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6077508 |
Urokinase plasminogen activator receptor as a target for diagnosis of metastases
The present invention relates to the use of molecules capable of specifically binding a urokinase plasminogen activator receptor (uPAR) as diagnostic reagents for the detection of metastases in...
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6077714 |
Method for the preparation of free radical pharmaceuticals diagnostics and devices using selenium conjugates
The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and...
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6074643 |
Site-directed chemotherapy of metastases
Provided for use in site-directed chemotherapy are compositions comprising chemotherapeutic agents targeted to either arrested metastatic cells via a cell-surface marker associated with metastasis;...
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6071490 |
Position emission tomography using gallium-68 chelates
A method of delivering Ga-68 to a target site is effected by administering a bi-specific antibody which specifically binds via a primary binding site to a substance produced by or associated with...
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6071491 |
Detection of necrotic malignant tissue and associated therapy
Disclosed are methods for identifying the presence of a tumor in a mammal, comprising the steps of obtaining an antibody against cell ghosts, wherein the antibody is specific to an intracellular...
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6051229 |
Human-human hybridom for neoplasms CLNH5 and CLNH11 specific antibody compositions
CLNH5 and CLNH11 specific hybridomas, human monoclonal antibodies and their uses are provided. The antibodies distinguish a human neoplastic cell from a normal cell of the same tissue type. The...
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6033667 |
Method for detecting the presence of P-selectin
The present invention relates to compositions and methods for treating inflammation and other pathological conditions using novel blocking P-selectin antibodies that inhibit adhesion of leukocytes...
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6024936 |
Antibody-based method of localizing activated thrombin receptors
The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at...
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6022522 |
Rigid bifunctional chelating agents
Bicyclo[2.2.2]octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo[2.2.1]heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably...
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6022541 |
Immunological preparation for concurrent specific binding to spatially exposed regions of vascular permeability factor bound in-vivo to a tumor associated blood vessel
The present invention provides an immunological preparation comprising not less than two types of conjugate molecules in admixture for concurrent specific binding to a spatially exposed region of...
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6020145 |
Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
The present invention relates to novel antibodies, antibody fragments and antibody conjugates and single-chain immunotoxins reactive with human carcinoma cells. More particularly, the antibodies,...
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6019969 |
Composition comprising antibody to macrophage-derived inflammatory mediator (MIP-α 1 and MIP-1β)
An inflammatory cytokine is disclosed which has been isolated from cells that have been incubated with a stimulator material. The inflammatory cytokine comprises a protein that is capable of...
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6010680 |
Thiolation of proteins for radionuclide-based radioimmunodetection and radioimmunotherapy
A method of radiolabeling a protein with a radionuclide including contacting the protein with a protected tertiary thiol-containing bifunctional chelating agent that is capable of reacting with the...
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6004535 |
Methods of imaging neoplastic disease and of detecting and quantifying MN protein/polypeptide using MN-specific antibodies
A new gene--MN--and proteins/polypeptides encoded therefrom are disclosed. Recombinant nucleic acid molecules for expressing MN proteins/polypeptides and fusion proteins are provided. Expression of...
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5994151 |
Selenium carrier conjugates
The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and...
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5981504 |
Genetic induction of receptors for targeted radiotherapy
The present invention provides a method to achieve radioisotopic localization at tumor sites, i.e., a method of enhancing radiolabeled ligand localization to a tumor in an individual in need of...
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5976877 |
Proteins produced by human lymphocytes DNA sequence encoding these proteins and their pharmaceutical and biological uses
Disclosed herein are monoclonal antibodies which specifically bind a protein comprising the peptide sequence represented by the sequence SEQ ID No. 1 or an immunogenic sequence of such a protein...
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5976492 |
Radioactive phosphorus labeled proteins for targeted radiotherapy
32 P- and 33 P-labeled proteins which are useful for radiotherapy are prepared by stably linking 32 P- or 33 P-containing molecules to targeting proteins in such a way that the targeting...
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5965132 |
Methods and compositions for targeting the vasculature of solid tumors
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects,...
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5965131 |
Delivery of diagnostic and therapeutic agents to a target site
An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the...
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5958374 |
Method for preparing radionuclide-labeled chelating agent-ligand complexes
Radionuclide-labeled chelating agent-ligand complexes that are useful in medical diagnosis or therapy are prepared by reacting a radionuclide, such as 90 Y or 111 In, with a polyfunctional...
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5948386 |
Conjugate and method for forming aminomethyl phosphorus conjugates
A method of forming phosphine-amine conjugates includes reacting a hydroxymethyl phosphine group of an amine-free first molecule with at least one free amine group of a second molecule to...
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5942602 |
Growth factor receptor antibodies
The present invention is related to single and double chain antibodies to EGF receptor. The invention also relates to toxin conjugates of such antibodies. These antibodies are useful for treating...
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5925353 |
Targeted radioimmunotherapy
A stent for the inhibition of restentosis. The stent is coated with an antigen which can be bound by a labelled antibody. The antibody is preferably labelled with a radioactive source. After the...
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5922618 |
Dye-labeled antibody conjugate and preparation method thereof
The invention relates to a dye-labeled antibody conjugate comprising an antibody conjugate and a cyanine dye. The dye-labeled antibody conjugate is prepared by polymerizing an antibody such as...
