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7358223 |
Biodegradable cationic polymers
Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
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7344700 |
Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
Provided is a class of radiolabeled androgen receptor targeting agents (ARTA), useful for prostate cancer imaging and in treating or preventing prostate cancer. The agents define a new-subclass of...
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7128895 |
Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability
The use of contrast agents of molecular weight lower than 5000 Dalton and including at least one residue of a biliary acid for the preparation of diagnostic contrast compositions for the...
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7101532 |
Liposome containing hydrophobic iodine compound
A liposome containing a hydrophobic iodine compound such as a 1,3,5-triiodobenzene derivative having at least one substituent containing 18 or more carbon atoms as a membrane component, and an...
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7067113 |
Methods for identifying compounds for regulating muscle mass or function using dopamine receptors
Screening methods for identifying compounds that bind to or activate (D 1 or D 5 dopamine receptors individually or in combination) or potentially regulate skeletal muscle mass or function in...
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7067109 |
Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids
Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor...
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6887861 |
Compounds for intracellular delivery of therapeutic moieties to nerve cells
A method for improving intracellular administration of a therapeutic agent is provided comprising: contacting cells with a compound comprising a charged derivative of a therapeutic agent having a...
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6818199 |
Media and methods for enhanced medical imaging
Metal nanoparticles are described that are useful for enhancing the contrast of x-rays or other radiation sources. A method is disclosed whereby the agents are administered intravenously or...
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6737039 |
Methods for detecting lesions in dense breast tissue using LHRH antagonists
Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a...
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6696038 |
Cationic lipopolymer as biocompatible gene delivery agent
A biodegradable, novel cationic lipopolymer comprising a branched polyethylenimine(PEI), a cholesterol derived lipid anchor, and a biodegradable linker which covalently links the branched PEI and...
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6635234 |
Preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning
Processes for the preparation, prepared solutions, and the use of radium-223 for the treatment of calcified tumors, bone tumors, treatment of bones, bone surfaces and soft tissues is described.
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6518246 |
Pharmaceutical composition and method for the treatment of neoplastic cells
A pharmaceutical composition and method, for treating human or non-human neoplastic disorders, e.g. colorectal disorders, comprising the administration of pharmaceutically effective amounts of...
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6455025 |
Polysaccharide-peptide derivatives
Polysaccharide-somatostatin analogs of the formula: wherein the somatostatin analog is directly or indirectly coupled from a terminal N-amino group of the somatostatin analog to a...
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6251363 |
Diagnostic and therapeutic alkylenediamine compounds and process
Diamine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The diamine compounds or...
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6056942 |
5-HT.sub.1A ligands
Selective 5-HT 1A antagonists radiolabelled with 3 H or 11 C are radiolabelled ligands useful, for example, in pharmacological screening procedures and in positron emission tomography (PET)...
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6045773 |
Method of detecting cyclooxygenase-2
The invention relates to a method of detecting concentrations of cyclooxygenase-2 in a mammal, the method comprising: administering to the mammal a diagnostically effective amount of a...
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6043026 |
Combination therapy for the prevention and treatment of osteoporosis
The combination of an estrogen receptor modulator and a growth hormone secretagogue is useful in the treatment or prevention of diseases involving bone resorption, especially osteoporosis.
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5981504 |
Genetic induction of receptors for targeted radiotherapy
The present invention provides a method to achieve radioisotopic localization at tumor sites, i.e., a method of enhancing radiolabeled ligand localization to a tumor in an individual in need of...
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5965132 |
Methods and compositions for targeting the vasculature of solid tumors
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects,...
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5948386 |
Conjugate and method for forming aminomethyl phosphorus conjugates
A method of forming phosphine-amine conjugates includes reacting a hydroxymethyl phosphine group of an amine-free first molecule with at least one free amine group of a second molecule to...
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5922302 |
Detection and therapy of lesions with biotin/avidin-metal chelating protein conjugates
Improved methods of detecting and/or treating lesions in a patient are provided. The improved methods comprise the steps of (a) parenterally injecting a subject with a targeting composition...
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5916537 |
Diagnostic and diagnosis method for central nervous abnormality and phenylketonuria
There is provided a diagnostic for central nervous abnormality, comprising a labeled transmitter substance of central nervous system or a labeled precursor of the transmitter substance, whose at...
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5911969 |
Pretargeting protocols for enhanced localization of active agents to target sites
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for...
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5888821 |
Cholesterol derivative for liposomal gene transfer
The invention relates to a new cholesterol derivative for liposomal gene transfer. Areas of application of the invention are medicine and genetic engineering. The new cholesterol derivative,...
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5874059 |
Microemulsions labelled with radioactivity used as means for targeting neoplastic cells
The present invention relates to a method for diagnosing neoplasms by means of injecting radioactively-labelled microemulsions into the blood circulation so as to localize neoplastic cells. This...
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5851781 |
Reagents and methods for the detection and quantification of testosterone in fluid samples
The present invention discloses novel immunogens, antibodies prepared from such immunogens, and labeled reagents useful in immunoassays for the detection and quantification of testosterone in a...
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5843396 |
Method for stabilizing radiolabeled organic compounds by adding a separate stabilizing compound
A stabilized composition comprising an organic compound labeled with a β-emitting radionuclide and a stabilizing effective amount of a non-radiolabeled stabilizing compound selected from the group...
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5837690 |
Derivatives of triterpenoid acids and uses thereof.
