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6458337 |
Diagnostic imaging contrast agent with improved in serum relaxivity
Compounds of the formula when chelated with metals exhibit improved serum relaxivity and are used in magnetic resonance imaging, particularly for imaging the blood pool.
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6455052 |
Enteric coating, comprising alginic acid, for an oral preparation
A composition for forming an enteric coating on a tablet, capsule or pellet for oral ingestion includes a liquid mixture of alginic acid particles dispersed in an aqueous solution of a binding...
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6455026 |
Use of protein tyrosine phosphatase zeta as a biomolecular target in the treatment and visualization of brain tumors
The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor...
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6451545 |
Monoclonal antibody specific to anti-human fibrin monomer, process for producing the same, hybridomas, and immunoassay method
Provided are a monoclonal antibody making it possible to detect a native fibrin monomer, which is produced at the initial state of blood coagulation, and soluble fibrin; a hybridoma; and an...
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6447747 |
Process for the preparation of radiopharmaceuticals
Process for the preparation of radiohalogenated radiopharmaceuticals by an electrophillic substitution, preferably halogenodestannylation reactions, by the reaction of an organometallic substituted...
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6436365 |
Process for therapeutic treatment of proliferative diseases
The invention relates to a process for therapeutic treatment of proliferative diseases, which is characterized in that first an administration catheter is placed on the site of the lesion, and a...
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6429018 |
Prenatal screening for Down's syndrome using hyperglycosylated gonadotropin
A prenatal screening method for Down's syndrome involves assaying for hyperglycosylated gonadotropin in biological test samples such as urine, plasma or serum obtained from pregnant women....
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6428767 |
Method for identifying the source of carbon in 1,3-propanediol
A new polypropylene terephthalate composition is provided. The polypropylene terephthalate is comprised of 1,3-propanediol and terephthalate. The 1,3-propanediol is produced by the bioconversion of...
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6416734 |
Recombinant alpha-fetoprotein for treating and diagnosing cancers
Disclosed is a method of inhibiting a neoplasm in a mammal, the method includes administering to the mammal a therapeutically effective amount of recombinant human alpha-fetoprotein.
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6410509 |
Use of MHC class II ligands as adjuvant for vaccination and of LAG-3 in cancer treatment
The present invention concerns the use of a MHC class II ligand, LAG-3, for the manufacture of a medicament for preventing or treating pathological conditions involving an antigen specific immune...
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6409987 |
Targeted agents useful for diagnostic and therapeutic applications
A selectively targeted agent comprising a dermatan sulfate having more than about 25% repeating L-iduronic acid→4,6-di-O-sulfated N-acetyl-D-galactosamine disaccharide units that is covalently...
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6399068 |
Method of treatment with a non-antigenic toxin-conjugate and fusion protein of internalizing receptor system
A conjugate of a toxin and a cytokine, and a fusion protein comprising a bispecific antibody that has a first specificity for a cell marker specific to a malignant cell and a second specificity for...
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6395256 |
Adenosine detection in small samples
The invention relates to a method for detecting adenosine with the inactive S-adenosyl homocysteine hydrolase's enzyme which selectively and only binds adenosine with high affinity. The inventive...
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RE37710 |
Radiometal-binding analogues of luteinizing hormone releasing hormone
Peptide, derivatives of leutenizing hormone releasing hormone that are capable of binding radionuclides are provided. The peptide derivatives are readily labeled with isotopes of rhenium or...
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6391279 |
Radioactive seeds for brachytherapy and a process for making the same
Novel radioactive seeds for brachytherapy and a reproducible method of manufacturing the seeds is described, wherein the seeds contain either Pd-103 or I-125 disposed within a cured resin matrix.
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6379650 |
Technetium 99m-N2S2-congo red complexes utilizing diamide dithiolate ligand systems for radioimaging
The present invention discloses a group of technetium 99m-N 2 S 2 -congo red complexes that utilize diamide dithiolate ligand systems to synthesize compounds for radioimaging. The complexes have...
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6375926 |
Labelled elastase inhibitors
A human leucocyte elastase (HLE) inhibitor labelled with a detector moiety where the inhibitor is synthetic and has a molecular weight of less than 2000, is useful for the diagnostic imaging of...
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6375930 |
Membrane incorporation of texaphyrins
Compositions having a texaphyrin-lipophilic molecule conjugate loaded into a biological vesicle and methods for imaging, diagnosis and treatment using the loaded vesicle are provided. For example,...
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6372194 |
MRI contrast media recognizing minor environmental changes
This relates to a contrast medium containing a complex of a gadolinium (Gd) type contrast agent and a polymer. More particularly, the contrast medium wherein the polymer capable of phase transit in...
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6373068 |
Apparatus and method for preparing radioactive medicines for administration
An irradiation vessel is made from such material and in such form that it can also be used as administration vessel of a medicine contained therein, this medicine first being irradiated with...
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6365128 |
Monitoring gastrointestinal function to guide care of high risk patients
A method of guiding the care of a critically ill patient or other high risk patient, said method comprising administering an effective dose of a gastric acid stimulant or suppressant agent and then...
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6358491 |
Somatostatin analogs
The invention provides novel peptide-based pharmacophores and compounds which bind somatostatin receptors with high affinity and which exhibit improved pharmacokinetic properties over known...
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6355444 |
Carcinoma associated antigen (SK1) monoclonal antibodies against SK1, methods of producing these antibodies and uses therefor
Carcinoma associated antigen (SK1) and monoclonal antibodies and methods for detecting and ameliorating malignant disease. The monoclonal antibodies are specifically reactive with epitopes present...
