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6908737 |
Systems and methods of conducting multiplexed experiments
A method for multiplexed detection and quantification of analytes by reacting them with probe molecules attached to specific and identifiable carriers. These carriers can be of different size,...
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6908594 |
Efficient microfluidic sealing
Improved sealing for microstructures in microfluidic devices having a plurality of units is provided by providing collars surrounding the openings to the microstructures, such as reservoirs. The...
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6905654 |
Method and apparatus for reducing static charges during polymerization of olefin polymers
The present invention relates to a method and apparatus for controlling static charges in a fluidized bed olefin polymerization reactor. Static charges which develop in the polymer products are...
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6905655 |
Modification of selectivity for sensing for nanostructure device arrays
An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are...
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6907354 |
Synthetic gas reactor system with gas or liquid injection
A synthetic gas generator and gas reactor test system. The system is configurable to provide a number of alternative flow paths, each with different furnace and reactor configurations. Various...
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6902704 |
Injection pump assembly for a combinatorial reactor and related method
An injection pump assembly 10 in a chemical delivery system for simultaneously delivering reagents into a combinatorial reactor system having multiple injectors. The assembly 10 has a plurality...
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6902701 |
Apparatus for sensing volatile organic chemicals in fluids
A chemical-sensing apparatus is formed from the combination of a chemical preconcentrator which sorbs and concentrates particular volatile organic chemicals (VOCs) and one or more chemiresistors...
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6902937 |
Method for the determination of low-concentration anions in the presence of an excess of another anion
This invention relates to methods and apparatus for detecting, quantifying, and/or identifying trace quantities of an anion in the presence of an excess of another anion. One apparatus comprises a...
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6899848 |
Automated sample treatment system: apparatus and method
A sample treatment system for automated extraction of compounds is disclosed. The system includes a housing defining an enclosure including a top cover having open ended chambers to receive sample...
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6900021 |
Microfluidic system and methods of use
This invention relates to a novel microfluidic device and methods of using this device to conduct in vitro studies on the reaction and effects of various compounds on cells. More particularly, it...
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6897026 |
Array imaging method
A method for imaging molecules contained in an array of discrete reaction sites on the surface of a solid support comprises:
(i) imaging the array and detecting a first molecule located on...
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6896850 |
Silicon nitride window for microsampling device and method of construction
A silicon nitride cuvette window for a microsampling device and method of construction are provided. The sample to be analyzed is drawn into the cuvette of the microsampling device. The silicon...
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6893823 |
Polynucleotide separation method and apparatus therefor
Different probes each having a specific base sequence are immobilized to each of independent areas formed on the surface of a substrate, complementary polynucleotides in a sample solution are...
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6893824 |
Gene detection system, gene detection device comprising same, detection method, and gene detecting chip
A gene detection system for detecting a target gene upon hybridization with a probe comprising a probe-immobilizing support on which a probe is immobilized, and heating and cooling means disposed...
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6893875 |
Method for assay of analyte by adjustment of chemiluminescence
A method for assay of an analyte by use of a material labeled with a chemiluminescent substance, which comprises adding a quencher and/or decreasing the specific activity of a chemiluminescent...
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6893816 |
Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
An improved microfabricated apparatus for conducting a multiplicity of individual and simultaneous binding reactions is described. The apparatus comprises a substrate on which are located discrete...
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6890757 |
Portable diagnostic system
A portable system for analysis of blood or other bodily fluids removable from a patient is disclosed. The system includes a temperature sensing device and a temperature control circuit. The...
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6890485 |
High throughput chemical handling system
A high throughput chemical handling system includes a chemical storage module, a transport module, and one or more liquid handling modules. The transport module may implement parallel chemical...
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6887362 |
Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
This invention relates to devices and methods for performing active, multi-step molecular and biological sample preparation and diagnostic analyses employing immunochemical techniques. It relates...
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6887429 |
Apparatus and method for automated medical diagnostic tests
A method and apparatus for the automation of existing medical diagnostic tests is described. This method, called sequential injection analysis, makes use of a pump, multi-position selection valve,...
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6887681 |
Apparatus and methods for chemiluminescent assays
Disclosed is a device and methods for the rapid chemiluminescence assay of surfaces to detect the presence of microbial contamination. The device and methods are suitable for use by untrained...
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6887713 |
Bioactive chip mass spectrometry
The present invention is directed to a bioactive probe or chip (BC) that allows for the isolation of analytes, such as biomolecules, followed by modification or bioreaction on these said analytes....
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6880384 |
Blood analyzer, blood sample handler, and method for handling a blood sample
A blood analyzer has a control system controlling the operation of the analyzer, a sensor measuring a parameter of a blood sample, exposure means exposing the sensor to the blood sample, reporting...
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6881381 |
Apparatus for marking and identifying liquids
A liquid can be marked for identification purposes with at least first and second miscible markers. The markers are mixed in the liquid so that the ratio of the concentration of the first marker to...
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6881317 |
Fractionation of macro-molecules using asymmetric pulsed field electrophoresis
A method and apparatus for fractionation of charged macro-molecules such as DNA is provided. DNA solution is loaded into a matrix including an array of obstacles. An alternating electric field...
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6881538 |
Array comprising diamond-like glass film
Materials for use in miniaturized arrays, the arrays, and methods of manufacturing. Materials for making arrays described include a substrate with a silicon-containing layer, optionally with...