Triterpenoid acid derivatives are described that exhibit dual pharmacophobic activities, specifically selectin ligand and leukotriene biosynthetic inhibitory activities, and that thus have...
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5738836 |
Composition for stabilizing radiolabeled organic compounds
A stabilized composition comprising an organic compound labeled with a β-emitting radionuclide and a stabilizing effective amount of a non-radiolabeled stabilizing compound selected from the group...
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5679318 |
Stable therapeutic radionuclide compositions and methods for preparation thereof
Stable therapeutic radionuclide compositions comprising, for example, 186 Re, 188 Re and 131 I stably bound to a proteinaceous targeting moiety and suitable for human in vivo administration...
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5667764 |
Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles
Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a...
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5635158 |
Peptides modified by the phosphine group for marking with 99M TC and 186-188 RE or paramagnetic agents
The peptides described are modified with the phosphine group and are useful for marking with 99m Tc and 186 -188 Re or paramagnetic agents for use in diagnosis and radiotherapy; in particular...
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5554602 |
Labelling of hormones with rhenium and tecnetium
The disclosed invention is drawn to the organometallic oestrogen complex of formula (I): ##STR1## in which A is a C 1 -7 alkylene radical or C 2 -7 alkenylene or alkynylene radical; M x is one or...
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5549883 |
Chemically defined polymeric carriers for release of covalently linked agents
A chemically defined polymeric carrier comprising a series of α-amino acids in any combination containing side chains to which diagnostic/therapeutic and chelating agents can be covalently joined...
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5538712 |
Cyclopentadienylcarbonyl 99MTC complexes, process for their production as well as their use in diagnostics
The invention relates to cyctopentadienylcarbonyl 99m Tc complexes of general formula I ##STR1## in which --XR can have various meanings. These new complexes of 99m technetium can be used in the...
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5482698 |
Detection and therapy of lesions with biotin/avidin polymer conjugates
Methods of detecting and/or treating lesions in a patient are provided. The methods are an improvement over known methods comprising the steps of (a) parenterally injecting a subject with a...
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5427766 |
Radiolabeled steroids for use in radiochemical-guided surgery
A method for detection and localization of tissues having estrogen receptors during surgery is disclosed. The method involves administering an effective amount of an estradiol derivative labeled...
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5395609 |
Synthetic peptides for use in tumor detection
Radioactively labelled peptides comprising oligopeptides of from 3 to 10 peptide units and containing the sequence RGD and particularly the oligopeptides RGDSY and RGDFY, are disclosed as in vivo...
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5387409 |
Boronic acid adducts of rhenium dioxime and technetium-99m dioxime complexes containing a biochemically active group
Boronic acid adducts of technetium-99m and radioactive rhenium dioxime complexes, each of which include biochemically active groups, are useful as diagnostic and therapeutic agents, respectively.
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5384113 |
Stabilizers to prevent autoradiolysis of radiolabeled peptides and proteins
Gentisic acid and its derivatives substantially inhibit peptide autoradiolysis. Gentisic acid or its derivatives may also be used in combination with other stabilizers such as inositol and ascorbic...
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5336483 |
Radiolabeled n-substituted-6-iodo-3,14-dihydroxy-4, 5α-epoxymorphinans, intermediates for producing the same, and a process for the preparation and methods of detecting opioid receptors
The present invention is directed to radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans, intermediates for producing the same, and a process for the preparation and methods of...
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5334369 |
Platelet receptor antagonists useful in detecting intravascular platelet aggregation
This invention provides novel compounds used in a method of determining platelet deposition. These compounds include 123 I-SAP and analogues. Also provided is a method of determining platelet...
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5326551 |
Nuclear imaging uses of radio-labelled atrial natriuretic factor
Uptake, binding, and/or displacement of atrial natriuretic factor in a target organ of a mammal can be quantified by nuclear imaging. A diagnostically effective amount of a radio-labelled mammalian...
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5286850 |
Antibody DTPA-type ligand conjugates
The subject matter of the present invention relates to bifunctional cyclohexyl DPTA ligands and methods for utilizing these compounds. Antibody DTPA-type ligand conjugates are also provided.
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5242678 |
BR*-diagnostics for monoamine receptors
Compounds of general Formula I labeled with 7 5 Br, 76 Br, 77 Br, 80m Br or 80 Br isotopes ##STR1## wherein R 6 is a C 1 -6 hydrocarbon residue and C 2 C 3 , C 9 C 10 is a single or a...
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5232684 |
Labelled resiniferatoxin, compositions thereof, and methods for using the same
The present invention relates to labelled resiniferatoxin and congeners thereof. Preferably, the labelled compounds of the invention are radio or fluorescently labelled. The invention is further...
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5227152 |
Radiopharmaceutical bacteriostats
Benzalkonium chloride and benzethonium chloride are each useful in radiopharmaceutical preparations as bacteriostatic agents which are compatible with anti-oxidants.
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5219555 |
Method for labeling proteins with technetium or rhenium
The invention relates to a method for labeling substances with--in particular radioactive--technetium or rhenium isotopes with the aid of N-substituted or C-substituted macrocyclic amine...
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5171563 |
Cleavable linkers for the reduction of non-target organ retention of immunoconjugates
A process for reducing the non-target organ accumulation of immunoconjugates administered in vivo during therapeutic or diagnostic procedures involves the use of immunoconjugates comprising linkers...
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5169933 |
Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable...
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