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5763164 |
Immunogenic cancer proteins and peptides and methods of use
The present invention relates to tumor specific antigens and functional proteins of a tumor cell preparable by identifying protein presents in the tumor cell that are selectively immunogenic for...
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5762907 |
Frozen radiopharmaceutical formulations
Radiopharmaceutical formulations for complexes comprising at least one radionuclide complexed with a ligand, or its physiologically-acceptable salts thereof, especially 153 ...
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5762906 |
Further improvements relating to radiolabelling of proteins
A structurally modified protein is provided that will bind to a tumor-associated structure wherein the amino group in at least one basic amino acid in the binding protein is structurally modified...
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5759513 |
Apparatus and process for preparing radioisotope-labeled reagent
Apparatus and process for non-pyrogenously preparing a radioisotope-labeled reagent that includes a plurality of raw material-holding containers, reaction vessels, and columns connected to each...
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5759519 |
Method for the intracellular delivery of biomolecules using thiocationic lipids
Lipid molecules bearing a cationic charge are described. These cationic lipids are useful in the delivery of biomolecules, such as oligonucleotides, nucleic acids, peptides, diagnostic imaging...
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5759514 |
Composition for delivery of toxic radioisotopes to the cell nucleus and use
A conjugate of a tumor cell-targeting protein or polypeptide and a nucleic acid-targeting small molecule labeled with an Auger electron-emitting radionuclide is useful for tumor therapy. The tumor...
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5759517 |
Hemoglobins as drug delivery agents
A tracer, such as a radioisotope, is conjugated to a hemoglobin-like protein, such as normal hemoglobin, for use as an in vitro diagnostic imaging agent.
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5759515 |
Polyvalent peptide pharmaceutical applications
High affinity linked, branched or linear repeat peptides containing two or more biological-function domains and at least one medically useful metal ion-binding domain are labeled with medically...
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5759516 |
Peptide-metal ion pharmaceutical preparation
Peptides containing a biological-function domain and a medically useful metal ion-binding domain are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of...
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5756067 |
Labelled diagnostic compositions and method of their use
This invention relates to a labelled diagnostic composition for testing presence of or propensity for atherosclerosis and coronary artery disease and the like comprising components which mimic...
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5753441 |
170-linked breast and ovarian cancer susceptibility gene
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian...
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5746996 |
Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
A method of radiolabeling a peptide, e.g., somatostatin or an analogue thereof or vasoactive intestinal peptide, with a radioisotope of technetium or rhenium, comprises the steps of: (a) reacting...
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5746997 |
Radiohalogenation of oligonucleotides via trialkylstannylaryl conjugates
Halogenated oligonucleotides and particularly radiohalogenated oligonucleotides are prepared by reacting a modified oligonucleotide with a trialkylstannylaryl reagent, such as an active ester of...
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5741661 |
Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are...
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5738838 |
IKVAV peptide radiopharmaceutical applications
Peptides useful for lung imaging, and preferably containing a biological-function domain which includes the sequence Ile-Lys-Val-Ala-Val (IKVAV) (SEQ. ID NO. 1) and a medically useful metal...
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5733528 |
Paramagnetic chelates for nuclear magnetic resonance diagnosis
New compounds endowed with a chelating property for paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging...
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5729821 |
Concentration of perrhenate and pertechnetate solutions
A method of preparing a concentrated solution of a carrier-free radioisotope which includes the steps of: a. providing a generator column loaded with a composition containing a parent...
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5723104 |
Monocyclic functional dyes for contrast enhancement in optical imaging
This invention provides functional dyes of the general formula: ##STR1## wherein R 1 , R 2 , and R 5 may be the same or different and are selected from the group consisting of hydrogen, C 1 -C 10...
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5723102 |
Process for the preparation of an organ-specific substance labeled with technetium-99m
The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ-specific substance, or an organ-specific substance which has...
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5720935 |
Rapid synthesis of radiolabeled pyrimidine nucleosides or nucleotides from stannyl precursors
A method of making a radiolabeled pyrimidine nucleoside or nucleotide is described. In the method, a stannylated pyrimidine nucleoside or nucleotide is contacted in an aqueous solution with a...
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5716595 |
Intraperative, intravascular and endoscopic tumor and lesion detection and therapy with monovalent antibody fragments
Methods are provided for close-range intraoperative, endoscopic and intravascular detection and treatment of lesions, including tumors and non-malignant lesions. The methods use agents labeled with...
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5714149 |
Crosslinked antibodies and processes for their preparation
Cross-linked antibody conjugates are described which have at least one interchain bridge containing a reporter or effector molecule. The bridge may be the residue of a homo-or heterofunctional...
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5711931 |
Technetium-99m labelled peptides for imaging inflammation
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to technetium-99m (Tc-99m) labeled leukocyte-binding peptides, methods...
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5705143 |
Biological targeting agents
A conjugate comprises a linear or cyclic synthetic peptide of 3-50 amino acids linked via one of its carboxyl groups and optionally via a linking group, to a polydentate metal chelating group, with...
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5702681 |
Method for detecting flukicidal activity
This invention relates to a method for detecting the flukicidal activity of a compound or compounds comprising feeding a portion of liver tissue of an animal treated with the compound or compounds...
