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7371722 |
Pharmaceutical preparations and medicine capable of generating and/or containing thrombin
The invention relates to a pharmaceutically active substance for producing a drug that is capable of generating thrombin or that contains thrombin and compositions comprising thereof. The...
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7368129 |
Amphiphilic materials and liposome formulations thereof
Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain...
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RE40300 |
Carbon dioxide enhancement of inhalation therapy
The present invention provides a method of increasing the deposition of aerosolized drug in the respiratory tract of an individual or animal, comprising the step of administering said aerosolized...
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7354567 |
Method of encapsulating metal complex within liposomes
An object of the present invention is to provide a method of producing liposome wherein a complex of a short half-life metallic radioactive nuclide such as 99m Tc and CD is encapsulated, with...
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7288243 |
Aerosol drug inhibition of lung metastases
The present invention provides a method of inhibiting growth of lung metastases in an individual comprising the steps of administering a dose of a lipid-drug enhancer liposomal complex and, in...
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7285289 |
Nanoparticle vaccines
The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed...
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7264790 |
1,3-glyceride compound having two iodophenyl groups
A compound represented by the following general formula (I) or a salt thereof:
wherein Ar 1 and Ar 2 independently represent a substituted or unsubstituted aryl group having at least one...
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7217427 |
Polymersomes and related encapsulating membranes
The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more...
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7208173 |
Mixed structures resulting from the incorporation of a biological macromolecule, especially of DNA, in a liquid crystal phase of amphiphiles, and vesicles obtained using these structures
The invention relates to a structured mixed phase formed by the incorporation of a biological macromolecule into a liquid-crystal phase of amphiphiles, preferably a lamellar phase, wherein said...
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7205006 |
Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same
A skin treatment composition comprising a Mahonia aquifolium extract in a liposome delivery system. The Mahonia aquifolium extract is present in the skin treatment composition in a range of...
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7166297 |
Lipid-based drug delivery systems against parasitic infections
The present invention is directed to a lipid-based delivery system for administration of an active drug substance selected from lysolipid derivatives which are particularly useful in the treatment...
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7157098 |
Gene therapy of tumors using non-viral delivery system
The present invention provides a pharmaceutical composition, comprising: (a) cationic lipids, wherein said lipids are a liposomal mixture of a diacyl-ethyl-phosphocholine and...
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7094771 |
Pharmaceutical composition for boron neutron capture therapy containing triphenylboroxin
A pharmaceutical composition for boron neutron capture therapy (BNCT), and in particular for BNCT on hepatoma is disclosed. The pharmaceutical composition contains a therapeutically effective...
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7094424 |
Cationic lipid compositions targeting angiogenic endothelial cells
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth....
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7070801 |
Sugar-modified liposome and products comprising the liposome
The present invention provides a sugar-modified liposome having a sugar chain bonded to its membrane surface, preferably through a linker protein, and having excellent absorption qualities,...
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7060292 |
Lipid structures and uses thereof
This invention features in vitro methods of determining the rate and extent to which test compounds, such as drug candidates, enter, move within, and traverse lipid-associated barriers. This...
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7060291 |
Modular targeted liposomal delivery system
A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound...
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7056653 |
Detection of binding of charged species using PH- or potential-sensitive probes
The extent of binding of a moiety, such as a biomolecule, to a surface, where the local environment at the surface has a pH or surface potential which is altered upon binding of the moiety, is...
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6991805 |
Temperature sensitive control of liposome-cell adhesion
The present invention provides a liposomal composition for targeted delivery of drugs. The composition comprises poloxamer molecules and liposomes encapsulating one or more delivery agents. At...
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6989196 |
Microencapsulation of magnetic material using heat stabilization
Microencapsulation methods and products are provided. The method includes forming, at a first temperature, a emulsion which comprises aqueous microdroplets, including the agent (e.g., a magnetic...
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6989153 |
Radiation sensitive liposomes
The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a...
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6986902 |
Polyanionic polymers which enhance fusogenicity
The present invention relates generally to the amphiphilic polyelectrolyte, poly(2-ethylacrylic acid) and covalently bonded lipids to generate Lipo-PEAA. These Lipo-PEAA are then used to make...
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6979460 |
Vinyl ether lipids with cleavable hydrophlic headgroups
A novel amphiphilic lipid compound having a cleavable, vinyl ether linked hydrophilic headgroup is described. Also described are liposomes containing the vinyl ether lipid compound, which may be...
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6974589 |
Neutral-cationic lipid for nucleic acid and drug delivery
A lipid represented by the formula:
wherein each of R 1 and R 2 is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0–20; L is selected from the group consisting...
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6962784 |
Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a VEGF...
