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7052677 |
Substituted octanuclear pyrazolato clusters with electron transfer and MRI contrast agent properties
The present invention is directed to an Fe(III) complex comprising a redox-active metal cluster in a chemically inert shell. The inventive complex has electron transfer and paramagnetic properties.
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7052673 |
Pharmaceuticals for the imaging of angiogenic disorders
The present invention describes novel compounds of the formula:
(Q) d —L n —C h ,
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7052672 |
Stabilized radiopharmaceutical compositions
The present invention relates to stabilized 99m Tc radiopharmaceutical compositions, which include both a radioprotectant and one or more antimicrobial preservative(s), and hence have an extended...
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7048907 |
Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
Stable isotope labeling and neutron activation to measure biological functions are provided, as are the use and method of adding a chemical monitor to correct for neutron flux to sample vials prior...
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7045127 |
Human anti-epidermal growth factor receptor single-chain antibodies
Human anti-epidermal growth factor receptor (EGFR) single-chain antibodies (scFvs) were isolated from a human IgM phage display library using purified epidermal growth factor receptor as antigen....
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7045503 |
Radiometal-binding peptide analogues
Novel metal binding ligands are disclosed that may be coupled to peptides for use in methods of diagnosis and therapy. Peptides containing the ligands are produced using a method wherein ligand...
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7045115 |
Drugs for the diagnosis of tissue-reproductive activity or the treatment of proliferative diseases
An agent which comprises, as an active ingredient, a radiolabeled compound as represented by the following formula or a pharmaceutically acceptable salt thereof:
wherein R 1 denotes hydrogen,...
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7045116 |
Treatment of osteomyelitis with radiopharmaceuticals
This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides...
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7037487 |
Method for diagnosing lactose intolerance and diagnostic kit for performing the method
The method for diagnosing lactose intolerance in patients by the oral administration of defined amounts of lactose, followed by assaying metabolites of lactose, is performed in a way where the...
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7037486 |
Labelled phosphoinositides and analogues
The present invention provides novel compounds comprising cellular phosphoinositides and analogues tagged with stable or radioactive isotopes. The present invention also provides novel methods for...
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7033572 |
Non-antigenic toxin-conjugate and fusion protein of internalizing receptor system
A conjugate of a toxin and a cytokine, and a fusion protein comprising a bispecific antibody that has a first specificity for a cell marker specific to a malignant cell and a second specificity for...
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7033571 |
Multiple stimulus reversible hydrogels
A polymeric solution capable of gelling upon exposure to a critical minimum value of a plurality of environmental stimuli is disclosed. The polymeric solution may be an aqueous solution utilized in...
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7029653 |
Method of the administration of drugs having binding affinity with plasma protein and preparation to be used in the method
A method of the administration of drugs with binding affinity for plasma protein and drugs regulating the effective ingredient dose of drugs with binding affinity for plasma protein; and a...
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7025949 |
In-vivo diagnostic method by means of near infrared radiation
This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific...
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7018611 |
Vitronectin receptor antagonist pharmaceuticals
The present invention describes novel compounds of the formula:
(Q) d —L n —C h ,
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7018614 |
Stabilization of radiopharmaceuticals labeled with 18-F
An 18 F isotope-labeled FDG radiopharmaceutical is stabilized against degradation in radiochemical purity due to radiolysis using selected amounts of ethyl alcohol that depend on the activity...
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7014838 |
Use of biomolecular targets in the treatment and visualization of brain tumors
The present invention relates to the use of proteins that are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor...
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7011817 |
Hydrophilic cyanine dyes
Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologues. The...
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7011816 |
Labeling targeting agents with gallium-68 and gallium-67
A method and compositions are described for labeling a targeting agent with Ga-68, in which eluate from an acid-eluted Ge-68/Ga-68 generator is combined with a macrocycle-containing targetable...
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7008613 |
Quaternary ammonium compounds
A compound of formula corresponding to either formula (Ia) or (Ib):
wherein:
M represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the...
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7005119 |
Stereoisomers of fatty acid analogs for diagnostic imaging
The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a...
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6998105 |
Low density radionuclide-containing particulate material
The invention relates to a particulate material consisting of a low density radiation-tolerant glass and a radionuclide incorporated into the low density glass or coated on the low density glass,...
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6991777 |
Methods for in vivo evaluation of physiological conditions and/or organ or system function including methods to evaluate cardiopulmonary disorders such as chronic heart failure using polarized 129 Xe
In certain embodiments, methods of the present invention obtain NMR spectroscopy signal data that corresponds to the behavior of the polarized 129 Xe at a selected site(s) in selected environments...