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5700444 |
Chemotactic peptide pharmaceutical applications
High affinity chemotactic peptides containing a biological-function domain which includes at least two linked N-formyl-Met-Leu-Phe sequences and a medically useful metal ion-binding domain are...
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5698583 |
Oligoelements and phospholipase A2 immuno-enhancer compositions, preparation thereof, and use thereof
An immuno-enhancer composition of at least one oligoelement selected from the group consisting of sodium selenite, magnesium chloride, manganese chloride, zinc chloride, cobalt, cerium, molybdenum,...
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5690905 |
Peptide-metal ion pharmaceutical labeling method
Peptides containing a biological-function domain and a medically useful metal ion-binding domain are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of...
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5686058 |
Radiolabelled nucleotide formulations stored in an unfrozen state
Additives are proposed for compositions comprising radiolabelled organic compounds e.g. 32P-labelled nucleotides. Stabilizers are selected from tryptophan, para-aminobenzoate, indoleacetate and the...
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5679318 |
Stable therapeutic radionuclide compositions and methods for preparation thereof
Stable therapeutic radionuclide compositions comprising, for example, 186 Re, 188 Re and 131 I stably bound to a proteinaceous targeting moiety and suitable for human in vivo administration...
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5670132 |
Modified radioantibody fragments for reduced renal uptake
PEG-modified-Tc-99m-radiolabeled antibody fragments are useful for radioimmunodetection of tumors and infectious lesions and display striking reductions in renal uptake and retention of...
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5667762 |
Method for preventing adhesion of thallium 201 to container
There is disclosed an agent for preventing the adhesion of thallium 201 to a container which comprises a reducing substance as an active ingredient. There is also disclosed a radioactive diagnostic...
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5665328 |
Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles
Compounds, compositions, their methods of preparation and use in binding bio-affecting substances to the surface membrane of bioparticles, such as enkaryotic cells, without producing appreciable...
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5662882 |
Radiopharmaceutical formulations having non-stannous reductants
The present invention relates to novel radiopharmaceutical imaging agents having non-stannous reductants. The present invention further relates to kits for forming radiopharmaceutical imaging...
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5660992 |
Sialic acid/fucose based assay reagents and assay methods
Compounds that are synthetically inexpensive to make relative to the naturally occurring selectin ligands and that retain selectin binding activity are described that have a three-dimensionally...
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5656253 |
Ligands useful in radiographic imaging
The present invention relates particularly to novel pyridine based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for...
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5645815 |
Radiolabled compounds for thrombus imaging
This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including...
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5639439 |
Gallium dimercaptosuccinate as a novel tumor imaging agent
Novel tumor imaging agents in which the dimercaptosuccinic acid was dissolved in phosphate buffer and labelled with radioisotope gallium. The product of gallium dimercaptosuccinate has been...
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5630786 |
Boron neutron capture enhancement of fast neutron therapy
Fast neutron therapy is significantly enhanced by irradiating target cells, either in vitro or in vivo, with fast neutrons in the presence of a boron neutron capture agent having a plurality, and...
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5628979 |
Reagent for tumor imaging and therapy
Novel oligopeptides are disclosed for in vivo tumor imaging and therapy. The novel oligopeptides are oligopeptides containing from 4 to 50 peptide units containing as a characteristic triplet...
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5609847 |
Treatment methods using metal-binding targeted polypeptide constructs
The invention relates to a method of treating a patient in need thereof, including a need for diagnosis or treatment, comprising the administration of a metal complex of a polypeptide construct....
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5603915 |
Process for manufacturing homeopathic medicines
A homeopathic medicine comprises a homeopathic carrier solution which is prepared by mixing a base solution of alcohol and water in the ratio of 1 part alcohol to 9 parts water, and subsequently...
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5580541 |
Method of conveying liquid materials and device for the automated elution of a radionuclidic generator
The invention relates to a method of conveying liquid materials in closed systems without mutual contamination, comprising flushing the conduit with an inert gas between introduction of the...
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5573747 |
Method for preparing a physiological isotonic pet radiopharmaceutical of .sup.62 Cu
A method of preparing a radiopharmaceutical in a form suitable for intravenous bolus injection is disclosed. The method comprises eluting 62 Cu from from an anion exchange column loaded with 62 ...
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5573750 |
Diagnostic imaging x-ray contrast agents
This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent...
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5571797 |
Method of inducing gene expression by ionizing radiation
The present invention provides a method for delivering ionizing radiation to specific tissues, resulting in the activation of a DNA molecule comprising a radiation responsive enhancer-promoter...
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5532122 |
Quantitation of gamma and x-ray emitting isotopes
For isotopes decaying by capture of an inner shell electron by the nucleus, coincident emission of X-ray and gamma photons may occur. The X-ray results from the drop of an outer shell electron to...
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5531978 |
Aminopolycarboxylic acids and derivatives thereof
There are provided chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and...
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5524622 |
Non-invasive method of determining inflammation of the gastrointestinal tract
A non-invasive method of determining the presence of inflammation in a region of the gastrointestinal tract of an organism comprises introducing an arterial dilating agent into the circulatory...
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5516881 |
Aminoxyl-containing radical spin labeling in polymers and copolymers
Aminoxyl-containing radical is provided in polymers and copolymers by replacing a hydroxyl moiety in a carboxyl group at a chain end of a starting material biodegradable polymer or copolymer with...
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