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5656501 |
Flow cell device for monitoring blood or other cell suspension under flow
A flow cell for monitoring blood or any other cell suspension under flow prises a rigid transparent base having a pair of holes with inlets and outlets. One hole transfers the cell suspension from...
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5652149 |
Mixing apparatus & method for an optical agglutination assay device
An assay device for detecting the presence of analytes in an unknown sample includes a reaction system wherein resilient storage reservoirs containing reagents are fluidly connected to a track...
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5646046 |
Method and instrument for automatically performing analysis relating to thrombosis and hemostasis
This invention relates to a novel, fully automated spectrophotometric analyzer and method used for testing blood samples in the clinical laboratory for thrombosis and hemostasis properties. The...
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5628961 |
Apparatus for assaying viscosity changes in fluid samples and method of conducting same
The present invention relates to an apparatus for conducting a variety of assays that are responsive to a change in the viscosity of a sample fluid and relates to methods of conducting such assays....
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5628963 |
Apparatus for quanitative evaluation of agglutination reactions
In the method for quantitative evaluation of agglutination reactions between a reagent and a biological fluid to be examined, the reagent and the biological fluid are intimately mixed by a...
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5629209 |
Method and apparatus for detecting viscosity changes in fluids
An apparatus for detecting changes in the viscosity of a fluid comprises a cartridge having a fluid receiving/dispensing reservoir, one or more fluid-receiving chambers, and a conduit that permits...
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5610027 |
Microphoto lysis-anlaysis process to measure cell characteristics
A method of determining cell membrane strength is disclosed, using focused light of selected frequency and energy density. The method is also useful in diagnosing the presence of certain diseases...
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5607830 |
Method for the continuous conditioning of a cell suspension
A method for the continuous conditioning of a cell suspension, more particularly whole blood, in order to obtain an erythrocyte concentrate which is returned to the patient by autotransfusion. In...
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5601995 |
Apparatus and method for detecting coagulation in blood samples
The method and apparatus are useful for determining a propensity of a blood sample to change from a liquid state to a coagulated state and additionally for measuring the propensity of a coagulated...
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5599718 |
Measurement of the thrombolytic activity of blood
An in vitro method of monitoring thrombolysis of an occlusive thrombus formed under conditions which simulate in vivo is described. Thrombus is formed in a capillary tube by causing blood to flow...
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5591403 |
Portable prothrombin time test apparatus and associated method of performing a prothrombin time test
A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the...
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5589394 |
Cell suspension preparation apparatus and method
Embodiments described herein provide apparatuses and methods for preparing fluid. In one method, a heater thermally associated with a housing for receiving fluid is operated to apply thermal energy...
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5578269 |
Automated blood analysis system with an integral centrifuge
A blood analysis system or instrument, generally, including an incubator station, a sample and reagent holding station, a pipette assembly, a centrifuge, an analysis station, and a transport...
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5575977 |
Apparatus for sedimentation based blood analysis
An apparatus and process for accurately determining settling data for the settling of erythrocyte cells from a plasma fluid in a test specimen of blood. The apparatus includes a settling tube, a...
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5567869 |
Method and apparatus for quantitation of relevant blood parameters
A method for quantitation of blood parameters comprises the steps: provision of a sample of plasma, serum or blood, entering the sample into a cuvette with an internal dimension less than 1 mm,...
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5558834 |
Device and method of seperating and assaying whole blood
An improved device and method of separating the cellular components of whole blood from plasma or serum and assaying the plasma or serum for a predetermined soluble constituent are disclosed. The...
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5534226 |
Portable test apparatus and associated method of performing a blood coagulation test
A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the...
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5527714 |
Process for determining concentration of an analyte in a sample by antigen/antibody mediated particle agglutination in the presence of insoluble contaminats
Particle size distributions with greatly improved accuracy are prepared for diagnostic analysis using antigen/antibody reactions to concentrate sensitized insoluble carriers into non-aggregated and...
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5526111 |
Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control
A method for calculating a coagulation characteristic of a sample of blood, a blood fraction, or a control comprises generating an output signal indicative of coagulation of the sample, sampling...
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5523238 |
Method and apparatus for determining platelet function in primary hemostasis
A method for determining a platelet function in a primary hemostasis is provided in which a blood sample or a platelet containing fraction thereof is introduced into a vessel having a flat bottom...
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5512432 |
Method detecting antigens and/or antibodies
A suspension of inert particles is prepared in an aqueous solution, to which an antibody or an antigen and a carrier-bound antigen or antibody, respectively, are added in any desired order. After...
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5502651 |
Potentiophotometric fibrinogen determination
An apparatus and a method are disclosed for measuring the concentration of fibrinogen that contributes to the clotting of blood. The apparatus utilizes a potentiophotometer that provides an output...
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5501982 |
Method of using a disposable reagent pack
Methods of using a disposable reagent pack with an analytical instrument to analyze a blood sample are provided. According to one embodiment, a disposable reagent pack comprising a sample well, a...
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5500187 |
Disposable optical agglutination assay device and method for use
An assay device for detecting the presence of analytes in an unknown sample including a reaction system wherein storage reservoirs containing reagent are fluidly connected to a track containing the...
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5491095 |
System and method for aggulutination detection
A system and method of determining absence or presence of an illicit substance in a flowing mixture of requisite reagents by agglutination or lack thereof. A plurality of photodetectors are...