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6991775 |
Peptide-based multimeric targeted contrast agents
Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
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6989378 |
Testosterone derivative
The invention is the novel androgen (7α,17β)-7-methyl-17-[(1-oxoundecyl)oxy]estr-4en-3one (MENT undecanoate). This compound distinguishes favourably from other testosterone derivatives in that it...
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6989140 |
Methods for cancer imaging
Methods are provided for cancer and pre-cancer detection by increased uptake of fluorophore glucose or deoxyglucose conjugates in cancerous and pre-cancerous cells relative to normal cells.
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6986880 |
Polymeric-matrix brachytherapy sources
Therapeutic sources for use in the practice of brachytherapy comprise a radioactive composite that includes (a) a polymeric matrix and (b) a radioactive powder, e.g. Pd-103 or I-125, consisting...
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6979436 |
Opioid metallopeptide compositions and methods
Metallopeptides and metallopeptide combinatorial libraries specific for opioids receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and...
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6979431 |
Method for labelling technetium or rhenium using borohydride exchange resin
A method for labelling a sulfide compound with technetium or rhenium, comprising the reaction of a disulfide compound with pertechnetate or perrhenate in the presence of borohydride exchange resin...
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6977141 |
Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes
Methods and materials for scintillation assays are disclosed. The scintillation assays rely on differences in general molecular property-based binding interactions, such as charge or...
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6977068 |
Method for detection of fibrin clots
A method for the detection of fibrin in a source, in particular the in vivo detection of a fibrin in a patient, the method comprising supplying to the source or patient an amount of a detectable...
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6974567 |
Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque
Detectably labeled macrophage scavenger receptor antagonists useful for the diagnosis and monitoring of various cardiovascular diseases including but not limited to atherosclerosis, vulnerable...
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6962687 |
Method and means for detecting inflammatory processes
A method of detecting inflammatory processes comprises (a) administering per-orally or per-rectally a composition comprising a diagnostically effective amount of L-[guanido- 15 N 2 ]-arginine,...
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6962690 |
Tissue specific fluorescent chelates possessing long wavelength UV excitation
Fluorescent chelates of lanthanide, terbium, europium and dysprosium with tetraazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These...
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6962686 |
Cell-specific gene delivery vehicles
A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic...
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6958141 |
Rhenium and technetium complexes containing a hypoxia-localizing moiety
Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a...
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6958140 |
Methods of imaging and targeting vasculature
Methods for imaging and targeting tumor vasculature are provided. Specifically, the methods for imaging and targeting tumor vasculature relate to using ephrin-B2 to image developing tumor...
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6953570 |
Porphyrins with enhanced multi-photon absorption cross-sections for photodynamic therapy
A method of increasing the multi-photon absorption cross-section of a porphyrin-based photosensitizer by attaching at least one TPA-chromophore at the meso- or beta-positions of a porphyrin...
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6936240 |
Method for the preparation of technetium or rhenium complex for radiopharmaceuticals
The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a...
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6926883 |
Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as imaging agents for diagnostic purposes. In accordance with the...
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6923950 |
System and method for radiographic imaging of tissue
System and method for radiographic imaging of tissue using a non-radioactive, radio-opaque imaging agent that accumulates intracellularly in tissue in proportion to its functional, or...
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6919067 |
Compositions comprising a tissue glue and therapeutic agents
The present invention concerns compositions comprising a radiotherapeutic agent, or an agent which can be converted to a radiotherapeutic, and a tissue glue. The compositions of the present...
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6916460 |
Macrocyclic chelants for metallopharmaceuticals
This invention relates to macrocyclic chelants comprised of one or two heteroatom-containing bridges, compositions containing them and their use in medicine, particularly in diagnostic imaging and...
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6913743 |
Near infrared imaging agent
This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific...
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6913767 |
Compositions for microencapsulation of antigens for use as vaccines
Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided...
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6902719 |
Reverse isotope dilution assay and lactose intolerance assay
A “reverse isotope dilution assay” herein, wherein a pathway that produces a given metabolite is assayed by diluting a labelled metabolite produced by a second constitutive pathway. In one...
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6896871 |
Biphosphonate conjugates and methods of making and using the same
The present invention is directed to particular bisphosphonate compounds, and in particular, to bisphosphonate conjugates that are useful in the treatment of soft tissues surrounding bone and...
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6896870 |
Diagnostic probes and therapeutics targeting uPA and uPAR
A uPAR-targeting protein or peptide is diagnostically or therapeutically labeled and used in methods of diagnosis of therapy. The labeled protein or peptide preferably has the following properties:...
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6896873 |
MR signal-emitting coatings
The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer...
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6896885 |
Combined use of anti-cytokine antibodies or antagonists and anti-CD20 for treatment of B cell lymphoma
The present invention discloses combined therapies for treating hematologic malignancies, including B cell lymphomas and leukemias or solid non-hematologic tumors, comprising administration of...
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