for radioimmunodetection of tumors and infectious lesions and display striking reductions in renal uptake and retention of...
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5660811 |
Isotopic tracer composition and method for making and using same
An isotopic tracer composition and methods of making and using same for radiological evaluation of body functions and diseases in a subject and for radiological therapy. The isotopic tracer...
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5648059 |
Methods for reducing non-target retention of immunoconjugates and metabolites thereof
Methods for reducing non-target retention of active moieties associated with immunoconjugates and their metabolites, and more specifically, for reducing renal retention of such active moieties, are...
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5648471 |
One vial method for labeling antibodies with Technetium-99m
A one vial method for labeling a sulfhydryl containing antibody or antibody fragment with technetium-99m is disclosed. The method comprises contacting an antibody mixture comprised of a sulfhydryl...
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5643549 |
Leukostimulatory agent for in vivo leukocyte tagging
Methods and reagents for the in vivo tagging of leukocytes, and in particular lymphocytes, with a leukostimulatory agent and a linked medically useful metal ion, including a radioisotope, and...
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5643550 |
Method of treating colorectal carcinoma lesion and composition for use therein
This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface...
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5641471 |
Method for preparing .sup.213 Bi for therapeutic use
The present invention relates to the field of site directed therapy. More specifically it relates to site directed radio therapy. It provides a method for production of radioimmuno conjugates and...
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5632969 |
N.sub.3 S.sub.2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
Novel N 3 S 2 chelating ligands can be chelated to a radiodetectable element, Tc or Re, and are useful for radiolabeling peptides. A group of peptides especially useful are somatostatin...
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5632968 |
Detection of cardiovascular lesions
This invention relates to reagents and methods for detecting and imaging cardiovascular lesions such as atherosclerotic plaques, vascular clots including thrombi and emboli, myocardial infarction,...
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5630996 |
Two-step pretargeting methods using improved biotin-active agent conjugates
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for...
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RE35500 |
Direct radiolabeling of antibodies and other proteins with technetium or rhenium
Proteins containing one or more disulfide bonds are radiolabeled with radionuclides of technetium or rhenium for use in diagnosis and treatment of a variety of pathologic conditions. Radiolabeling...
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5626830 |
Anti-myosin mouse monoclonal antibody and method of use for diagnosis of myocardial infarction
A monoclonal antibody or antigen binding fragment thereof which recognizes light meromyosin fragments of α- and β-type human cardiac myosin heavy chains that remain in situ after myocardial cell...
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5624659 |
Method of treating brain tumors expressing tenascin
Methods of treating solid and cystic tumors are disclosed. The method comprises administering to a subject afflicted with a cystic tumor an antibody which binds to tenascin in a therapeutically...
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5612032 |
Method for diagnosing tumors using mouse monoclonal antibodies
The subject invention relates to monoclonal antibodies and uses thereof. In particular, the invention relates to three monoclonal antibodies, referred to as B1, B3, and B5, which are useful in the...
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5612016 |
Conjugates of antibodies and bifunctional ligands
Provided are conjugates useful in cancer, cardiovascular or infectious disease detection and/or therapy. The conjugate is of a ligand and protein. The ligand has a moiety capable of binding to...
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5609846 |
Radiolabelled antibody cytotoxic therapy of infectious or autoimmune disease
Anticancer, antimicrobial and autoimmune disease, and anti-organ rejection therapy using cytotoxic agents is improved using cytokines to prevent, mitigate or reverse adverse radiation-induced or...
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RE35457 |
Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction
Proteins are radiolabeled with radionuclides of technetium or rhenium by a process in which the disulfide bonds of the protein are first partially reduced with stannous salts or other disulfide...
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5595721 |
Radioimmunotherapy of lymphoma using anti-CD20
Methods for the treatment of lymphoma by adminstration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled...
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5589154 |
Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
Methods for preventing or treating vascular hemorrhaging such as that incident to thrombolytic therapy, or characteristic of Alzheimer's and related diseases are provided. Such methods provide...
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5578287 |
Three-step pretargeting methods using improved biotin-active agent
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, three-step pretargeting methods are described.
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5571797 |
Method of inducing gene expression by ionizing radiation
The present invention provides a method for delivering ionizing radiation to specific tissues, resulting in the activation of a DNA molecule comprising a radiation responsive enhancer-promoter...
