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7632683 |
Method, apparatus, reagent kit and reagent for distinguishing erythrocytes in a biological specimen
A method for distinguishing erythrocytes in a biological specimen, includes preparing a sample liquid so as to cause damage to a cell membrane of yeast-like fungi without hemolyzing erythrocytes in...
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7632653 |
Membrane-based assay devices that utilize time-resolved fluorescence
A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes time-resolved fluorescence to detect the signals...
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7628958 |
Reaction detecting device
An object is to provide a reaction detecting device in which a height dimension of the device itself can be set to be small to realize space saving, unevenness of measurement sensitivity for each...
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7618792 |
Multiplexed detection of anti-red cell alloantibodies
Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events...
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7618587 |
Analyzers and methods of analyzing blood
Analyzers and methods of analysis are described for performing blood cell counting and immunoassay on a whole blood specimen in one measurement section. An assay sample is prepared by blending...
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7615369 |
Reconfigurable protein patterning using electrowetting microelectrodes
A protein patterning electrode device consisting of capacitor microelectrode arrays coated with a protein non-adherent layer is provided. Operation of the electrode is based on a phenomenon called...
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7615762 |
Method and apparatus for low quantity detection of bioparticles in small sample volumes
A novel apparatus and method is described for detection of very small quantities (a few hundred molecules) of bioparticles in nanoliter/picoliter quantities of a sample. The apparatus involves a...
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7615190 |
Microdevice and method for detecting a characteristic of a fluid
A microdevice for supporting a flowing fluid is disclosed. In one embodiment, the microdevice includes a substrate and a pair of generally parallel, spaced wall members on the substrate. At least...
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7615377 |
Fluorescein-based metal sensors
The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same.
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7608465 |
Multi-analyte diagnostic test for thyroid disorders
Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and...
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7604981 |
Excitable target marker detection
A variety of types of molecules are detected and/or analyzed using an integrated micro-circuit arrangement. According to an example embodiment of the present invention, a micro-circuit arrangement...
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7598093 |
Nanoparticle and microparticle based detection of cellular products
Embodiments of the present invention relate to devices and methods for detecting cellular products using detection particles having product-specific detection reagents and having a characteristic...
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7599060 |
Optical scanning configurations, systems, and methods involving at least one actuator for scanning a scan head
An optical system includes a sample substrate having a surface, the surface defining a 2-dimensional sample plane. The system includes an excitation source configured to provide excitation light to...
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7598087 |
Protein imprinted polymers with integrated emission sites
This invention provides protein or polypeptide imprinted polymers with integrated emission sites (PIPIES) for detecting the presence of a protein or polypeptide analyte comprising templated sites...
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7595197 |
Automated sample analysis
Samples of materials used in industrial processes are analyzed to determine the concentration of certain materials of interest. The quantitative analysis of samples for these materials is provided...
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7591979 |
Enhanced monitor system for water protection
An automatic, self-contained device for detecting toxic agents in a water supply includes an analyzer for detecting at least one toxic agent in a water sample, introducing means for introducing a...
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7592184 |
Ammonia detection and measurement device
There is disclosed an apparatus and method for detecting and measuring volatile acidic or basic components including ammonia, ammonium, or volatile amines (compound) in a gas or liquid state fluid....
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7585466 |
Automatic genotype determination
Genotypes of a subject may be determined by analyzing a biological sample. Measurements of the intensity of allele specific signals may be obtained and used to generate reaction values. These...
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7582482 |
Continuous ion species removal device and method
Apparatus and method for treating a liquid sample stream including at least one analyte ion species and matrix ion species of opposite charge to said one analyte ion species. The liquid sample...
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7582473 |
Apparatus and method for analyzing bacteria
An apparatus for analyzing bacteria is described that includes an analyte sample preparing section for preparing an analyte sample from a specimen; a detector for detecting optical information from...
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7569395 |
Method and apparatus for measuring oxygen concentration
An apparatus and non-invasive method of measuring oxygen by exciting a luminescent compound disposed in a container and then measuring the intensity of the light emitted by the excited luminescent...
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7569188 |
Surface plasmon amplification by stimulated emission of radiation (SPASER)
A nanostructure is used to generate a highly localized nanoscale optical field. The field is excited using surface plasmon amplification by stimulated emission of radiation (SPASER). The SPASER...
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7566569 |
Method for measuring surface temperature
The present invention relates to a method for measuring a surface temperature using is a fluorescent temperature sensor or optical thermometer. The sensor includes a solution of...
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7564045 |
Optical assay system
An optical reader for an optical assay arrangement including a polymeric sample substrate having a reaction-site surface provided with protruding microstructures and at least one reaction-site...
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7556773 |
Analyzer device and method
An analyzer for oxidizing and measuring samples containing some liquid comprising: a reactor vessel; a sample pump; a base pump connected to a base reservoir; an ozone generator adapted to create...
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7556772 |
Liquid analyser
A liquid analyser has a reactor portion and an associated measurement portion. A sample pump is operable to deliver a liquid sample to a reactor vessel. A base pump supplys a base solution to the...