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6881578 |
Analyte concentration determination meters and methods of using the same
Devices and methods for determining the concentration of an analyte in a physiological sample are provided. The subject devices are meters characterized by having an internal structure that...
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6878540 |
Device for lysing cells, spores, or microorganisms
A device for use with an ultrasonic transducer to lyse components of a fluid sample comprises a cartridge having a lysing chamber, an inlet port in fluid communication with the lysing chamber, and...
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6879915 |
Chemical array fabrication and use
A method of using an addressable array of biopolymers on a substrate includes receiving the addressable array and an associated machine readable identifier carried on an array substrate or array...
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6875579 |
Device for binding molecules, molecular groups, molecular parts and/or cells
The present invention relates to a device for binding molecules, molecular groups, molecular parts and/or cells contained in a liquid to target structures, the device having at least one object...
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6875403 |
Method and apparatus for reproducible sample injection on microfabricated devices
Fixed volumes of samples are metered into the reaction channel of a microfluidic device using one or more slidable blocks having at least one fixed-length sample metering channel. In another aspect...
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6872570 |
Laboratory method for tempering reaction samples
A laboratory device for jointly tempering reaction samples in at least two steps in respectively assigned, specified temperature ranges, which are carried out repeatedly and consecutively as...
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6871118 |
Method for detecting and controlling hydrate formation at any point of a pipe carrying multiphase petroleum fluids
Method intended for continuous detection and control of hydrate formation at any point of a pipe carrying multiphase petroleum fluids. The method uses a compositional code allowing to simulate the...
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6869763 |
Microarray chip and method for indexing the same
A method for indexing and coding element information of at least one biological element provided on a microarray chip thereby identifying the microarray chip. Some of the element spots arranged on...
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6867049 |
Method for obtaining increased particle concentration for optical examination
The present invention relates to a method and apparatus for analyzing a blood or other biological fluid sample in a quiescent state, whereby particulate constituents of biological samples that...
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6868309 |
Dialysis machine with symmetric multi-processing (SMP) control system and method of operation
A method and control system computing platform for a dialysis machine that uses Symmetric Multi-Processing (SMP) architecture. The SMP architecture tightly couples multiple (e.g., 2) independent...
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6867050 |
Apparatus and methods for chemical synthesis
Apparatuses and methods are described for parallel oligonucleotide synthesis of hundreds of different sequences and lengths at a time. Standard phosphoramidite chemistry is employed. The syntheses...
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6866821 |
Automatic diagnostic apparatus
Automatic diagnostic apparatus includes: a controller for controlling operation of the apparatus and for processing data; a sensing system operably connected to the controller for performing an...
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6866819 |
Sensor for detecting small concentrations of a target matter
A sensor for detecting a target matter includes a chemical sensitive layer that is operable to react when exposed to the target matter and a piezoresistive material coupled to the chemical...
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6868308 |
Operation guidance method of clinical system
An operation guidance method of clinical system which enables a doctor or nurse unskilled in testing to operate the clinical system without operation error by providing operation guidance. In the...
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6867857 |
Flow cell for optical analysis of a fluid
A flow cell for performing optical analysis of a fluid is provided. The flow cell comprises a monolithic cell housing that defines a detection chamber, fluid inlet and outlet ports and illumination...
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6864095 |
Method for making an optical fiber chemical sensor comprising a colored indicator, useful in particular for measuring nitric acid
The invention concerns the production of a chemical sensor which can be used to measure nitric acidity. This sensor is produced using a sol-gel method for depositing a porous film, containing a...
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6861265 |
Flow cytometer droplet formation system
A droplet forming flow cytometer system allows high speed processing without the need for high oscillator drive powers through the inclusion of an oscillator or piezoelectric crystal within the...
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6858184 |
Microlaboratory devices and methods
Disclosed herein are apparatuses and devices, and methods for using and making the same, for use in performing desired activities in an automated, microscale format. Microparticles are ushered...
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6858440 |
Tapered tubular optical waveguide probe for magnetic focusing immunosensors
A waveguide probe for the detection of pathogens in a sample which comprises a laser, a first and a second tubes that converge at a point to form a proximal end. A magnet is positioned in the end...
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6855293 |
Fluids manipulation device with format conversion
A fluid management apparatus includes a substrate having a first surface and a second surface opposite to the first surface. A plurality of fluid inlets, which are preferably media reservoirs, are...
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6855501 |
Transfer of arrayed chemical compositions
Nucleotide preparations are transferred from a first substrate to a second substrate. One transfer method includes forming a patterned dry particulate deposition on a first substrate; positioning...
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6852541 |
Rapid assay for testing overall oxidative stress
The invention relates to an assay for testing oxidative stress of a subject by measurement of oxidants in biological fluids such as urine, plasma, bioreactor medium and respiratory aspirants. There...
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6852287 |
Microfluidic devices having a reduced number of input and output connections
A system and method for reducing the number of input/output connections required to connect a microfluidic substrate to an external controller for controlling the substrate. In one example, a...
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6852547 |
Dynamically formed rotors for lock-in amplifier detection
A method for measuring low levels of a substance in a sample includes the formation of a rotor from paramagnetic particles in a substantially uniform magnetic field. The rotor is rotated by...
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