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6962747 |
Self-assembled lipid bilayer materials
The present invention is a self-assembling material comprised of stacks of lipid bilayers formed in a columnar structure, where the assembly process is mediated and regulated by chemical...
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6958160 |
Self forming, thermodynamically stable liposomes and their applications
A liposome suspension forms spontaneously upon adding a lipid composition to an aqueous solution. The liposomes include diacylglycerol-PEG compounds. The melting point of the diacylglycerol-PEG is...
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6916488 |
Amphiphilic polymeric vesicles
Vesicles made from amphiphilic copolymers are disclosed. The amphiphilic copolymers can be ABA copolymers, where one of A and B is hydrophilic and the other is hydrophobic. AB copolymers can also...
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6899863 |
Method for preparing membrane vesicles
This invention relates to a method of preparing membrane vesicles from a biological sample, characterised in that it comprises at least one anion exchange and/or gel permeation chromatography...
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6890901 |
Hyaluronic drug delivery system
Pharmaceutical compositions comprising a mixture of hyaluronic acid and liposomes. Preferably, the pharmaceutical compositions further include a pharmaceutically active substance such as...
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6818227 |
Liposome composition and method for administration of a radiosensitizer
A method for administering a radiosensitizer to a tumor site in a subject is described. The method includes preparing liposomes composed of a vesicle-forming lipid and a lipid-derivatized...
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6787154 |
Artificial antigen presenting cells
The present invention is directed to artificial antigen presenting cells and methods of making artificial antigen presenting cells. Such artificial antigen presenting cells may be used in certain...
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6749831 |
Vaccine against lipopolysaccharide core
Compare core LPS (lacking O-polysaccharide side chains) from Gram-negative bacteria are incorporated into a vaccine typically in liposomes. The complete core of E. coli K 12 is particularly...
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6726925 |
Temperature-sensitive liposomal formulation
A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid...
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6726894 |
Transport vehicles for macromolecules
The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing...
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6685911 |
Sensitization process for antigen-presenting cells and means for implementing the process
The object of the invention is a novel sensitization process for antigen-presenting cells, novel means for implementing the process and novel membrane vesicles possessing immunogenic potency. The...
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RE38407 |
Pain management with liposome-encapsulated analgesic drugs
Liposome-encapsulated opioid analgesic agents delivered by the pulmonary route provide local, or systemic analgesia superior to that produced by the solution form of these agents administered by...
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6680047 |
Diagnostic/therapeutic agents
Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or...
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6676963 |
Ligand-targeted emulsions carrying bioactive agents
A composition for use in delivering a bioactive agent to targeted tissues or cells comprises: (a) a site-specific targeting ligand; (b) a lipid encapsulated oil in water emulsion; and (c) a...
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6645463 |
Blood-pool selective carrier for lipophilic imaging agents
A surface-modified lipoprotein-like oil-in-water emulsion useful as a blood-pool selective delivery vehicle for lipophilic imaging agents or lipophilic derivatives of water-soluble imaging agents....
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6635234 |
Preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning
Processes for the preparation, prepared solutions, and the use of radium-223 for the treatment of calcified tumors, bone tumors, treatment of bones, bone surfaces and soft tissues is described.
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6627218 |
Cationic amphiphiles of cholesterol
A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and...
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6596543 |
Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
The present invention relates generally to the field of prothrombin time reagents for determining dysfunction in the coagulation system and more specifically to reagents made from native...
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6592843 |
Radioactive therapeutic liposomes
The present invention relates to a conjugator system comprising liposomes with ionophores, and with chelator solution and alpha-particle emitting radionuclide(s) located inside of the liposome....
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6586001 |
Neutral lipopolymer and liposomal compositions containing same
Liposomes containing PEG-substituted neutral lipopolymers provide similar circulation times to liposomes incorporating conventional, negatively charged PEG-substituted phospholipids. Use of the...
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6582918 |
Platelet derived growth factor (PDGF) nucleic acid ligand complexes
This invention discloses a method for preparing a complex comprised of a PDGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a PDGF...
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6569451 |
Targeted polymerized liposome diagnostic and treatment agents
Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting...
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6562371 |
Liposomes
This invention provides a liposome having a drug included therein, which has active targeting property and ensured stability in blood and can be used effectively in the diagnosis and/or treatment...
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6562316 |
Drug delivery system with two-step targeting
The present invention relates to a drug delivery system with two-step targeting, which comprises a combination: (a) a lipid carrier provided with cell targeting agent(s) to target the drug delivery...
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6517808 |
Methods for boron delivery to mammalian tissue
Boron neutron capture therapy can be used to destroy tumors. This treatment modality is enhanced by delivering compounds to the tumor site where the compounds have high concentrations of boron, the...
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