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5902566 |
Process for producing yttrium-90-labelled protein substrate
A process for the production of yttrium-90, generated by radioactive decay of strontium-90, by means of a generator including a column containing strontium-90 adsorbed on a cation-exchange resin,...
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5879656 |
Methods of treating metastatic colorectal cancer with ST receptor binding compounds
Conjugated compounds which comprises an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier or...
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5876691 |
Antibody against carcionembryonic antigen (CEA)
The invention provides an antibody specific for carcinoembryonic antigen (CEA) which has a dissociation constant (Kd; of less than 5.0 nM for said antigen. The antibody is generally a single chain...
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5871711 |
Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to...
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5871937 |
Acute phase protein modulating endotoxic activity of lipopolysaccharides, assay methods and polypeptides
A lipopolysaccharide binding protein is disclosed as are an assay method, polypeptides and antibodies related to that binding protein. The binding protein: (a) is present in impure form in acute...
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5863517 |
Process for the preparation of an organ-specific substance labeled with technetium-99m
A process for the preparation of an organ-specific substance labeled with technetium-99m The invention relates to a process for the preparation of an organ-specific substance labeled with...
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5861139 |
Direct labeling of peptides with metal ions
Proteins containing one or more disulfide bonds or monosulfides are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of pathologic conditions. Labeling is...
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5855866 |
Methods for treating the vasculature of solid tumors
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunologically-based reagents. In particular aspects, antibodies carrying...
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5843685 |
Production of chimeric mouse-human antibodies with specificity to human tumor antigens
The invention is directed to a chimeric immunoglobulin that recognizes the human tumor antigen bound by antibody ING-1, its production, and use.
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5843396 |
Method for stabilizing radiolabeled organic compounds by adding a separate stabilizing compound
A stabilized composition comprising an organic compound labeled with a β-emitting radionuclide and a stabilizing effective amount of a non-radiolabeled stabilizing compound selected from the group...
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5840272 |
Imaging infectious foci with human IgM 16.88
A method for imaging foci of infection by administering radiolabeled human IgM 16.88 and detecting sites of localization.
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5817313 |
Monoclonal antibodies and conjugates thereof useful for the treatment of cancer
The invention provides a novel treatment of cancer using a monoclonal antibody that recognizes cell surface antigens present on a number of tumor cells, including ovarian, esophageal and cervical...
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5814295 |
Determination of lymph nodes enriched in tumor reactive cells their proliferation and their use in adoptive cellular therapy
The present invention is directed to a method for reliably determining lymph nodes enriched in tumor reactive cells, e.g., CD4+tumor-specific lymphocytes. This method includes the steps of...
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5811098 |
Antibodies to HER4, human receptor tyrosine kinase
The molecular cloning, expression, and biological characteristics of a novel receptor tyrosine kinase related to the epidermal growth factor receptor, termed HER4/p180 erbB4 , are described....
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5807879 |
Biotinidase-resistant biotinylated compound and methods of use thereof
The present invention provides biotinylated compounds useful for delivering a molecule to a target site, and methods of making biotinylated compounds. The biotinylated compounds are covalent...
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5800802 |
Chelator IDAC-2
A method for removing unbound labeling reagent from a composition comprising bound and unbound labeling reagents in which a chelator-matrix conjugate capable of binding unbound labeling reagent is...
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5795560 |
Targeting protein-diagnostic/therapeutic agent conjugates having Schiff base linkages
Targeting protein-diagnostic/therapeutic agent conjugates joined by stabilized Schiff base linkages are disclosed. Schiff base linkage of targeting protein and agent is accomplished without...
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5776093 |
Method for imaging and treating organs and tissues
Provided are methods and compositions for detecting and treating normal, hypoplastic, ectopic or remnant tissue, organ or cells in a mammal. The method comprises parenterally injecting a mammalian...
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5773228 |
Activation-dependent protein expressed on the surface of activated platelets and antibodies thereto
The present invention provides a thrombin-activated platelet protein (TAPP). The protein is selectively expressed on the surface of thrombin-activated platelets. Antibodies which selectively bind...
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5770198 |
Platelet-specific chimeric 7E3 immunoglobulin
Platelet-specific, chimeric immunoglobulin and immunoglobulin fragments are described. The chimeric molecules are made up of a nonhuman antigen binding region and a human constant region. Preferred...
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5770176 |
Assays for functional nuclear receptors
Methods and test kits for detecting, or detecting and quantitating functional nuclear receptors in cell or tissue samples are disclosed. Such methods provide highly sensitive assays requiring small...
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5766570 |
Lymphocyte activation antigens and antibodies thereto
HB15-related lymphocyte activation antigens, and nucleic acid sequences encoding HB15-related antigens are disclosed. Also disclosed are antibodies reactive with HB15.
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5766571 |
Method of treating human breast cancer by administration of radiolabeled antibody and unsaturated fatty acids
An improved in vivo method of inhibiting or retarding the growth of malignant tumor cells in a subject comprises administering the subject antitumor therapy, the improvement comprising...
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5753204 |
Biosynthetic binding proteins for immunotargeting
Disclosed is a formulation for targeting an epitope on an antigen expressed in a mammal. The formulation comprises a pharmaceutically acceptable carrier together with a dimeric biosynthetic...
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5744119 |
Preparation of a radioconjugate formulation
The present invention is directed to a method of labeling a protein conjugate with a radionuclide to form a radioconjugate comprising reacting: (a) the radionuclide; and (b) the protein conjugate...
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