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6350430 |
Melanocortin receptor ligands and methods of using same
The invention provides ligands for melanocortin receptors. For example, the invention provides the melanocortin receptor peptide ligand Ac-Nlc-Gln-His-(p(I)-D-Phe)-Arg-(D-Trp)-Cly-NH 2 , (SEQ ID...
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6348184 |
Radiopharmaceutical compositions and matrices and uses thereof
Novel radiopharmaceutical compositions comprising, in combination with a pharmaceutically acceptable carrier, a radioactive salt of pyrophosphoric acid. Also provided are novel radiopharmaceutical...
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6342201 |
Complex compounds for diagnosis of vascular diseases
The present invention concerns novel complexes for use in the diagnosis of vascular diseases, methods of manufacturing such complexes and diagnostic agents containing them. These complexes strongly...
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6338835 |
Radioprotectant for peptides labeled with radioisotope
A method of ameliorating degradation radiolabeled peptides, especially radiolabeled proteins such as antibodies, by including povidone, also widely known as polyvinylpyrrolidone or PVP, as a...
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6337627 |
System of providing medical treatment
The invention describes methods for locating a treatment device disposed within a living body by means of magnetic fields that are produced by Barkhausen jumps, principally from amorphous tag wires...
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6335028 |
Implantable particles for urinary incontinence
The invention encompasses the treatment of urinary incontinence, gastroesophageal reflux disease and the amelioration of skin wrinkles using biocompatible hydrophilic cationic microparticles and a...
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6334995 |
Process for the preparation of technetium-99m diethylene triamine penta-acetic acid diester
A technetium-99m radiolabelled diethylene triamine pentaacetic acid diester kit and process for its preparation for the diagnosis of renal disorders wherein technetium-99m diethylene triamine...
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6334996 |
Chelators that predominantely form a single stereoisomeric species upon coordination to a metal center
The labeling of biologically important molecules via a bifunctional chelator can result in the formation of isomers or multiple species, which can have significant impact on the biological...
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6333020 |
Methods for treating AVM's using radio active compositions
Disclosed are methods for treating AVMs in a mammal by use of a radiation composition.
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6331285 |
Structurally determined cyclic metallo-constructs and applications
A metallo-construct, which may be a peptide, is provided for use as a biological, therapeutic, diagnostic imaging, or radiotherapeutic agent, and for use in library or combinatorial chemistry...
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6331284 |
P202 is a tumor suppressor
The present invention relates generally to the fields of cancer therapy and gene therapy. More particularly, the invention demonstrates methods for repressing or preventing transformation and...
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6322771 |
Induction of pharmacological stress with adenosine receptor agonists
A method is provided employing A 2A adenosine receptor agonists as vasodilators to detect the presence and assess the severity of coronary artery stenosis.
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6322770 |
Indazole vitronectin receptor antagonist pharmaceuticals
The present invention d ribs novel compounds of the formula: (Q) d --L n --C h , useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of...
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6319488 |
Contrast medium for near infrared diagnosis
This invention relates to colloidal systems charged with polymethine dyes and having suitable photophysical and pharmacological properties, their use as a contrast medium in fluorescence and...
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6314314 |
Method for locating an internal bleeding site in a human body
A technique for localizing an internal bleeding site in the human body is provided. The technique entails the injection of radioactively labelled protein or factor used in the clotting process in...
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6312679 |
Dense star polymer conjugates as dyes
Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These...
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6303101 |
Bismuth compounds
The use in diagnostic imaging, in particular X-ray, MRI, ultrasound and scintigraphy, of contrast agents comprising bismuth clusters and/or organic bismuth compounds, and contrast media containing...
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6299857 |
Cardiovascular and thrombus imaging agents, methods and kits
The invention provides cardiovascular imaging agents comprising a radionuclide in association with a nucleotide polyphosphate targeting molecule. Methods for using the cardiovascular imaging agents...
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6299856 |
Collagen-based delivery of radioactivity for use in brachytherapy
Disclosed herein is a method for treating a malignancy in an animal by introducing into the animal a radioactive isotope, or stable element subsequently made radioactive, covalently linked to a...
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6299860 |
Method for viewing diseased tissue located within a body cavity
Methods are provided for in vivo detection of tissue associated with a disease state in a subject, such as tissue located in a body opening. In the invention method, the subject is administered a...
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6296833 |
Human calcium-sensing receptor in the detection and treatment of cancer
The present invention is directed to methods for treating cancer patients by administering ligands that bind with specificity to the calcium-sensing receptor. In addition, the invention is directed...
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6294151 |
Isotopic urea tablets
The present invention provides a tablet containing isotope-labeled urea and an inorganic compound.
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6284220 |
Noninvasive imaging of nucleic acid vectors
Nucleic acid-imaging compositions and methods for noninvasive imaging of a nucleic acid introduced into somatic tissues of an animal or human are disclosed. The noninvasive imaging enables...
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6280703 |
Simultaneous multimodal measurement of physiological function
A method of measuring physiological function of a group of body cells, includes the step of selecting a detectable agent capable of absorbing or emitting a measurable electromagnetic emission. The...
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6277356 |
Peptides
Compounds of formula I ##STR1## wherein M is a cation equivalent and A is Phe or Tyr, in free form or in salt form are useful as radio pharmaceuticals when complexed with a radionuclide.
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6274118 |
Localization and therapy of non-prostatic endocrine cancer with agents directed against prostate specific antigen
It was discovered that prostate-specific antigen is produced by non-prostatic endocrine cancers. It was further discovered that non-prostatic endocrine cancers with steroid receptors can be...
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6270744 |
Diagnostic agent for angiopathic diseases
A diagnostic agent for angiopathic diseases containing a monoclonal antibody against human smooth muscle myosin or active fragments of the antibody labeled with a radioactive isotope; a kit...
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