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7310147 |
Robotic apparatus for picking of cells and other applications with integrated spectroscopic capability
A robotic apparatus of the kind having a sample manipulation head with associated positioning system mounted above the main bed of the apparatus, as used for picking of cells, in particular animal...
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7300800 |
Analyte detection system
An analyte detection system utilizing a combination of fluorescent labels for labeling particles and an analyte specific fluorescent analyte detection dye. The particles contain a combination of...
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7288227 |
Biochip reader with enhanced illumination and bioarray positioning apparatus
A method of illumination and illumination apparatus are provided in a biochip reader. Illumination is provided by a non-collimated laser source or a light emitting diode (LED). The light is...
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7286224 |
Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems
An apparatus images a surface. An imager stage linearly translates the surface in a first direction. A light path has a first end defining an input aperture perpendicular to the first direction and...
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7279339 |
Reagent for an immunoassay
The present invention relates to (1) A reagent for an immunoassay of a target substance existing in a free form and a bound form in a specimen, comprising a latex 1 which is immobilized with a...
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7279323 |
Method for conducting receptor-ligand association reaction and reactor used therefor
A method for conducting a receptor-ligand association reaction includes the steps of dipping a biochemical analysis unit including a substrate formed with a plurality of absorptive regions which...
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7276368 |
Enhanced waveguide and method
The present invention provides an optical assay apparatus that includes a light source module and an optical sensor. The light source module produces light having a range of propagation angles. The...
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7271249 |
Biosensors, method for obtaining the same and uses thereof
The invention relates to biosensors, methods for obtaining them and their use fro detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a...
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7270970 |
Point of care diagnostic systems
Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and...
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7264972 |
Method and apparatus for sorting biological cells with a MEMS device
A micromechanical actuator for sorting hematopoietic stem cells for use in cancer therapies. The actuator operates by diverting cells into one of a number of possible pathways fabricated in the...
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7264971 |
Read-head for optical diagnostic device
A readhead for a photometric diagnostic instrument includes a housing adapted for incorporation within the photometric diagnostic instrument, and an elongated sample table operatively engaged with...
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7258990 |
Alleviation of non-specific binding in microarray assays
A post-incubation treatment is employed to effectively remove targets, such as proteins/protein complexes, or other label-bearing moieties that may non-specifically bind to a microarray substrate...
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7256892 |
Measuring instrument and fluorometric method
A measuring instrument that comprises a light source unit 1 capable of emitting light having different wavelengths, a light receiving unit 2 that outputs an electrical signal corresponding to...
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7250304 |
Functional assay of high-density lipoprotein
This invention provides novel assays that are prognostic and/or diagnostic for atherosclerosis or risk of atherosclerosis. It was discovered that high density lipoprotein (HDL) or components...
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7248359 |
Combining multi-spectral light from spatially separated sources
Systems and methods for biological sample detection by combining and directing light with an optical blender that provides a composite beam from spatially and spectrally distinct non-parallel light...
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7247489 |
Ion-detecting microspheres and methods of use thereof
This invention provides methods of using ion-detecting microspheres containing an ionphore and a chromoionphore in clinical laboratory instrumentation such as flow cytometry for sample analysis. In...
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7244622 |
Device and method for multiple analyte detection
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention...
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7241381 |
Method and apparatus for detecting chemical binding
The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit...
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7235406 |
Nucleic acid analysis device
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention...
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7232691 |
Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres
The present invention is directed to processes of separating, analyzing and/or collecting selected species within a target sample by use of magnetic microspheres including magnetic particles, the...
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7232687 |
Multiple sorter monitor and control subsystem for flow cytometer
An optical illumination and monitoring subsystem controls the operation of a flow cytometer having a carrier fluid that flows along a channel coupled to a droplet generator, which controls a point...
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7229838 |
MEMS actuator and method of manufacture for MEMS particle sorting device
A micromechanical particle sorting chip uses an actuator divided into two parts to direct a component of interest into one of a plurality of possible exit paths, based on detection of a fluorescent...
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7229837 |
Enhanced photophysics of conjugated polymers
A particulate fluorescent conjugated polymer surfactant complex and method of making and using same. The particles are between about 15 and about 50 nm and when formed from a lipsome surfactant...
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7229835 |
Amine detection method and materials
A compound linked to a solid support (R) through a divalent linker moiety (X) and which is represented by the following formula:
is disclosed. In particular, the...
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7226563 |
Ion-detecting sensors comprising plasticizer-free copolymers
Plasticizer-free ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers...
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7224826 |
Fluorescent intensity measuring method and apparatus
A fluorescent image is obtained by emitting the light with a wavelength which excites a labelling fluorescent substance, a mask is created by a foreign matter area image extracted from an image of...
