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7387771 |
Method for producing an injectable medicament preparation
The invention relates to a method for producing injectable medicament preparations containing a therapeutically and/or diagnostically effective substance which is comprised of an active agent, of a...
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7384977 |
Water soluble paclitaxel prodrugs
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or...
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7384624 |
Oral contrast and method of producing the oral contrast
Oral contrast compositions are used as an aid for CAT scans and are ideally fast-flowing and good tasting for assisting in quick preparation of a patient in today's extremely active and busy...
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7384623 |
High energy phototherapeutic agents
High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive...
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7381407 |
Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods...
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7381400 |
Injection of a radioactive dye for sentinel lymph node identification
A one-step procedure for sentinel lymph node identification and biopsy using a single compound, a radiolabeled, low molecular weight dye (e.g., 125 I-labeled methylene blue). This radiolabled dye...
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7381399 |
Technetium-dipyridine complexes, and methods of use thereof
One aspect of the invention relates to novel complexes of technetium (Tc) with various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a...
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7378079 |
Agents for imaging and diagnostic methods using them
The present invention provides novel compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their plasma membrane, while binding to a lesser...
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7378077 |
High dose radionuclide complexes for bone marrow suppression
The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases,...
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7364719 |
Vasoregulating compounds and methods of their use
Methods and compounds are described for regulating blood pressure in a subject. Specific embodiments are methods for reversing vasodilation of blood vessels, by administering to a subject a...
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7357928 |
Method for the diagnosis and prognosis of malignant diseases
Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
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7357915 |
Method of imaging cell death in vivo
A method of imaging apoptosis in vivo, using radiolabeled annexin, is described.
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7357913 |
Methods for detecting, prognosing, or monitoring a disorder by comparing relative flux rates of two or more biological molecules in vivo
The invention relates to techniques for measuring and comparing relative molecular flux rates of different biological molecules by administering isotope-labeled water to one or more tissues or...
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7354567 |
Method of encapsulating metal complex within liposomes
An object of the present invention is to provide a method of producing liposome wherein a complex of a short half-life metallic radioactive nuclide such as 99m Tc and CD is encapsulated, with...
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7351542 |
Methods of modulating tubulin deacetylase activity
The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention...
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7351401 |
Thioflavin derivatives for use in the antemortem diagnosis of Alzheimers disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
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7351399 |
Prodrugs for phosphorus-containing compounds
Prodrugs of formula I, their uses, their intermediates, and their method of manufacture are described:
and pharmaceutically acceptable prodrugs and salts thereof.
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7351398 |
Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic thioether.
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7351397 |
Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy chromans
Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic 6-hydroxy-chroman derivative.
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7347984 |
Mammalian agmatinase inhibitory substance
The present invention provides for methods and compounds for treating brain trauma and disorders such as: ischemia, stroke, neurodegenerative disorders, opioid addiction, idiopathic pain, epilepsy,...
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7344702 |
Contrast agents for myocardial perfusion imaging
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds...
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7344701 |
Xanthene dyes
The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like....
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7344700 |
Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
Provided is a class of radiolabeled androgen receptor targeting agents (ARTA), useful for prostate cancer imaging and in treating or preventing prostate cancer. The agents define a new-subclass of...
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7341708 |
Methods for producing pure amino acid chelate complexes, and uses thereof
A two-stage method of preparing essentially pure amino acid chelates, wherein the first stage comprises contacting a metal ion from a metal oxide or hydroxide with an amino acid thereby producing a...
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7335347 |
Methods for purifying radiolabelled compounds
One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a...
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7329414 |
Biodegradable polymer for marking tissue and sealing tracts
A tissue marker formed of a biodegradable polymer having drug-delivery capabilities is combined with a sealant that encapsulates the tissue marker and which serves to help anchor the tissue marker...
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7329401 |
Cyclooxygenase-2 selective agents useful as imaging probes and related methods
This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2...
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7329400 |
Generator for rhenium-188
Radioisotope generators comprising inorganic layered hydroxide composition, such as magnesium aluminates and lithium aluminates. These inorganic layered hydroxides form anion exchange materials...
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7329222 |
Comparative field analysis (CoMFA) utilizing topomeric alignment of molecular fragments
The static and electrostatic interaction energy fields between probe atoms and the atoms of a topomerically aligned fragment placed in a three-dimensional grid may be used to derive a CoMFA model....
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7320784 |
Immobilized labeling compounds and methods
The invention includes methods and compounds for labelling conjugates with metals which comprise the steps of coupling the conjugate to a support surface; introducing a complex-forming metal to the...
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7320783 |
Methods and compositions for the enhancement of wound healing
The present invention relates to methods and compositions for wound healing, and in particular, methods and compositions to promote and enhance wound healing. In particular, the present invention...
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7314609 |
Stereoisomers of fatty acid analogs for diagnostic imaging
The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a...
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7311655 |
Method for manufacturing radioactive brachytherapy source material, brachytherapy source material and encapsulated radioactive brachytherapy source
The invention relates to a method for producing a radioactive brachytherapy source material comprising indium-114m in radioactive equilibrium with indium-114 as main radioactive isotopes. A new...
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7306786 |
Calcium phosphate cements comprising a water-soluble contrast agent
Methods are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products and include a contrast agent. In the subject methods, dry reactants that include a...
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7306785 |
Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety...
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7306784 |
Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant...
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7303739 |
Prodrugs for liver specific drug delivery
The present invention is directed towards novel cyclic phosph(oramid)ate prodrugs of alcohol-, amine-, and thiol-containing drugs, their preparation, their synthetic intermediates, and their uses....
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7300644 |
Targeted combination immunotherapy
The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities,...
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7294480 |
High throughput screening assays using fatty acid synthetic enzymes
High throughput screening assays for the identification of potential therapeutic agents able to modulate the activity of enzymes of fatty acid biosynthesis, especially desaturases and/or elongases,...
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7294329 |
Poly(vinyl acetal) coatings for implantable medical devices
A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a polyacetal-based polymer.
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7288534 |
Sphingomyelin enhancement of tumor therapy
Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing...
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7288244 |
Determining vulnerable plaque in blood vessels
The invention is based on the realisation that inflamed plaques in blood vessel walls, which are potentially vulnerable to rupture, can be detected at elevated temperatures which are lower than...
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7279150 |
Chelating agents with lipophilic carriers
Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the...
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7279149 |
Amino acid composition with increased blood brain barrier permeability
An amino acid composition with improved blood brain barrier permeability comprising an amino acid polymer, wherein the amino acid comprises at least one asparagyl-4-aminobutane or...
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7273601 |
Preparation of radiolabelled haloaromatics via polymer-bound intermediates
According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate...
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7273600 |
[18F]-furanosylpurine derivatives and uses thereof
2′-Deoxy-2′-[ 18 F]-labeled and 3′-deoxy-3′-[ 18 F]-labeled purine nucleoside analogs such as [ 18 F]-FAA and [ 18 F]-FXA have been found to have desirable properties for use as imaging...
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7270800 |
Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
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7270799 |
Perturbed membrane-binding compounds and methods of using the same
The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis...
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7265199 |
Poly-tri-fluoro-ethoxypolyphosphazene coverings and films
The present invention relates to an anti-thrombogenic, physically well-tolerated polymer and its use for manufacturing sheaths and films as a component of therapeutic devices for preventing...
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7261876 |
Multivalent constructs for therapeutic and diagnostic applications
The invention provides compositions and methods for therapeutic and diagnostic applications.
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