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7384623 |
High energy phototherapeutic agents
High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive...
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7378079 |
Agents for imaging and diagnostic methods using them
The present invention provides novel compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their plasma membrane, while binding to a lesser...
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7368254 |
Lipid-based systems for targeting diagnostic agents
The invention relates to targeting of diagnostic agents by use of lipid-based compositions. The invention is useful in the diagnosis of various disorders which are associated with or resulting from...
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7329400 |
Generator for rhenium-188
Radioisotope generators comprising inorganic layered hydroxide composition, such as magnesium aluminates and lithium aluminates. These inorganic layered hydroxides form anion exchange materials...
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7320784 |
Immobilized labeling compounds and methods
The invention includes methods and compounds for labelling conjugates with metals which comprise the steps of coupling the conjugate to a support surface; introducing a complex-forming metal to the...
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7311655 |
Method for manufacturing radioactive brachytherapy source material, brachytherapy source material and encapsulated radioactive brachytherapy source
The invention relates to a method for producing a radioactive brachytherapy source material comprising indium-114m in radioactive equilibrium with indium-114 as main radioactive isotopes. A new...
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7306786 |
Calcium phosphate cements comprising a water-soluble contrast agent
Methods are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products and include a contrast agent. In the subject methods, dry reactants that include a...
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7294329 |
Poly(vinyl acetal) coatings for implantable medical devices
A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a polyacetal-based polymer.
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7279150 |
Chelating agents with lipophilic carriers
Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the...
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7279149 |
Amino acid composition with increased blood brain barrier permeability
An amino acid composition with improved blood brain barrier permeability comprising an amino acid polymer, wherein the amino acid comprises at least one asparagyl-4-aminobutane or...
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7265199 |
Poly-tri-fluoro-ethoxypolyphosphazene coverings and films
The present invention relates to an anti-thrombogenic, physically well-tolerated polymer and its use for manufacturing sheaths and films as a component of therapeutic devices for preventing...
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7255850 |
Methods for measuring rates of reserve cholesterol transport in vivo, as an index of anti-atherogenesis
The present invention relates to biochemical methods for determining reverse cholesterol transport. Specifically, the rates of the two arms of reverse cholesterol transport (HDL or first arm and...
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7217410 |
Surface modified protein microparticles
A microparticle contains a cross-linked protein shell, and a surface coating.
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7169588 |
Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
A new polypropylene terephthalate composition is provided. The polypropylene terephthalate is comprised of 1,3-propanediol and terephthalate. The 1,3-propanediol is produced by the bioconversion of...
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7150867 |
Radionuclide-coated particulate material
This invention relates to a particulate material comprising an inorganic low density, radiation tolerant core coated with a radionuclide, processes for its production and a method of radiation...
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7078013 |
Pretargeting methods and compounds
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for...
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6998105 |
Low density radionuclide-containing particulate material
The invention relates to a particulate material consisting of a low density radiation-tolerant glass and a radionuclide incorporated into the low density glass or coated on the low density glass,...
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6991775 |
Peptide-based multimeric targeted contrast agents
Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
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6989196 |
Microencapsulation of magnetic material using heat stabilization
Microencapsulation methods and products are provided. The method includes forming, at a first temperature, a emulsion which comprises aqueous microdroplets, including the agent (e.g., a magnetic...
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6962687 |
Method and means for detecting inflammatory processes
A method of detecting inflammatory processes comprises (a) administering per-orally or per-rectally a composition comprising a diagnostically effective amount of L-[guanido- 15 N 2 ]-arginine,...
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6869588 |
Stimulus sensitive gel with radioisotope and methods of making
The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth-]acrylamide derivative and a...
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6808930 |
Therapeutic agents
An agent comprising a protein complex comprising an oligomeric form of α-lactalbumin (MAL) and a further reagent which is combined with MAL such that it is carried into the nucleoplasm of cells...
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6759028 |
Methods for treating AVM's using radioactive compositions
Disclosed are methods for treating AVMs in a mammal by use of a radiation composition.
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6730286 |
Manufacturing process to control particle size
A process for preparing a sterile injectable suspension of radiolabeled macroaggregated serum albumin suitable for use in scanning a mammalian patient consisting of: 1) purifying serum albumin...
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6676963 |
Ligand-targeted emulsions carrying bioactive agents
A composition for use in delivering a bioactive agent to targeted tissues or cells comprises: (a) a site-specific targeting ligand; (b) a lipid encapsulated oil in water emulsion; and (c) a...
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6635234 |
Preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning
Processes for the preparation, prepared solutions, and the use of radium-223 for the treatment of calcified tumors, bone tumors, treatment of bones, bone surfaces and soft tissues is described.
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6623721 |
Bifunctional chelating compounds containing hydroxamic acid residues
New types of hydroxamic acid-based bifunctional chelators are provided. These chelators are designed to chelate metal ions that can be detected either by their paramagnetic or radioactive...