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5569446 |
Radiohalogenation of proteins using trihalophenyl derivatives
Compounds, useful as radiolabeling reagents, including a trihalogenated phenyl ring and having the formula ##STR1## wherein X 1 , X 2 and X 3 are halogens, one of which may be a radiohalogen, are...
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5558852 |
Methods of treating melanomas and gliomas with monoclonal antibody Me1-14
Methods of treating solid or cystic tumors are disclosed. The method comprises administering to a human subject afflicted with a tumor an antibody in a therapeutically effective amount, wherein the...
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5540908 |
Detection of hypoxia with reagents containing 2-nitroimidazole compounds and methods of making such reagents
Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly...
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5538726 |
Method and compositions for delivering cytotoxic agents to cancer
A method of treating solid tumor cancer in a living being by prolonging the time a therapeutically effective agent remains in the tumor. The method comprises the steps of selecting particles of an...
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5525337 |
Monoclonal antibody binding cell surface antigens for diagnosing cancer
Monoclonal antibody K1 binds to an epitope on the surface of cells of some human tumors, but not to many important normal tissues. Unlike similar antigenic sites such as CA125, this epitope is not...
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5514363 |
Method for radiolabeling antibody fragments
A protein containing at least one pendant sulfhydryl group is directly radiolabeled with a radiometal which binds tightly to sulfhydryl groups, using one or more pendant sulfhydryl groups on the...
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5512443 |
Second generation monoclonal antibodies having binding specificity to TAG-72 and human carcinomas and methods for employing the same
The present invention relates to second generation monoclonal antibodies having binding specificity to a tumor associated glycoprotein having an approximate molecular weight of >10 6 d...
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5498499 |
Peptides and antibodies that inhibit platelet adhesion
A polypeptide analog capable of immunologically mimicking a linear hGPIIb antigenic determinant expressed when platelet-associated GPIIb-IIIa binds fibrinogen is disclosed. An antibody that...
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RE35152 |
Method for the diagnosis and treatment of inflammation
The invention relates to a method of detecting an inflammation site in an individual by administering to the individual a diagnostically effective amount of detectably labeled immunoglobulin or...
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5489525 |
Monoclonal antibodies to prostate cells
Monoclonal antibodies are provided which bind to an antigen associated with prostate cells, including prostate cancers. The monoclonal antibodies and recombinant forms thereof are used individually...
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5482040 |
Biostaging of adenocarcinomas utilizing radiolabeled tumor-associated glycoprotein antibodies
Broadly, the present invention is directed to a method for reliably staging adenocarcinomas typified by colorectal cancer in patients who are undergoing surgery therefor. The method includes the...
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5482698 |
Detection and therapy of lesions with biotin/avidin polymer conjugates
Methods of detecting and/or treating lesions in a patient are provided. The methods are an improvement over known methods comprising the steps of (a) parenterally injecting a subject with a...
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5474755 |
Tumor associated monoclonal antibodies
This invention relates to monoclonal antibody 88BV59 produced by B-cell lines derived from B-cells of cancer patients actively immunized with autologous tumor antigen. These monoclonal antibodies...
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5470571 |
Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425
Monoclonal antibody 425 having properties particularly beneficial for anti-tumor therapy has been raised. MAb 425 antibody binds to EGF-receptors and inhibits their bioactivities. The amount of...
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5468468 |
Method for making a monoclonal antibody, monoclonal antibodies to α P D
Potent neutralizing monoclonal antibodies to the human α PDGF receptor (α PDGFR) and fragments thereof are described. These monoclonal antibodies specifically bind to an epitope on α PDGFR,...
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5460785 |
Direct labeling of antibodies and other protein with metal ions
Proteins containing one or more dtsulfide bonds or monosulfides are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of pathologtc conditions. Labeling is...
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5439665 |
Detection and treatment of infectious and inflammatory lesions
A polyspecific anti-leukocyte antibody conjugate for targeting foci of leukocyte accretion comprises an immunoreactive polyspecific composite of at least two different substantially monospecific...
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5431897 |
Method of imaging colorectal carcinoma lesion and composition for use therein
This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface...
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