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7105149 |
Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/myeloma
This invention provides an isolated nucleic acid molecule which encodes immunoglobulin receptor, Immunoglobulin superfamily Receptor Translocation Associated, IRTA, protein. Provided too, are the...
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7097985 |
Antibodies to human chemokine beta-9
Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for...
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7094404 |
Method for treating malignancy and autoimmune disorders in humans using tac antibodies
The present invention relates to a method for treating conditions associated with elevated levels of Tac-positive cells, including malignancy and autoimmune disorders and for preventing allograft...
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7087395 |
Vitamin D assay
The present invention features a kit and a method of using the kit for determining a concentration of a vitamin D component. The kit comprises a releasing composition and a detecting composition....
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7067109 |
Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids
Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor...
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7067110 |
Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen...
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7060272 |
Death domain containing receptor-4 agonist antibodies and methods
The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid...
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7056680 |
Antibodies to claudin-50 polypeptide
The sequence of a cDNA encoding Claudin-50 and sequence of Claudin-50 protein are disclosed. The cDNA can be used to express the protein or portions thereof or to obtain antibodies capable of...
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7045127 |
Human anti-epidermal growth factor receptor single-chain antibodies
Human anti-epidermal growth factor receptor (EGFR) single-chain antibodies (scFvs) were isolated from a human IgM phage display library using purified epidermal growth factor receptor as antigen....
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7029652 |
Method of treating tumors
A method of treating tumors, such as prostate tumors, breast tumors, non-Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an...
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7026456 |
Antibodies against human IL-12
The present invention relates to novel p75 heterodimer specific anti-human IL-12 antibodies that are characterized by a higher potency and greater efficacy in neutralizing human IL-12 bioactivity...
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7014838 |
Use of biomolecular targets in the treatment and visualization of brain tumors
The present invention relates to the use of proteins that are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor...
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7011816 |
Labeling targeting agents with gallium-68 and gallium-67
A method and compositions are described for labeling a targeting agent with Ga-68, in which eluate from an acid-eluted Ge-68/Ga-68 generator is combined with a macrocycle-containing targetable...
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6953567 |
Fluorination of proteins and peptides for F-18 positron emission tomography
Thiol-containing peptides can be radiolabeled with fluorine-18 (F-18) by reacting a peptide comprising a free thiol group with an F-18-bound labelling reagent which also has a group that is...
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6919067 |
Compositions comprising a tissue glue and therapeutic agents
The present invention concerns compositions comprising a radiotherapeutic agent, or an agent which can be converted to a radiotherapeutic, and a tissue glue. The compositions of the present...
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6893625 |
Chimeric antibody with specificity to human B cell surface antigen
A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production,...
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6863887 |
Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis
The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered...
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6846476 |
Treatment of B-cell associated diseases
Treatment of B-cell associated diseases including autoimmune and B-cell malignancies such as leukemias, lymphomas, using the combination of an anti-CD20 antibody, preferably RITUXAN® and a...
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6835370 |
Diagnosis and treatment of malignant neoplasms
The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an...
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6827925 |
Specific binding proteins including antibodies which bind to the necrotic center of tumors, and uses thereof
Specific binding members, based on the third CDR of the antibody NHS76 (SEQ ID NO: 2) are provided, together with their use in methods of treatment and diagnosis.
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6790661 |
System for detecting bacteria in blood, blood products, and fluids of tissues
The invention provides methods for screening for the presence of a clinically relevant amount of bacteria in donor blood or a blood product from a donor mammal, particularly blood or a blood...
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6773928 |
Compositions and methods for enhancing bioassay performance
Compositions of matter and methods for enhancing bioassay performance are disclosed. More particularly, the composition of matter comprises a molecularly compact polymer-ligand conjugate capable of...
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6760612 |
Method for detecting lymphoid tissue in tumor progression
A method is provided for detecting lymphoid tissues containing shed tumor antigen in an individual. A detector molecule, with binding specificity for shed tumor antigen, is administered to an...
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6743411 |
Extracorporal system for treating disease with radionucleotides
A composition of matter comprises a pathogen-targeting organic moiety which is conjugated to a radioisotope which has a half-life of less than 100 days. The composition can be synthesized by...
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6740304 |
Receptor binding conjugates
The present invention relates to a receptor binding conjugate which consists of an antibody, a radionuclide and folate or a folate derivative, wherein or not the conjugate possesses dual binding...
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6733743 |
Methods to impair hematologic cancer progenitor cells and compounds related thereto
Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous...