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6562318 |
Particular agents
A novel means of pharmaceutical delivery for therapy or prophylaxis or to assist surgical or diagnostic operations on the living body is provided by agents which undergo neuronal endocytosis and...
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6537518 |
Particulate material
A particulate material comprises hollow or cup-shaped ceramic microspheres having a diameter in the range of from 5 to 200 microns, the microspheres being formed from a base material comprising...
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6517809 |
Process for preparing a reactive pharmaceutical product for the detection of gastrointestinal disorder caused by bacteria in the gastrointestinal superior tract
The invention relates to the diagnosis in a human or lower animal subject of a gastrointestinal disorder of the upper gastrointestinal tract caused by bacteria using a breath test. In one aspect...
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6428767 |
Method for identifying the source of carbon in 1,3-propanediol
A new polypropylene terephthalate composition is provided. The polypropylene terephthalate is comprised of 1,3-propanediol and terephthalate. The 1,3-propanediol is produced by the bioconversion of...
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6379648 |
Biodegradable glass compositions and methods for radiation therapy
A nonradioactive glass in particulate form adapted for radiation therapy in a mammal comprise a biodegradable rare earth-lithium borate glass material of a specified composition which, upon being...
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6264913 |
Non-invasive test for assessing bacterial overgrowth of the small intestine
Provided herein is a novel breath test for assessing bacterial overgrowth. The test involves administration of a labeled sorbitol or sorbitol derivative to a subject and measurement of the label in...
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6241963 |
Dopamine and serotonin transporter ligands and imaging agents
This invention presents a series novel tropane-based derivatives complexed with either technetium or rhenium that are specific for central nervous system receptors, in particular, dopamine or...
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6171575 |
Method of radioisotopic assessment of the integrity and function of the nose-brain barrier
A radioisotopic assessment of the integrity of the nose-brain barrier was performed on an anosmic patient by spraying an aliquot of a mixture of 99mTc-DTPA and hyaluronidase onto the olfactory...
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6168777 |
Methods for treating prostate tumors using radioactive compositions
Disclosed are methods for treating solid mass prostate tumors in a male mammal by use of a radiation composition.
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6165988 |
Medicament in particulate form
The medicament in particulate form has one or more anionic or partially anionic active substances bound to a carrier material. The carrier material includes particulate copolymer or homopolymer of...
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6153170 |
Charcoal-radionuclide agents for measurement of gastrointestinal transit
A unit dosage form is provided which comprises an effective amount of a radioisotope adsorbed onto activated charcoal, and which is preferably enterically coated. The unit dosage form is useful for...
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6149889 |
Radioactive particles and methods for preparing same
A nuclear medical drug for localize radiotheraphy of a tumor and methods for its preparation. The drug includes a radioactive ceramic or glass particle having biocompatiblity. Ceramic or glass...
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6117413 |
Radionuclide-binding compound, a radionuclide delivery system, a method of making a radium complexing compound, a method of extracting a radionuclide, and a method of delivering a radionuclide
The invention pertains to compounds which specifically bind radionuclides, and to methods of making radionuclide complexing compounds. In one aspect, the invention includes a radionuclide delivery...
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6114175 |
Compound for the antemortem diagnosis of Alzheimer's Disease and in vivo imaging and prevention of amyloid deposition
Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to...
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6099821 |
Nuclear scintigraphic assessment of mucosal function
A method is provided for assessing the functional integrity of a mucosal membrane, comprising: (a) locally administering a dosage of a radionuclide to the surface of a mucosal membrane of a mammal;...
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6045773 |
Method of detecting cyclooxygenase-2
The invention relates to a method of detecting concentrations of cyclooxygenase-2 in a mammal, the method comprising: administering to the mammal a diagnostically effective amount of a...
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6027709 |
Fluorescent cyanine dyes
New fluorescent cyanine dyes are useful as reporter groups for labeling biomolecules.
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6013242 |
Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression
Biologically active derivatives of the tropane ring system are provided which selectively bind either to the 5-HT or DA reuptake site, leading to compounds which have use for the treatment of...
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6004532 |
Formulation for Tin-.sup.117m /diethylenetriaminepentaacetic acids
The invention provides improved formulations of 117m Sn (Sn 4 +) DTPA which allow higher doses of 117m Sn (Sn 4 +) to be administered than were previously possible. Methods for making...
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5958371 |
Site specific binding system, nuclear imaging compositions and methods
A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated...
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5948385 |
Antimicrobial materials
An antimicrobial material incorporated with a molecular halogen is provided. The antimicrobial material includes a plastic material and a molecular halogen entrapped within the plastic material. A...
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5948384 |
Particulate agents
A novel means of pharmaceutical delivery for therapy of prophylaxis or to assist surgical or diagnostic operations on the living body is provided by neuronal endocytosis and axonal transport...
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5942209 |
Method of local radiotherapy by polymerizing a material in vivo to form a hydrogel
Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms,...
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