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7223604 |
Methods and kits for the detection of erythrocytes
Methods and kits useful in the detection of occult blood in biological samples and specimens, for example to screen for colorectal cancer or detect blood in samples ex vivo, e.g., at a crime scene....
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7223367 |
Chemical sensor arrangement
The present invention relates to a chemical sensor arrangement having an analyte sensitive indicator wherein the analyte sensitive indicator has at least one nanoparticle. The invention further...
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7221455 |
Integrated, fluorescence-detecting microanalytical system
The present invention relates to a functionally integrated microanalytical system for performing fluorescence spectroscopy. A source of fluorescence-exciting radiation, typically a LED, is...
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7220594 |
Method and apparatus for sorting particles with a MEMS device
A micromechanical particle sorting chip uses laser light directed through at least one of a reflective and refractive surface to come to a focus in an optically transparent layer. The laser light...
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7217393 |
Apparatus and method for process monitoring
An apparatus is provided for testing fluid samples includes a sensor, which can be light source, directed to a flow cell and a photo sensor for detecting a light beam reflected from the flow cell....
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7214543 |
Method and apparatus for sensing nitroaromatics
The subject invention pertains to a method and apparatus for sensing nitroaromatics. The subject invention can utilize luminescent, for example fluorescent and/or electroluminescent, aryl...
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7214538 |
Device and method for the determination of lithium ion concentration in a biological fluid
The present invention relates to a novel device and method for the detection of lithium ions in a biological fluid. In a preferred embodiment, the present invention provides a novel compound and a...
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7214346 |
Optoelectronic detection system
The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir...
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7211443 |
Device and method for multiple analyte detection
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention...
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7208286 |
Bioluminescent bioreporter integrated circuit devices and methods for detecting ammonia
Monolithic bioelectronic devices for the detection of ammonia includes a microorganism that metabolizes ammonia and which harbors a lux gene fused with a heterologous promoter gene stably...
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7208122 |
Emissive polymers and devices incorporating these polymers
The present invention relates to a class of luminescent and conductive polymer compositions having chromophores, and particularly solid films of these compositions exhibiting increased luminescent...
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7208121 |
Plasticizer-free-ion-detective sensors
A plasticizer-free ion detective sensor for detecting a target ion in a sample is provided. The sensor comprises a copolymer of methacrylate monomers with pendant alkyl groups of different length,...
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7201879 |
Aerosol into liquid collector for depositing particles from a large volume of gas into a small volume of liquid
An aerosol-into-liquid collector (ALC) for collecting gas-borne particles from a large volume of gas such as air into a small volume of liquid is described. The ALC uses a linear quadrupole to...
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7201878 |
Aerosol particle analyzer for measuring an analyte in airborne particles
Aerosol particle analyzer (APA) for measuring an analyte in airborne particle is described. Airborne particles are first given an electrical charge and then drawn in air past an oppositely charged...
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7201876 |
Ion-detecting sensors comprising plasticizer-free copolymers
Ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers having pendent...
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7198939 |
Apparatus for interrogating an addressable array
A method and apparatus of interrogating an addressable array unit, which includes a substrate, a light reflecting layer on a front side of the substrate, and a plurality of features on a front side...
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7198756 |
Non-invasive measurement of pH
There is a need within the medical community for non-invasive instruments to measure critical physiologic parameters at the point of care. Such a technique may be applicable to a wide variety of...
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7192777 |
Apparatus and method for process monitoring
An apparatus is provided for testing fluid samples includes a sensor, which can be light source, directed to a flow cell and a photo sensor for detecting a light beam reflected from the flow cell....
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7189573 |
Apparatus and method for process monitoring
An apparatus is provided for testing fluid samples includes a sensor, which can be light source, directed to a flow cell and a photo sensor for detecting a light beam reflected from the flow cell....
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7189366 |
Molecular tag reader
Near infrared molecular assays can be used to detect small quantities of a molecule of interest in vivo or in vitro using laser dyes. A hand-held portable device is provided which can rapidly read...
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7189361 |
Analytical device with lightguide Illumination of capillary and microgrooves arrays
An analytical cell including a lightguide with a plurality of conduits filled with a migration medium. The medium, the lightguide and a surrounding medium have refractive indices selected such that...
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7189354 |
Optically and fluidically enhanced in vitro diagnostic test chamber
An enclosed chamber is used in a system for screening of a liquid specimen through binding assays. The enclosed chamber includes an inlet, an outlet, and a plurality of discrete reactant containing...
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7183103 |
Instrument for monitoring polymerase chain reaction of DNA
An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of...
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7179654 |
Biochemical assay with programmable array detection
A biochemical sensor apparatus having an optical radiation source, a sensor array, and a photodetector array is disclosed. Each sensor of the sensor array includes fluorophores for fluorescence...
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