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6726894 |
Transport vehicles for macromolecules
The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing...
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6716410 |
Reagents and methods for diagnosing, imaging and treating atherosclerotic disease
The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL...
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6706252 |
Method of treating disease with radioisotopes conjugated to bioactive substances
A composition of matter comprises a pathogen-targeting organic moiety which is conjugated to a radioisotope which has a half-life of less than 100 days. The composition can be synthesized by...
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6685912 |
Post-labeling stabilization of radiolabeled proteins and peptides
The subject invention relates to the use of ascorbic acid and derivatives thereof in stabilizing radiolabeled proteins and peptides against oxidation loss of radiolabel and autoradiolysis. Ascorbic...
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6676941 |
Antibody conjugate formulations for selectively inhibiting VEGF
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
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6676924 |
CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies
A humanized monoclonal antibody, comprising the complementarity-determining regions of a parental murine Class III, anti-CEA monoclonal antibody engrafted to the framework regions of a heterologous...
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6652836 |
Method for viewing tumor tissue located within a body cavity
Methods are provided for in vivo detection of diseased tissue in a subject, such as tumor tissue located in a body opening, by administering to the subject a biologically compatible fluorescing...
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6638725 |
Method for assaying receptor binding property and reagent for the assay
The present invention provides a method capable of simultaneous processing of plural test samples for the receptor binding property of a chemical substance, which does not require immobilization of...
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6638508 |
Modified avidin-type molecules as targeting agents for the liver and cells of the reticuloendothelial system
The present invention relates to avidin-type molecules having 2,4,6-trinitrophenyl or lactosyl groups or being complexed with an antibody specific to the avidin-type molecule, which shifts the...
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6635234 |
Preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning
Processes for the preparation, prepared solutions, and the use of radium-223 for the treatment of calcified tumors, bone tumors, treatment of bones, bone surfaces and soft tissues is described.
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6569112 |
Extracorporeal affinity adsorption device
Extracorporeal affinity adsorption treatments which are aimed at the substantial removal of two or more compounds that are etiological in the pathogenesis of diseases in man provide effective...
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6565827 |
Radioimmunotherapy of lymphoma using anti-CD20 antibodies
Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies...
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6540980 |
Method of detecting endometriosis
Kits for detecting and treating endometriosis are provided, which contain a targeting molecule comprising an eosinophil peroxidase-binding component. Methods of detecting and treating endometriosis...
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6541462 |
Sphingomyelin enhancement of tumor therapy
Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing...
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6521230 |
CD25 binding molecules
Monoclonal antibodies to the CD25 antigen are characterized by the amino acid sequence of their hypervariable regions. Initially produced in murine form, they may be converted to chimeric or...
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6503478 |
Chemically specific imaging of tissue
Disclosed are methods and materials for obtaining spatially resolved images of specific types of tissues. The method for imaging tissue comprises administering to the tissue a deuterated imaging...
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6495137 |
Humanized anti-tag-72 monoclonal antibodies using human subgroup 4 kappa light chains
Novel composite and humanized anti-TAG-72 monoclonal antibodies, antibody fragments, and derivatives thereof using human subgroup IV kappa light chain framework regions.
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6471960 |
Methods for the prevention or treatment of alzheimer's disease
Methods for preventing or treating vascular hemorrhaging such as that incident to thrombolytic therapy, or characteristic of Alzheimer's and related diseases are provided. Such methods provide...
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6461824 |
Production of chimeric antibodies with specificity to human tumor antigens
The invention is directed to chimeric immunoglobulins that recognize a human tumor antigen bound by antibody, ING-2, ING-3, ING-4 or KM10, the production of such chimeric immunoglobulins, and their...
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6455026 |
Use of protein tyrosine phosphatase zeta as a biomolecular target in the treatment and visualization of brain tumors
The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor...
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6455043 |
Combination therapies for B-cell lymphomas comprising administration of anti-CD20 antibody
New combined therapeutic regimens for treatment of B-cell lymphomas are disclosed which comprise in particular administration of anti-CD20 antibodies to patients having low-, intermediate- or...
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6451313 |
CD4-gamma2 and CD4-IGG2 chimeras
This invention provides an expression vector encoding a CD4-gamma2 chimeric heavy chain homodimer. This invention also provides an expression vector encoding the heavy chains of a CD4-IgG2 chimeric...
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6416738 |
Pretargeting methods and compounds
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin, as well...
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6416758 |
Antibody conjugate kits for selectively inhibiting VEGF
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
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