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5491067 |
Agglutination reaction and separation vessel
A vessel for conducting blood cell agglutination assays is disclosed. A barrier retains reactants in an upper chamber during incubation, then, in response to a force, permits reagents to enter a...
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5486335 |
Analysis based on flow restriction
Disclosed are devices and methods for detecting the presence of a preselected analyte in a fluid sample. The invention provides a device comprising a solid substrate, typically on the order of a...
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5470534 |
Analytical system useful in diagnosis of the condition of a disease
In a first measurement stage, reaction solutions of samples are optically measured by a biochemical analyzer, and the measurement result of the analysis item which is an index of the disease status...
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5464776 |
Method for preparing a dual pathway clotting enhancer for blood collection tube
A blood collection assembly includes a container, optionally covered by a puncturable septum and evacuated. A clotting enhancer in the container activates both the intrinsic and extrinsic...
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5464752 |
Automated analyzer for screening cells or formed bodies for enumeration of populations expressing selected characteristics
A method and apparatus for automatically and rapidly, retrieving, counting and/or analyzing at least one selected white blood cell population and/or subset thereof of a whole blood sample or...
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5456885 |
Fluid collection, separation and dispensing tube
A tube for collection, separation and dispensation of a two-phase fluid is provided with a elongated rigid tubular container having a fluid entry end a closable end and a float. The float retained...
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5455009 |
Blood collection assembly including clot-accelerating plastic insert
A blood collection assembly includes a tube, which may be glass or plastic, and a plastic insert therein. The insert has been plasma-treated to change the surface chemistry and render it clot...
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5451525 |
Method and materials for determining particle count in a flow cytometer
A method is provided to ascertain the total number of cells per unit volume of a cell specimen in an apparatus which does not measure the volume of a suspension containing the specimen as it is...
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5449622 |
Method and apparatus for analyzing stained particles
In a stained particle analyzing method and apparatus for staining a test sample containing suspended particles, shooting an image of the stained sample, and classifying the particles and computing...
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5443959 |
Method of assaying fibrinogen, dry reagent therefor, and process for the preparation thereof
A dry reagent consisting essentially of (a) a protein having thrombin activity, (b) at least one additive selected from the group consisting of amino acid, a salt thereof and saccharide and...
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5441892 |
Blood clot mass measuring technique
A clot mass condition of blood is evaluated by initially forming the clot in the sample of the blood and thereafter allowing the clot to condense. The initial formation of the clot is determined by...
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5432084 |
Device for in vitro bleeding time determination
A low cost, disposable device for in vitro determination of bleeding time is detachably connectable to the end of a syringe. The device includes a hollow body having inlet and outlet ports and a...
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5427959 |
Apparatus and method for measuring specimen
On a slab-like board formed of a transparent material is closely attached a wedge-shaped transparent cover member provided with a recess in a central inner portion, thereby to form a clearance. The...
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5426054 |
Process and apparatus for determining an optimal energy insertion in coagulating systems
A determination of optimal energy insertion, or input, results from a measurement of opacity at various heights in a fluid coagulating system and at the same time from measuring a deviation width...
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5391352 |
Blood analysis apparatus
A system for analyzing a sample of fluid for a plurality of characteristics comprising a cuvette with a plurality of chambers for fluid to be analyzed; a housing assembly having a frame and a...
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5389555 |
Particle pattern judging method
Particle pattern judging method in which a particle pattern formed on the bottom surface of a reaction vessel by an immunological agglutinated reaction is measured in an optical manner; a variation...
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5380490 |
Apparatus for measuring a test specimen
An apparatus is so constructed as to measure a specific substance in a test specimen by the degree of the aggregation of carrier particles in a reaction solution in which the test specimen is mixed...
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5378431 |
Dual pathway clotting enhancer for blood collection tube
A blood collection assembly includes a container, optionally covered by a puncturable septum and evacuated. A clotting enhancer in the container activates both the intrinsic and extrinsic...
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5374396 |
Syringe injection system for measuring non-volatile residue in solvents
The concentration of non-volatile residue in a test solvent is determined by generating multiple liquid droplets from a liquid stream including the solvent and ultrapure water. The droplets are...
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5369033 |
Supercritical fluid contamination monitor
A system for monitoring changes in the amount of contaminants present in a flowing stream of supercritical fluid. A sample stream is removed from a flowing stream of supercritical fluid and...
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5369037 |
Simultaneous multiple assays
A particle agglutination-based, stable kinetic method for simultaneously determining the concentrations of multiple analytes in a single fluid sample with the addition of a single reagent, that...
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5362653 |
Examination of objects of macromolecular size
In a method and apparatus for examining samples comprising individual objects (28) of macromolecular or similar size, or smaller, an instrument element (14) comprises a substrate (16) overlaid with...
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5352413 |
Device for the safe removal of blood from a supply vessel
The invention pertains to a device for the safe removal of blood from a supply vessel with an aperture holder in which a part having an aperture is held and to which a capillary is attached,...
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5350676 |
Method for performing fibrinogen assays using dry chemical reagents containing magnetic particles
An apparatus and a method for performing a fibrinogen assay are disclosed. The reaction slide bears a sample well for receiving a liquid sample and a reaction chamber in fluid communication with...
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5326535 |
Tube having unitary blood coagulation activator and method for its preparation
A blood collection container is coated on its inside wall with a unitarily immobilized clotting activator. The activator may be applied to the surface by an adhesive or by rendering the inside wall...
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