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6410509 |
Use of MHC class II ligands as adjuvant for vaccination and of LAG-3 in cancer treatment
The present invention concerns the use of a MHC class II ligand, LAG-3, for the manufacture of a medicament for preventing or treating pathological conditions involving an antigen specific immune...
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6399068 |
Method of treatment with a non-antigenic toxin-conjugate and fusion protein of internalizing receptor system
A conjugate of a toxin and a cytokine, and a fusion protein comprising a bispecific antibody that has a first specificity for a cell marker specific to a malignant cell and a second specificity for...
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6383487 |
Methods of treatment using CD25 binding molecules
Novel monoclonal antibodies to the CD25 antigen are characterized by the amino acid sequence of their hypervariable regions. Initially produced in murine form, they may be converted to chimeric or...
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6379647 |
Use of mononuclear phagocytes in in vivo imaging of hypoxic/ischaemic tissue
The invention relates to the imaging, preferably of hypoxic or ischaemic sites using mononuclear phagocytes. Specifically, the migratory behavior of the mononuclear phagocytes is exploited with a...
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6375925 |
Methods and reagents for non-invasive imaging of atherosclerotic plaque
The invention provides reagents and methods for their use in in vivo diagnosis of atherosclerosis. In particular, the invention provides monoclonal antibodies which bind oxidation specific epitopes...
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6361954 |
Methods of immunoassay for human CDC6
The invention pertains to novel genes which function in the regulation of DNA replication and/or entry of a cell into mitosis. Tile invention also pertains to novel proteins encoded by the genes...
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6358490 |
Three-step pretargeting methods and compounds
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, three-step pretargeting methods are described.
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6355444 |
Carcinoma associated antigen (SK1) monoclonal antibodies against SK1, methods of producing these antibodies and uses therefor
Carcinoma associated antigen (SK1) and monoclonal antibodies and methods for detecting and ameliorating malignant disease. The monoclonal antibodies are specifically reactive with epitopes present...
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6342221 |
Antibody conjugate compositions for selectively inhibiting VEGF
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
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6331175 |
Method and kit for imaging and treating organs and tissues
Provided are methods and compositions for detecting and treating normal, hypoplastic, ectopic or remnant tissue, organ or cells in a mammal. The method comprises parenterally injecting a mammalian...
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6331301 |
Antibodies specific for vascular endothelial growth factor-B
VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides,...
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6331286 |
Methods for high energy phototherapeutics
Methods of treating and imaging diseased tissue having the steps of administering a radiosensitizer agent proximate to or into the diseased tissue; and treating the diseased tissue with x-rays or...
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6299860 |
Method for viewing diseased tissue located within a body cavity
Methods are provided for in vivo detection of tissue associated with a disease state in a subject, such as tissue located in a body opening. In the invention method, the subject is administered a...
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6296833 |
Human calcium-sensing receptor in the detection and treatment of cancer
The present invention is directed to methods for treating cancer patients by administering ligands that bind with specificity to the calcium-sensing receptor. In addition, the invention is directed...
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6296849 |
Methods and compositions including a 13kDa B. burgdorferi protein
All Borrelia burgdorferi sensu lato isolates characterized to date have one or a combination of several major outer surface proteins (Osp). Mutants of B. burgdorferi lacking Osp proteins were...
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6294172 |
Monoclonal antibodies with specificity for membrane-associated antigens
Monoclonal antibodies with specificity for membrane-associated antigens and methods of using them in detection of tumor-associated antigens arc described.
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6287536 |
Two-step pretargeting methods using improved bidtin-active agent conjugates
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for...
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6274118 |
Localization and therapy of non-prostatic endocrine cancer with agents directed against prostate specific antigen
It was discovered that prostate-specific antigen is produced by non-prostatic endocrine cancers. It was further discovered that non-prostatic endocrine cancers with steroid receptors can be...
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6274314 |
Diagnostic assay for the modified nucleosides pseudouridine, 7-methyladenosine, or 1-methyladenosine
The present invention relates to an assay for the detection of modified nucleoside levels in a patient. Detection of the modified nucleoside levels in a patient having a disease such as cancer...
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6270744 |
Diagnostic agent for angiopathic diseases
A diagnostic agent for angiopathic diseases containing a monoclonal antibody against human smooth muscle myosin or active fragments of the antibody labeled with a radioactive isotope; a kit...
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6268159 |
Imaging of colorectal cancer using ST receptor binding compounds
Conjugated compounds which comprises an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier or...
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6264949 |
Noninvasive agents for diagnosis and prognosis of the progression of fibrosis
The present invention relates to the use of molecules capable of specifically binding a β PDGFR as diagnostic reagents for the detection of fibrosis in vivo. Such fibrosis can include, but are not...
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6261535 |
Diagnostic methods for targeting the vasculature of solid tumors
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects,...
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6251362 |
Method of establishing the optimal radiation dose
A method for determining the number of millicuries to be administered to a patient so as to deliver a given centigray (cGy) dose to either the patient's lean body or the patient's total body. The...
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6241961 |
Radioimmuno conjugates for use in human therapy and method for their preparation
The invention relates to a type of radioimmuno-conjugates where the α-radiators or the β-radiators are stably coupled to the antibody with or without the use of a complex-forming agent and...
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6238872 |
Targeted therapy to a biomedical device
A biomedical device assembly, such as a stent, for the targeted treatment of a tissue, such as the inhibition of restentosis. The stent is coated with an antigen, which is an example of a lock. The...
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6228362 |
Boron neutron capture therapy using pre-targeting methods
The present invention provides a method for targeting boron atoms to tumor cells in a patient. The method includes the steps of (A) administering a targeting composition comprising a conjugate of...