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7553453 |
Assay implementation in a microfluidic format
An assay implementation in a microfluidic format in a cartridge relating to a point-of-care instrument platform for monitoring and diagnosing infectious diseases (e.g., AIDS and malaria). The...
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7553448 |
Electrochemiluminescence flow cell and flow cell components
An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium,...
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7550267 |
Microscale diffusion immunoassay utilizing multivalent reactants
An improved microscale diffusion immunoassay utilizing multivalent reactants is disclosed. In particular, a method for detecting the presence of analyte particles in an analyte fluid is disclosed,...
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7537934 |
Chemiluminescence sensor array
Embodiments of the invention relate to integrated chemiluminescence devices and methods for monitoring molecular binding utilizing these devices and methods. These devices and methods can be used,...
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7537732 |
Method and apparatus for assaying wood pulp fibers
Paper pulp is added to a stain solution. The stain solution and pulp fibers are mixed to form a slurry. Samples are removed from the slurry and are admixed with dilution water and a bleach. Then,...
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7534576 |
Method and a device for the evaluation of biopolymer fitness
A Method for identifying one or a small number of molecules, especially in a dilution of ≦1 μM, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules...
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7531349 |
Standoff bioagent-detection apparatus and method using multi-wavelength differential laser-induced fluorescence
A standoff bioagent-detection apparatus and method use a direct ultraviolet source to detect bioagents. In some embodiments, a standoff bioagent-detection apparatus and method use laser-induced...
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7531363 |
Particle detection using fluorescence
Detection systems and methods for capturing and analyzing particles within a particle sample are provided. The detection system may include, for example, a particle concentrator that can be used to...
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7521179 |
Thermo-optical analysis system for biological reactions
The invention relates to a reaction device, comprising a sample chamber matrix ( 1 ), comprising at least two reaction chambers ( 2 ) whose walls are permeable with respect to electromagnetic...
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7517660 |
Optoelectronic sensor
A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where...
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7517695 |
Local flow and shear stress sensor based on molecular rotors
A method for detecting local shear stress values using molecular rotors that allows for an extremely sensitive determination of a shear stress field or a flow field, even at very low flow rates. In...
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7507582 |
Method and device for multicolour 2-photon fluorescence coincidence analysis
A method of fluorescence measurement on analytes, marked with different fluorescent markers, which have spectrally different fluorescence emissions, in a sample is described, having the following...
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7507548 |
Multidimensional detection of aberrant phenotypes in neoplastic cells to be used to monitor minimal disease levels using flow cytometry measurements
A method for detecting aberrant phenotypes expressed by neoplastic cells includes the steps of: 1) staining one or more normal/reactive samples and one neoplastic sample with multiple combinations...
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7504072 |
Biopolymeric array scanning devices that focus on the far side of an array and methods for using the same
Array scanning methods that focus on the far side and devices configured for use in the same are provided. In reading arrays according to the subject methods, an array is placed in a reading...
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7501285 |
Detection and classification of heavy hydrocarbon contamination in refinery process streams via spectrofluorometry
A method and apparatus for determining the presence of heavy hydrocarbons (including those from unprocessed crude oil) in distillate streams and/or reformer feed includes taking at least one...
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7497993 |
Fluorescent temperature sensor
The present invention is a fluorescent temperature sensor or optical thermometer. The sensor includes a solution of 1,3-bis(1-pyrenyl)propane within a 1-butyl-1-1-methylpyrrolidinium...
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7498164 |
Instrument for monitoring nucleic acid sequence amplification reaction
An instrument is provided that can monitor nucleic acid sequence amplifications reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter...
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7494770 |
Mesoscale polynucleotide amplification analysis
Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide polymerization reaction. The devices comprise a substrate microfabricated to define a...
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7491544 |
Chiral piperidine and quinucledine ligands
Zn(II) is selectively detected in a sample by contacting the sample with a tripodal ligand with a piperidine or quinuclidine scaffold, one of which acts as a zinc sensor, in which the rigidity of...
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7482167 |
Microbead-based test methods for fluorescence imaging systems
The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.
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7476544 |
Method of judging homogenization/reaction completion and method of measuring solution concentration using the same
It is intended to provide a method for determining homogenization and/or reaction completion, capable of making the measurement time necessary and sufficient and enhancing the measurement speed,...
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7473396 |
Device for containing, reacting and measuring, and method of containing, reacting and measuring
The invention relates to a device for containing, reacting and measuring, and a method of containing, reacting and measuring, and provides a device for containing, reacting and measuring, and a...
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7462325 |
Luminescent polymer particles
This invention involves a series of articles, dispersions, compositions, methods, and kits. Several aspects of the invention involve dispersed particles made from polymers having a delocalized...
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7456026 |
Imaging fluorescence correlation spectroscopy for analysis of molecular interactions in low volumes
An arrangement for the detection of fluorescent light with at least one imaging microscope unit and at least one device component for analyzing molecular interactions in small volumes, wherein...
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