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6221352 |
Method of preventing the proliferation of Vβ14 or Vβ17-Expressing T cells
The present invention provides vaccines and a means of vaccinating a vertebrate so as to prevent or control specific T cell mediated pathologies, including autoimmune diseases and the unregulated...
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6217867 |
Non-lethal methods for conditioning a recipient for bone marrow transplantation
The present invention relates to non-lethal methods of conditioning a recipient for bone marrow transplantation. In particular, it relates to the use of nonlethal doses of total body irradiation,...
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6193948 |
Antigen recognized by patients with antibody associated paraneoplastic sensory neuronopathy, DNA encoding same and uses thereof
An isolated nucleic acid sequence encoding Hu paraneoplastic antigenic polypeptide is provided by this invention. This invention also provides a purified Hu antigenic polypeptide and compositions...
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6190640 |
Method for treating neoplasia using humanized antibodies which bind to antigen A33
The invention involves the therapeutic use of humanized antibodies, fragments, etc., which bind to the antigen A33. These antibody molecules are useful in the treatment of various neoplasias,...
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6174513 |
Stabilization of peptides and proteins for radiopharmaceutical use
Surfactants alone or in combination with salts are used to stabilize radiolabeled peptides and proteins contained in diagnostic or therapeutic radiopharmaceutical compositions.
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6174691 |
Minimum recognition unit of a PEM mucin tandem repeat specific monoclonal antibody
The peptide EPPT (Glu-Pro-Pro-Thr)(SEQ I YD NO:1) selectively binds a mucin expressed by epithelial tumors. It may be incorporated into larger molecules, such as, peptides consisting of the...
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6174530 |
Homogeneous polyoxime compositions and their preparation by parallel assembly
Provided by this invention are essentially homogeneous, defined compositions of matter comprising a baseplate structure having a plurality of oxime bonds, wherein each oxime bond links a...
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6165988 |
Medicament in particulate form
The medicament in particulate form has one or more anionic or partially anionic active substances bound to a carrier material. The carrier material includes particulate copolymer or homopolymer of...
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6153440 |
Simultaneous measurement of free triiodothyronine and free thyroxine by equilibrium dialysis and immunoassay
The present invention provides methods for the simultaneous measurement of triiodothyronine (T 3 ) and thyroxine (T 4 ) in biological fluids such as serum by direct equilibrium dialysis and...
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6146614 |
Method for determining lymphocyte distribution and trafficking in mammals using imaging
Methods for determining lymphocyte distribution and trafficking in a mammal are described. Either a labeled ligand capable of interacting specifically with the lymphocytes of the mammal is...
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6143273 |
Therapeutic composition containing antibodies to soluble polypeptide fractions of LAG-3 protein
Soluble polypeptide fraction consisting of all or part of one at least one of the four immunoglobulin-type extracellular LAG-3 protein domains (amino acids 1-159, 160-230, 240-330 and 331-412 of...
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6132976 |
Immunoassays for the measurement of collagen denaturation and cleavage in cartilage
The present invention relates to a method for detecting cartilage degradation in a biological sample by identifying the presence of unwound type II collagen in the biological sample, said method...
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6130050 |
Method for detection of growth differentiation factor-12 polypeptide
Growth differentiation factor-12 (GDF-12) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-12...
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6123915 |
Methods for using agents that bind to VCAM-1
A therapeutic method of modulating the immune response, by administering to a patient an amount of IL-4 effective to promote peripheral blood lymphocyte adhesion to microvascular endothelial cells...
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6120768 |
Dota-biotin derivatives
A radionuclide-chelator conjugate composition for detecting and/or treating lesions in a patient in a pre-targeting protocol which comprises pre-targeting the target cell, tissue, or pathogen with...
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6117631 |
Detection of antigens via oligonucleotide antibody conjugates
The present invention provides a method of detecting antigens, which comprises immobilizing an antigen to a solid support and contacting the solid support with a means for hybridizing a labeled...
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6117413 |
Radionuclide-binding compound, a radionuclide delivery system, a method of making a radium complexing compound, a method of extracting a radionuclide, and a method of delivering a radionuclide
The invention pertains to compounds which specifically bind radionuclides, and to methods of making radionuclide complexing compounds. In one aspect, the invention includes a radionuclide delivery...
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6113897 |
Antibodies and their use
A monoclonal or polyclonal antibody directed against urokinase plasminogen activator receptor (u-PAR), or a subsequence, analogue or glycosylation variant thereof. Antibodies are disclosed which...
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6093381 |
Modulation of the sensitivity of tumor cells to chemotherapeutics
Disclosed is a method for improving the treatment of a cancer patient which is undergoing (adjuvant) chemotherapy. Prior to or concomitant with the patient receiving adjuvant chemotherapy, the...
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6090408 |
Use of polymerized lipid diagnostic agents
Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting...
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6090366 |
Process for the preparation of an organ specific antibodies labeled with technetium-99m
A process for the preparation of an organ-specific substance labeled with technetium-99m The invention relates to a process for the preparation of an organ-specific substance labeled with...
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6077499 |
Targeted combination immunotherapy of cancer
The invention provides compositions, methods and kits for effecting therapy of a tumor in a patient. The compositions comprise (A) a first conjugate comprising a targeting moiety, a first member of...
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6077508 |
Urokinase plasminogen activator receptor as a target for diagnosis of metastases
The present invention relates to the use of molecules capable of specifically binding a urokinase plasminogen activator receptor (uPAR) as diagnostic reagents for the detection of metastases in...
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